| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C E Strong, D P Hagarty, A Brea Guerrero, K J Schoepfer, S M Cajuste, M Kabba. Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific reports. vol 10. issue 1. 2021-03-09. PMID:33154463. |
the nucleus accumbens (nac), considered the hub of reward circuitry, is comprised of two medium spiny neuron (msn) subtypes that are classified by their enrichment of dopamine 1 (d1) or 2 (d2) receptors. |
2021-03-09 |
2023-08-13 |
rat |
| Joo Han Lee, Efrain A Ribeiro, Jeongseop Kim, Bumjin Ko, Hope Kronman, Yun Ha Jeong, Jong Kyoung Kim, Patricia H Janak, Eric J Nestler, Ja Wook Koo, Joung-Hun Ki. Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction. Biological psychiatry. vol 88. issue 10. 2021-03-08. PMID:32622465. |
cholinergic interneurons (chins) in the nucleus accumbens (nac) play critical roles in processing information related to reward. |
2021-03-08 |
2023-08-13 |
Not clear |
| Rajpreet Chahal, Kristen Delevich, Jaclyn S Kirshenbaum, Lauren R Borchers, Tiffany C Ho, Ian H Gotli. Sex differences in pubertal associations with fronto-accumbal white matter morphometry: Implications for understanding sensitivity to reward and punishment. NeuroImage. vol 226. 2021-03-01. PMID:33249215. |
given the role of the orbitofrontal cortex (ofc) and nucleus accumbens (nacc) in reward and punishment-related behaviors, we tested in a cross-sectional study whether males and females (n = 156, 89 females; ages 9-14 years) differ in the association between pubertal stage and fixel-based morphometry of wm fibers connecting the ofc and nacc (i.e., the fronto-accumbal tract). |
2021-03-01 |
2023-08-13 |
human |
| Tangfeng Su, Lei Pe. Acupuncture and oxytocinergic system: The promising treatment for autism. Translational neuroscience. vol 12. issue 1. 2021-02-27. PMID:33633868. |
ot was found to facilitate the endocannabinoid-mediated social reward processes in the nucleus accumbens of the mouse brain. |
2021-02-27 |
2023-08-13 |
mouse |
| Grace McIlvain, Rebecca G Clements, Emily M Magoon, Jeffrey M Spielberg, Eva H Telzer, Curtis L Johnso. Viscoelasticity of reward and control systems in adolescent risk taking. NeuroImage. vol 215. 2021-02-19. PMID:32298793. |
the socioemotional system (e.g., nucleus accumbens), which is instrumental in reward response, shows a relatively earlier development trajectory than the cognitive control system (e.g., medial prefrontal cortex), which regulates impulse response. |
2021-02-19 |
2023-08-13 |
Not clear |
| Shuang-Qi Gao, Hai Zhang, Jin-Gang He, Hui-Ling Zheng, Pei-Wei Zhang, Jun-Feng Xu, Zu-Cheng Shen, Huan-Huan Zhao, Fang Wang, Zhuang-Li Hu, Jian-Guo Che. Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory. Addiction biology. vol 25. issue 2. 2021-02-16. PMID:31056833. |
neuronal hmgb1 in nucleus accumbens regulates cocaine reward memory. |
2021-02-16 |
2023-08-13 |
Not clear |
| Kevin G Bath, Scott J Russo, Kristen E Pleil, Eric S Wohleb, Ronald S Duman, Jason J Radle. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. Neurobiology of stress. vol 7. 2021-02-15. PMID:29276735. |
dr. scott russo highlighted the impact of chronic social defeat stress in adolescent mice on the development and plasticity of reward circuity, with a focus on glutamatergic development in the nucleus accumbens and mesolimbic dopamine system, and the implications of these changes for disruptions in social and hedonic response, key processes disturbed in depressive pathology. |
2021-02-15 |
2023-08-13 |
mouse |
| Aimilia Lydia Kalafateli, Cajsa Aranäs, Elisabet Jerlha. Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice. Psychopharmacology. vol 237. issue 11. 2021-01-27. PMID:32651639. |
the identification of amylin receptors in areas processing reward, namely laterodorsal tegmental area (ldtg), ventral tegmental area (vta), and nucleus accumbens (nac), has attributed them a role as reward regulators. |
2021-01-27 |
2023-08-13 |
mouse |
| Samuel Rupprechter, Liana Romaniuk, Peggy Series, Yoriko Hirose, Emma Hawkins, Anca-Larisa Sandu, Gordon D Waiter, Christopher J McNeil, Xueyi Shen, Mathew A Harris, Archie Campbell, David Porteous, Jennifer A Macfarlane, Stephen M Lawrie, Alison D Murray, Mauricio R Delgado, Andrew M McIntosh, Heather C Whalley, J Douglas Steel. Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32385498. |
increased depressive symptom severity was related to decreased reward signals in areas which included the nucleus accumbens in 475 participants. |
2021-01-19 |
2023-08-13 |
human |
| Yao Wang, Zheng Liu, Li Cai, Rong Guo, Yan Dong, Yanhua H Huan. A Critical Role of Basolateral Amygdala-to-Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31924324. |
the nucleus accumbens (nac) is a reward processing hub sensitive to acute sleep deprivation. |
2021-01-06 |
2023-08-13 |
Not clear |
| Matthew T Birnie, Cassandra L Kooiker, Annabel K Short, Jessica L Bolton, Yuncai Chen, Tallie Z Bara. Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance. Biological psychiatry. vol 87. issue 10. 2021-01-06. PMID:32081365. |
focusing on amygdala nuclei and their projections, we provide evidence suggesting that aberrant crf expression and function may underlie augmented connectivity of the nucleus accumbens with fear/anxiety regions, disrupting the function of this critical locus of pleasure and reward. |
2021-01-06 |
2023-08-13 |
Not clear |
| Antonella Pisera-Fuster, Maria Paula Faillace, Ramon Bernabe. Pre-Exposure to Nicotine with Nocturnal Abstinence Induces Epigenetic Changes that Potentiate Nicotine Preference. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31848934. |
zebrafish exposed to d/n-nicotine showed high levels of acetylated histone 3 and pcreb immunoreactivity differentially found in nuclei of the dopaminergic reward circuit in zebrafish homologous to the ventral tegmental area, nucleus accumbens and dorsal habenula. |
2020-12-29 |
2023-08-13 |
zebrafish |
| Hasan Alhaddad, Woonyen Wong, Adam T Sari, Laura E Crotty Alexander, Youssef Sar. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. vol 8. issue 4. 2020-12-26. PMID:33137879. |
in this study, we evaluated the effect of three months' continuous exposure to e-cig vapor (juul pods), containing a high nicotine concentration, on the expression of glutamate receptors and transporters in drug reward brain regions such as the nucleus accumbens (nac) core (nac-core), nac shell (nac-shell) and hippocampus (hip) in female c57bl/6 mice. |
2020-12-26 |
2023-08-13 |
mouse |
| Kenneth D Car. Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs. Current pharmaceutical design. vol 26. issue 20. 2020-12-22. PMID:32013842. |
food restriction has been shown to increase the reward magnitude of diverse drugs of abuse, and these effects have been attributed to neuroadaptations in the dopamine-innervated nucleus accumbens. |
2020-12-22 |
2023-08-13 |
rat |
| Sabyasachi Dash, Muthukumar Balasubramaniam, Freddyson J Martínez-Rivera, Arthur Godino, Emily G Peck, Srinivas Patnaik, Mrutyunjay Suar, Erin S Calipari, Eric J Nestler, Fernando Villalta, Chandravanu Dash, Jui Pandhar. Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32641757. |
levels of mir-124 were also downregulated upon acute or chronic cocaine exposure in the mouse nucleus accumbens (nac)-a key reward region of brain. |
2020-12-21 |
2023-08-13 |
mouse |
| b' Mia Haaranen, Annika Sch\\xc3\\xa4fer, Vilja J\\xc3\\xa4rvi, Petri Hyyti\\xc3\\xa. Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats. Frontiers in behavioral neuroscience. vol 14. 2020-12-18. PMID:33328918.' |
these data demonstrate that the anterior insula, along with the amygdala and nucleus accumbens, has a key role in controlling alcohol drinking by providing excitatory input to the central amygdala and nucleus accumbens to enhance alcohol reward. |
2020-12-18 |
2023-08-13 |
rat |
| Jeff Boissoneault, Bethany Stennett, Michael E Robinso. Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures. Drug and alcohol dependence. vol 207. 2020-11-23. PMID:31891860. |
the nucleus accumbens (nac) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mpfc), amygdala, and insula). |
2020-11-23 |
2023-08-13 |
Not clear |
| Richard Quansah Amissah, Sandrine Chometton, Juliane Calvez, Genevieve Guèvremont, Elena Timofeeva, Igor Timofee. Differential Expression of DeltaFosB in Reward Processing Regions Between Binge Eating Prone and Resistant Female Rats. Frontiers in systems neuroscience. vol 14. 2020-11-13. PMID:33177996. |
the number of Δfosb-expressing neurons was: (1) higher in bep than ber rats in reward processing areas [medial prefrontal cortex (mpfc), nucleus accumbens (acb), and ventral tegmental area (vta)]; (2) similar in taste processing areas [insular cortex, ic and parabrachial nucleus (pbn)]; and (3) higher in the paraventricular nucleus of bep than ber rats, but not different in the locus coeruleus (lc), which are stress processing structures. |
2020-11-13 |
2023-08-13 |
rat |
| Maaly Nassa. The neurocognitive gains of diagnostic reasoning training using simulated interactive veterinary cases. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31882714. |
further, applying linear mixed-effects modelling on graph centrality metrics revealed the central roles of the creative semantic (inferior frontal, middle frontal and angular gyrus and parahippocampus) and reward systems (orbital gyrus, nucleus accumbens and putamen) in driving pre-training diagnostic reasoning; whereas, regions implicated in inductive reasoning (superior temporal and medial postcentral gyrus and parahippocampus) were the main post-training hubs. |
2020-11-05 |
2023-08-13 |
human |
| Yozo Ishiuj. Addiction and the itch-scratch cycle. What do they have in common? Experimental dermatology. vol 28. issue 12. 2020-10-28. PMID:31482585. |
reward systems, including the ventral tegmental area (vta), nucleus accumbens (nac) and striatum, are important for brain processing of both addiction and itch. |
2020-10-28 |
2023-08-13 |
human |