| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Yamada, M Tachibana, K Kuriyam. Neurochemical changes in the cholinergic system of the rat lateral vestibular nucleus following hemilabyrinthectomy. Archives of oto-rhino-laryngology. vol 245. issue 4. 1988-11-23. PMID:3263110. |
the content of acetylcholine (ach) and the activity of acetylcholinesterase in the lvn showed no significant changes at any time interval. |
1988-11-23 |
2023-08-11 |
rat |
| W G McBride, L J Hick. Acetylcholine and choline levels in rabbit fetuses exposed to anticholinergics. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 5. issue 2. 1988-11-21. PMID:3503493. |
it has been hypothesized that acetylcholine, choline acetylase and acetylcholinesterase may have an ontogenic and trophic influence in the embryo, and that therefore certain drugs may produce malformations via their effect on the acetylcholine and choline levels in the fetus. |
1988-11-21 |
2023-08-11 |
rabbit |
| R A Ginatullin, R N Khazipo. [Role of the density of cholinoreceptors in the mechanisms slowing a drop in the postsynaptic current]. Biulleten' eksperimental'noi biologii i meditsiny. vol 106. issue 8. 1988-10-21. PMID:3416047. |
the ability of some factors to prolong epc decay (acetylcholinesterase inhibition, ethanol) was reduced after acetylcholine receptors (achr) density decreased upon treatment with alpha-bungarotoxin. |
1988-10-21 |
2023-08-11 |
Not clear |
| R Quirio. Characterization and autoradiographic distribution of hemicholinium-3 high-affinity choline uptake sites in mammalian brain. Synapse (New York, N.Y.). vol 1. issue 4. 1988-10-20. PMID:3138770. |
this hypothesis is also supported by quantitative autoradiographic data which demonstrate that the discrete distribution of [3h]hc-3 binding sites correlates very well with the known distribution of other cholinergic markers such as choline acetyltransferase (chat), acetylcholinesterase (ache), hacu, and [3h]ah-5183 (blocker of the vesicular transport of acetylcholine). |
1988-10-20 |
2023-08-11 |
rat |
| H Kobayashi, A Yuyama, T Ohkawa, T Kajit. Effect of single or chronic injection with a carbamate, propoxur, on the brain cholinergic system and behavior of mice. Japanese journal of pharmacology. vol 47. issue 1. 1988-10-06. PMID:3411818. |
single injection caused an increase in brain acetylcholine (ach) content at 10 and 60 min; and it caused decreases in acetylcholinesterase (ache) activity at 10, 60 and 180 min, high-affinity choline uptake into synaptosomes at 10 and 60 min, and [3h]quinuclidinyl benzilate (qnb) binding at 10 min without causing any change in choline acetyltransferase (chat) activity. |
1988-10-06 |
2023-08-11 |
mouse |
| M E Clinton, K E Misulis, W D Dettbar. Effects of phenytoin, ketamine, and atropine methyl nitrate in preventing neuromuscular toxicity of acetylcholinesterase inhibitors soman and diisopropylphosphorofluoridate. Journal of toxicology and environmental health. vol 24. issue 4. 1988-09-26. PMID:3411630. |
toxic manifestations of acetylcholinesterase inhibitors (ache-i) include muscle twitching and muscle fiber necrosis, in addition to muscarinic manifestations of acetylcholine excess. |
1988-09-26 |
2023-08-11 |
rat |
| D Sutoo, K Akiyama, I Maed. [The development of a high sensitivity and high linearity fluorescence microphotometry system for distribution analysis of neurotransmitter in the brain]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 91. issue 4. 1988-08-23. PMID:2899040. |
in this study, immunohistochemical distribution and intensity of acetylcholine, choline acetyltransferase and acetylcholinesterase in the rat cervical spinal cord were measured. |
1988-08-23 |
2023-08-11 |
rat |
| D H Small, I W Chub. Identification of a trypsin-like site associated with acetylcholinesterase by affinity labelling with [3H]diisopropyl fluorophosphate. Journal of neurochemistry. vol 51. issue 1. 1988-07-27. PMID:3379413. |
in addition to its ability to hydrolyze acetylcholine, purified eel acetylcholinesterase possesses a trypsin-like endopeptidase activity. |
1988-07-27 |
2023-08-11 |
Not clear |
| R A Giniatullin, S K Bal'tser, E M Volko. [Effect of vinblastine and colchicine on the postsynaptic membrane of the myoneural junction in the frog]. Neirofiziologiia = Neurophysiology. vol 20. issue 1. 1988-07-26. PMID:2837669. |
both vb and cch accelerated the epc decay when acetylcholinesterase was inhibited; they also caused a pronounced depression in the trains of epc (10 hz) and trains of responses to acetylcholine application (5-10 hz). |
1988-07-26 |
2023-08-11 |
Not clear |
| M H Abernethy, H P Fitzgerald, K M Aher. An enzymatic method for erythrocyte acetylcholinesterase. Clinical chemistry. vol 34. issue 6. 1988-07-25. PMID:2837347. |
the acetylcholinesterase (ec 3.1.1.7) in 50 microl of a 61-fold dilution of erythrocytes in water hydrolyzes acetylcholine during a timed 20-min reaction at 37 degrees c. the resulting choline is measured by use of choline oxidase coupled to peroxidase, with phenol and aminoantipyrene to give a pink product that absorbs maximally at 500 nm. |
1988-07-25 |
2023-08-11 |
Not clear |
| S J Kish, L Schut, J Simmons, J Gilbert, L J Chang, M Rebbeto. Brain acetylcholinesterase activity is markedly reduced in dominantly-inherited olivopontocerebellar atrophy. Journal of neurology, neurosurgery, and psychiatry. vol 51. issue 4. 1988-07-15. PMID:3164041. |
the activity was measured of the acetylcholine catabolising enzyme acetylcholinesterase (ache) in brain after necropsy of seven patients from one established pedigree with dominantly-inherited olivopontocerebellar atrophy (opca), a cerebellar ataxia disorder in which neuropathological changes are assumed to be primarily restricted to cerebellum, lower brain stem and spinal cord. |
1988-07-15 |
2023-08-11 |
Not clear |
| P Aa. The toxic effect of an AChE-inhibitor on the cholinergic nervous system in airway smooth muscle. Toxicology. vol 49. issue 1. 1988-06-30. PMID:3376127. |
excessive cholinergic stimulation of presynaptic muscarinic cholinergic receptors, due to complete inhibition of acetylcholinesterase (ache) by o-(1,2,2-trimethylpropyl)-methyl-phosphonofluoridate (soman), reduced the release of acetylcholine (ach) from cholinergic nerves in rat bronchi by almost 25%. |
1988-06-30 |
2023-08-11 |
rat |
| L G Cost. Interactions of neurotoxicants with neurotransmitter systems. Toxicology. vol 49. issue 2-3. 1988-06-28. PMID:2897731. |
organophosphorus insecticides owe their acute toxicity to inhibition of acetylcholinesterase and accumulation of acetylcholine at cholinergic receptors. |
1988-06-28 |
2023-08-11 |
Not clear |
| C R Lupica, R F Berma. Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not. Brain research bulletin. vol 20. issue 2. 1988-06-24. PMID:3370504. |
despite the depletion of acetylcholine (ach), as determined by acetylcholinesterase (ache) and choline acetyltransferase (chat) assays, no significant alterations in kindling parameters were observed. |
1988-06-24 |
2023-08-11 |
rat |
| M Alkondon, K S Rao, E X Albuquerqu. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:2452874. |
interactions of the oximes pyridine-2-aldoxime (2-pam) and 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino++ +)-2-oxapropane dichloride (hi-6), reactivators of phosphorylated acetylcholinesterase enzyme, with the nicotinic acetylcholine receptor-ion channel complex were studied using electrophysiological techniques. |
1988-06-16 |
2023-08-11 |
Not clear |
| L J Reed, J de Belleroch. Increased polyphosphoinositide responsiveness in the cerebral cortex induced by cholinergic denervation. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361311. |
parameters of cholinergic function, namely, acetylcholinesterase activity, muscarinic acetylcholine receptor number, and the depolarisation-induced release of acetylcholine, fall in ipsilateral cortex subsequent to lesion. |
1988-06-02 |
2023-08-11 |
rat |
| G Kounenis, M Koutsoviti-Papadopoulou, V Elezoglo. The excitatory effect of the new histamine H2-receptor antagonist nizatidine (LY 139037) on the guinea pig ileum. Journal of pharmacobio-dynamics. vol 10. issue 11. 1988-05-24. PMID:2895808. |
these findings suggest that nizatidine exerts an excitatory effect on the guinea pig ileum which seems to be associated with the cholinergic system, probably through a direct and/or an indirect mechanism (inhibition of acetylcholinesterase and/or increased release of acetylcholine). |
1988-05-24 |
2023-08-11 |
Not clear |
| H Kobayashi, A Yuyama, M Ishihara, N Matsusak. Effects of arsenic on cholinergic parameters in brain in vitro. Neuropharmacology. vol 26. issue 12. 1988-04-07. PMID:3437937. |
arsenite, at concentrations greater than 10(-4) m, inhibited depolarized and nondepolarized release of acetylcholine (ach) from cerebral slices, the synthesis of ach in the slices, high-affinity uptake of choline into synaptosomes and activity of acetylcholinesterase (ache). |
1988-04-07 |
2023-08-11 |
mouse |
| T Wichmann, R B Illing, K Stark. Evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893996. |
acetylcholinesterase staining and studies on the uptake of [3h]choline into the subsequent efflux of tritium from collicular slices were carried out in order to provide evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. |
1988-04-05 |
2023-08-11 |
rabbit |
| P B Clarke, D W Hommer, A Pert, L R Skirbol. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:3437988. |
dopaminergic neurons of the substantia nigra pars compacta are excited by nicotine and acetylcholine, and possess both high-affinity nicotine binding sites and intense acetylcholinesterase activity, consistent with a cholinoceptive role. |
1988-04-05 |
2023-08-11 |
rat |