| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Soreq, H Zaku. Amplification of butyrylcholinesterase and acetylcholinesterase genes in normal and tumor tissues: putative relationship to organophosphorous poisoning. Pharmaceutical research. vol 7. issue 1. 1990-03-12. PMID:2405380. |
further analysis revealed that both the che and the ache genes, encoding acetylcholinesterase (acetylcholine acetyl hydrolase; ec 3.1.1.7), are amplified in leukemias and platelet disorders and that the tumorigenic expression of these genes in ovarian carcinomas is associated with their frequent coamplification in these tumors. |
1990-03-12 |
2023-08-11 |
Not clear |
| C G Rousseaux, A K Du. Pharmacology of HI-6, an H-series oxime. Canadian journal of physiology and pharmacology. vol 67. issue 10. 1990-03-09. PMID:2692793. |
hi-6, and other h-series oximes, apparently act in a number of ways: reactivation of acetylcholinesterase, blockage of ganglia and muscarinic receptors, stimulation of vasopressor and respiratory centre receptors, chemical combination with agents, restoration of neuromuscular transmission, retardation of the formation of the aged inhibitor-enzyme complex, and (or) inhibition of the release of acetylcholine. |
1990-03-09 |
2023-08-11 |
Not clear |
| R H Kennedy, E Seife. Aging: effects on chronotropic actions of muscarinic agonists in isolated rat atria. Mechanisms of ageing and development. vol 51. issue 1. 1990-03-05. PMID:2299892. |
these data suggest that the enhanced sensitivity to the direct chronotropic action of acetylcholine is the result of aging-related reductions in acetylcholinesterase activity. |
1990-03-05 |
2023-08-11 |
rat |
| A L Harvey, E G Rowa. Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. Advances in neurology. vol 51. 1990-02-08. PMID:2294657. |
effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. |
1990-02-08 |
2023-08-11 |
Not clear |
| P Ghosh, S Bhattacharya, S Bhattachary. Impact of nonlethal levels of Metacid-50 and carbaryl on thyroid function and cholinergic system of Channa punctatus. Biomedical and environmental sciences : BES. vol 2. issue 2. 1990-01-25. PMID:2511899. |
with regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine (t3) and thyroxine (t4) profiles, a biphasic response pattern was elicited in channa punctatus chronically exposed to nonlethal doses of locally used pesticides, namely, metacid-50 and carbaryl. |
1990-01-25 |
2023-08-11 |
Not clear |
| P Ghosh, S Bhattacharya, S Bhattachary. Impact of nonlethal levels of Metacid-50 and carbaryl on thyroid function and cholinergic system of Channa punctatus. Biomedical and environmental sciences : BES. vol 2. issue 2. 1990-01-25. PMID:2511899. |
data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesterase activity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholine accumulation and t3 level. |
1990-01-25 |
2023-08-11 |
Not clear |
| H Kobayashi, A Yuyama, K Shioya, K Sat. Effects of carbamate, BPMC, on the central cholinergic functions and behavior of mice. Nihon juigaku zasshi. The Japanese journal of veterinary science. vol 51. issue 4. 1990-01-10. PMID:2585933. |
bpmc increased levels of acetylcholine (ach) in the forebrain for up to 6 hr, and decreased acetylcholinesterase (ache) activity for up to 24 hr. |
1990-01-10 |
2023-08-11 |
mouse |
| G M De Montis, P Devoto, D Meloni, A Porcella, P Saba, A Tagliamont. Resistance to extrapyramidal effects of opiates in rats chronically treated with SCH 23390. Journal of neuroscience research. vol 24. issue 2. 1989-12-28. PMID:2531233. |
on the other hand, decreased ac sensitivity to acetylcholine (ach) inhibition observed in the striatum of rats chronically treated with dfp, an irreversible blocker of acetylcholinesterase, appeared to be secondary to the downregulation of muscarinic receptors and thus did not modify the opiate inhibitory capacity. |
1989-12-28 |
2023-08-11 |
rat |
| X C Tang, P De Sarno, K Sugaya, E Giacobin. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. Journal of neuroscience research. vol 24. issue 2. 1989-12-28. PMID:2585551. |
the present study represents the first comprehensive investigation of the effect of huperzine a (hup-a), a new cholinesterase inhibitor (chei) isolated from a lycopodium species, upon acetylcholinesterase (ache) activity, acetylcholine (ach) levels and release, and cholinergic receptors in rat brain following acute i.m. |
1989-12-28 |
2023-08-11 |
mouse |
| C S Payne, M Saeed, A D Wolf. Ligand stabilization of cholinesterases. Biochimica et biophysica acta. vol 999. issue 1. 1989-12-19. PMID:2804138. |
stabilization of fetal bovine serum (fbs) acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7) (ache) and human butyrylcholinesterase (acylcholine acylhydrolase, ec 3.1.1.8) (buche) by ligands and inhibitors was studied as a function of physical and chemical perturbation. |
1989-12-19 |
2023-08-11 |
human |
| F Dexter, M N Levy, Y Rud. Mathematical model of the changes in heart rate elicited by vagal stimulation. Circulation research. vol 65. issue 5. 1989-12-07. PMID:2805246. |
the model incorporated a stimulation-mediated depletion of the releasable pool of acetylcholine (ach) in the nerve endings, the in vitro reaction kinetics of acetylcholinesterase, and the electrical activity of a pacemaker cell with six membrane ionic currents. |
1989-12-07 |
2023-08-11 |
Not clear |
| P Kouniniotou-Krontiri, S Tsakiri. Time dependence of Li+ action on acetylcholinesterase activity in correlation with spontaneous quantal release of acetylcholine in rat diaphragm. The Japanese journal of physiology. vol 39. issue 3. 1989-11-07. PMID:2552204. |
time dependence of li+ action on acetylcholinesterase activity in correlation with spontaneous quantal release of acetylcholine in rat diaphragm. |
1989-11-07 |
2023-08-11 |
rat |
| H Yoshino, R Suzuki, M Hanad. [Effects of acetylcholine and carbachol on the iris sphincter]. Nippon Ganka Gakkai zasshi. vol 93. issue 4. 1989-11-02. PMID:2801352. |
acetylcholinesterase activity in this tissue strongly inhibited the acetylcholine action, in order to protect the nerve terminals from random depolarization due to the released acetylcholine. |
1989-11-02 |
2023-08-11 |
rabbit |
| S N Abramson, Z Radic, D Manker, D J Faulkner, P Taylo. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Molecular pharmacology. vol 36. issue 3. 1989-10-26. PMID:2779521. |
because onchidal is an acetate ester similar to acetylcholine, its ability to interact with nicotinic acetylcholine receptors and acetylcholinesterase was investigated. |
1989-10-26 |
2023-08-11 |
Not clear |
| S N Abramson, Z Radic, D Manker, D J Faulkner, P Taylo. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Molecular pharmacology. vol 36. issue 3. 1989-10-26. PMID:2779521. |
although onchidal did not prevent the binding of 125i-alpha-bungarotoxin to nicotinic acetylcholine receptors, it inhibited acetylcholinesterase in a progressive, apparently irreversible, manner. |
1989-10-26 |
2023-08-11 |
Not clear |
| H A Tilson, R D Schwartz, S F Ali, R L McLam. Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by [3H]-acetylcholine. Neuropharmacology. vol 28. issue 8. 1989-10-20. PMID:2779754. |
lesions in the nucleus basalis in the rat are known to decrease presynaptic markers for acetylcholine, including levels of cholineacetyltransferase (chat), high affinity uptake of choline and levels of acetylcholinesterase. |
1989-10-20 |
2023-08-11 |
rat |
| W Regenold, D M Araujo, R Quirio. Quantitative autoradiographic distribution of [3H]AF-DX 116 muscarinic-M2 receptor binding sites in rat brain. Synapse (New York, N.Y.). vol 4. issue 2. 1989-10-19. PMID:2781464. |
although [3h]af-dx 116 binding was broadly distributed in multiple subfields of the hippocampus, [3h]acetylcholine binding was discretely distributed in a manner resembling that of acetylcholinesterase staining. |
1989-10-19 |
2023-08-11 |
rat |
| F Dagani, D Curti, F Marzatic. Effect of Ca2+-homopantothenate and mild hypoxia on some enzyme activities evaluated in subcellular fractions from different rat brain regions. Molecular and chemical neuropathology. vol 10. issue 3. 1989-10-03. PMID:2548516. |
the effect of ca2+-homopantothenate (hopa) treatment (250 mg/kg for 5 d) has been studied by evaluating the specific activity of enzymes related to: glycolytic pathway (hexokinase, phosphofructokinase, pyruvate kinase, lactate dehydrogenase), tricarboxylic acid cycle (citrate synthase, malate dehydrogenase), mitochondrial electron transfer chain (succinate dehydrogenase, cytochrome oxidase), nadh redox state (nadh cytochrome c reductase), acetylcholine metabolism (acetylcholinesterase), and glutamate metabolism (glutamate dehydrogenase). |
1989-10-03 |
2023-08-11 |
rat |
| S G Cohen, E Salih, M Solomon, S Howard, S B Chishti, J B Cohe. Reactions of 1-bromo-2-[14C]pinacolone with acetylcholinesterase from Torpedo nobiliana. Effects of 5-trimethylammonio-2-pentanone and diisopropyl fluorophosphate. Biochimica et biophysica acta. vol 997. issue 3. 1989-10-03. PMID:2765553. |
it was examined as an active-site directed label for acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7) (acche). |
1989-10-03 |
2023-08-11 |
cat |
| A D Wolf. The monoclonal antibody AE-2 modulates fetal bovine serum acetylcholinesterase substrate hydrolysis. Biochimica et biophysica acta. vol 997. issue 3. 1989-10-03. PMID:2765560. |
the monoclonal antibody (mab) ae-2 decreases the rate of hydrolysis of acetylthiocholine (atc) by fetal bovine serum acetylcholinesterase (acetylcholine acetylhydrolase ec 3.1.1.7) (fbs-ache) (doctor, b.p. |
1989-10-03 |
2023-08-11 |
cattle |