| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P V Piazza, M Le Moa. Glucocorticoids as a biological substrate of reward: physiological and pathophysiological implications. Brain research. Brain research reviews. vol 25. issue 3. 1998-04-29. PMID:9495563. |
the rewarding effects of glucocorticoids are probably mediated by a glucocorticoid-induced stimulation of the mesencephalic dopaminergic transmission, one of the principal neural substrates of reward. |
1998-04-29 |
2023-08-12 |
Not clear |
| S A Kushner, S L Dewey, C Kornetsk. Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds. Psychopharmacology. vol 133. issue 4. 1998-01-22. PMID:9372539. |
these data demonstrate that, at the doses tested, gvg is more effective at modulating basal reward thresholds that at modulating thresholds lowered by cocaine, implying that as dopaminergic activity increases, gabaergic activity must also increase in order to exert its inhibitory influence on dopaminergic activity. |
1998-01-22 |
2023-08-12 |
rat |
| A W Bergen, J Kokoszka, R Peterson, J C Long, M Virkkunen, M Linnoila, D Goldma. Mu opioid receptor gene variants: lack of association with alcohol dependence. Molecular psychiatry. vol 2. issue 6. 1998-01-15. PMID:9399694. |
this hypothesis is supported by the effects of alcohol on beta-endorphin release, of mu opioid receptor agonists and antagonists on alcohol consumption, and by the activation of the dopaminergic reward system by both alcohol and opiates. |
1998-01-15 |
2023-08-12 |
mouse |
| S Ivanová, A J Greensha. Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron. Psychopharmacology. vol 134. issue 2. 1998-01-09. PMID:9399383. |
these data are consistent with the proposal that repeated daily injections of nicotine positively effect a mesolimbic dopaminergic substrate of reward. |
1998-01-09 |
2023-08-12 |
Not clear |
| I Pérez de Castro, A Ibáñez, P Torres, J Sáiz-Ruiz, J Fernández-Piquera. Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics. vol 7. issue 5. 1997-12-08. PMID:9352568. |
this work provides a new evidence of the implication of the dopaminergic reward pathways, now through the involvement of drd4, in the aetiology of this impulsive disorder. |
1997-12-08 |
2023-08-12 |
human |
| D J Vandenbergh, L A Rodriguez, I T Miller, G R Uhl, H M Lachma. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. American journal of medical genetics. vol 74. issue 4. 1997-11-06. PMID:9259381. |
comt plays a prominent role in dopaminergic circuits important for drug reward, and comt alleles encode enzymes whose activities vary from three- to four-fold. |
1997-11-06 |
2023-08-12 |
human |
| W Gong, J B Justice, D Neil. Dissociation of locomotor and conditioned place preference responses following manipulation of GABA-A and AMPA receptors in ventral pallidum. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 5. 1997-10-29. PMID:9278955. |
in addition, it was argued that the gabaergic projection from nucleus accumbens to ventral pallidum may not be involved in the processing of reward initiated from dopaminergic activation in nucleus accumbens. |
1997-10-29 |
2023-08-12 |
Not clear |
| N Takahashi, L L Miner, I Sora, H Ujike, R S Revay, V Kostic, V Jackson-Lewis, S Przedborski, G R Uh. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 18. 1997-10-01. PMID:9275230. |
to assess vesicular contributions to amphetamine-induced locomotion, amphetamine-induced reward, and sequestration and resistance to dopaminergic neurotoxins, we have constructed transgenic vmat2 knockout mice. |
1997-10-01 |
2023-08-12 |
mouse |
| P Desai, M Roy, A Roy, S Brown, D Smelso. Impaired color vision in cocaine-withdrawn patients. Archives of general psychiatry. vol 54. issue 8. 1997-09-16. PMID:9283503. |
the main reinforcing effect of cocaine happens by altering dopaminergic neurotransmission in the brain reward systems. |
1997-09-16 |
2023-08-12 |
Not clear |
| K Blum, E R Braverman, S Wu, J G Cull, T J Chen, J Gill, R Wood, A Eisenberg, M Sherman, K R Davis, D Matthews, L Fischer, N Schnautz, W Walsh, A A Pontius, M Zedar, G Kaats, D E Coming. Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB). Molecular psychiatry. vol 2. issue 3. 1997-07-30. PMID:9152988. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been implicated in reward mechanisms in the brain. |
1997-07-30 |
2023-08-12 |
Not clear |
| J E Rose, W A Corrigal. Nicotine self-administration in animals and humans: similarities and differences. Psychopharmacology. vol 130. issue 1. 1997-07-18. PMID:9089846. |
the mesolimbic dopamine pathway has been implicated in nicotine reward based on animal studies, and research with humans suggests a role for dopaminergic processes as well. |
1997-07-18 |
2023-08-12 |
human |
| D E Comings, R Gade, S Wu, C Chiu, G Dietz, D Muhleman, G Saucier, L Ferry, R J Rosenthal, H R Lesieur, L J Rugle, P MacMurra. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Molecular psychiatry. vol 2. issue 1. 1997-06-25. PMID:9154217. |
abnormalities in the dopaminergic reward pathways have frequently been implicated in substance abuse and addictive behaviors. |
1997-06-25 |
2023-08-12 |
human |
| E P Nobl. Polymorphisms of the D2 dopamine receptor gene and alcoholism and other substance use disorders. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1997-04-07. PMID:8974314. |
moreover, reduced dopaminergic function has been found in subjects carrying the drd2 a1 allele, suggesting that the drd2 may be a reinforcement or reward gene. |
1997-04-07 |
2023-08-12 |
human |
| M Roy, A Roy, J Williams, L Weinberger, D Smelso. Reduced blue cone electroretinogram in cocaine-withdrawn patients. Archives of general psychiatry. vol 54. issue 2. 1997-03-13. PMID:9040283. |
the main reinforcing effect of cocaine is alteration of dopaminergic neurotransmission in the brain reward systems. |
1997-03-13 |
2023-08-12 |
Not clear |
| M E Old. Dopaminergic basis for the facilitation of brain stimulation reward by the NMDA receptor antagonist, MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813611. |
dopaminergic basis for the facilitation of brain stimulation reward by the nmda receptor antagonist, mk-801. |
1996-12-18 |
2023-08-12 |
rat |
| M E Old. Dopaminergic basis for the facilitation of brain stimulation reward by the NMDA receptor antagonist, MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813611. |
the similarity between the effects of mk-801 and those of amphetamine and between the effects of pretreatment with the dopamine receptor antagonists before mk-801 and before amphetamine suggests that dopaminergic activity played a significant role in the action underlying the effects of mk-801 on brain stimulation reward. |
1996-12-18 |
2023-08-12 |
rat |
| S Higuchi, T Muramatsu, S Matsushita, M Murayam. No evidence of association between structural polymorphism at the dopamine D3 receptor locus and alcoholism in the Japanese. American journal of medical genetics. vol 67. issue 4. 1996-12-13. PMID:8837712. |
dopaminergic systems mediate reward mechanisms and are involved in reinforcing self-administration of dependence-forming substances, including alcohol. |
1996-12-13 |
2023-08-12 |
Not clear |
| L G Schmidt, M Dettling, K J Graef, A Heinz, S Kuhn, J Podschus, H Rommelspache. Reduced dopaminergic function in alcoholics is related to severe dependence. Biological psychiatry. vol 39. issue 3. 1996-12-05. PMID:8837980. |
with a view to the role of dopamine (da) systems in reward processes and considering recent studies linking specific alleles at the da-d2 receptor gene locus with alcoholism (especially with severe types) dopaminergic functions were evaluated in 49 alcoholics using growth hormone (gh) response to da receptor agonist apomorphine (0.01 mg/kg subcutaneously). |
1996-12-05 |
2023-08-12 |
Not clear |
| P Martel, M Fantin. Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study. Pharmacology, biochemistry, and behavior. vol 53. issue 1. 1996-10-24. PMID:8848454. |
mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study. |
1996-10-24 |
2023-08-12 |
rat |
| K Blum, P J Sheridan, R C Wood, E R Braverman, T J Chen, J G Cull, D E Coming. The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. Journal of the Royal Society of Medicine. vol 89. issue 7. 1996-10-04. PMID:8774539. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been profoundly implicated in reward mechanisms in the brain. |
1996-10-04 |
2023-08-12 |
Not clear |