| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
5-ht(2c) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. |
2016-06-13 |
2023-08-13 |
mouse |
| Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto, Kunihiro Matsumot. Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans. Nature communications. vol 7. 2016-06-07. PMID:26790951. |
here we show that in caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-ht) in axotomized non-serotonergic neurons via hif-1, a hypoxia-inducible transcription factor, and that 5-ht subsequently promotes axon regeneration by autocrine signalling through the ser-7 5-ht receptor. |
2016-06-07 |
2023-08-13 |
caenorhabditis_elegans |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
a number of serotonin receptor positron emission tomography (pet) radioligands have been shown to be sensitive to changes in extracellular serotonin concentration, in a generalization of the well-known dopamine competition model. |
2016-06-02 |
2023-08-13 |
human |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
high doses of selective serotonin reuptake inhibitors (ssris) decrease serotonin receptor availability in monkey brain, consistent with increased serotonin concentrations. |
2016-06-02 |
2023-08-13 |
human |
| Sjoerd J Finnema, Christer Halldin, Benny Bang-Andersen, Christoffer Bundgaard, Lars Fard. Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study. Psychopharmacology. vol 232. issue 21-22. 2016-06-02. PMID:25980484. |
however, two recent studies on healthy human subjects, using a single, lower and clinically relevant ssri dose, showed increased cortical serotonin receptor radioligand binding, suggesting potential decreases in serotonin concentration in projection regions when initiating treatment. |
2016-06-02 |
2023-08-13 |
human |
| R A Abzalov, R R Abzalov, A M Valeev, N I Abzalov, A A Gulyako. Role of 5-HT(2B) Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart. Bulletin of experimental biology and medicine. vol 159. issue 3. 2016-05-23. PMID:26201901. |
role of 5-ht(2b) serotonin receptor agonist in the regulation of pumping function of the heart. |
2016-05-23 |
2023-08-13 |
rat |
| Guadalupe Mengod, José M Palacios, Roser Corté. Cartography of 5-HT1A and 5-HT2A Receptor Subtypes in Prefrontal Cortex and Its Projections. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25739427. |
5-ht receptors were first visualized using radioligand autoradiography in the late 1980s and early 1990s and showed, in contrast to 5-ht innervation, a differential distribution of binding sites associated with different 5-ht receptor subtypes. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Leiser, Yan Li, Alan L Pehrson, Elena Dale, Gennady Smagin, Connie Sanche. Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25746856. |
serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-ht receptor mechanisms and concerted effects of 5-ht receptors exemplified by the multimodal antidepressant vortioxetine. |
2016-04-19 |
2023-08-13 |
Not clear |
| Nadia Khan, Ahsana Dar Farooq, Bassem Sade. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug design, development and therapy. vol 9. 2016-04-18. PMID:26185418. |
interestingly, the synergistic effect observed for aa with 5-ht was, also, blocked by the 5-ht receptor blockers cyproheptadine (ic50=22.0 ± 7 μmol/l), ketanserin (ic50=152 ± 23 μmol/l), phospholipase c (plc) inhibitor (u73122; ic50=6.1 ± 0.8 μmol/l), and mitogen activated protein kinase (mapk) inhibitor (pd98059; ic50=3.8 ± 0.5 μmol/l). |
2016-04-18 |
2023-08-13 |
human |
| Bo-Mi Song, Serge Faumont, Shawn Lockery, Leon Aver. Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans. eLife. vol 2. 2016-04-11. PMID:23390589. |
the released serotonin activates the feeding response mainly by acting humorally and directly activates ser-7, a type 7 serotonin receptor, in mc motor neurons in the feeding organ. |
2016-04-11 |
2023-08-12 |
caenorhabditis_elegans |
| Jacob Sutton, Jeff Stroup, Mo So. Linezolid-induced serotonin toxicity in a patient not taking monoamine oxidase inhibitors or serotonin receptor antagonists. Proceedings (Baylor University. Medical Center). vol 29. issue 2. 2016-04-01. PMID:27034576. |
linezolid-induced serotonin toxicity in a patient not taking monoamine oxidase inhibitors or serotonin receptor antagonists. |
2016-04-01 |
2023-08-13 |
Not clear |
| Wenjing Law, Leah M Wuescher, Amanda Ortega, Vera M Hapiak, Patricia R Komuniecki, Richard Komunieck. Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening. PLoS pathogens. vol 11. issue 4. 2016-03-29. PMID:25928899. |
specifically, 5-ht paralyzed c. elegans 5-ht receptor null animals expressing either nematode, insect or human orthologues of a key gαo-coupled 5-ht1-like receptor in the cholinergic motor neurons. |
2016-03-29 |
2023-08-13 |
human |
| Gordon F Buchanan, Haleigh R Smith, Amanda MacAskill, George B Richerso. 5-HT2A receptor activation is necessary for CO2-induced arousal. Journal of neurophysiology. vol 114. issue 1. 2016-03-28. PMID:25925320. |
these data identify the 5-ht(2a) receptor as an important mediator of co2-induced arousal and suggest that, while 5-ht neurons can be independently activated to drive co2-induced arousal, in the absence of 5-ht neurons and endogenous 5-ht, 5-ht receptor activation can act in a permissive fashion to facilitate co2-induced arousal via another as yet unidentified chemosensor system. |
2016-03-28 |
2023-08-13 |
mouse |
| Ross D Hoehn, David Nichols, Hartmut Neven, Sabre Kai. Neuroreceptor activation by vibration-assisted tunneling. Scientific reports. vol 5. 2016-02-29. PMID:25909758. |
we found that non-endogenous agonists of the serotonin receptor share a particular iet spectral aspect both amongst each other and with the serotonin molecule: a peak whose intensity scales with the known agonist potencies. |
2016-02-29 |
2023-08-13 |
Not clear |
| H Lefebvre, C Duparc, G Prévost, M C Zennaro, J Bertherat, E Louise. Paracrine control of steroidogenesis by serotonin in adrenocortical neoplasms. Molecular and cellular endocrinology. vol 408. 2016-02-08. PMID:25433205. |
in the human adrenal gland, 5-ht, released by subcapsular mast cells, stimulates corticosteroid production through a paracrine mode of communication which involves 5-ht receptor type 4 (5-ht4) primarily located in zona glomerulosa. |
2016-02-08 |
2023-08-13 |
human |
| John D McCorvy, Bryan L Rot. Structure and function of serotonin G protein-coupled receptors. Pharmacology & therapeutics. vol 150. 2016-02-08. PMID:25601315. |
the first serotonin crystal structures not only provide the first evidence of serotonin receptor topography but also provide mechanistic explanations into functional selectivity or biased agonism. |
2016-02-08 |
2023-08-13 |
Not clear |
| Yasuyuki Nakamura, Jun Ishii, Akihiko Kond. Applications of yeast-based signaling sensor for characterization of antagonist and analysis of site-directed mutants of the human serotonin 1A receptor. Biotechnology and bioengineering. vol 112. issue 9. 2016-01-20. PMID:25850571. |
the monoamine neurotransmitter serotonin (5-ht) regulates a wide spectrum of human physiology through the 5-ht receptor family. |
2016-01-20 |
2023-08-13 |
human |
| Scott F Leiser, Hillary Miller, Ryan Rossner, Marissa Fletcher, Alison Leonard, Melissa Primitivo, Nicholas Rintala, Fresnida J Ramos, Dana L Miller, Matt Kaeberlei. Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science (New York, N.Y.). vol 350. issue 6266. 2016-01-12. PMID:26586189. |
this prolongevity signal requires the serotonin biosynthetic enzyme tph-1 in neurons and the serotonin receptor ser-7 in the intestine. |
2016-01-12 |
2023-08-13 |
mouse |
| Haritha Durairaj, Michael D Steury, Narayanan Parameswara. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25744603. |
to determine if the effects of paroxetine are mediated via modulation of the 5-ht system, we treated macrophages with 5-ht or 5-ht receptor antagonist (ly215840) in the presence of lps and/or paroxetine. |
2016-01-04 |
2023-08-13 |
mouse |
| Jimena Laporta, Kimberly P Keil, Chad M Vezina, Laura L Hernande. Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice. PloS one. vol 9. issue 10. 2015-12-28. PMID:25299122. |
mammary expression of serotonin receptor isoform 2b and its downstream pathways (plcβ3, pkc and map-erk1/2) are also decreased by serotonin deficiency, which might explain the numerous phenotypic alterations described above. |
2015-12-28 |
2023-08-13 |
mouse |