| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel S Dichter, Jennifer N Felder, Steven R Green, Alison M Rittenberg, Noah J Sasson, James W Bodfis. Reward circuitry function in autism spectrum disorders. Social cognitive and affective neuroscience. vol 7. issue 2. 2012-06-06. PMID:21148176. |
group × reward-type-interaction tests revealed robust interaction effects in bilateral nucleus accumbens during reward anticipation and in ventromedial prefrontal cortex during reward outcomes, indicating differential responses contingent on reward type in these regions. |
2012-06-06 |
2023-08-12 |
human |
| Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M Reye. Epigenetic dysregulation of the dopamine system in diet-induced obesity. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22220805. |
dopamine (da) system changes in response to hf diet have been observed in the hypothalamus, important in the homeostatic control of food intake, as well as within the central reward circuitry [ventral tegmental area (vta), nucleus accumbens (nac), and pre-frontal cortex (pfc)], critical for coding the rewarding properties of palatable food and important in hedonically driven feeding behavior. |
2012-06-01 |
2023-08-12 |
mouse |
| Kenneth Blum, Eliot Gardner, Marlene Oscar-Berman, Mark Gol. "Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22236117. |
addictive drugs have in common that they are voluntarily selfadministered, they enhance (directly or indirectly) dopaminergic synaptic function in the nucleus accumbens (nac), and they stimulate the functioning of brain reward circuitry (producing the "high" that drug users seek). |
2012-05-31 |
2023-08-12 |
Not clear |
| Matthew R Holahan, Erin P Westby, Katrina Alber. Comparison of the MK-801-induced appetitive extinction deficit with pressing for reward and associated pERK1/2 staining in prefrontal cortex and nucleus accumbens. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22182675. |
comparison of the mk-801-induced appetitive extinction deficit with pressing for reward and associated perk1/2 staining in prefrontal cortex and nucleus accumbens. |
2012-05-24 |
2023-08-12 |
Not clear |
| Narcisse P Bichot, Matthew T Heard, Robert Desimon. Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys. Journal of neuroscience methods. vol 199. issue 2. 2012-05-21. PMID:21704383. |
stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys. |
2012-05-21 |
2023-08-12 |
monkey |
| Ruud van Zessen, Jana L Phillips, Evgeny A Budygin, Garret D Stube. Activation of VTA GABA neurons disrupts reward consumption. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445345. |
in addition, direct activation of vta gaba projections to the nucleus accumbens (nac) resulted in detectable gaba release but did not alter reward consumption. |
2012-05-15 |
2023-08-12 |
Not clear |
| Karolina P Skibicka, Caroline Hansson, Emil Egecioglu, Suzanne L Dickso. Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addiction biology. vol 17. issue 1. 2012-05-14. PMID:21309956. |
we further investigated ghrelin's effects on key mesolimbic reward nodes, the ventral tegmental area (vta) and nucleus accumbens (nacc), by evaluating the effects of chronic central ghrelin treatment on the expression of genes encoding major reward neurotransmitter receptors, namely dopamine and acetylcholine. |
2012-05-14 |
2023-08-12 |
Not clear |
| Alessandra Lintas, Ning Chi, Nicole M Lauzon, Stephanie F Bishop, Ninglei Sun, Huibing Tan, Steven R Laviolett. Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. The European journal of neuroscience. vol 35. issue 2. 2012-05-08. PMID:22236063. |
the basolateral amygdala (bla), ventral tegmental area and nucleus accumbens (nac) form a functionally connected neural circuit involved in the processing of opiate-related reward and memory. |
2012-05-08 |
2023-08-12 |
rat |
| Michael D Roberts, Leigh Gilpin, Kyle E Parker, Thomas E Childs, Matthew J Will, Frank W Boot. Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:22001493. |
dopamine signaling in the nucleus accumbens (nac) has been postulated to influence reward development towards drugs of abuse and exercise. |
2012-04-16 |
2023-08-12 |
rat |
| John W Muschamp, Christina L Nemeth, Alfred J Robison, Eric J Nestler, William A Carlezo. ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biological psychiatry. vol 71. issue 1. 2012-03-30. PMID:21962331. |
elevated expression of the transcription factor Δfosb accompanies repeated exposure to drugs of abuse, particularly in brain areas associated with reward and motivation (e.g., nucleus accumbens). |
2012-03-30 |
2023-08-12 |
Not clear |
| José Martínez-Hernández, Enrique Lanuza, Fernando Martínez-Garcí. Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual pheromones. Behavioural brain research. vol 226. issue 2. 2012-03-25. PMID:22019343. |
therefore, dopamine in the medial shell of the nucleus accumbens has a different role on the reward of sexual pheromones and sucrose. |
2012-03-25 |
2023-08-12 |
mouse |
| N D Volkow, G-J Wang, J H Newcorn, S H Kollins, T L Wigal, F Telang, J S Fowler, R Z Goldstein, N Klein, J Logan, C Wong, J M Swanso. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20856250. |
to evaluate this hypothesis, we performed secondary analyses to assess the correlation between the pet measures of dopamine d2/d3 receptor and dopamine transporter availability (obtained with [(11)c]raclopride and [(11)c]cocaine, respectively) in the dopamine reward pathway (midbrain and nucleus accumbens) and a surrogate measure of trait motivation (assessed using the achievement scale on the multidimensional personality questionnaire or mpq) in 45 adhd participants and 41 controls. |
2012-03-05 |
2023-08-12 |
human |
| Makoto Taniguchi, Maria B Carreira, Laura N Smith, Benjamin C Zirlin, Rachael L Neve, Christopher W Cowa. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. vol 73. issue 1. 2012-03-05. PMID:22243750. |
importantly, we show that dephosphorylation of hdac5 s279 in the nucleus accumbens suppresses the development, but not expression, of cocaine reward behavior in vivo. |
2012-03-05 |
2023-08-12 |
Not clear |
| B M Sharp, H Chen, S Gong, X Wu, Z Liu, K Hiler, W L Taylor, S G Matt. Gene expression in accumbens GABA neurons from inbred rats with different drug-taking behavior. Genes, brain, and behavior. vol 10. issue 7. 2012-02-22. PMID:21745336. |
on the basis of their pivotal role in drug reward, we hypothesized that differences in basal gene expression in gabaergic neurons projecting from nucleus accumbens (nacc) to ventral pallidum (vp) play a role in vulnerability to drug-taking behavior. |
2012-02-22 |
2023-08-12 |
rat |
| Srikanth Padmala, Luiz Pesso. Reward reduces conflict by enhancing attentional control and biasing visual cortical processing. Journal of cognitive neuroscience. vol 23. issue 11. 2012-02-08. PMID:21452938. |
finally, reward increased functional connectivity between the right ips and both bilateral putamen and bilateral nucleus accumbens during the cue phase, a relationship that covaried with across-individual sensitivity to reward in the case of the right nucleus accumbens. |
2012-02-08 |
2023-08-12 |
human |
| Eszter Bálint, Szilvia Mezey, András Csilla. Efferent connections of nucleus accumbens subdivisions of the domestic chicken (Gallus domesticus): an anterograde pathway tracing study. The Journal of comparative neurology. vol 519. issue 15. 2012-01-12. PMID:21618229. |
envisaged as a limbic-motor interface, the mammalian nucleus accumbens (ac) is responsible for motivation, emotionality, and reward mechanisms. |
2012-01-12 |
2023-08-12 |
chicken |
| Amy R Furay, Ross A McDevitt, Klaus A Miczek, John F Neumaie. 5-HT1B mRNA expression after chronic social stress. Behavioural brain research. vol 224. issue 2. 2011-12-21. PMID:21718722. |
the 5-ht(1b) receptor is expressed in nucleus accumbens (nac) projection neurons and modulates drug reward mechanisms and there is evidence suggesting that stress alters the regulation and function of these receptors. |
2011-12-21 |
2023-08-12 |
rat |
| Anna M Lee, Robert O Messin. Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 38. 2011-12-12. PMID:21911393. |
protein kinase c epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens. |
2011-12-12 |
2023-08-12 |
mouse |
| Allison Brager, Rebecca A Prosser, J David Glas. Acamprosate-responsive brain sites for suppression of ethanol intake and preference. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 4. 2011-12-06. PMID:21697518. |
four days before ethanol reintroduction, mice received bilateral blank or acamprosate-containing microimplants releasing ∼50 ng/day into reward [ventral tegmental (vta), peduculopontine tegmentum (ppt), and nucleus accumbens (na)] and circadian [intergeniculate leaflet (igl) and suprachiasmatic nucleus (scn)] areas. |
2011-12-06 |
2023-08-12 |
mouse |
| Amanda M Dossat, Nicole Lilly, Kristen Kay, Diana L William. Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 41. 2011-12-06. PMID:21994361. |
one such region is the nucleus accumbens (nac), which plays a role in reward and motivated behavior. |
2011-12-06 |
2023-08-12 |
rat |