| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhong-Min Wu, Li-Hua Yang, Rong Cui, Gui-Lian Ni, Feng-Tian Wu, Yong Lian. Contribution of Hippocampal 5-HT Cellular and molecular neurobiology. vol 37. issue 4. 2017-04-17. PMID:27324798. |
while certain 5-ht receptor subtypes are likely critical for the symptoms of ptsd, few studies have examined the role of 5-ht |
2017-04-17 |
2023-08-13 |
Not clear |
| Yasuhiro Nakamura, Kazue Ise, Yuto Yamazaki, Fumiyoshi Fujishima, Keely M McNamara, Hironobu Sasan. Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer. Indian journal of pathology & microbiology. vol 60. issue 1. 2017-03-13. PMID:28195088. |
among these, increased expression of serotonin receptor especially that of 5-hydroxytryptamine receptor type 4 (5-htr4) has been recently proposed to be involved in autocrine/paracrine mechanisms of castration-resistant prostate cancer, but the presence and clinical significance of 5-htr4 in hormone-naive prostate cancer (hnpc) and its interaction with hormonal signaling pathways have remained virtually unknown. |
2017-03-13 |
2023-08-13 |
Not clear |
| Cigdem Selli, Metiner Tosu. Effects of cyclopiazonic acid and dexamethasone on serotonin-induced calcium responses in vascular smooth muscle cells. Journal of physiology and biochemistry. vol 72. issue 2. 2017-03-06. PMID:26944908. |
furthermore, 5-ht receptor antagonist methysergide partially inhibited cpa-potentiated 5-ht contractions. |
2017-03-06 |
2023-08-13 |
rat |
| X G Zhang, H Zhang, X L Liang, Q Liu, H Y Wang, B Cao, J Cao, S Liu, Y J Long, W Y Xie, D Z Pen. Epigenetic mechanism of maternal post-traumatic stress disorder in delayed rat offspring development: dysregulation of methylation and gene expression. Genetics and molecular research : GMR. vol 15. issue 3. 2017-02-27. PMID:27706597. |
enzyme-linked immunosorbent assays showed that serotonin receptor (5-ht) and dopamine levels were significantly lower in ptsd offsprings than in control offsprings. |
2017-02-27 |
2023-08-13 |
rat |
| Guiqin Xie, Wanhong Zuo, Liangzhi Wu, Wenting Li, Wei Wu, Alex Bekker, Jiang-Hong Y. Serotonin modulates glutamatergic transmission to neurons in the lateral habenula. Scientific reports. vol 6. 2017-02-17. PMID:27033153. |
type 2 and 3 serotonin receptor antagonists attenuated serotonin's potentiation. |
2017-02-17 |
2023-08-13 |
rat |
| Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Azam Shah Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perima. Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-06. PMID:27570173. |
further investigation with 5-ht receptor antagonists methiothepin (5-ht |
2017-02-06 |
2023-08-13 |
mouse |
| Jo Sourbron, Henning Schneider, Angéla Kecskés, Yusu Liu, Ellen M Buening, Lieven Lagae, Ilse Smolders, Peter de Witt. Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. ACS chemical neuroscience. vol 7. issue 5. 2017-01-27. PMID:26822114. |
in a clinical study, add-on treatment with fenfluramine, a potent 5-hydroxytryptamine (5-ht) releaser activating multiple 5-ht receptor subtypes, made 70% of ds children seizure free. |
2017-01-27 |
2023-08-13 |
human |
| Peter J Gagolewicz, Hans C Dringenber. Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo. Neural plasticity. vol 2016. 2016-12-30. PMID:27247804. |
while 5-ht application (0.1-10 mm) itself did not alter ltp levels, the broad-acting 5-ht receptor antagonists methiothepin (1 mm) resulted in a clear facilitation of ltp in adult animals, an effect that was mimicked by the selective 5-ht1a receptor antagonist way 100635 (1 mm). |
2016-12-30 |
2023-08-13 |
rat |
| C L Muller, A M J Anacker, J Veenstra-VanderWeel. The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience. vol 321. 2016-12-13. PMID:26577932. |
a knock-in mouse model of one of these variants, sert gly56ala, recapitulates the hyperserotonemia biomarker and shows increased brain serotonin clearance, increased serotonin receptor sensitivity, and altered social, communication, and repetitive behaviors. |
2016-12-13 |
2023-08-13 |
mouse |
| Ryo Hotta, Lily Cheng, Hannah K Graham, Nandor Nagy, Jaime Belkind-Gerson, George Mattheolabakis, Mansoor M Amiji, Allan M Goldstei. Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo. Biomaterials. vol 88. 2016-12-13. PMID:26922325. |
since serotonin (5-ht) promotes enteric neuronal growth during embryonic development, we hypothesized that serotonin receptor agonism would augment growth of neurons from transplanted enscs. |
2016-12-13 |
2023-08-13 |
mouse |
| Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, Sylvie Dirrig-Grosch, Stéphane Dieterlé, Andoni Echaniz-Laguna, Yves Larmet, Kathrin Müller, Jochen H Weishaupt, Dietmar R Thal, Wouter van Rheenen, Kristel van Eijk, Roland Lawson, Laurent Monassier, Luc Maroteaux, Anne Roumier, Philip C Wong, Leonard H van den Berg, Albert C Ludolph, Jan H Veldink, Anke Witting, Luc Dupui. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26744351. |
here we observed that the serotonin 2b receptor (5-ht2b), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of als. |
2016-11-08 |
2023-08-13 |
mouse |
| Knud Larsen, Jamal Momeni, Leila Farajzadeh, Christian Bendixe. Differential A-to-I RNA editing of the serotonin-2C receptor G-protein-coupled, HTR2C, in porcine brain tissues. Biochimie. vol 121. 2016-10-25. PMID:26707647. |
the htr2c gene encodes the 5-hydroxytryptamine (serotonin) receptor 2c, g-protein-coupled protein which functions as a serotonin receptor. |
2016-10-25 |
2023-08-13 |
human |
| Hyo Jung Kim, Sang Won Shin, Eun-Kee Song, Na-Ri Lee, Jun Suk Kim, Jin Seok Ahn, Hwan-Jung Yun, Yo-Han Cho, Keon Uk Park, Si-Young Kim, Joung Soon Jang, Sang-We Kim, Hyun Woo Lee, Se Ryeon Lee, Yang Soo Kim, Soon Nam Lee, Yoon Ho Ko, Hwa Jung Kim, Jin-Hyoung Kan. Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21. The oncologist. vol 20. issue 12. 2016-09-21. PMID:26512046. |
a combination of serotonin receptor (5-hydroxytryptamine receptor type 3) antagonists, nk-1 receptor antagonist, and steroid improves the complete response (cr) of chemotherapy-induced nausea and vomiting (cinv) in cancer patients. |
2016-09-21 |
2023-08-13 |
Not clear |
| Hua Sui, Hanchen Xu, Qing Ji, Xuan Liu, Lihong Zhou, Haiyan Song, Xiqiu Zhou, Yangxian Xu, Zhesheng Chen, Jianfeng Cai, Guang Ji, Qi L. 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway. Oncotarget. vol 6. issue 28. 2016-07-19. PMID:26214021. |
overexpression of 5-hydroxytryptamine (5-ht) in human cancer contributes to tumor metastasis, but the role of 5-ht receptor family in cancer has not been thoroughly explored. |
2016-07-19 |
2023-08-13 |
mouse |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
in this article, we attempt to develop a conceptual framework in which the effects of 5-ht, selective serotonin reuptake inhibitors (ssris), and vortioxetine on gaba and glutamate neurotransmission can be understood in the pfc and striatum-2 regions with roles in cognition and substantially different 5-ht receptor expression patterns. |
2016-07-19 |
2023-08-13 |
Not clear |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
thus, we review the anatomy of the neuronal microcircuitry in the pfc and striatum, anatomical data on 5-ht receptor expression within these microcircuits, and electrophysiological evidence on the effects of 5-ht on the behavior of each cell type. |
2016-07-19 |
2023-08-13 |
Not clear |
| Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser, Gennady Smagin, Christina K Olsen, Connie Sanche. Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26346726. |
furthermore, hippocampal cells often co-express multiple 5-ht receptor subtypes that can have either complementary or opposing effects on cell function, adding to the complexity of 5-ht neurotransmission. |
2016-07-19 |
2023-08-13 |
Not clear |
| Hitoshi Watanabe, Tatsuya Nakano, Ryo Saito, Daisuke Akasaka, Kazuki Saito, Hideki Ogasawara, Takeshi Minashima, Kohtaro Miyazawa, Takashi Kanaya, Ikuro Takakura, Nao Inoue, Ikuo Ikeda, Xiangning Chen, Masato Miyake, Haruki Kitazawa, Hitoshi Shirakawa, Kan Sato, Kohji Tahara, Yuya Nagasawa, Michael T Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi As. Serotonin Improves High Fat Diet Induced Obesity in Mice. PloS one. vol 11. issue 1. 2016-07-08. PMID:26766570. |
the elevation of these gene mrna expressions by 5-ht injection was inhibited by treatment with 5-ht receptor (5htr) 2a or 7 antagonists. |
2016-07-08 |
2023-08-13 |
mouse |
| Michael S Virk, Yotam Sagi, Lucian Medrihan, Jenny Leung, Michael G Kaplitt, Paul Greengar. Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 3. 2016-06-14. PMID:26733685. |
here we show that, in mice, 5-ht depolarizes cholinergic interneurons (chis) of the dst whereas hyperpolarizing chis from the vst by acting on different 5-ht receptor isoforms. |
2016-06-14 |
2023-08-13 |
mouse |
| Agnieszka Nikiforu. Targeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date. CNS drugs. vol 29. issue 4. 2016-06-13. PMID:25721336. |
the 5-ht7 (5-hydroxytryptamine 7, serotonin 7) receptor is one of the most recently identified members of the serotonin receptor family. |
2016-06-13 |
2023-08-13 |
mouse |