| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Reithmann, H J Berger, G Hilf, K Werda. The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes. Archives of toxicology. vol 65. issue 6. 1991-11-18. PMID:1929874. |
the stimulatory action of hgg-12 on muscarinic acetylcholine receptors which has been described by several authors is, therefore, suggested to be due to partial inhibition of acetylcholinesterase by the oxime rather than to direct agonism at muscarinic acetylcholine receptors. |
1991-11-18 |
2023-08-11 |
Not clear |
| T Arendt, M M Schugens, V Big. The cholinergic system and memory: amelioration of ethanol-induced memory deficiency by physostigmine in rat. Acta neurobiologiae experimentalis. vol 50. issue 4-5. 1991-11-13. PMID:2130647. |
profound reductions of acetylcholine content, the activities of choline acetyltransferase and acetylcholinesterase and choline uptake were observed in the cortex, hippocampus, substantia innominata and striatum four weeks after withdrawal from ethanol. |
1991-11-13 |
2023-08-11 |
rat |
| J M Palacios, H W Boddeke, E Pombo-Villa. Cholinergic neuropharmacology: an update. Acta psychiatrica Scandinavica. Supplementum. vol 366. 1991-10-24. PMID:1654727. |
compounds affecting acetylcholine synthesis, storage and release, affecting the enzyme acetylcholinesterase, acting on nicotinic cholinergic receptors, as well as compounds acting on muscarinic cholinergic receptors are reviewed. |
1991-10-24 |
2023-08-11 |
Not clear |
| A T Reddy, K Ayyanna, K Yellamm. Sensitivity of brain cholinesterase to cypermethrin toxicity in freshwater teleost Tilapia mossambica. Biochemistry international. vol 23. issue 5. 1991-10-01. PMID:1883402. |
cypermethrin at sublethal concentrations induced significant changes in acetylcholinesterase (ache) activity and acetylcholine (ach) content in the brain tissue of both juvenile and adult-fish. |
1991-10-01 |
2023-08-11 |
Not clear |
| M S Reddy, K V Ra. Phosphamidon, methylparathion and dichlorvos impact on tissue oxidative metabolism in penaeid prawn, Metapenaeus monoceros. Biochemistry international. vol 23. issue 3. 1991-09-23. PMID:1877982. |
the opi are found to inhibit the activity levels of acetylcholinesterase, succinate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase, lactate dehydrogenase and cytochrome-c-oxidase and cause accumulation of acetylcholine in the hepatopancreas and muscle tissues. |
1991-09-23 |
2023-08-11 |
Not clear |
| C Smith, C Tenn, R Annet. Some biochemical and behavioural aspects of the paradoxical sleep window. Canadian journal of psychology. vol 45. issue 2. 1991-09-20. PMID:1873751. |
then animals were immediately sacrificed, and whole brain biochemical analyses were done on levels of acetylcholine (ach) and activity of acetylcholinesterase (ache). |
1991-09-20 |
2023-08-11 |
rat |
| B G Wallac. The mechanism of agrin-induced acetylcholine receptor aggregation. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 331. issue 1261. 1991-08-29. PMID:1677470. |
for example, the specializations contain aggregates of acetylcholine receptors and acetylcholinesterase. |
1991-08-29 |
2023-08-11 |
Not clear |
| C G Benishin, R Lee, L C Wang, H J Li. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology. vol 42. issue 4. 1991-08-22. PMID:1852782. |
in vitro studies show that rb1 has no effect on quinuclidinyl benzylate binding or on acetylcholinesterase activity, but facilitates the release of acetylcholine (ach) from hippocampal slices. |
1991-08-22 |
2023-08-11 |
rat |
| H J Kreienkamp, C Weise, R Raba, A Aaviksaar, F Huch. Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 14. 1991-08-14. PMID:2068091. |
a peptide of acetylcholinesterase (acchoease; acetylcholine acetylhydrolase, ec 3.1.1.7) from the venom of the cobra naja naja oxiana labeled by the affinity reagent n,n-dimethyl-2-phenylaziridinium (dpa) has been identified. |
1991-08-14 |
2023-08-11 |
Not clear |
| K R Rajeswari, M Satyanarayan. Cholinergic components in human gingiva in healthy and inflamed states. Indian journal of dental research : official publication of Indian Society for Dental Research. vol 2. issue 2-3. 1991-07-25. PMID:2096961. |
acetylcholine (ach) and acetylcholinesterase (ache) are main components in cholinergic nervous system. |
1991-07-25 |
2023-08-11 |
human |
| V De Wilde, D Vogelaers, F Colardyn, G Vanderstraeten, K Van den Neucker, J De Bleecker, J De Reuck, M Van den Heed. Postsynaptic neuromuscular dysfunction in organophosphate induced intermediate syndrome. Klinische Wochenschrift. vol 69. issue 4. 1991-07-10. PMID:1645823. |
it is hypothesized that the pathophysiologic process underlying the syndrome is the result of a time-confined phenomenon, which includes both changes in the postsynaptic structures by a desensitization process and a gradually restoring ratio of acetylcholine to acetylcholinesterase. |
1991-07-10 |
2023-08-11 |
Not clear |
| A Sepp, J Jär. Alkylation of acetylcholinesterase anionic centre with aziridinium ion accelerates the enzyme acylation step. Biochimica et biophysica acta. vol 1077. issue 3. 1991-06-17. PMID:2029540. |
affinity labelling of acetylcholinesterase (ec 3.1.1.7, acetylcholine acetylhydrolase) anionic centre with n,n-dimethyl-2-phenylaziridinium ion accelerates the hydrolysis of non-ionic acetic esters by increasing the rate of the enzyme acylation step at least 500-times while the rate of the deacylation step remains unchanged. |
1991-06-17 |
2023-08-11 |
Not clear |
| N Yamazaki, K Kato, E Kurihara, A Nagaok. Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats. Psychopharmacology. vol 103. issue 2. 1991-06-12. PMID:2027921. |
learning was significantly impaired at 3.75 nmol af64a, a dose at which significant reduction in acetylcholine level and choline acetyltransferase and acetylcholinesterase activity in the hippocampus was observed but changes in monoamine levels in the hippocampus, general behavior, or sensory sensitivity were not observed. |
1991-06-12 |
2023-08-11 |
rat |
| C L Armour, P R Johnson, L A Alouan, J L Blac. Substance P-induced contraction of rabbit airways: mechanism of action. Journal of applied physiology (Bethesda, Md. : 1985). vol 70. issue 2. 1991-06-04. PMID:1708758. |
the present detailed study investigated whether substance p-induced contraction in rabbit isolated bronchus and trachea is due to the release of endogenous acetylcholine or in bronchus is due to histamine release and whether substance p is metabolized by the enzymes enkephalinase and acetylcholinesterase. |
1991-06-04 |
2023-08-11 |
human |
| E E Mena, M C Desa. High-affinity [3H]THA (tetrahydroaminoacridine) binding sites in rat brain. Pharmaceutical research. vol 8. issue 2. 1991-05-31. PMID:2023867. |
the binding of [3h]tha to membranes does not appear to be related to receptors for several neurotransmitters/neuromodulators, including acetylcholine and other acetylcholinesterase inhibitors. |
1991-05-31 |
2023-08-11 |
rat |
| R K McBride, D J Zwierzynski, K K Stone, D J Culp, M G Mari. Variable effects of soman on macromolecular secretion by ferret trachea. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 16. issue 1. 1991-05-28. PMID:2019349. |
additional experiments utilizing acetylcholine and the acetylcholinesterase inhibitor, physostigmine, suggest that inhibition of secretion by high concentrations of soman may be due to a secondary antagonistic effect of soman on muscarinic receptors. |
1991-05-28 |
2023-08-11 |
Not clear |
| S A Greenfiel. A noncholinergic action of acetylcholinesterase (AChE) in the brain: from neuronal secretion to the generation of movement. Cellular and molecular neurobiology. vol 11. issue 1. 1991-05-15. PMID:2013059. |
in various brain regions, there is a puzzling disparity between large amounts of acetylcholinesterase and low levels of acetylcholine. |
1991-05-15 |
2023-08-11 |
Not clear |
| L Wuarin, N Sidel. Differential susceptibilities of spinal cord neurons to retinoic acid-induced survival and differentiation. Developmental biology. vol 144. issue 2. 1991-05-03. PMID:2010040. |
these results were supported by measured levels of acetylcholinesterase (ache), choline acetyltransferase (chat), and glutamic acid decarboxylase (gad) activities, key enzymes of acetylcholine and gamma-aminobutyric acid metabolism, respectively, which showed ra-induced increases in ache and chat levels but no elevations of gad activity. |
1991-05-03 |
2023-08-11 |
rat |
| M W Brightman, D L Simpson, J H Tao-Cheng, J P Bressler, O Okuda, L Chan. Some neuronal properties of PC12 cells differentiated by the K-ras oncogene. Journal of neurocytology. vol 19. issue 5. 1991-04-24. PMID:1981788. |
compared to naive pc12 cells, k-ras infected pc12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine. |
1991-04-24 |
2023-08-11 |
rat |
| S J Hong, C C Chan. Nicotinic actions of oxotremorine on murine skeletal muscle. Evidence against muscarinic modulation of acetylcholine release. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:2073579. |
the augmentation by oxotremorine of evoked acetylcholine release persisted in preparations pretreated with neostigmine (1 microm) and tetrodotoxin (20 nm), which inhibited acetylcholinesterase and oxotremorine-induced spontaneous neural discharges. |
1991-04-18 |
2023-08-11 |
mouse |