| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh Chandra, Jeffrey D Lenz, Amy M Gancarz, Dipesh Chaudhury, Gabrielle L Schroeder, Ming-Hu Han, Joseph F Cheer, David M Dietz, Mary Kay Lob. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Frontiers in molecular neuroscience. vol 6. 2013-06-10. PMID:23745104. |
these d1-msns in the nucleus accumbens (nac) positively regulate drug seeking, reward, and locomotor behavioral effects as well as the morphological adaptations of psychostimulant drugs. |
2013-06-10 |
2023-08-12 |
rat |
| Ulf J Müller, Jürgen Voges, Johann Steiner, Imke Galazky, Hans-Jochen Heinze, Michaela Möller, Jared Pisapia, Casey Halpern, Arthur Caplan, Bernhard Bogerts, Jens Kuh. Deep brain stimulation of the nucleus accumbens for the treatment of addiction. Annals of the New York Academy of Sciences. vol 1282. 2013-06-03. PMID:23227826. |
in this review, beginning with an introduction of deep brain stimulation (dbs), we highlight the importance of the nucleus accumbens (nac) in the context of the reward circuitry and addictive behavior. |
2013-06-03 |
2023-08-12 |
Not clear |
| Kia J Jackson, Sarah S Sanjakdar, Xiangning Chen, M Imad Dama. Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226481. |
camkiv protein levels were also increased in the nucleus accumbens of c57bl/6 mice after nicotine reward. |
2013-05-28 |
2023-08-12 |
mouse |
| Pamela J Kennedy, Jian Feng, A J Robison, Ian Maze, Ana Badimon, Ezekiell Mouzon, Dipesh Chaudhury, Diane M Damez-Werno, Stephen J Haggarty, Ming-Hu Han, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature neuroscience. vol 16. issue 4. 2013-05-21. PMID:23475113. |
induction of histone acetylation in the nucleus accumbens (nac), a key brain reward region, promotes cocaine-induced alterations in gene expression. |
2013-05-21 |
2023-08-12 |
mouse |
| V M Pickel, E T Shobin, D A Lane, K Macki. Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals. Neuroscience. vol 227. 2013-05-09. PMID:22863674. |
the ventral pallidum (vp) is a major recipient of inhibitory projections from nucleus accumbens (acb) neurons that differentially express the reward (enkephalin) and aversion (dynorphin)-associated opioid peptides. |
2013-05-09 |
2023-08-12 |
mouse |
| A J Rodrigues, P Leão, J M Pêgo, D Cardona, M M Carvalho, M Oliveira, B M Costa, A F Carvalho, P Morgado, D Araújo, J A Palha, O F X Almeida, N Sous. Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids. Molecular psychiatry. vol 17. issue 12. 2013-05-07. PMID:21968930. |
these animals presented prominent changes in the nucleus accumbens (nacc), a key component of the mesolimbic reward circuitry; specifically, cell numbers and dopamine (da) levels were significantly reduced, whereas da receptor 2 (drd2) mrna expression levels were markedly upregulated in the nacc. |
2013-05-07 |
2023-08-12 |
rat |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
drugs of abuse induce neuroplasticity in the natural reward pathway, specifically the nucleus accumbens (nac), thereby causing development and expression of addictive behavior. |
2013-04-24 |
2023-08-12 |
rat |
| Valorie N Salimpoor, Iris van den Bosch, Natasa Kovacevic, Anthony Randal McIntosh, Alain Dagher, Robert J Zatorr. Interactions between the nucleus accumbens and auditory cortices predict music reward value. Science (New York, N.Y.). vol 340. issue 6129. 2013-04-24. PMID:23580531. |
interactions between the nucleus accumbens and auditory cortices predict music reward value. |
2013-04-24 |
2023-08-12 |
Not clear |
| Valorie N Salimpoor, Iris van den Bosch, Natasa Kovacevic, Anthony Randal McIntosh, Alain Dagher, Robert J Zatorr. Interactions between the nucleus accumbens and auditory cortices predict music reward value. Science (New York, N.Y.). vol 340. issue 6129. 2013-04-24. PMID:23580531. |
importantly, the auditory cortices, amygdala, and ventromedial prefrontal regions showed increased activity during listening conditions requiring valuation, but did not predict reward value, which was instead predicted by increasing functional connectivity of these regions with the nucleus accumbens as the reward value increased. |
2013-04-24 |
2023-08-12 |
Not clear |
| Janine M Prast, Kai K Kummer, Constanze M Barwitz, Christian Humpel, Georg Dechant, Gerald Zerni. Acetylcholine, drug reward and substance use disorder treatment: intra- and interindividual striatal and accumbal neuron ensemble heterogeneity may explain apparent discrepant findings. Pharmacology. vol 90. issue 5-6. 2013-04-23. PMID:23018268. |
in this commentary, we try to reconcile apparently discrepant animal behavioral, human behavioral and clinical data with a unifying hypothesis positing that the modulation of drug-versus natural stimuli-mediated reward by cholinergic interneurons in the nucleus accumbens (and the dorsal striatum) is restricted to distinct neuron ensembles that show considerable intra- and interindividual variation with respect to their spatial distribution. |
2013-04-23 |
2023-08-12 |
human |
| D Shabashov, E Shohami, R Yak. Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. Journal of molecular neuroscience : MN. vol 47. issue 3. 2013-04-11. PMID:22127928. |
here we show that inhibition of pkmζ in the nucleus accumbens (nac) shell, a major component of the reward system that plays an important role in mediating drug craving and relapse, by a selective inhibitor ζ inhibitory peptide (zip), abolished cocaine-induced conditioned place preference (cpp). |
2013-04-11 |
2023-08-12 |
Not clear |
| James M Bjork, Ashley R Smith, Gang Chen, Daniel W Homme. Psychosocial problems and recruitment of incentive neurocircuitry: exploring individual differences in healthy adolescents. Developmental cognitive neuroscience. vol 1. issue 4. 2013-03-12. PMID:21927631. |
finally, a psychophysiological interaction (ppi) analysis indicated that increased connectivity between nucleus accumbens and portions of anterior cingulate and mfc as a function of reward prospects also correlated with dusi-opd. |
2013-03-12 |
2023-08-12 |
Not clear |
| Mei-Hong Qiu, Wei Liu, Wei-Min Qu, Yoshihiro Urade, Jun Lu, Zhi-Li Huan. The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. PloS one. vol 7. issue 9. 2013-03-06. PMID:23029032. |
we proposed that the nucleus accumbens (nac) that receives the ventral tegmental area dopamine inputs play an important role not only in reward and addiction but also in sleep-wake cycle and in mediating modafinil-induced arousal. |
2013-03-06 |
2023-08-12 |
Not clear |
| Przemysław Biliński, Andrzej Wojtyła, Lucyna Kapka-Skrzypczak, Roman Chwedorowicz, Małgorzata Cyranka, Tadeusz Studzińsk. Epigenetic regulation in drug addiction. Annals of agricultural and environmental medicine : AAEM. vol 19. issue 3. 2013-03-04. PMID:23020045. |
recent data suggest that repeated exposure to certain drugs promotes changes in levels of histone acetylation, phosphorylation and methylation, together with alterations in dna methylation levels in the neurons of the brain reward centre, localised in the nucleus accumbens (nac) region of the limbic system. |
2013-03-04 |
2023-08-12 |
Not clear |
| Takatoshi Hikida, Satoshi Yawata, Takashi Yamaguchi, Teruko Danjo, Toshikuni Sasaoka, Yanyan Wang, Shigetada Nakanish. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 1. 2013-02-27. PMID:23248274. |
pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. |
2013-02-27 |
2023-08-12 |
Not clear |
| Karina Possa Abrahao, Maria Lucia Oliveira Souza-Formigon. Behavioral sensitization to ethanol results in cross-sensitization to MK-801 but not to NMDA administered intra-accumbens. Behavioural brain research. vol 235. issue 2. 2013-02-25. PMID:22871257. |
few studies have directly investigated the subsequent neuroadaptations in the nucleus accumbens (nac), the central area of the brain reward system, after chronic ethanol administration. |
2013-02-25 |
2023-08-12 |
mouse |
| Haosheng Sun, Ian Maze, David M Dietz, Kimberly N Scobie, Pamela J Kennedy, Diane Damez-Werno, Rachael L Neve, Venetia Zachariou, Li Shen, Eric J Nestle. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197736. |
here, we show that chronic morphine, like cocaine, decreases g9a expression, and global levels of h3k9me2, in mouse nucleus accumbens (nac), a key brain reward region. |
2013-02-19 |
2023-08-12 |
mouse |
| Cheng-Shu Li, Sooyoung Chung, Da-Peng Lu, Young K Ch. Descending projections from the nucleus accumbens shell suppress activity of taste-responsive neurons in the hamster parabrachial nuclei. Journal of neurophysiology. vol 108. issue 5. 2013-02-01. PMID:22696536. |
the nucleus accumbens is one of the critical neural substrates of the reward system, and the nucleus accumbens shell region (nacsh) is associated with feeding behavior. |
2013-02-01 |
2023-08-12 |
human |
| Roee Admon, Maya Bleich-Cohen, Ronit Weizmant, Michael Poyurovsky, Sarit Faragian, Talma Hendle. Functional and structural neural indices of risk aversion in obsessive-compulsive disorder (OCD). Psychiatry research. vol 203. issue 2-3. 2013-01-28. PMID:22959813. |
furthermore, they displayed higher amygdala activation to threat; lower nucleus accumbens (nacc) activation to reward and reduced functional connectivity of the amygdala and nacc to two frontal regions, the orbito-frontal cortex (ofc) and the dorsal anterior cingulate cortex (dacc), respectively. |
2013-01-28 |
2023-08-12 |
Not clear |
| Snežana Urošević, Paul Collins, Ryan Muetzel, Kelvin Lim, Monica Lucian. Longitudinal changes in behavioral approach system sensitivity and brain structures involved in reward processing during adolescence. Developmental psychology. vol 48. issue 5. 2013-01-25. PMID:22390662. |
this decline is combined with a decrease in left nucleus accumbens (nacc) volume, a key structure for reward processing, from the late teens into the early 20s. |
2013-01-25 |
2023-08-12 |
human |