| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ream Al-Hasani, Raajaram Gowrishankar, Gavin P Schmitz, Christian E Pedersen, David J Marcus, Sofia E Shirley, Taylor E Hobbs, Abigail J Elerding, Sophie J Renaud, Miao Jing, Yulong Li, Veronica A Alvarez, Julia C Lemos, Michael R Brucha. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature neuroscience. vol 24. issue 10. 2021-10-08. PMID:34385700. |
the long-range gabaergic input from the ventral tegmental area (vta) to the nucleus accumbens (nac) is relatively understudied, and therefore its role in reward processing has remained unknown. |
2021-10-08 |
2023-08-13 |
mouse |
| Yongxiang Li, Lvshuang Chen, Weijie Zhao, Lijuan Sun, Ruixue Zhang, Shuqing Zhu, Kailai Xie, Xiajie Feng, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Lina Wang, Qingyan Jian. Food reward depends on TLR4 activation in dopaminergic neurons. Pharmacological research. vol 169. 2021-10-04. PMID:33971268. |
conditional deletion of tlr4 also decreased the activity of da neurons while suppressing the expression of tyrosine hydroxylase (th) in the vta, which regulates the concentration of da in the nucleus accumbens (nac) to affect food reward. |
2021-10-04 |
2023-08-13 |
mouse |
| Anna Brancato, Valentina Castelli, Gianluca Lavanco, Giuseppe Tringali, Vincenzo Micale, Martin Kuchar, Cesare D'Amico, Giuseppe Pizzolanti, Salvatore Feo, Carla Cannizzar. Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572345. |
binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (nac). |
2021-10-01 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Abbas Haghparas. Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31436887. |
the nucleus accumbens (nac) is a central component of the brain reward system. |
2021-09-28 |
2023-08-13 |
rat |
| Christina N Rogers Flattery, Daniel J Coppeto, Kiyoshi Inoue, James K Rilling, Todd M Preuss, Larry J Youn. Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species. Brain structure & function. 2021-09-23. PMID:34482474. |
one notable difference is the lack of oxtr in reward regions such as the ventral pallidum and nucleus accumbens in chimpanzees, whereas oxtr is found in these regions in humans. |
2021-09-23 |
2023-08-13 |
human |
| Chenbo Wang, Chaofei Bao, Jiatao Gao, Yujin Gu, Xiao-Wei Don. Pain modulates neural responses to reward in the medial prefrontal cortex. Human brain mapping. vol 41. issue 5. 2021-09-16. PMID:31785068. |
whole-brain fmri analysis revealed that the main effect of outcome (win vs. loss) activated a typical network of the reward neural circuitry, including the medial prefrontal cortex (mpfc) and the bilateral nucleus accumbens (nacc). |
2021-09-16 |
2023-08-13 |
human |
| Grau-Perales Alejandro Borja, Expósito Alejandro Navarro, Gómez-Chacón Beatriz, Morón Ignacio, Gallo Milagro. Accumbens and amygdala in taste recognition memory: The role of d1 dopamine receptors. Neurobiology of learning and memory. vol 174. 2021-09-15. PMID:32707274. |
given the involvement of the nucleus accumbens in reward and of the amygdala in emotional memories, we applied c-fos immunohistochemistry as an index of neural activity in wistar rats that were exposed to a vinegar solution for one, two or six days. |
2021-09-15 |
2023-08-13 |
rat |
| Saeedeh Nasrollahi, Sara Karimi, Gholamali Hamidi, Monireh Naderitehrani, Alireza Abe. Blockade of the orexin 1 receptors in the nucleus accumbens' shell reversed the reduction effect of olanzapine on motivation for positive reinforcers. Neuroscience letters. vol 762. 2021-09-14. PMID:34311049. |
the nucleus accumbens (nac) is a region of the neural system that serves effort-related high reward choices andthe orexin 1 receptor (ox1r) is distributed extensively throughout the nucleus accumbens shell (acbs). |
2021-09-14 |
2023-08-13 |
rat |
| Sheketha R Hauser, Robert A Waeiss, Andrei I Molosh, Gerald A Deehan, Richard L Bell, William J McBride, Zachary A Rod. Atrial natriuretic peptide (ANP): A novel mechanism for reducing ethanol consumption and seeking behaviors in female alcohol preferring (P) rats. Peptides. vol 134. 2021-09-08. PMID:32882352. |
anp receptors are present in the mesocorticolimbic (mcl) reward pathway of the brain, which includes the nucleus accumbens (acb) and the ventral tegmental area (vta). |
2021-09-08 |
2023-08-13 |
rat |
| Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarih. The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats. Behavioral and brain functions : BBF. vol 17. issue 1. 2021-09-02. PMID:33612106. |
the nucleus accumbens (nac) plays a principal role in drug reward. |
2021-09-02 |
2023-08-13 |
rat |
| Amy E Kwarteng, Muhammad M Rahman, Dylan G Gee, M Alejandra Infante, Susan F Tapert, Brenda L Curti. Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study. Addictive behaviors. vol 122. 2021-09-02. PMID:34246036. |
we examined how parental substance use history relates to reward system functioning, specifically nucleus accumbens (nacc) and putamen activation at age 9-10 in the adolescent brain cognitive development (abcd) study. |
2021-09-02 |
2023-08-13 |
Not clear |
| Laura L Giacometti, Kelsey Chandran, Laura A Figueroa, Jacqueline M Barke. Astrocyte modulation of extinction impairments in ethanol-dependent female mice. Neuropharmacology. vol 179. 2021-08-27. PMID:32801026. |
using a chemogenetic strategy, we demonstrate that modulating astrocyte function via chemogenetic activation of gq-signaling in nucleus accumbens astrocytes transiently rescued extinction in ethanol-dependent females without impacting basal reward seeking. |
2021-08-27 |
2023-08-13 |
mouse |
| Claire E Stelly, Kasey S Girven, Merridee J Lefner, Kaitlyn M Fonzi, Matthew J Wana. Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33452431. |
specifically, a cue that always follows the previous reward by a short delay (high reward rate) evokes a larger dopamine response in the nucleus accumbens (nac) core relative to a distinct cue that always follows the prior reward by a long delay (low reward rate). |
2021-08-27 |
2023-08-13 |
rat |
| Sohini Dutta, Jasmin Beaver, Carly J Halcomb, Aaron M Jasno. Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear. Neurobiology of stress. vol 15. 2021-08-27. PMID:34355048. |
the nucleus accumbens (nac), consisting of core (nacc) and shell (nacs) sub-regions, has primarily been studied as a locus mediating the effects of drug reward and addiction. |
2021-08-27 |
2023-08-13 |
mouse |
| Anja Richter, Fabian Reinhard, Bernd Kraemer, Oliver Grube. A high-resolution fMRI approach to characterize functionally distinct neural pathways within dopaminergic midbrain and nucleus accumbens during reward and salience processing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32546416. |
a high-resolution fmri approach to characterize functionally distinct neural pathways within dopaminergic midbrain and nucleus accumbens during reward and salience processing. |
2021-08-10 |
2023-08-13 |
human |
| Hassan Jorjani, Marzieh Joneidi, Abbas Ali Vafaei, Ali Rashidy-Pour, Hamidreza Sameni, Ahmad Reza Bandegi, Behpour Yousefi, Hossein Miladi-Gorj. Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats. Pharmacology, biochemistry, and behavior. vol 201. 2021-08-10. PMID:33444602. |
microinjection of the bdnf receptor antagonist ana-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of bdnf levels and apoptotic cells in rats. |
2021-08-10 |
2023-08-13 |
rat |
| Yasaman Razavi, Sara Karimi, Saeideh Karimi-Haghighi, Soghra Hesam, Abbas Haghparas. Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Canadian journal of physiology and pharmacology. vol 98. issue 11. 2021-08-02. PMID:32574519. |
neural circuitry comprising the nucleus accumbens (nac), prefrontal cortex (pfc), amygdala (amy), and hippocampus (hip) are the main components of the reward circuit. |
2021-08-02 |
2023-08-13 |
rat |
| Rui Liu, Yun Wang, Xiongying Chen, Zhifang Zhang, Le Xiao, Yuan Zho. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33662708. |
the nucleus accumbens (nac) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (mdd). |
2021-07-30 |
2023-08-13 |
Not clear |
| Hee-Dae Kim, Jing Wei, Tanessa Call, Nicole Teru Quintus, Alexander J Summers, Samantha Carotenuto, Ross Johnson, Xiaokuang Ma, Chenxi Xu, Jin G Park, Shenfeng Qiu, Deveroux Ferguso. Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens. Molecular psychiatry. 2021-07-13. PMID:34253865. |
in the reward circuitry, the nucleus accumbens (nac) is a key brain region of depression pathophysiology, possibly based on differential activity of d1- or d2- medium spiny neurons (msns). |
2021-07-13 |
2023-08-13 |
mouse |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |