| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui She. Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34624424. |
impairment of learning and memory function caused by lack of sleep is a common physiological phenomenon of which underlying changes in synaptic plasticity in the hippocampus are not well understood. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui She. Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34624424. |
the possible different effects of sleep deprivation (sd) lasting for various durations on learning and memory function and hippocampal synaptic plasticity are still not completely clear. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui She. Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34624424. |
then, hippocampal synaptic plasticity was evaluated after all behavioural experiments. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui She. Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34624424. |
specifically, 24 h rem sd improved novelty-related olm, accompanied by a significantly increased hippocampal synaptic plasticity, including gain of dendritic spines, increased expression of hippocampal glua1, and enhanced long-term potentiation (ltp), whereas 48 h rem sd showed no effect on olm or the hippocampal synaptic plasticity mentioned above; however, 72 h rem sd impaired novelty-related olm and weakened hippocampal synaptic plasticity, including serious loss of dendritic spines, decreased expression of hippocampal glua1, and significantly attenuated ltp. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui She. Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34624424. |
our results suggest that rem sd of various durations has different effects on both novelty-related olm and hippocampal synaptic plasticity. |
2021-12-11 |
2023-08-13 |
mouse |
| Judit Català-Solsona, Alfredo J Miñano-Molina, José Rodríguez-Álvare. Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience. vol 14. 2021-12-11. PMID:34880728. |
nr4a2 transcription factor in hippocampal synaptic plasticity, memory and cognitive dysfunction: a perspective review. |
2021-12-11 |
2023-08-13 |
Not clear |
| Judit Català-Solsona, Alfredo J Miñano-Molina, José Rodríguez-Álvare. Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience. vol 14. 2021-12-11. PMID:34880728. |
recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group a, member 2 (nr4a2/nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. |
2021-12-11 |
2023-08-13 |
Not clear |
| Judit Català-Solsona, Alfredo J Miñano-Molina, José Rodríguez-Álvare. Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience. vol 14. 2021-12-11. PMID:34880728. |
in this review, we highlight the specific effects of nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions. |
2021-12-11 |
2023-08-13 |
Not clear |
| Gholam Hossein Meftahi, Mahnaz Bayat, Amir Hossein Zarifkar, Somaye Akbari, Afshin Borhani Haghighi, Maryam Naseh, Amirhossein Yousefi Nejad, Masoud Haghan. Treatment with edaravone improves the structure and functional changes in the hippocampus after chronic cerebral hypoperfusion in rat. Brain research bulletin. vol 174. 2021-12-10. PMID:34116172. |
therefore, most likely through the improvement of mda level, and the hippocampal cell number and volume, edr leads to recovery of synaptic plasticity and behavioral performance. |
2021-12-10 |
2023-08-13 |
rat |
| J Fernández-Felipe, B Merino, A B Sanz-Martos, A Plaza, A Contreras, V Naranjo, L Morales, J A Chowen, V Cano, M Ruiz-Gayo, N Del Olm. Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice. Psychoneuroendocrinology. vol 133. 2021-12-10. PMID:34624673. |
accordingly, hippocampal synaptic plasticity mechanisms underlying memory, and gene expression of nmda receptor subunits are modulated by both diets. |
2021-12-10 |
2023-08-13 |
mouse |
| Aliza A Le, Julian Quintanilla, Mohammad Amani, Daniele Piomelli, Gary Lynch, Christine M Gal. Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents. Neurobiology of disease. vol 162. 2021-12-10. PMID:34838664. |
persistent sexually dimorphic effects of adolescent thc exposure on hippocampal synaptic plasticity and episodic memory in rodents. |
2021-12-10 |
2023-08-13 |
Not clear |
| Aaron D Milstein, Yiding Li, Katie C Bittner, Christine Grienberger, Ivan Soltesz, Jeffrey C Magee, Sandro Roman. Bidirectional synaptic plasticity rapidly modifies hippocampal representations. eLife. vol 10. 2021-12-10. PMID:34882093. |
bidirectional synaptic plasticity rapidly modifies hippocampal representations. |
2021-12-10 |
2023-08-13 |
Not clear |
| Anna Tyrtyshnaia, Anatoly Bondar, Sophia Konovalova, Igor Manzhul. Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884587. |
thus, synaptamide has a beneficial effect on hippocampal functioning, including synaptic plasticity and hippocampus-dependent cognitive processes in neuropathic pain. |
2021-12-10 |
2023-08-13 |
mouse |
| Malgorzata Borczyk, Kasia Radwanska, K Peter Gies. The importance of ultrastructural analysis of memory. Brain research bulletin. vol 173. 2021-12-09. PMID:33984429. |
here, we systematically compare how long-term potentiation of synaptic transmission (ltp) (a primary form of synaptic plasticity and cellular model of memory) and behavioral training affect hippocampal glutamatergic synapses at the ultrastructural level enabled by electron microscopy. |
2021-12-09 |
2023-08-13 |
mouse |
| Francesca Romana Rizzo, Livia Guadalupi, Krizia Sanna, Valentina Vanni, Diego Fresegna, Francesca De Vito, Alessandra Musella, Silvia Caioli, Sara Balletta, Silvia Bullitta, Antonio Bruno, Ettore Dolcetti, Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Georgia Mandolesi, Diego Centonze, Antonietta Gentil. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34391817. |
indeed, exercise significantly reduced microgliosis in the ca1 area, the expression of tumour necrosis factor (tnf) in microglia and, to a lesser extent, the hippocampal level of interleukin 1 beta (il-1β), previously shown to contribute to aberrant synaptic plasticity in the eae hippocampus. |
2021-12-09 |
2023-08-13 |
mouse |
| Jing Gao, Wenxin Zhang, Xueqing Chai, Xiaoyue Tan, Zhuo Yan. Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease. Brain research bulletin. vol 178. 2021-12-09. PMID:34838642. |
moreover, hippocampal synaptic plasticity (long-term potentiation and depotentiation) and the levels of synaptic proteins in hippocampus were decreased after mptp treatment. |
2021-12-09 |
2023-08-13 |
mouse |
| Jing Gao, Wenxin Zhang, Xueqing Chai, Xiaoyue Tan, Zhuo Yan. Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease. Brain research bulletin. vol 178. 2021-12-09. PMID:34838642. |
aep knockout ameliorated the cognition and the synaptic plasticity defects in the hippocampus. |
2021-12-09 |
2023-08-13 |
mouse |
| Ying Yu, Zhaokun Shi, Dan Xu, Ying Li, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32497709. |
the latter inhibits the hippocampal bdnf pathway, leading to the disruption of hippocampal neurogenesis, apoptosis and decreased synaptic plasticity. |
2021-12-06 |
2023-08-13 |
rat |
| Yu Feng, Rengfei Shi, Jingyun Hu, Shujie Lo. Effects of neural-derived estradiol on actin polymerization and synaptic plasticity-related proteins in prefrontal and hippocampal cells of mice. Steroids. vol 177. 2021-12-06. PMID:34715132. |
neural-derived 17β-estradiol (e2) plays an important role in the synaptic plasticity of the hippocampus and prefrontal cortex, but the mechanism is not well defined. |
2021-12-06 |
2023-08-13 |
mouse |
| Yu Feng, Rengfei Shi, Jingyun Hu, Shujie Lo. Effects of neural-derived estradiol on actin polymerization and synaptic plasticity-related proteins in prefrontal and hippocampal cells of mice. Steroids. vol 177. 2021-12-06. PMID:34715132. |
this study was designed to explore the effect and mechanism of neural-derived e2 on synaptic plasticity of the hippocampus and prefrontal cortex. |
2021-12-06 |
2023-08-13 |
mouse |