| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
the mice were intraperitoneally injected with casr inhibitor (nps2143) 30 min before cih exposure and the results demonstrated casr inhibitor alleviated the apoptosis and synaptic plasticity deficit in the hippocampus of cih mice. |
2023-01-04 |
2023-08-14 |
mouse |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
overall, our findings revealed that casr held a critical function on cih-induced cognitive dysfunction in mice by accelerating hippocampal neuronal apoptosis and reducing synaptic plasticity via augmenting casr-pkc-erk1/2 pathway; otherwise, inhibition of casr alleviated cih-induced cognitive dysfunction. |
2023-01-04 |
2023-08-14 |
mouse |
| Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubin. Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations. iScience. vol 26. issue 1. 2022-12-30. PMID:36582822. |
impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal gabaergic-bdnf/trkb signaling alterations. |
2022-12-30 |
2023-08-14 |
mouse |
| Yiyi Li, Hongyu Chen, Jianhao Wang, Jiabei Wang, Xuan Niu, Chao Wang, Dongdong Qin, Fang Li, Yamei Wang, Jing Xiong, Songyan Liu, Liqin Huang, Xi Zhang, Feng Gao, Dandan Gao, Mingxia Fan, Xuan Xiao, Zhi-Hao Wan. Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice. Frontiers in molecular neuroscience. vol 15. 2022-12-29. PMID:36578534. |
furthermore, hfd impaired synaptic plasticity and decreased surface expression of glutamate receptors in the hippocampus of wild-type (wt) mice, but not in c/ebpβ heterozygous knockout mice. |
2022-12-29 |
2023-08-14 |
mouse |
| Janine I Rossato, Andressa Radiske, Maria Carolina Gonzalez, Lia R M Bevilaqua, Martín Cammarot. On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory. Frontiers in behavioral neuroscience. vol 16. 2022-12-29. PMID:36578877. |
c-jun n-terminal kinase (jnk) phosphorylates the transcription factor c-jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. |
2022-12-29 |
2023-08-14 |
rat |
| Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisett. Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease. Molecular psychiatry. 2022-12-28. PMID:36577843. |
we additionally show that hcq exerts dose-dependent effects on late long-term potentiation (ltp) and rescues impaired hippocampal synaptic plasticity prior to significant accumulation of amyloid plaques and neurodegeneration in app/ps1 mice. |
2022-12-28 |
2023-08-14 |
mouse |
| Jie Guo, Ying-Qian Zhao, Hua Li, Gai-Yue Zhang, Yuan-Rong Lu, Pan-Pan Guo, Qiang Wan. [Effect of electroacupuncture on hippocampal synaptic plasticity and complement dependent memory impairment in Parkinson's disease dementia mice]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 12. 2022-12-26. PMID:36571217. |
[effect of electroacupuncture on hippocampal synaptic plasticity and complement dependent memory impairment in parkinson's disease dementia mice]. |
2022-12-26 |
2023-08-14 |
mouse |
| Hardy Hagena, Martin Stacho, Arthur Laja, Denise Manahan-Vaugha. Strain-dependent regulation of hippocampal long-term potentiation by dopamine D1/D5 receptors in mice. Frontiers in behavioral neuroscience. vol 16. 2022-12-22. PMID:36545120. |
the c57bl/6 mouse is an extremely popular murine strain used in studies of hippocampal synaptic plasticity and spatial learning. |
2022-12-22 |
2023-08-14 |
mouse |
| Yi-Fang Wu, Kai-Yan Jin, Da-Peng Wang, Qi Lin, Jun Sun, Shao-Hua Su, Jian Ha. VEGF loaded nanofiber membranes inhibit chronic cerebral hypoperfusion-induced cognitive dysfunction by promoting HIF-1a/VEGF mediated angiogenesis. Nanomedicine : nanotechnology, biology, and medicine. 2022-12-22. PMID:36549557. |
vegf-nfms sticking decreased the number of tunel-positive cells in surgical temporal cortex, ameliorated impaired synaptic plasticity, and inhibited the release of pro-inflammatory cytokines and the activation of microglia and astrocytes in surgical temporal cortex and hippocampus. |
2022-12-22 |
2023-08-14 |
rat |
| Somoday Hazra, Joyeeta Dutta Hazra, Rani Amit Bar-On, Yanhong Duan, Shahaf Edut, Xiaohua Cao, Gal Richter-Levi. The role of hippocampal CaMKII in resilience to trauma-related psychopathology. Neurobiology of stress. vol 21. 2022-12-19. PMID:36532378. |
in light of the established role of hippocampal synaptic plasticity in stress and the essential role of ca2+/calmodulin-dependent protein kinase ii (camkii) in hippocampal based synaptic plasticity, we pharmacologically inhibited camkii or knocked-down (kd) αcamkii (in two separate experiments) in the dorsal dentate gyrus of the hippocampus (ddg) following exposure to the same trauma paradigm. |
2022-12-19 |
2023-08-14 |
rat |
| Yibo Li, Hongfang Wang, Yanjing Gao, Runjiao Zhang, Qing Liu, Wenmeng Xie, Ziyu Liu, Dandan Geng, Lei Wan. Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533129. |
aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. |
2022-12-19 |
2023-08-14 |
mouse |
| Xueping Yao, Xiaoqun Qin, Hui Wang, Jiaoyun Zheng, Zhi Peng, Jie Wang, Horst Christian Weber, Rujiao Liu, Wenrui Zhang, Ji Zeng, Suhui Zuo, Hui Chen, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan, Xiangping Q. Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. Stress (Amsterdam, Netherlands). vol 26. issue 1. 2022-12-15. PMID:36520154. |
lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. |
2022-12-15 |
2023-08-14 |
mouse |
| Sohrab Anvari, Forough Foolad, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollah. A distinct impact of repeated morphine exposure on synaptic plasticity at Schaffer collateral-CA1, temporoammonic-CA1, and perforant pathway-dentate gyrus synapses along the longitudinal axis of the hippocampus. Hippocampus. 2022-12-14. PMID:36514833. |
a distinct impact of repeated morphine exposure on synaptic plasticity at schaffer collateral-ca1, temporoammonic-ca1, and perforant pathway-dentate gyrus synapses along the longitudinal axis of the hippocampus. |
2022-12-14 |
2023-08-14 |
rat |
| Laura Bellingacci, Martina Tallarico, Andrea Mancini, Alfredo Megaro, Carmen De Caro, Rita Citraro, Giovambattista De Sarro, Alessandro Tozzi, Massimiliano Di Filippo, Miriam Sciaccaluga, Emilio Russo, Antonio Leo, Cinzia Cost. Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis. Neuropharmacology. 2022-12-12. PMID:36502868. |
we aimed to investigate whether the non-competitive block of ampars was able to counteract the alteration of hippocampal epileptic threshold, and of synaptic plasticity linked to aβ oligomers accumulation, being this glutamate receptor a valuable specific therapeutic target. |
2022-12-12 |
2023-08-14 |
mouse |
| Laura Bellingacci, Martina Tallarico, Andrea Mancini, Alfredo Megaro, Carmen De Caro, Rita Citraro, Giovambattista De Sarro, Alessandro Tozzi, Massimiliano Di Filippo, Miriam Sciaccaluga, Emilio Russo, Antonio Leo, Cinzia Cost. Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis. Neuropharmacology. 2022-12-12. PMID:36502868. |
thus, targeting ampars might be a valuable strategy to reduce both hippocampal networks hyperexcitability and synaptic plasticity deficits induced by aβ oligomers accumulation. |
2022-12-12 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. |
2022-12-09 |
2023-08-14 |
mouse |
| Matthew L Mendoza, Lilyana D Quigley, Thomas Dunham, Lenora J Vol. KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner. iScience. vol 25. issue 12. 2022-12-05. PMID:36465112. |
these data suggest that kibra serves a unique role in adult hippocampal function through regulation of basal and activity-dependent ampar proteostasis that supports synaptic plasticity. |
2022-12-05 |
2023-08-14 |
mouse |
| Yuan Liu, Zhong Chen, Wei Lin, Yifei Zhou, Zihan Liu, Ruixia Zhao, Yu Chen, Bin Wu, Aiqin Chen, Chun Li. Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome. Frontiers in cellular neuroscience. vol 16. 2022-12-05. PMID:36467610. |
furthermore, bioinformatic analysis and experimental data showed that ezh2 is a circkcnk9/mir-124-3p target gene, and increased ezh2 expression was involved in visceral hypersensitivity and anxiety in ibs-like rats by enhancing hippocampal synaptic plasticity. |
2022-12-05 |
2023-08-14 |
rat |
| Jaan Aru, Moritz Drüke, Juhan Pikamäe, Matthew E Larku. Mental navigation and the neural mechanisms of insight. Trends in neurosciences. 2022-12-03. PMID:36462993. |
our framework connects the dots between research on creativity, mental navigation, and specific synaptic plasticity mechanisms in the hippocampus. |
2022-12-03 |
2023-08-14 |
Not clear |
| Yu-Jiao Li, Xiao-Lu He, Jie-Yu Zhang, Xue-Jiao Liu, Jia-Long Liang, Qing Zhou, Guo-Hua Zho. 8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice. Metabolic brain disease. 2022-12-01. PMID:36456714. |
our results demonstrated that 8-oas (0.2, 2, 20 mg/kg) administration dose-dependently ameliorated behavioral abnormalities in sd mice, accompanied with restored synaptic plasticity and reduced shrinkage and loss of hippocampal neurons. |
2022-12-01 |
2023-08-14 |
mouse |