| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Martin-Soelch, A F Chevalley, G Künig, J Missimer, S Magyar, A Mino, W Schultz, K L Leender. Changes in reward-induced brain activation in opiate addicts. The European journal of neuroscience. vol 14. issue 8. 2001-12-18. PMID:11703464. |
many studies indicate a role of the cerebral dopaminergic reward system in addiction. |
2001-12-18 |
2023-08-12 |
human |
| B L Schmidt, C H Tambeli, R W Gear, J D Levin. Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564423. |
the nucleus accumbens, as part of the mesolimbic dopaminergic reward pathway, mediates both addiction to and withdrawal from substances of abuse. |
2001-12-04 |
2023-08-12 |
rat |
| L N Voruganti, P Slomka, P Zabel, A Mattar, A G Awa. Cannabis induced dopamine release: an in-vivo SPECT study. Psychiatry research. vol 107. issue 3. 2001-12-04. PMID:11566433. |
this observation offers a plausible biological explanation for the psychotogenic effects of cannabis in vulnerable individuals, and also raises speculations about an interaction between cannabinoid and dopaminergic systems in the brain reward pathways. |
2001-12-04 |
2023-08-12 |
Not clear |
| K K Kampe, C D Frith, R J Dolan, U Frit. Reward value of attractiveness and gaze. Nature. vol 413. issue 6856. 2001-12-04. PMID:11595937. |
depending on the direction of gaze, attractiveness can thus activate dopaminergic regions that are strongly linked to reward prediction, indicating that central reward systems may be engaged during the initiation of social interactions. |
2001-12-04 |
2023-08-12 |
Not clear |
| U Gschwandtner, J Aston, S Renaud, P Fuh. Pathologic gambling in patients with Parkinson's disease. Clinical neuropharmacology. vol 24. issue 3. 2001-10-04. PMID:11391129. |
the significance of an insufficient dopaminergic reward system in patients with stereotypical addictive-like behavior (e.g., pathologic gambling) is discussed in this report. |
2001-10-04 |
2023-08-12 |
Not clear |
| F Giuliano, J Allar. Dopamine and sexual function. International journal of impotence research. vol 13 Suppl 3. 2001-09-20. PMID:11477488. |
it is noteworthy that these participations of the dopaminergic system are not specific to sexual behaviour but rather reflect the more general involvement of dopamine in the regulation of cognitive, integrative and reward processes. |
2001-09-20 |
2023-08-12 |
rat |
| K Schmidt, B Nolte-Zenker, J Patzer, M Bauer, L G Schmidt, A Hein. Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence. Pharmacopsychiatry. vol 34. issue 2. 2001-08-09. PMID:11302566. |
one hypothesis suggests that dopaminergic stimulation of the brain reward system reinforces behavior because it is experienced as pleasurable, and that dopaminergic dysfunction leads to anhedonia, the inability to experience pleasure. |
2001-08-09 |
2023-08-12 |
human |
| K Schmidt, B Nolte-Zenker, J Patzer, M Bauer, L G Schmidt, A Hein. Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence. Pharmacopsychiatry. vol 34. issue 2. 2001-08-09. PMID:11302566. |
an alternative hypothesis assumes that dopaminergic stimulation does not promote pleasure or "liking" of a reward but rather mediates "wanting" of a reward, and suggests that dopaminergic dysfunction is associated with a failure to be motivated by stimuli that indicate reward. |
2001-08-09 |
2023-08-12 |
human |
| K Schmidt, B Nolte-Zenker, J Patzer, M Bauer, L G Schmidt, A Hein. Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence. Pharmacopsychiatry. vol 34. issue 2. 2001-08-09. PMID:11302566. |
these findings indicate that patients with dopaminergic dysfunction are not unable to experience pleasure, but may fail to be motivated by environmental stimuli to seek reward. |
2001-08-09 |
2023-08-12 |
human |
| S R Laviolette, D van der Koo. GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. The European journal of neuroscience. vol 13. issue 5. 2001-07-12. PMID:11264674. |
gaba(a) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. |
2001-07-12 |
2023-08-12 |
Not clear |
| S R Laviolette, D van der Koo. GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. The European journal of neuroscience. vol 13. issue 5. 2001-07-12. PMID:11264674. |
in the midbrain ventral tegmental area (vta), both dopaminergic and nondopaminergic neural substrates mediate various behavioural reward phenomena. |
2001-07-12 |
2023-08-12 |
Not clear |
| S R Laviolette, D van der Koo. GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. The European journal of neuroscience. vol 13. issue 5. 2001-07-12. PMID:11264674. |
these results suggest that, within the vta, a single gaba(a) receptor substrate controls bidirectional reward signalling between dopaminergic and nondopaminergic brain reward systems. |
2001-07-12 |
2023-08-12 |
Not clear |
| G Yadid, D H Overstreet, A Zange. Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression. Brain research. vol 896. issue 1-2. 2001-06-28. PMID:11277971. |
the dopaminergic mesolimbic system has a key role in motivation and reward, and stressful stimuli appear to alter its functionality. |
2001-06-28 |
2023-08-12 |
rat |
| J Wolfart, H Neuhoff, O Franz, J Roepe. Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331374. |
the physiological activity of dopaminergic midbrain (da) neurons is important for movement, cognition, and reward. |
2001-06-21 |
2023-08-12 |
mouse |
| E B Bunney, S B Appel, M S Brodi. Electrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303060. |
these data suggest that cocaethylene acts through a serotonergic mechanism at low concentrations to potentiate ethanol excitation of reward neurons and through a dopaminergic mechanism at high concentrations. |
2001-05-21 |
2023-08-12 |
rat |
| E B Bunney, S B Appel, M S Brodi. Electrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303060. |
these effects of cocaethylene are likely to contribute to the synergistic effect on the dopaminergic reward pathway when ethanol and cocaine are used together; this may help to explain the high incidence of coabuse of ethanol and cocaine. |
2001-05-21 |
2023-08-12 |
rat |
| M Gerlach, D Blum-Degen, G Ransmayr, F Leblhuber, V Pedersen, P Riedere. Expression, but not activity, of neuronal nitric oxide synthase is regionally increased in the alcoholic brain. Alcohol and alcoholism (Oxford, Oxfordshire). vol 36. issue 1. 2001-05-10. PMID:11139418. |
interestingly, nnos protein content was increased in the frontal cortex and the nucleus accumbens, brain regions which are suggested to be involved in the dopaminergic mesolimbic reward system. |
2001-05-10 |
2023-08-12 |
Not clear |
| K Blum, E R Braverman, J M Holder, J F Lubar, V J Monastra, D Miller, J O Lubar, T J Chen, D E Coming. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of psychoactive drugs. vol 32 Suppl. 2001-04-26. PMID:11280926. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been implicated in reward mechanisms. |
2001-04-26 |
2023-08-12 |
Not clear |
| C Perrone-Capano, U Di Porzi. Genetic and epigenetic control of midbrain dopaminergic neuron development. The International journal of developmental biology. vol 44. issue 6. 2001-03-29. PMID:11061432. |
the relatively few dopaminergic (da) neurons in the mammalian brain regulate many important neural functions, including motor integration, neuroendocrine hormone release, cognition, emotive behaviors and reward. |
2001-03-29 |
2023-08-12 |
Not clear |
| I Fried, C L Wilson, J W Morrow, K A Cameron, E D Behnke, L C Ackerson, N T Maidmen. Increased dopamine release in the human amygdala during performance of cognitive tasks. Nature neuroscience. vol 4. issue 2. 2001-03-22. PMID:11175882. |
the amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes, particularly those involving associations between novel stimuli and reward. |
2001-03-22 |
2023-08-12 |
human |