| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N D Volkow, J S Fowle. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cerebral cortex (New York, N.Y. : 1991). vol 10. issue 3. 2000-04-27. PMID:10731226. |
we postulate that intermittent dopaminergic activation of reward circuits secondary to drug self-administration leads to dysfunction of the orbitofrontal cortex via the striato-thalamo-orbitofrontal circuit. |
2000-04-27 |
2023-08-12 |
human |
| J Hennig, C Toll, P Schonlau, S Rohrmann, P Nette. Endocrine responses after d-fenfluramine and ipsapirone challenge: further support for Cloninger's tridimensional model of personality. Neuropsychobiology. vol 41. issue 1. 2000-03-21. PMID:10629434. |
the tridemensional model of personality introduced by cloninger relates aspects of novelty seeking to the dopaminergic, harm avoidance (ha) to the serotonergic, and reward dependence to the noradrenergic neurotransmitter system. |
2000-03-21 |
2023-08-12 |
human |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| M S Brodie, C Pesold, S B Appe. Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcoholism, clinical and experimental research. vol 23. issue 11. 1999-12-30. PMID:10591603. |
ethanol directly excites dopaminergic ventral tegmental area reward neurons. |
1999-12-30 |
2023-08-12 |
Not clear |
| M Barrot, M Vallée, M A Gingras, M Le Moal, W Mayo, P V Piazz. The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564382. |
in this report, we studied the action of preg-s on the activity of the mesencephalic dopaminergic projection to the nucleus accumbens which is considered one of the biological substrates of motivation and reward. |
1999-12-08 |
2023-08-12 |
rat |
| M Barrot, M Vallée, M A Gingras, M Le Moal, W Mayo, P V Piazz. The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564382. |
both the direct effect of preg-s and the influence of this hormone on the dopaminergic response to the pharmacological reward provided by the opiate morphine, were studied by means of microdialysis. |
1999-12-08 |
2023-08-12 |
rat |
| R Spanagel, F Weis. The dopamine hypothesis of reward: past and current status. Trends in neurosciences. vol 22. issue 11. 1999-12-07. PMID:10529820. |
thus, mesolimbic dopaminergic neurons have an important function in the acquisition of behavior reinforced by natural reward and drug stimuli. |
1999-12-07 |
2023-08-12 |
Not clear |
| S Jones, J A Kaue. Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 22. 1999-12-02. PMID:10559387. |
the ventral tegmental area (vta) is the origination zone for dopaminergic neurons involved in reward and addictive properties of a variety of abused substances. |
1999-12-02 |
2023-08-12 |
Not clear |
| G Chouinard, R Mille. A rating scale for psychotic symptoms (RSPS) part I: theoretical principles and subscale 1: perception symptoms (illusions and hallucinations). Schizophrenia research. vol 38. issue 2-3. 1999-11-04. PMID:10463458. |
the scale links specific symptoms of psychopathology to dysfunction and overactivity of dopaminergic mechanisms underlying the processes of reward and selective attention. |
1999-11-04 |
2023-08-12 |
Not clear |
| M Garzón, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. The Journal of comparative neurology. vol 410. issue 2. 1999-10-21. PMID:10414527. |
cholinergic activation of dopaminergic neurons in the ventral tegmental area (vta) is thought to play a major role in cognitive functions and reward. |
1999-10-21 |
2023-08-12 |
rat |
| J L Contreras-Vidal, W Schult. A predictive reinforcement model of dopamine neurons for learning approach behavior. Journal of computational neuroscience. vol 6. issue 3. 1999-08-31. PMID:10406133. |
the former type of signal is consistent with the responses of dopaminergic neurons, while the latter signal is consistent with reward expectancy responses reported in the prefrontal cortex. |
1999-08-31 |
2023-08-12 |
Not clear |
| T P Piepponen, A Honkanen, T Kivastik, A Zharkovsky, A Turtia, J A Mikkola, L Ahte. Involvement of opioid mu1-receptors in opioid-induced acceleration of striatal and limbic dopaminergic transmission. Pharmacology, biochemistry, and behavior. vol 63. issue 2. 1999-08-20. PMID:10371653. |
these findings emphasize the role of mu1-opioid receptors in opioid reward, in which the mesolimbic dopaminergic system is considered to be importantly involved. |
1999-08-20 |
2023-08-12 |
rat |
| N P Murphy, Y Lee, N T Maidmen. Orphanin FQ/nociceptin blocks acquisition of morphine place preference. Brain research. vol 832. issue 1-2. 1999-08-18. PMID:10375664. |
orphanin fq/nociceptin (ofq/n) suppresses the activity of the dopaminergic mesolimbic reward pathway yet reportedly fails to produce conditioned place aversion or preference. |
1999-08-18 |
2023-08-12 |
rat |
| W C Gamberino, M S Gol. Neurobiology of tobacco smoking and other addictive disorders. The Psychiatric clinics of North America. vol 22. issue 2. 1999-08-12. PMID:10385935. |
considerable evidence shows that these dopaminergic projections are involved in the positive brain reward, which drives addictive disorders; however, recent studies also implicate the neurotransmitters glutamate and serotonin in learning and sensitization to drug use. |
1999-08-12 |
2023-08-12 |
Not clear |
| A Hein. [Anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407834. |
[anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?]. |
1999-08-12 |
2023-08-12 |
Not clear |
| A Hein. [Anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407834. |
the dopaminergic reward system is activated by primary rewarding factors such as food, sexual activity and parental care. |
1999-08-12 |
2023-08-12 |
Not clear |
| A Hein. [Anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407834. |
indications of a dysfunction of the dopaminergic reward system are found in major depression, schizophrenia, and addictive disorders. |
1999-08-12 |
2023-08-12 |
Not clear |
| A Hein. [Anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407834. |
it has been hypothesized that dysfunction of the dopaminergic reward system is associated with anhedonia, the inability to experience pleasure. |
1999-08-12 |
2023-08-12 |
Not clear |
| A Hein. [Psychopathological correlates of dopaminergic dysfunction in alcoholic and schizophrenic patients]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407835. |
it has been suggested that anhedonia, the loss of pleasure, is associated with a dysfunction of the dopaminergic reward system in schizophrenic and alcohol-dependent patients. |
1999-08-12 |
2023-08-12 |
Not clear |
| K Cho, H J Littl. Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area. Neuroscience. vol 88. issue 3. 1999-08-02. PMID:10363821. |
the ventral tegmental area is involved in reward processes and in drug dependence and sends dopaminergic projections to the nucleus accumbens and prefrontal cortex. |
1999-08-02 |
2023-08-12 |
Not clear |