| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Brudzynski, B Eckersdorf, H Golebiewsk. Evidence for involvement of endogenous acetylcholine in emotional-aversive response in the cat. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 5. 1991-04-08. PMID:2293258. |
on the other hand, intracerebral injections of physostigmine (100 micrograms/microliter), an acetylcholinesterase inhibitor which elevates the level of endogenous acetylcholine, induced the fully developed emotional-aversive response comparable with natural behaviour and with responses induced by carbachol (10 micrograms/microliter). |
1991-04-08 |
2023-08-11 |
dog |
| C R Schätz, C Geula, M Mesula. Competitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer's disease. Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:2290622. |
butyrylcholine was much more effective than acetylcholine in reducing the histochemical reaction for acetylcholinesterase not only in neuronal fibers, but also in plaques and tangles. |
1991-04-01 |
2023-08-11 |
Not clear |
| T Rothe, U K Hanisch, K Krohn, R Schliebs, W Härtig, H H Webster, D Biesol. Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury. Somatosensory & motor research. vol 7. issue 4. 1991-03-29. PMID:1963253. |
investigations in individual cortical layers revealed that the decrease of both choline acetyltransferase activity and high-affinity choline uptake sites was mainly due to reductions in cortical layer v. acetylcholinesterase activity and [3h]quinuclidinyl benzilate binding to muscarinic acetylcholine receptors were not affected by unilateral transection of the sciatic nerve. |
1991-03-29 |
2023-08-11 |
rat |
| P J Bushnell, S S Padilla, T Ward, C N Pope, V B Olszy. Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1994004. |
behavioral effects of organophosphates (ops) typically decrease with repeated exposure, despite persistence of op-induced inhibition of acetylcholinesterase (ache) and downregulation of muscarinic acetylcholine (ach) receptors. |
1991-03-21 |
2023-08-11 |
rat |
| R von Bernhardi, H Ayal, N C Inestros. Carrageenans solubilize asymmetric acetylcholinesterase from nicotinic cholinergic synapses. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 96. issue 1. 1991-03-18. PMID:1980885. |
acetylcholinesterase (ache) catalyzes the hydrolysis of acetylcholine at cholinergic synapses in both vertebrate and invertebrates organisms. |
1991-03-18 |
2023-08-11 |
Not clear |
| D A Godfrey, R F Judkins, G J Wiet, J A Parli, C D Ross, A M Rubi. Enzymes of transmitter and energy metabolism in cat middle ear muscles. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 103. issue 5 ( Pt 1). 1991-03-01. PMID:1980532. |
activities of the enzymes choline acetyltransferase (chat) and acetylcholinesterase (ache), which metabolize the neuromuscular transmitter acetylcholine, and malate and lactate dehydrogenase (mdh and ldh), enzymes of oxidative and glycolytic energy metabolism, respectively, were measured in the middle ear muscles of the cat. |
1991-03-01 |
2023-08-11 |
cat |
| S G Cohen, S B Chishti, D A Bell, S I Howard, E Salih, J B Cohe. General occurrence of binding to acetylcholinesterase-substrate complex in noncompetitive inhibition and in inhibition by substrate. Biochimica et biophysica acta. vol 1076. issue 1. 1991-02-20. PMID:1986784. |
to assess the relative importance of binding to enzyme-substrate complex (e.s) and to acetylenzyme (ea), noncompetitive inhibition has been studied in hydrolysis by acetylcholinesterase (acche) of cationic and uncharged substrates - acetylcholine (acch), 3,3-dimethylbutyl acetate, n-butyl acetate, 2-(methylammonio)ethyl acetate, 2- (n,n-diethyl-n-n-butylammonio)ethyl acetate (debaac) and 2-(methylsulfonyl)ethyl acetate. |
1991-02-20 |
2023-08-11 |
Not clear |
| Z Radić, E Reiner, P Taylo. Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives. Molecular pharmacology. vol 39. issue 1. 1991-02-19. PMID:1987454. |
we have measured the ability of acetylcholine, acetylthiocholine, haloxon [di-(2-chloroethyl)3-chloro-4-methylcoumarin-7-ylphosphate] , and a coumarin derivative (3-chloro-7-hydroxy-4-methylcoumarin) to dissociate propidium from the peripheral anionic site of torpedo californica acetylcholinesterase. |
1991-02-19 |
2023-08-11 |
Not clear |
| C S Heck, P A McKinle. Age-dependent changes in acetylcholinesterase activity in the primary somatosensory cortex of the cat. Brain research. Developmental brain research. vol 56. issue 2. 1991-02-07. PMID:2261681. |
as cortical reorganization in cat somatosensory cortex has been shown to be age-dependent and acetylcholinesterase and acetylcholine have been implicated in the shaping of sensory responses during the developmental process, we decided to investigate the biochemical changes that occur in acetylcholinesterase during postnatal development of the primary somatosensory cortex in normal cat. |
1991-02-07 |
2023-08-11 |
cat |
| G B Koelle, M S Ha. Effects of glycyl-L-glutamine and methylprednisolone on maintenance of acetylcholinesterase of transected rat sciatic nerves. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 23. 1991-01-16. PMID:2251290. |
rats were sacrificed at intervals of 2, 4, or 6 days; the peripheral portions of the sciatic nerves were excised, homogenized, and centrifuged, and the supernates were assayed for acetylcholinesterase (acchoease; acetylcholine acetylhydrolase, ec 3.1.1.7) and protein. |
1991-01-16 |
2023-08-11 |
rat |
| P de Boer, B H Westerink, A S Hor. The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: interaction with autoreceptor responses. Neuroscience letters. vol 116. issue 3. 1990-12-31. PMID:2243615. |
the effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: interaction with autoreceptor responses. |
1990-12-31 |
2023-08-11 |
rat |
| P de Boer, B H Westerink, A S Hor. The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: interaction with autoreceptor responses. Neuroscience letters. vol 116. issue 3. 1990-12-31. PMID:2243615. |
furthermore it is shown that under physiological conditions the muscarinic autoreceptors are not fully occupied, since infusion of 1 microm atropine did not affect the release of acetylcholine when no acetylcholinesterase inhibitor was added to the perfusion ringer. |
1990-12-31 |
2023-08-11 |
rat |
| R K Gordon, R R Gray, P K Chian. Vasoactive intestinal polypeptides induce guinea-pig ileum contraction by causing release of endogenous acetylcholine. Archives internationales de pharmacodynamie et de therapie. vol 305. 1990-12-27. PMID:2241424. |
the relative potency of vip(gp), vip(hpr), and acetylcholine was 50 to 100 times more potent in inducing contraction in ileums of which the acetylcholinesterase was inactivated by paraoxon than in the controls. |
1990-12-27 |
2023-08-11 |
Not clear |
| R K Gordon, R R Gray, P K Chian. Vasoactive intestinal polypeptides induce guinea-pig ileum contraction by causing release of endogenous acetylcholine. Archives internationales de pharmacodynamie et de therapie. vol 305. 1990-12-27. PMID:2241424. |
the secreted acetylcholine was quantified by high-performance liquid chromatography using electrochemical detection and an immobilized-enzyme column consisting of choline oxidase and acetylcholinesterase. |
1990-12-27 |
2023-08-11 |
Not clear |
| B V Manyam, E Giacobini, J A Collive. Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington's disease. Journal of neurology. vol 237. issue 5. 1990-12-04. PMID:2146369. |
the caudate nucleus has the highest acetylcholinesterase (ache) activity in the brain and it has been shown that autopsied brain tissue of patients with huntington's disease (hd) have reduced levels of acetylcholine. |
1990-12-04 |
2023-08-11 |
Not clear |
| O G Nilsson, P Kalén, E Rosengren, A Björklun. Acetylcholine release in the rat hippocampus as studied by microdialysis is dependent on axonal impulse flow and increases during behavioural activation. Neuroscience. vol 36. issue 2. 1990-11-15. PMID:2215927. |
low baseline levels of acetylcholine (about 0.3 pmol/15 min sample) could be detected in the absence of acetylcholinesterase inhibition in all animals. |
1990-11-15 |
2023-08-11 |
rat |
| E F Reichman, D C Beeb. Acetylcholinesterase activity as a marker for the development of the ciliary epithelium in the chicken embryo. Experimental eye research. vol 51. issue 3. 1990-10-24. PMID:2401347. |
the function of acetylcholinesterase in the developing ciliary epithelium is unknown, but from the data currently available it is unlikely to be involved in the degradation of acetylcholine. |
1990-10-24 |
2023-08-11 |
rat |
| P Cumming, P B Reiner, S R Vincen. Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA). Biochemical pharmacology. vol 40. issue 6. 1990-10-22. PMID:2403387. |
9-amino-1,2,3,4-tetrahydroacridine (tha), an inhibitor of acetylcholinesterase, has been proposed as a treatment for alzheimer's disease on the basis of its ability to increase cerebral levels of acetylcholine. |
1990-10-22 |
2023-08-11 |
rat |
| G Malinger, H Zakut, H Sore. Cholinoceptive properties of human primordial, preantral, and antral oocytes: in situ hybridization and biochemical evidence for expression of cholinesterase genes. Journal of molecular neuroscience : MN. vol 1. issue 2. 1990-09-27. PMID:2641279. |
functional acetylcholine receptors were electrophysiologically demonstrated in amphibian and mammalian oocyte membranes, and activity of the acetylcholine-hydrolyzing enzyme, acetylcholinesterase (ache), was biochemically measured in the exceptionally big oocytes of the frog xenopus laevis. |
1990-09-27 |
2023-08-11 |
human |
| J Sánchez-Yagüe, J A Cabezas, M Llanill. Subcellular distribution and characterization of acetylcholinesterase activities from sheep platelets: relationships between temperature-dependence and environment. Blood. vol 76. issue 4. 1990-09-18. PMID:2383654. |
acetylcholinesterase is a key enzyme in cholinergic neurotransmission for hydrolyzing acetylcholine and has been shown to possess arylacylamidase activity in addition to esterase activity. |
1990-09-18 |
2023-08-11 |
Not clear |