| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lijuan Wang, Jiaxin Wang, Jialin Wang, Zicong Guo, Zaigui Li, Ju Qiu, Lili Wan. Soluble and insoluble dietary fiber at different ratios: Hydration characteristics, rheological properties, and ameliorative effects on constipation. Food chemistry: X. vol 24. 2024-12-05. PMID:39634524. |
the contents of 5-hydroxytryptamine, acetylcholinesterase and gastrin reached the maximum value when the idf ratio was 50 %. |
2024-12-05 |
2024-12-07 |
Not clear |
| Soon Seok Kim, Sangwoo Lee, Kojo Eghan, Donggon Yoo, Hang-Suk Chun, Woo-Keun Ki. Adverse effects of diethyl phthalate and butyl benzyl phthalate on circadian rhythms and sleep patterns in zebrafish larvae. Ecotoxicology and environmental safety. vol 288. 2024-11-21. PMID:39571256. |
additionally, exposure to bbzp led to increased acetylcholinesterase (ache) and dopamine (da) levels, and a decrease in 5-hydroxytryptamine (5-ht) levels. |
2024-11-21 |
2024-11-24 |
human |
| Priyanka Agrawal, Pallavi Singh, K P Sing. Vilazodone exposure during pregnancy: Effects on embryo-fetal development, pregnancy outcomes and fetal neurotoxicity by BDNF/Bax-Bcl2/5-HT mediated mechanisms. Neurotoxicology. 2024-11-12. PMID:39532268. |
these effects were associated with developmental neurotoxicity, which manifested as decreased fetal brain size and weight, a substantial reduction in neocortical layer thickness, brain-derived neurotrophic factor (bdnf) expression, serotonin, dopamine, and norepinephrine neurotransmitter levels (5-ht, da, and ne), and increased apoptotic activity (bax and bcl-2 ratio) and acetylcholinesterase levels in the developing brain. |
2024-11-12 |
2024-11-17 |
rat |
| Noreen Samad, Aqsa Hameed, Natasha Manzoor, Sadia Shoukat, Ali Irfan, Gamal A Shazly, Arslan Khalid, Umer Ejaz, Saima Khaliq, Emilio Mateev, Yousef A Bin Jarda. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Experimental gerontology. 2024-11-03. PMID:39490558. |
d-gal-induced decreased antioxidant enzymes, and acetylcholine levels, while increased oxidative stress markers, neuro-inflammatory cytokines, serotonin metabolism, and acetylcholinesterase (ache) activity were prevented by nn administration at both doses. |
2024-11-03 |
2024-11-06 |
rat |
| Christophe Rochais, Cédric Lecoutey, Julien Lalut, Audrey Davis, Emilie Duval, Florence Gaven, Stacy Largillière, Gérald Née, Sophie Corvaisier, Jana Sopkova de Oliveira Santos, Marc Since, Thomas Freret, Romain Legrand, Noëlle Callizot, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagn. Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT European journal of medicinal chemistry. vol 280. 2024-10-25. PMID:39454222. |
synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-ht in this work, we exemplified the "copride" family of drug candidates able to both inhibit acetylcholinesterase and to activate 5-ht |
2024-10-25 |
2024-10-29 |
Not clear |
| Dhaliya Salam Abdul, Preeja Gopalakrishna Pillai, Senthilkumar Deiva Sigaman. Ethanolic extracts of Sterculia guttata: Exploring the neuroprotective effects on memory and cognitive impairment in scopolamine-induced Alzheimer's disease rats. Pakistan journal of pharmaceutical sciences. vol 37. issue 5. 2024-10-06. PMID:39369442. |
esg treatment mitigated scopolamine-induced changes in acetylcholinesterase, dopamine, serotonin, glutamate, and gaba levels, suggesting neuroprotection. |
2024-10-06 |
2024-10-09 |
rat |
| Noha N Nasr, Ali M El-Hagrassi, Yomna R Ahmed, Manal A Hame. GC/MS and LC-ESI-MS analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid-β-peptide, Tau protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl3-Induced Alzheimer's Disease in Rats. Chemistry & biodiversity. 2024-10-05. PMID:39367808. |
malondialdehyde (mda), reduced glutathione (gsh), superoxide dismutase (sod), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6), amyloid-β-peptide (aβ-peptide), tau protein, acetylcholinesterase (ache), serotonin (5-ht), dopamine (da) and nor-adrenaline (ne) levels were estimated. |
2024-10-05 |
2024-10-08 |
rat |
| Rashin Bahrami, Maryam Pourhajibagher, Nariman Nikparto, Abbas Bahado. The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review. Journal of dental sciences. vol 19. issue 4. 2024-09-30. PMID:39347022. |
apdt induces analgesia by releasing neurotransmitters such as β-endorphin, serotonin, and acetylcholinesterase. |
2024-09-30 |
2024-10-02 |
Not clear |
| Eman N Hosny, Hussein G Sawie, Mayada M El-Gizawy, Haitham S Mohammed, Abdel Razik Faraag, Yasser A Khadraw. Therapeutic Effects of Alpha Lipoic Acid and/or Caffeine-Loaded Chitosan Nanoparticles on Memory Impairment and Neurochemical Changes in High-Fat Diet-Induced Obese Rats. Physiology & behavior. 2024-09-17. PMID:39288867. |
the levels of serotonin (5-ht), dopamine (da), norepinephrine (ne), lipid peroxidation (mda), nitric oxide (no), reduced glutathione (gsh), interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), leptin (lep) and ghrelin (ghr) and the activities of monoamine oxidase (mao), acetylcholinesterase (ache) and na |
2024-09-17 |
2024-09-20 |
rat |
| Hussam A Althagaf. Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole. Metabolic brain disease. 2024-08-12. PMID:39133453. |
further, cga pre-treatment caused significant increases in acetylcholinesterase (ache) activity and brain-derived neurotrophic factor (bdnf) levels, along with marked increases in dopamine, norepinephrine, and serotonin levels. |
2024-08-12 |
2024-08-14 |
mouse |
| Benneth Ben-Azu, Pere-Ebi Y Toloyai, Adaeze Adebesin, Vivian O Ojiokor, Olusegun G Adebayo, Aliance Romain Fokoua, Goodes E Moke, Elo J Ejukolemu, Ife-Oluwa O Akpojevughe, Abdulkareem M Abdulkadir, Ephraim Okwuch. Alcohol-exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin. Alcohol (Fayetteville, N.Y.). 2024-08-02. PMID:39094850. |
sps-ethanol exacerbates dopamine, serotonin, and glutamic acid decarboxylase alterations, and monoamine oxidase-b and acetylcholinesterase hyperactivities in the striatum, pfc, and hippocampus, respectively, which were prevented by morin. |
2024-08-02 |
2024-08-06 |
mouse |
| Gianfabio Giorgioni, Alessandro Bonifazi, Luca Botticelli, Carlo Cifani, Federica Matteucci, Emanuela Micioni Di Bonaventura, Maria Vittoria Micioni Di Bonaventura, Mario Giannella, Alessandro Piergentili, Alessia Piergentili, Wilma Quaglia, Fabio Del Bell. Advances in drug design and therapeutic potential of selective or multitarget 5-HT1A receptor ligands. Medicinal research reviews. 2024-05-29. PMID:38808959. |
the structure-activity relationship studies (sar) performed over the last years have been devoted to three main goals: (i) design and synthesis of 5-ht1a-r selective/preferential ligands; (ii) identification of 5-ht1a-r biased agonists, differentiating pre- versus post-synaptic agonism and signaling cellular mechanisms; (iii) development of multitarget compounds endowed with well-defined poly-pharmacological profiles targeting 5-ht1a-r along with other serotonin receptors, serotonin transporter (sert), d2-like receptors and/or enzymes, such as acetylcholinesterase and phosphodiesterase, as a promising strategy for the management of complex psychiatric and neurodegenerative disorders. |
2024-05-29 |
2024-06-03 |
Not clear |
| Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. |
in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. |
2024-05-04 |
2024-05-07 |
mouse |
| Al-Sayeda Al-Sayed Newairy, Fatma Ahmad Hamaad, Mayssaa Moharm Wahby, Mamdooh Ghoneum, Heba Mohamed Abdo. Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3β signaling in the cerebral cortex of male diabetic rats. PloS one. vol 19. issue 4. 2024-04-29. PMID:38683825. |
in addition, these treatments improved neurochemical levels, including acetylcholine, dopamine, and serotonin levels as well acetylcholinesterase and monoamine oxidase activities. |
2024-04-29 |
2024-05-03 |
rat |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Heba-Tallah Abd Elrahim Abd Elkader, Marium Marzoq Hussein, Nema A Mohammed, Heba M Abdo. The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-15. PMID:38099937. |
our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in tmx-treated rats. |
2023-12-15 |
2023-12-17 |
rat |
| Chinedu Charles Onyekweli, Benneth Ben-Azu, O Mega Oyovwi, E Kingsley Nwangwa, I Simon Ovuakporaye, Goodies Emuesiri Moke, Ejime Agbonifo-Chijiokwu, B Oghenetega Onome, Victor Emojevwe, A Rume Rot. Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced hormonal dysregulation, testicular and brain oxidative stress and neurochemical changes in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-14. PMID:38097001. |
afterwards, serum sex hormones, insulin-glucose balance, serotonin concentration, acetylcholinesterase activity, sperm features, antioxidants, and the markers of oxido-nitrergic, autophagy and apoptotic mediators were assessed. |
2023-12-14 |
2023-12-17 |
rat |
| Chinedu Charles Onyekweli, Benneth Ben-Azu, O Mega Oyovwi, E Kingsley Nwangwa, I Simon Ovuakporaye, Goodies Emuesiri Moke, Ejime Agbonifo-Chijiokwu, B Oghenetega Onome, Victor Emojevwe, A Rume Rot. Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced hormonal dysregulation, testicular and brain oxidative stress and neurochemical changes in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-14. PMID:38097001. |
egcg reversed rapamycin exacerbated hfd-induced alterations in spermatogenesis, insulin-glucose balance, reproductive hormones, oxido-nitrergic stress, and altered serotonin, acetylcholinesterase levels, and autophagic and apoptotic activities in rats' testes and brains respectively. |
2023-12-14 |
2023-12-17 |
rat |
| Shuangfeng Liu, Yan Zhao, Sijin Li, Yanan Li, Li Liu, Jun Sheng, Yang Tian, Xiaoyu Ga. Network pharmacology combined with an animal model to reveal the material basis and mechanism of Amomum villosum in alleviating constipation in mice. Gene. vol 897. 2023-12-12. PMID:38065427. |
in addition, it is possible to improve constipation symptoms by regulating serum neurotransmitters and gastrointestinal motility-related factors, such as the serum content of 5-hydroxytryptamine (5-ht) and acetylcholinesterase (ache) and the mrna expression of 5-hydroxytryptamine receptor 4 (5-ht4), stem cell factor (scf), stem cell factor receptor (c-kit) and smooth muscle myosin light chain kinase (smmlck) in the colon. |
2023-12-12 |
2023-12-17 |
mouse |
| Heba-Tallah Abd Elrahim Abd Elkader, Ahmed S Al-Sham. Chronic exposure to bisphenol A induces behavioural, neurochemical, histological, and ultrastructural alterations in the ganglia tissue of the date mussels Lithophaga lithophaga. Environmental science and pollution research international. 2023-09-28. PMID:37768489. |
bpa causes neurotoxicity, as evidenced by concentration-dependent inhibition of acetylcholinesterase, dopamine, and serotonin. |
2023-09-28 |
2023-10-07 |
human |