| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nii A Add. An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety. Neuron. vol 109. issue 16. 2021-08-25. PMID:34411537. |
an ongoing saga of nicotine complexity and dopamine heterogeneity: nicotine activation and inhibition mediating reward and anxiety. |
2021-08-25 |
2023-08-13 |
Not clear |
| Nii A Add. An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety. Neuron. vol 109. issue 16. 2021-08-25. PMID:34411537. |
their findings provide new understanding of the functional role of ventral tegmental area (vta) dopamine neurons and reveal topographically distinct, pathway-specific, and opposite dopaminergic responses to nicotine that likely mediate reward and anxiety, respectively. |
2021-08-25 |
2023-08-13 |
Not clear |
| Lauren Wills, Paul J Kenn. Addiction-related neuroadaptations following chronic nicotine exposure. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33742685. |
different nachr subtypes are expressed in brain reward and aversion circuits and nicotine intake is titrated to maximally engage reward-enhancing nachrs while minimizing the recruitment of aversion-promoting nachrs. |
2021-08-24 |
2023-08-13 |
Not clear |
| Lauren Wills, Paul J Kenn. Addiction-related neuroadaptations following chronic nicotine exposure. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33742685. |
here, we review some of the key advances in our understanding of the mechanisms by which nicotine acts on brain reward and aversion circuits and the adaptations that occur in these circuits that may drive addiction to nicotine-containing tobacco products. |
2021-08-24 |
2023-08-13 |
Not clear |
| Pretal P Muldoon, Lois S Akinola, Joel E Schlosburg, Aron H Lichtman, Laura J Sim-Selley, Anu Mahadevan, Benjamin F Cravatt, M Imad Dama. Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. Neuropharmacology. vol 176. 2021-08-13. PMID:32479813. |
inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. |
2021-08-13 |
2023-08-13 |
mouse |
| Pretal P Muldoon, Lois S Akinola, Joel E Schlosburg, Aron H Lichtman, Laura J Sim-Selley, Anu Mahadevan, Benjamin F Cravatt, M Imad Dama. Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. Neuropharmacology. vol 176. 2021-08-13. PMID:32479813. |
previous reports suggest that pharmacological and genetic blockade of cb1 receptors attenuate nicotine reinforcement and reward; while exogenous agonists enhanced these abuse-related behaviors. |
2021-08-13 |
2023-08-13 |
mouse |
| Pretal P Muldoon, Lois S Akinola, Joel E Schlosburg, Aron H Lichtman, Laura J Sim-Selley, Anu Mahadevan, Benjamin F Cravatt, M Imad Dama. Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. Neuropharmacology. vol 176. 2021-08-13. PMID:32479813. |
in this study, we utilized complementary genetic and pharmacologic approaches to test the hypothesis that increasing the levels of the endocannabinoid 2-arachindonoylglycerol (2-ag), will enhance nicotine reward by stimulating neuronal cb1 receptors. |
2021-08-13 |
2023-08-13 |
mouse |
| Theresa Patten, Mariella De Bias. History repeats itself: Role of characterizing flavors on nicotine use and abuse. Neuropharmacology. vol 177. 2021-08-12. PMID:32497589. |
it also discusses ways in which preclinical and clinical studies could improve our understanding of the mechanisms by which flavors may alter nicotine reward and reinforcement. |
2021-08-12 |
2023-08-13 |
Not clear |
| Lauren C Smith, Olivier Georg. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. vol 178. 2021-08-12. PMID:32758566. |
cannabinoid receptor agonists and antagonists interact with the dopamine reward pathway and show efficacy in reducing nicotine addiction-like behaviors in preclinical studies. |
2021-08-12 |
2023-08-13 |
Not clear |
| Angela M Lee, Mohammad Shahid Mansuri, Rashaun S Wilson, TuKiet T Lam, Angus C Nairn, Marina R Picciott. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers in molecular neuroscience. vol 14. 2021-08-03. PMID:34335180. |
overall, this study identifies significant sex differences in the proteome of the mesolimbic system, at baseline and after nicotine reward or withdrawal, which may help explain differential trajectories and susceptibility to nicotine addiction in males and females. |
2021-08-03 |
2023-08-13 |
mouse |
| Magalie Lenoir, Amy K Starosciak, Jennifer Ledon, Caitlin Booth, Elena Zakharova, Dean Wade, Beatrice Vignoli, Sari Izenwasse. Sex differences in conditioned nicotine reward are age-specific. Pharmacology, biochemistry, and behavior. vol 132. 2021-07-27. PMID:25735492. |
sex differences in conditioned nicotine reward are age-specific. |
2021-07-27 |
2023-08-13 |
rat |
| Magalie Lenoir, Amy K Starosciak, Jennifer Ledon, Caitlin Booth, Elena Zakharova, Dean Wade, Beatrice Vignoli, Sari Izenwasse. Sex differences in conditioned nicotine reward are age-specific. Pharmacology, biochemistry, and behavior. vol 132. 2021-07-27. PMID:25735492. |
women constitute half of all smokers and many studies suggest that adult males and females differ in factors that maintain tobacco smoking, yet there is limited information about sex differences in nicotine reward during adolescence. |
2021-07-27 |
2023-08-13 |
rat |
| Dana Zeid, Lisa R Goldberg, Laurel R Seemiller, Sean Mooney-Leber, Philip B Smith, Thomas J Goul. Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner. Neurotoxicology and teratology. vol 85. 2021-07-21. PMID:33727150. |
our laboratory recently published data showing that nicotine reward and hippocampal gene expression involved in stress pathways were perturbed in f1 offspring of male c57bl/6j mice chronically exposed to nicotine. |
2021-07-21 |
2023-08-13 |
mouse |
| Maria Paula Faillace, Ramón O Bernabe. Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish. Current neuropharmacology. 2021-07-19. PMID:34279203. |
nicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. |
2021-07-19 |
2023-08-13 |
zebrafish |
| Joyce Dieleman, Guillaume Sescousse, Marloes Kleinjan, Roy Otten, Maartje Luijte. Investigating the association between smoking, environmental tobacco smoke exposure and reward-related brain activity in adolescent experimental smokers. Addiction biology. 2021-07-15. PMID:34263512. |
it remains unclear whether nicotine uptake caused by environmental tobacco smoke (ets) exposure, known to be associated with future smoking, might prompt similar changes in the brain's reward system, rendering adolescents vulnerable for development of nicotine dependence. |
2021-07-15 |
2023-08-13 |
Not clear |
| Yuan-Bing Huang, Ze-Gang Ma, Chao Zheng, Xiao-Kuang K Ma, Devin H Taylor, Ming Gao, Ronald J Lukas, Jie W. Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells. Acta pharmacologica Sinica. 2021-07-13. PMID:34253876. |
it is well known that nachrs play critical roles in mediating nicotine reward and addiction. |
2021-07-13 |
2023-08-13 |
human |
| Martin A Fuentes-Cano, Dulce J Bustamante-Valdez, Pilar Durá. Perinatal exposure to nicotine disrupts circadian locomotor and learning efficiency rhythms in juvenile mice. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32789697. |
nicotine, as an alkaloid, alters the reward system acting as acetylcholine (ach) agonist on nicotinic cholinergic receptors (nachrs). |
2021-07-06 |
2023-08-13 |
mouse |
| E Carstens E, M Iodi Carsten. Sensory effects of nicotine and tobacco. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2021-07-02. PMID:33955474. |
ingestion of nicotine by smoking, vaping or other means elicits various effects including reward, antinociception, and aversion due to irritation, bitter taste and unpleasant side effects such as nausea and dizziness. |
2021-07-02 |
2023-08-13 |
human |
| Nailyam Nasirova, Lely A Quina, Shoshana Novik, Eric E Turne. Genetically Targeted Connectivity Tracing Excludes Dopaminergic Inputs to the Interpeduncular Nucleus from the Ventral Tegmentum and Substantia Nigra. eNeuro. vol 8. issue 3. 2021-07-02. PMID:34088738. |
a working model has emerged in which nicotine use may be determined by the balance of reinforcement mediated in part by nicotine effects on dopamine reward pathways, and an aversive "brake" on nicotine consumption encoded in the mhb-ip pathway. |
2021-07-02 |
2023-08-13 |
Not clear |
| Alexandra N Palmisano, Robert S Astu. Nicotine Facilitation of Conditioned Place Preference to Food Reward in Humans. Substance use & misuse. vol 55. issue 13. 2021-06-24. PMID:32720546. |
nicotine facilitation of conditioned place preference to food reward in humans. |
2021-06-24 |
2023-08-13 |
Not clear |