| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L G Cost. Interactions of neurotoxicants with neurotransmitter systems. Toxicology. vol 49. issue 2-3. 1988-06-28. PMID:2897731. |
organophosphorus insecticides owe their acute toxicity to inhibition of acetylcholinesterase and accumulation of acetylcholine at cholinergic receptors. |
1988-06-28 |
2023-08-11 |
Not clear |
| C R Lupica, R F Berma. Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not. Brain research bulletin. vol 20. issue 2. 1988-06-24. PMID:3370504. |
despite the depletion of acetylcholine (ach), as determined by acetylcholinesterase (ache) and choline acetyltransferase (chat) assays, no significant alterations in kindling parameters were observed. |
1988-06-24 |
2023-08-11 |
rat |
| M Alkondon, K S Rao, E X Albuquerqu. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:2452874. |
interactions of the oximes pyridine-2-aldoxime (2-pam) and 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino++ +)-2-oxapropane dichloride (hi-6), reactivators of phosphorylated acetylcholinesterase enzyme, with the nicotinic acetylcholine receptor-ion channel complex were studied using electrophysiological techniques. |
1988-06-16 |
2023-08-11 |
Not clear |
| L J Reed, J de Belleroch. Increased polyphosphoinositide responsiveness in the cerebral cortex induced by cholinergic denervation. Journal of neurochemistry. vol 50. issue 5. 1988-06-02. PMID:3361311. |
parameters of cholinergic function, namely, acetylcholinesterase activity, muscarinic acetylcholine receptor number, and the depolarisation-induced release of acetylcholine, fall in ipsilateral cortex subsequent to lesion. |
1988-06-02 |
2023-08-11 |
rat |
| G Kounenis, M Koutsoviti-Papadopoulou, V Elezoglo. The excitatory effect of the new histamine H2-receptor antagonist nizatidine (LY 139037) on the guinea pig ileum. Journal of pharmacobio-dynamics. vol 10. issue 11. 1988-05-24. PMID:2895808. |
these findings suggest that nizatidine exerts an excitatory effect on the guinea pig ileum which seems to be associated with the cholinergic system, probably through a direct and/or an indirect mechanism (inhibition of acetylcholinesterase and/or increased release of acetylcholine). |
1988-05-24 |
2023-08-11 |
Not clear |
| H Kobayashi, A Yuyama, M Ishihara, N Matsusak. Effects of arsenic on cholinergic parameters in brain in vitro. Neuropharmacology. vol 26. issue 12. 1988-04-07. PMID:3437937. |
arsenite, at concentrations greater than 10(-4) m, inhibited depolarized and nondepolarized release of acetylcholine (ach) from cerebral slices, the synthesis of ach in the slices, high-affinity uptake of choline into synaptosomes and activity of acetylcholinesterase (ache). |
1988-04-07 |
2023-08-11 |
mouse |
| T Wichmann, R B Illing, K Stark. Evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893996. |
acetylcholinesterase staining and studies on the uptake of [3h]choline into the subsequent efflux of tritium from collicular slices were carried out in order to provide evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. |
1988-04-05 |
2023-08-11 |
rabbit |
| P B Clarke, D W Hommer, A Pert, L R Skirbol. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:3437988. |
dopaminergic neurons of the substantia nigra pars compacta are excited by nicotine and acetylcholine, and possess both high-affinity nicotine binding sites and intense acetylcholinesterase activity, consistent with a cholinoceptive role. |
1988-04-05 |
2023-08-11 |
rat |
| B Pilo, S P Meha. Effect of cholinesterase inhibitors on acetylcholine and insulin induced glucose uptake and certain hepatic enzymes in pigeon liver: an in vitro study. Indian journal of physiology and pharmacology. vol 31. issue 3. 1988-03-16. PMID:3323058. |
acetylcholine induced glucose uptake can be predictably potentiated by inhibiting acetylcholinesterase activity. |
1988-03-16 |
2023-08-11 |
pigeon |
| B A Chase, D R Kanke. On the role of normal acetylcholine metabolism in the formation and maintenance of the Drosophila nervous system. Developmental biology. vol 125. issue 2. 1988-03-08. PMID:3123293. |
by using mutations at the ace and cha loci, which respectively encode the degradative and synthetic enzymes for acetylcholine (ach), acetylcholinesterase (ache), and choline acetyltransferase (chat), we have been able to disrupt acetylcholine metabolism in situ. |
1988-03-08 |
2023-08-11 |
drosophila_melanogaster |
| M A Smith, Y M Yao, N E Reist, C Magill, B G Wallace, U J McMaha. Identification of agrin in electric organ extracts and localization of agrin-like molecules in muscle and central nervous system. The Journal of experimental biology. vol 132. 1988-03-07. PMID:2828510. |
the portion of the muscle fibre's basal lamina that occupies the synaptic cleft at the neuromuscular junction contains molecules that cause the aggregation of acetylcholine receptors and acetylcholinesterase on regenerating muscle fibres. |
1988-03-07 |
2023-08-11 |
Not clear |
| M A Smith, Y M Yao, N E Reist, C Magill, B G Wallace, U J McMaha. Identification of agrin in electric organ extracts and localization of agrin-like molecules in muscle and central nervous system. The Journal of experimental biology. vol 132. 1988-03-07. PMID:2828510. |
agrin, which is extracted from basal lamina-containing fractions of the torpedo electric organ and causes the formation of acetylcholine receptor and acetylcholinesterase aggregates on cultured myotubes, may be similar, if not identical, to the acetylcholine receptor- and acetylcholinesterase-aggregating molecules at the neuro-muscular junction. |
1988-03-07 |
2023-08-11 |
Not clear |
| G H Sterling, P H Doukas, R J Sheldon, J J O'Neil. In vivo protection against soman toxicity by known inhibitors of acetylcholine synthesis in vitro. Biochemical pharmacology. vol 37. issue 3. 1988-02-25. PMID:3337738. |
soman inhibits the enzyme acetylcholinesterase, essentially irreversibly, producing an accumulation of acetylcholine (ach) which is responsible for many of its toxic effects. |
1988-02-25 |
2023-08-11 |
rat |
| R M Nitkin, M A Smith, C Magill, J R Fallon, Y M Yao, B G Wallace, U J McMaha. Identification of agrin, a synaptic organizing protein from Torpedo electric organ. The Journal of cell biology. vol 105. issue 6 Pt 1. 1988-02-05. PMID:2826489. |
extracts of the electric organ of torpedo californica contain a proteinaceous factor that causes the formation of patches on cultured myotubes at which acetylcholine receptors (achr), acetylcholinesterase (ache), and butyrylcholinesterase (buche) are concentrated. |
1988-02-05 |
2023-08-11 |
Not clear |
| M Schmidt, M F Humphrey, H Wässl. Action and localization of acetylcholine in the cat retina. Journal of neurophysiology. vol 58. issue 5. 1988-01-29. PMID:3694255. |
the effects of acetylcholine (ach), the muscarinic antagonist scopolamine (sco), the nicotinic antagonist dihydro-beta-erythroidine (dbe), and the acetylcholinesterase inhibitor physostigmine (phy) on maintained and light-evoked ganglion cell discharge was examined using iontophoresis techniques. |
1988-01-29 |
2023-08-11 |
rat |
| N M Barnes, B Costall, A F Fell, R J Naylo. An HPLC assay procedure of sensitivity and stability for measurement of acetylcholine and choline in neuronal tissue. The Journal of pharmacy and pharmacology. vol 39. issue 9. 1987-12-21. PMID:2890738. |
the method is based on the separation of acetylcholine and choline by reversed-phase hplc, passing the eluent into a post-column reactor containing choline oxidase and acetylcholinesterase covalently bound to vinyl sulphone bonded onto a hydroxyethyl methacrylate support, and electrochemical detection of the hydrogen peroxide formed. |
1987-12-21 |
2023-08-11 |
Not clear |
| G J Markelonis, T H O. Transferrin: assay of myotrophic effects and method for immunocytochemical localization. Methods in enzymology. vol 147. 1987-12-14. PMID:3312942. |
the trophic effects of a growth factor such as tf can be assessed on muscle cultures by the determination of such parameters as acetylcholinesterase and acetylcholine receptors. |
1987-12-14 |
2023-08-11 |
chicken |
| T Somasekhar, R V Krishnamoorth. Time course changes in levels of ascorbic acid, acetylcholine and acetylcholinesterase activity in sciatectomized muscles of the frog Rana cyanophlictis Schn. Indian journal of experimental biology. vol 25. issue 3. 1987-11-25. PMID:3666813. |
time course changes in levels of ascorbic acid, acetylcholine and acetylcholinesterase activity in sciatectomized muscles of the frog rana cyanophlictis schn. |
1987-11-25 |
2023-08-11 |
Not clear |
| C R Schätz, R W Ve. High-resolution localization of acetylcholinesterase at the rat neuromuscular junction. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 35. issue 11. 1987-11-20. PMID:3655326. |
to overcome the limited ultrastructural resolution of conventional acetylcholinesterase (ache) ultrahistochemistry, acetylcholine (atch) was used to reduce the rate of enzymic thiocholine liberation. |
1987-11-20 |
2023-08-11 |
rat |
| M Simonneau, L Tau. Properties of miniature postsynaptic currents during depolarization-induced release at a cholinergic neuroneuronal synapse. Cellular and molecular neurobiology. vol 7. issue 2. 1987-11-16. PMID:3652114. |
power spectra obtained after the application of inhibitors of acetylcholinesterase (ache), with or without curare, suggested that acetylcholine (ach) does not accumulate during large depolarizations. |
1987-11-16 |
2023-08-11 |
aplysia |