| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in sd rat offspring during adolescence and adulthood via hdac2-mediated histone deacetylation. |
2022-10-20 |
2023-08-14 |
rat |
| Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Ni. Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation. Ecotoxicology and environmental safety. vol 246. 2022-10-20. PMID:36265406. |
all of the results suggest that prenatal b[a]p exposure impairs cognitive function and hippocampal synaptic plasticity of offspring in adolescence and adulthood, and hdac2-mediated histone deacetylation plays a crucial role in these deficits. |
2022-10-20 |
2023-08-14 |
rat |
| Yufang Yang, Xiaoshuang Zhang, Dongxue Li, Rong Fang, Zishan Wang, Di Yun, Mo Wang, Jinghui Wang, Hongtian Dong, Zhaoliang Fei, Qing Li, Zhaolin Liu, Chenye Shen, Jian Fei, Mei Yu, Thomas Behnisch, Fang Huan. NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters ad-like pathology. Human molecular genetics. 2022-10-14. PMID:36229920. |
here we show that conditional nrsf/rest knockout either in the dorsal telencephalon or specially in neurons induced an age-dependently diminished retrieval performance in spatial or fear conditioning memory tasks and altered hippocampal synaptic transmission and activity-dependent synaptic plasticity. |
2022-10-14 |
2023-08-14 |
mouse |
| Rut Fadó, Anna Molins, Rocío Rojas, Núria Casal. Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235789. |
we observe that memory and learning deficits mediated by high-fat/high-sugar diets, even over short exposure times, are associated with reduced arborization, widened synaptic cleft, narrowed post-synaptic zone, and decreased activity-dependent synaptic plasticity in the hippocampus, and also observe that these alterations correlate with deregulation of the ampa-type glutamate ionotropic receptors (ampars) that are crucial to neuroplasticity. |
2022-10-14 |
2023-08-14 |
human |
| Kunrui Du, Shaojie Yang, Jingji Wang, Guoqi Zh. Acupuncture Interventions for Alzheimer's Disease and Vascular Cognitive Disorders: A Review of Mechanisms. Oxidative medicine and cellular longevity. vol 2022. 2022-10-10. PMID:36211826. |
focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, ad characteristic proteins, intestinal microbiota, neuroinflammation, microrna expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. |
2022-10-10 |
2023-08-14 |
Not clear |
| Narongrit Thongon, Siriporn Chamniansawa. Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats. Metabolic brain disease. 2022-10-01. PMID:36181652. |
we examined the hippocampal protein expression of synaptic plasticity proteins, including the ampa receptor subunit glua1, postsynaptic density-95 (psd-95), and activity-regulated cytoskeleton-associated protein (arc), and the hippocampal expression and localization of androgen receptor (ar). |
2022-10-01 |
2023-08-14 |
rat |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
ablating pyramidal neuron sert (sertpyramidΔ) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. |
2022-09-30 |
2023-08-14 |
mouse |
| Li Hao, Yiming Wu, Jin Xie, Xinwang Che. Electroacupuncture Enhances Cognitive Deficits in a Rat Model of Rapid Eye Movement Sleep Deprivation via Targeting MiR-132. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-09-26. PMID:36159559. |
the current data demonstrate that ea at gv20 and gv14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via mir-132 in a sleep-deprived rat model. |
2022-09-26 |
2023-08-14 |
rat |
| Baorui Guo, Yu Xia, Chunlin Wang, Feng Wang, Chun Zhang, Lifei Xiao, Xian Zhang, Yuan Meng, Yangyang Wang, Jiangwei Ding, Lei Wang, Changliang Zhu, Shucai Jiang, Xianhao Huo, Yangyang Sun, Peng Gao, Ji Wu, Baoli Yu, Junming Huo, Tao Su. Decreased cognitive function of ALG13KO female mice may be related to the decreased plasticity of hippocampal neurons. Neuropeptides. vol 96. 2022-09-24. PMID:36152356. |
moreover, it may have lowered the synaptic plasticity in various areas of the hippocampus, thus resulting in decreased dendrite length, complexity, and dendrite spine density, which affected the hippocampal function and reduced the cognitive function in female mice. |
2022-09-24 |
2023-08-14 |
mouse |
| Irene Sánchez-Rodríguez, Sara Temprano-Carazo, Danko Jeremic, Jose Maria Delgado-Garcia, Agnès Gruart, Juan D Navarro-López, Lydia Jiménez-Día. Recognition Memory Induces Natural LTP-like Hippocampal Synaptic Excitation and Inhibition. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142727. |
here, to study synaptic plasticity phenomena during recognition memory in the dorsal hippocampus, field postsynaptic potentials (fpsps) evoked at the ca3-ca1 synapse were recorded in freely moving mice during object-recognition task performance. |
2022-09-23 |
2023-08-14 |
mouse |
| Hamish Stevens-Bullmore, Don Kulasiri, Sandhya Samarasingh. A Modeling and Analysis Study Reveals That CaMKII in Synaptic Plasticity Is a Dominant Affecter in CaM Systems in a T286 Phosphorylation-Dependent Manner. Molecules (Basel, Switzerland). vol 27. issue 18. 2022-09-23. PMID:36144710. |
nmdar-dependent synaptic plasticity in the hippocampus consists of two opposing forces: long-term potentiation (ltp), which strengthens synapses and long-term depression (ltd), which weakens synapses. |
2022-09-23 |
2023-08-14 |
Not clear |
| Yanan Li, Qi Zhang, Wenyu Yan, Xupeng Wang, Jiaxu Yu, Chunping Yin, Qi Zhou, Zhiyong Hou, Qiujun Wan. Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity. Frontiers in aging neuroscience. vol 14. 2022-09-23. PMID:36147703. |
young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity. |
2022-09-23 |
2023-08-14 |
mouse |
| Yanan Li, Qi Zhang, Wenyu Yan, Xupeng Wang, Jiaxu Yu, Chunping Yin, Qi Zhou, Zhiyong Hou, Qiujun Wan. Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity. Frontiers in aging neuroscience. vol 14. 2022-09-23. PMID:36147703. |
together, these findings suggest that young plasma reverses anesthesia- and surgery-induced cognitive impairment in aged rats and that the mechanism is associated with the activation of the trkb/erk/creb signaling pathway and improvement in hippocampal synaptic plasticity. |
2022-09-23 |
2023-08-14 |
mouse |
| Ève Honoré, Inês Belo do Nascimento, Isabel Laplante, Jean-Claude Lacaill. Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons. Molecular brain. vol 15. issue 1. 2022-09-19. PMID:36123709. |
stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons. |
2022-09-19 |
2023-08-14 |
mouse |
| Anna L Arzuaga, Daisy D Edmison, Jessica Mroczek, John Larson, Michael E Ragozzin. Prenatal Stress and Fluoxetine Exposure in Mice Differentially Affect Repetitive Behaviors and Synaptic Plasticity in Adult Male and Female Offspring. Behavioural brain research. 2022-09-18. PMID:36116737. |
the present study investigated in c57bl/6j pregnant mice whether restraint stress (g4-18) and/or treatment with the ssri fluoxetine (g8-18) affects autism-related behaviors and hippocampal synaptic plasticity in male and female offspring. |
2022-09-18 |
2023-08-14 |
mouse |
| Xian-Guo Li. Normalization of Neuroinflammation: A New Strategy for Treatment of Persistent Pain and Memory/Emotional Deficits in Chronic Pain. Journal of inflammation research. vol 15. 2022-09-16. PMID:36110505. |
the abnormal expression of ion channels and pathological synaptic plasticity in spinal dorsal horn and in hippocampus are resulting from neuroinflammation. |
2022-09-16 |
2023-08-14 |
Not clear |
| Xu Tan, Xiaoyu Liu, E Liu, Min Liu, Shouhong Mu, Zhaofang Hang, Weikai Han, Tingting Wang, Yang Zhang, Jing Zhang, Qingwei Yue, Jinhao Su. Astrocyte-derived lactate/NADH alters methamphetamine-induced memory consolidation and retrieval by regulating neuronal synaptic plasticity in the dorsal hippocampus. Brain structure & function. 2022-09-16. PMID:36112231. |
astrocyte-derived lactate/nadh alters methamphetamine-induced memory consolidation and retrieval by regulating neuronal synaptic plasticity in the dorsal hippocampus. |
2022-09-16 |
2023-08-14 |
mouse |
| Qingqing Li, Xiao Wang, Zhao Hua Wang, Zhenzong Lin, Jieyi Yang, Jichun Chen, Rui Wang, Wenfeng Ye, Ya Li, Yingying Wu, Aiguo Xua. Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice. Human vaccines & immunotherapeutics. 2022-09-16. PMID:36113067. |
bacillus calmette - guerin (bcg) is an immune regulator that can enhance hippocampal synaptic plasticity in rats; however, it is unclear whether it can improve synaptic function in a mouse model with alzheimer's disease (ad). |
2022-09-16 |
2023-08-14 |
mouse |
| Kangyu Jin, Shiyi Zhang, Chaonan Jiang, Ripeng Liu, Bing Chen, Haoyang Zhao, Qin Zhang, Zhe Shen, Pengfeng Xu, Xiaohan Hu, Jianping Jiao, Jing Lu, Manli Huan. The role of reelin in the pathological mechanism of depression from clinical to rodents. Psychiatry research. vol 317. 2022-09-14. PMID:36103758. |
previous studies have suggested that synaptic plasticity in the hippocampus plays an important role in depression pathogenesis. |
2022-09-14 |
2023-08-14 |
rat |
| Kangyu Jin, Shiyi Zhang, Chaonan Jiang, Ripeng Liu, Bing Chen, Haoyang Zhao, Qin Zhang, Zhe Shen, Pengfeng Xu, Xiaohan Hu, Jianping Jiao, Jing Lu, Manli Huan. The role of reelin in the pathological mechanism of depression from clinical to rodents. Psychiatry research. vol 317. 2022-09-14. PMID:36103758. |
reelin is expressed mainly in the frontal lobe and hippocampus, and is closely associated with neurodevelopment and synaptic plasticity. |
2022-09-14 |
2023-08-14 |
rat |