| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
on the last day of exposure, behaviour, accumulation, embryotoxicity, acridine orange staining, antioxidant enzyme assay, acetylcholinesterase assay, nitric oxide (no) estimation, along with neurotransmitter (serotonin, dopamine) quantification and gene expression using qrt-pcr (bdnf, p53, bcl-2, caspase-3, caspase-9) were performed. |
2023-07-16 |
2023-08-14 |
human |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
moreover, polystyrene microplastics exposure resulted in reduced acetylcholinesterase activity leading to elevated no concentration along with altered serotonin and dopamine levels and subsequently leading to down-regulated bdnf gene expression and modulated downstream apoptotic signalling, confirming the neurotoxicity potential of microplastics causing neuronal dysfunction. |
2023-07-16 |
2023-08-14 |
human |
| Fatemeh Abedini, Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Sergio Lira, Ghasem Ahangar. Serotonin Receptors and Acetylcholinesterase Gene Expression Alternations: The Potential Value on Tumor Microenvironment of Gastric Cancer. Oncology. 2023-05-26. PMID:37231904. |
serotonin receptors and acetylcholinesterase gene expression alternations: the potential value on tumor microenvironment of gastric cancer. |
2023-05-26 |
2023-08-14 |
Not clear |
| Fatemeh Abedini, Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Sergio Lira, Ghasem Ahangar. Serotonin Receptors and Acetylcholinesterase Gene Expression Alternations: The Potential Value on Tumor Microenvironment of Gastric Cancer. Oncology. 2023-05-26. PMID:37231904. |
our purpose is to expose probable changes in serotonin receptors, acetylcholinesterase and monoamine oxidase a gene expression in gastric cancer. |
2023-05-26 |
2023-08-14 |
Not clear |
| Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zhen. Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention. Aging and disease. 2023-05-18. PMID:37199575. |
moreover, clinical efforts have successfully given birth to many practical pharmaceutic strategies, such as anti-inflammatory medications, acetylcholinesterase inhibitors, and selective serotonin reuptake inhibitors, as well as diverse rehabilitative modalities to help patients physically and mentally. |
2023-05-18 |
2023-08-14 |
Not clear |
| Battistina Asproni, Marco Catto, Giovanni Loriga, Gabriele Murineddu, Paola Corona, Rosa Purgatorio, Elena Cichero, Paola Fossa, Naomi Scarano, Antón L Martínez, José Brea, Gérard A Pinn. Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT Bioorganic & medicinal chemistry. vol 84. 2023-04-01. PMID:37003157. |
novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-ht a library of eighteen thienocycloalkylpyridazinones was synthesized for human acetylcholinesterase (hache) and butyrylcholinesterase (hbche) inhibition and serotonin 5-ht |
2023-04-01 |
2023-08-14 |
human |
| Merel A van der Most, Ignacio Miro Estruch, Nico W van den Brin. Contrasting dose response relationships of neuroactive antidepressants on the behavior of C. elegans. Ecotoxicology and environmental safety. vol 250. 2023-01-07. PMID:36608562. |
therefore, the current study was performed into the behavioral effects (activity, feeding and chemotaxis) in caenorhabditis elegans as the model organism of the selective serotonin reuptake inhibitors fluoxetine and sertraline and the acetylcholinesterase inhibiting pesticide chlorpyrifos, using a wide range of concentrations (ng/l to mg/l). |
2023-01-07 |
2023-08-14 |
caenorhabditis_elegans |
| Edem Ekpenyong Edem, Uyi Emmanuel Okhonmina, Kate Eberechukwu Nebo, Elizabeth Toyin Akinluyi, Daniel Akinwale Ikuelogbon, Adedamola Adediran Fafure, Ayodeji Augustine Olabiyi, Mujeeb Adekunle Adedoku. Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research. 2022-11-26. PMID:36434357. |
the combination of chronic sleep deprivation and high-dose caffeine treatment produced varying degrees of behavioural impairments, depletion of antioxidants, serotonin, and an upregulation of acetylcholinesterase (ache) activity in the prefrontal cortex. |
2022-11-26 |
2023-08-14 |
rat |
| Ashraf Albrakat. Monosodium glutamate induces cortical oxidative, apoptotic, and inflammatory challenges in rats: the potential neuroprotective role of apigenin. Environmental science and pollution research international. 2022-11-05. PMID:36334201. |
regarding the levels of neurotransmitters, our results revealed that apigenin augmented the activity of acetylcholinesterase (ache) markedly, and levels of brain monoamines (dopamine, norepinephrine, and serotonin) accompanied by lessening the activity of monoamine oxidase (mao) as compared to msg treatment. |
2022-11-05 |
2023-08-14 |
rat |
| Fang Wang, Teng Jia, Yu Wang, Haiyuan Hu, Yuying Wang, Li Chang, Xiaojun Shen, Gaisheng Li. Polycyclic aromatic hydrocarbons exposure was associated with microRNA differential expression and neurotransmitter changes: a cross-sectional study in coal miners. Environmental science and pollution research international. 2022-09-26. PMID:36161575. |
compared to the low pah exposure group, the high-exposure group had higher levels of 5-hydroxytryptamine (5-ht), epinephrine (e), and acetylcholine (ach), and lower levels of acetylcholinesterase (ache). |
2022-09-26 |
2023-08-14 |
human |
| Wajeeha Waseem, Fareeha Anwar, Uzma Saleem, Bashir Ahmad, Rehman Zafar, Asifa Anwar, Muhammad Saeed Jan, Umer Rashid, Abdul Sadiq, Tariq Ismai. Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: ACS omega. vol 7. issue 30. 2022-08-08. PMID:35936440. |
at the end of the study, different biochemical markers in the brain were estimated like neurotransmitters (dopamine, serotonin and adrenaline), oxidative stress markers (superoxide dismutase, glutathione, and catalase), acetylcholinesterase (ache), tau proteins, and amyloid-β levels. |
2022-08-08 |
2023-08-14 |
mouse |
| Huiting Yang, Xiaohong Gu, Huihui Chen, Qingfei Zeng, Zhigang Mao, Miao Jin, Hongmin Li, You Ge, Jinmiao Zha, Christopher J Martyniu. Transcriptome profiling reveals toxicity mechanisms following sertraline exposure in the brain of juvenile zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 242. 2022-08-05. PMID:35930839. |
the activity of acetylcholinesterase (ache) was significantly induced by 10 and 100 μg/l of ser, and the serotonin (5-ht) level was significantly increased by all three concentrations of ser. |
2022-08-05 |
2023-08-14 |
cat |
| Noreen Samad, Arooj Nasir, Muhammad Habib Ur Rehman, Sheraz Ahmed Bhatti, Imran Imra. Adenosine protects D-galactose induced alterations in rat model of aging via attenuating neurochemical profile and redox status. Metabolic brain disease. 2022-07-23. PMID:35870061. |
administration of ad also decreased malondialdehyde (mda) levels, increased antioxidant enzymes activity; decreased acetylcholinesterase (ache) activity, increased 5-hydroxytryptamine (5-ht, serotonin) metabolism and normalized histopathological alteration in the hippocampus. |
2022-07-23 |
2023-08-14 |
rat |
| R Kh Lyukmanov, A A Rimkevichus, E V Gnedovskaya, N A Suponev. [Pharmacotherapy in post-stroke rehabilitation]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 6. 2022-06-27. PMID:35758946. |
the article presents data on the conditions of use and efficacy of botulinum toxin preparations, oral muscle relaxants, selective serotonin reuptake inhibitors, acetylcholinesterase inhibitors and a glutamatergic transmission modulator in post-stroke neurorehabilitation, and provides recommendations for their rational and safe use. |
2022-06-27 |
2023-08-14 |
Not clear |
| Dongdong Lu, Yu Pi, Hao Ye, Yujun Wu, Yu Bai, Shuai Lian, Dandan Han, Dongjiao Ni, Xinhua Zou, Jinbiao Zhao, Shuai Zhang, Bas Kemp, Nicoline Soede, Junjun Wan. Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745241. |
prs and kon significantly increased the level of gut motility regulatory factors, 5-hydroxytryptamine (5-ht), motilin (mtl), and acetylcholinesterase (ache) in serum. |
2022-06-24 |
2023-08-14 |
Not clear |
| Basma Youssef, Kholoud S Ramadan, Shaimaa ElShebiney, Ehab A Ibrahi. Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats. Journal of food biochemistry. 2022-03-29. PMID:35348229. |
cums significantly increased the levels of plasma malondialdehyde (mda), cortisol, and pro-inflammatory cytokines (tnf-α and il-6), in addition to enhancing acetylcholinesterase (ache) activity while plasma total antioxidant capacity and serotonin level were reduced. |
2022-03-29 |
2023-08-13 |
rat |
| Princewill Ikechukwu Ugwu, Benneth Ben-Azu, Sandra Ugonne Ugwu, Christian I Uruaka, Chinecherem Choice Nworgu, Pamela Onyinye Okorie, Kizito Oluchukwu Okafor, Kenneth Kelechi Anachuna, Melford Uche Elendu, Amogechukwu Onyinye Ugwu, Ugochukwu Bond Anyaehie, Azubuike A Nwankwo, Eme Effiom Osi. Putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin. Brain research bulletin. 2022-03-12. PMID:35278662. |
the decreased serotonin in the prefrontal-cortex and dopamine in the striatum, elevated levels of noradrenaline and acetylcholinesterase in the prefrontal-cortex and hippocampus with corresponding decrease in bdnf were reversed by quercetin. |
2022-03-12 |
2023-08-13 |
mouse |
| Yang Yang, Jinhe Chang, Donghui Wang, Hao Ma, Yuanbo Li, Yongquan Zhen. Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio). Archives of toxicology. vol 95. issue 12. 2021-11-03. PMID:34635929. |
importantly, the decreased activity of acetylcholinesterase (ache) and the increased contents of neurotransmitters such as serotonin (5-ht) and norepinephrine (ne), along with transcriptional changes of nervous system related genes were observed following 4 days exposure to thifluzamide. |
2021-11-03 |
2023-08-13 |
zebrafish |
| Hanan A Edres, Nabil M Taha, Mohamed A Lebda, Mohamed S Elfek. The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats. Environmental science and pollution research international. vol 28. issue 41. 2021-10-26. PMID:34120280. |
the obvious brain oxidative injuries contributed to distinct brain dysfunction that was assured by alteration of brain neurotransmitters (serotonin, dopamine, acetylcholine, and acetylcholinesterase) and pathological brain lesions. |
2021-10-26 |
2023-08-13 |
rat |
| Aida M Abd El-Sattar El-Azzouny, Mohamed Nabil Aboul-Enein, Mohamed Farouk Hamiss. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug development research. vol 81. issue 7. 2021-10-05. PMID:32385857. |
it exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-hiv, antidiabetic, anticancer, sirtuin inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. |
2021-10-05 |
2023-08-13 |
Not clear |