| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Pu, Guo-Bin Bao, Nan-Jie Xu, Lan Ma, Gang Pe. Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880521. |
given the known effects of opiates such as morphine and heroin on hippocampal function, we investigated the potential effect of chronic opiate treatment on long-term potentiation (ltp) at ca1 synapses in rat hippocampus, a leading experimental model for studying synaptic plasticity. |
2002-03-22 |
2023-08-12 |
rat |
| Lu Pu, Guo-Bin Bao, Nan-Jie Xu, Lan Ma, Gang Pe. Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880521. |
these findings demonstrated that chronic opiate treatment can significantly modulate synaptic plasticity in the hippocampus, leading to an opiate dependence of the plasticity. |
2002-03-22 |
2023-08-12 |
rat |
| Alexander Kulla, Denise Manahan-Vaugha. Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 2. 2002-03-14. PMID:11739263. |
these results strongly support a role for 5-ht(4) receptors in hippocampal synaptic plasticity and provide an important link to findings with regard to the involvement of 5-ht in processes related to learning and memory. |
2002-03-14 |
2023-08-12 |
rat |
| Lauren T Knapp, Eric Klan. Potentiation of hippocampal synaptic transmission by superoxide requires the oxidative activation of protein kinase C. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 3. 2002-02-27. PMID:11826097. |
potentiation of hippocampal synaptic transmission by superoxide requires the oxidative activation of protein kinase c. recent evidence suggests that reactive oxygen species (ros), including superoxide, are not only neurotoxic but function as small messenger molecules in normal neuronal processes such as synaptic plasticity. |
2002-02-27 |
2023-08-12 |
Not clear |
| Inah Lee, Raymond P Kesne. Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory. Nature neuroscience. vol 5. issue 2. 2002-02-26. PMID:11780144. |
n-methyl-d-aspartate (nmda) receptor-dependent synaptic plasticity in the mammalian hippocampus is essential for learning and memory. |
2002-02-26 |
2023-08-12 |
mouse |
| R Tonini, S Franceschetti, D Parolaro, M Sala, E Mancinelli, S Tininini, R Brusetti, G Sancini, R Brambilla, E Martegani, E Sturani, R Zippe. Involvement of CDC25Mm/Ras-GRF1-dependent signaling in the control of neuronal excitability. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749043. |
mice lacking ras-grf1 (-/-) are severely impaired in amygdala-dependent long-term synaptic plasticity and show higher basal synaptic activity at both amygdala and hippocampal synapses (brambilla et al., 1997). |
2002-02-21 |
2023-08-12 |
mouse |
| J F MacDonald, S A Kotecha, W Y Lu, M F Jackso. Convergence of PKC-dependent kinase signal cascades on NMDA receptors. Current drug targets. vol 2. issue 3. 2002-02-19. PMID:11554554. |
synaptic plasticity, or long-term potentiation (ltp), of excitatory synapses in the hippocampus contributes to learning and the establishment of spatial memories. |
2002-02-19 |
2023-08-12 |
Not clear |
| M R Fo. 17beta-estradiol: effect on CA1 hippocampal synaptic plasticity. Neurobiology of learning and memory. vol 76. issue 3. 2002-01-31. PMID:11726235. |
17beta-estradiol: effect on ca1 hippocampal synaptic plasticity. |
2002-01-31 |
2023-08-12 |
Not clear |
| M R Fo. 17beta-estradiol: effect on CA1 hippocampal synaptic plasticity. Neurobiology of learning and memory. vol 76. issue 3. 2002-01-31. PMID:11726235. |
this paper reviews the recent results that have led to a better understanding of how the sex hormone estrogen influences synaptic plasticity in an important structure within the mammalian brain responsible for learning and memory: the hippocampus. |
2002-01-31 |
2023-08-12 |
Not clear |
| M J Kahana, D Seelig, J R Madse. Theta returns. Current opinion in neurobiology. vol 11. issue 6. 2002-01-28. PMID:11741027. |
recent physiological studies have implicated theta - a high-amplitude 4-8 hz oscillation that is prominent in rat hippocampus during locomotion, orienting and other voluntary behaviors - in synaptic plasticity, information coding and the function of working memory. |
2002-01-28 |
2023-08-12 |
human |
| M W Jones, H M Peckham, M L Errington, T V Bliss, A Routtenber. Synaptic plasticity in the hippocampus of awake C57BL/6 and DBA/2 mice: interstrain differences and parallels with behavior. Hippocampus. vol 11. issue 4. 2002-01-23. PMID:11530843. |
synaptic plasticity in the hippocampus of awake c57bl/6 and dba/2 mice: interstrain differences and parallels with behavior. |
2002-01-23 |
2023-08-12 |
mouse |
| L J Shanley, A J Irving, J Harve. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11734601. |
leptin enhances nmda receptor function and modulates hippocampal synaptic plasticity. |
2002-01-23 |
2023-08-12 |
Not clear |
| L J Shanley, A J Irving, J Harve. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11734601. |
in the hippocampus, an area of the brain involved in learning and memory, we have found that leptin facilitates the induction of synaptic plasticity. |
2002-01-23 |
2023-08-12 |
Not clear |
| L J Shanley, A J Irving, J Harve. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11734601. |
these data indicate that a novel action of leptin in the cns is to facilitate hippocampal synaptic plasticity via enhanced nmda receptor-mediated ca(2+) influx. |
2002-01-23 |
2023-08-12 |
Not clear |
| O Thibault, R Hadley, P W Landfiel. Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739583. |
elevated postsynaptic [ca2+]i and l-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. |
2002-01-23 |
2023-08-12 |
rat |
| O Thibault, R Hadley, P W Landfiel. Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739583. |
however, it is still not known whether (1) intracellular [ca(2+)](i) is altered in aged brain neurons during synaptically activated neuronal activity; (2) altered [ca(2+)](i) is directly correlated with impaired neuronal plasticity; or (3) the previously observed age-related increase in l-type voltage-sensitive ca(2+) channel (l-vscc) density in hippocampal neurons is sufficient to impair synaptic plasticity. |
2002-01-23 |
2023-08-12 |
rat |
| B D Philpot, M P Weisberg, M S Ramos, N B Sawtell, Y P Tang, J Z Tsien, M F Bea. Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex. Neuropharmacology. vol 41. issue 6. 2002-01-10. PMID:11640931. |
unlike the hippocampus, in vitro synaptic plasticity of the visual cortex was unaltered by nr2b overexpression. |
2002-01-10 |
2023-08-12 |
mouse |
| M Kokaia, K Holmberg, A Nanobashvili, Z Q Xu, Z Kokaia, U Lendahl, S Hilke, E Theodorsson, U Kahl, T Bartfai, O Lindvall, T Hökfel. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 24. 2002-01-08. PMID:11698649. |
frequency facilitation of field excitatory postsynaptic potentials, a form of short-term synaptic plasticity assessed in hippocampal slices, was reduced in mossy fiber-ca3 cell synapses of galanin-overexpressing mice, indicating suppressed glutamate release. |
2002-01-08 |
2023-08-12 |
mouse |
| N Mons, V Enderlin, R Jaffard, P Higuere. Selective age-related changes in the PKC-sensitive, calmodulin-binding protein, neurogranin, in the mouse brain. Journal of neurochemistry. vol 79. issue 4. 2001-12-20. PMID:11723178. |
these data suggest that age-related changes of post-synaptic ng in selected brain areas, and particularly in hippocampus, may contribute to altered ca(2+)/calmodulin-signalling pathways and to region-specific impairments of synaptic plasticity and cognitive decline. |
2001-12-20 |
2023-08-12 |
mouse |
| M D Glitsch, J J Jac. Evidence that glutamate acting on presynaptic type-II metabotropic glutamate receptors alone does not fully account for the phenomenon of depolarisation-induced suppression of inhibition in cerebellar Purkinje cells. Pflugers Archiv : European journal of physiology. vol 442. issue 3. 2001-12-12. PMID:11484772. |
depolarisation-induced suppression of inhibition (dsi) is a form of short-term synaptic plasticity at gamma-aminobutyric-acid-(gaba)ergic synapses between principal neurons and interneurons in both the cerebellum and the hippocampus. |
2001-12-12 |
2023-08-12 |
Not clear |