| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Künig, K L Leenders, C Martin-Sölch, J Missimer, S Magyar, W Schult. Reduced reward processing in the brains of Parkinsonian patients. Neuroreport. vol 11. issue 17. 2001-03-01. PMID:11117472. |
the pattern observed in the controls demonstrates the role in reward processing of dopaminergic mesolimbic pathways in the healthy human brain, whereas the pattern in the parkinsonian patients suggests the involvement of compensatory cortical loops in the diseased brain. |
2001-03-01 |
2023-08-12 |
human |
| M Barrot, M C Rettori, B Guardiola-Lemaître, C Jarry, M Le Moal, P V Piazz. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens. The European journal of neuroscience. vol 12. issue 12. 2001-02-15. PMID:11122366. |
in this report we analysed the influence of these sites on the functional activity of the mesolimbic dopaminergic transmission, one of the major brain systems involved in the regulation of motivation and reward. |
2001-02-15 |
2023-08-12 |
rat |
| L Pan. Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries? Molecular psychiatry. vol 5. issue 5. 2001-02-01. PMID:11032379. |
in this respect the mesocorticolimbic dopaminergic circuits have long been misconceptualized as simple reward or reinforcement systems. |
2001-02-01 |
2023-08-12 |
human |
| E F McKinney, R T Walton, P Yudkin, A Fuller, N A Haldar, D Mant, M Murphy, K I Welsh, S E Marshal. Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. Pharmacogenetics. vol 10. issue 6. 2001-01-25. PMID:10975602. |
central dopaminergic reward pathways give rise to dependence and are activated by nicotine. |
2001-01-25 |
2023-08-12 |
Not clear |
| N M Dawson, E H Hamid, M F Egan, G E Meredit. Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment. Synapse (New York, N.Y.). vol 39. issue 1. 2001-01-25. PMID:11071712. |
these results show that blockade of dopaminergic receptors with haloperidol rapidly downregulates bdnf in reward and emotional centers of the brain. |
2001-01-25 |
2023-08-12 |
rat |
| S Dehaene, J P Changeu. Reward-dependent learning in neuronal networks for planning and decision making. Progress in brain research. vol 126. 2001-01-18. PMID:11105649. |
their central hypothesis is that tentative rules of behavior, which are coded by clusters of active neurons in prefrontal cortex, are selected or rejected based on an evaluation by this reward signal, which may be conveyed, for instance, by the mesencephalic dopaminergic neurons with which the prefrontal cortex is densely interconnected. |
2001-01-18 |
2023-08-12 |
human |
| D E Comings, K Blu. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in brain research. vol 126. 2001-01-18. PMID:11105655. |
the dopaminergic and opioidergic reward pathways of the brain are critical for survival since they provide the pleasure drives for eating, love and reproduction; these are called 'natural rewards' and involve the release of dopamine in the nucleus accumbens and frontal lobes. |
2001-01-18 |
2023-08-12 |
human |
| M D Wood, I Boyfield, D J Nash, F R Jewitt, K Y Avenell, G J Rile. Evidence for antagonist activity of the dopamine D3 receptor partial agonist, BP 897, at human dopamine D3 receptor. European journal of pharmacology. vol 407. issue 1-2. 2000-12-29. PMID:11050289. |
the dopaminergic system has long been implicated in the mechanisms of reward and addiction. |
2000-12-29 |
2023-08-12 |
human |
| H L Rowley, S A Butler, M R Prow, S G Dykes, S Aspley, I C Kilpatrick, D J Hea. Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats. Synapse (New York, N.Y.). vol 38. issue 2. 2000-11-28. PMID:11018791. |
these findings therefore suggest that dopaminergic reward mechanisms are not involved in the reduction of food intake by sibutramine. |
2000-11-28 |
2023-08-12 |
rat |
| T R Wade, H de Wit, J B Richard. Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology. vol 150. issue 1. 2000-10-11. PMID:10867981. |
effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. |
2000-10-11 |
2023-08-12 |
rat |
| G P Chrouso. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 24 Suppl 2. 2000-10-10. PMID:10997609. |
thus, crh and the lc/ne system stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticipatory and reward phenomena, and the amygdala, which are responsible for the generation of fear. |
2000-10-10 |
2023-08-12 |
human |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
nicotine reinforces smoking behavior by activating nicotinic acetylcholine receptors (nachrs) in the midbrain dopaminergic (da) reward centers, including the ventral tegmental area (vta). |
2000-09-26 |
2023-08-12 |
Not clear |
| L A Sell, J S Morris, J Bearn, R S Frackowiak, K J Friston, R J Dola. Neural responses associated with cue evoked emotional states and heroin in opiate addicts. Drug and alcohol dependence. vol 60. issue 2. 2000-09-20. PMID:10940548. |
self-reports of 'urge to use' correlated strongly with increased regional blood flow (rcbf) in the inferior frontal and orbitofrontal cortex target regions of the mesolimbic dopaminergic system, implicated in conditioning and reward. |
2000-09-20 |
2023-08-12 |
human |
| C H Lammers, J Diaz, J C Schwartz, P Sokolof. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889548. |
the mesolimbic dopaminergic system is a neuroanatomical key structure for reward and motivation upon which previous studies indicated that antidepressant drugs exert a stimulatory influence, via still unknown neurobiological mechanisms. |
2000-09-14 |
2023-08-12 |
Not clear |
| E P Nobl. Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. European psychiatry : the journal of the Association of European Psychiatrists. vol 15. issue 2. 2000-08-17. PMID:10881203. |
it is hypothesized that in an effort to compensate for deficiencies in the dopaminergic system, substance abusers may seek to stimulate the mesocorticolimbic circuits of the brain, long thought to be important in behavioral reward and reinforcement. |
2000-08-17 |
2023-08-12 |
human |
| E B Bunney, S B Appel, M S Brodi. Cocaine potentiates ethanol-induced excitation of dopaminergic reward neurons in the ventral tegmental area. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773006. |
cocaine potentiates ethanol-induced excitation of dopaminergic reward neurons in the ventral tegmental area. |
2000-06-21 |
2023-08-12 |
rat |
| C L Duvauchelle, A Ikegami, S Asami, J Robens, K Kressin, E Castaned. Effects of cocaine context on NAcc dopamine and behavioral activity after repeated intravenous cocaine administration. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799668. |
in two conditioning experiments, identical procedures (previously shown to produce place preferences for a cocaine-paired environment) were used to assess dopaminergic and behavioral activity correlates of cocaine reward conditioning and sensitization. |
2000-06-21 |
2023-08-12 |
Not clear |
| C L Duvauchelle, A Ikegami, S Asami, J Robens, K Kressin, E Castaned. Effects of cocaine context on NAcc dopamine and behavioral activity after repeated intravenous cocaine administration. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799668. |
the present study uniquely demonstrates concurrent context-dependent potentiation of behavioral and dopaminergic responses to cocaine occurring in conjunction with cocaine reward. |
2000-06-21 |
2023-08-12 |
Not clear |
| M S Szczypka, M A Rainey, R D Palmite. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nature genetics. vol 25. issue 1. 2000-06-12. PMID:10802666. |
dopaminergic neurons in the substantia nigra and ventral tegmental area project to the caudate putamen and nucleus accumbens, where they modulate movement and reward. |
2000-06-12 |
2023-08-12 |
mouse |
| M Barrot, M Marinelli, D N Abrous, F Rougé-Pont, M Le Moal, P V Piazz. The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent. The European journal of neuroscience. vol 12. issue 3. 2000-05-22. PMID:10762327. |
the dopaminergic projection to the shell of the nucleus accumbens is the most reactive to stress, reward and drugs of abuse and this subregion of the nucleus accumbens is also considered a target of therapeutic effects of atypical antipsychotic drugs (apd). |
2000-05-22 |
2023-08-12 |
rat |