| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carina Soares-Cunha, Nivaldo A P de Vasconcelos, Bárbara Coimbra, Ana Verónica Domingues, Joana M Silva, Eduardo Loureiro-Campos, Rita Gaspar, Ioannis Sotiropoulos, Nuno Sousa, Ana João Rodrigue. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31462765. |
the classical view on the field postulates that nac dopamine receptor d1-expressing medium spiny neurons (d1-msns) convey reward signals, while dopamine receptor d2-expressing msns (d2-msns) encode aversion. |
2021-05-14 |
2023-08-13 |
Not clear |
| M J Castelhano-Carlos, S Aslani, N Sous. The Impact of Physical Enrichment in the Structure of the Medial Prefrontal Cortex and Nucleus Accumbens of the Adult Male Rat Brain. Neuroscience. vol 454. 2021-05-14. PMID:32058067. |
herein, we assessed neuronal plasticity as a consequence of living in the phw, by comparing the structure of the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac), two brain areas involved in the circuitry regulating motivation and reward. |
2021-05-14 |
2023-08-13 |
rat |
| Erin W Noye Tuplin, Faye Chleilat, Erna Alukic, Raylene A Reime. The Effects of Human Milk Oligosaccharide Supplementation During Critical Periods of Development on the Mesolimbic Dopamine System. Neuroscience. vol 459. 2021-05-14. PMID:33588004. |
the brain reward system, specifically the mesolimbic dopamine (da) projections from the ventral tegmental area (vta) to nucleus accumbens (nac) is involved in the motivation and preference for food. |
2021-05-14 |
2023-08-13 |
human |
| Daniel J Christoffel, Jessica J Walsh, Boris D Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K Ravikumar, Hemmings Wu, Casey H Halpern, Robert C Malenk. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33837200. |
here, we show that modulation of prefrontal cortex (pfc) and anterior paraventricular thalamus (apvt) excitatory inputs to the nucleus accumbens (nac), a key node of reward circuitry, has opposing effects on high fat intake in mice. |
2021-05-03 |
2023-08-13 |
mouse |
| Daniel J Christoffel, Jessica J Walsh, Boris D Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K Ravikumar, Hemmings Wu, Casey H Halpern, Robert C Malenk. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33837200. |
these results demonstrate that input-specific nac circuit adaptations occur with repeated exposure to a potent natural reward and suggest that neuromodulatory interventions may be therapeutically useful for individuals with pathologic hedonic feeding. |
2021-05-03 |
2023-08-13 |
mouse |
| Natalie N Nawarawong, Christopher M Olse. Within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortex. Behavioural brain research. vol 379. 2021-04-30. PMID:31614186. |
this suggests that the nac shell, but not the nac core or pfc, may play an important role in general reward processing by engaging a similar network of neurons. |
2021-04-30 |
2023-08-13 |
mouse |
| E Alvarez-Salas, F Gama, G Matamoros-Trejo, M I Amaya, P de Gortar. TRH in the nucleus accumbens acts downstream to α-MSH to decrease food intake in rats. Neuroscience letters. vol 739. 2021-04-30. PMID:32980456. |
the nucleus accumbens (nac) is part of the latter, a brain circuit involved in processing reward stimuli and the appetitive motivation of feeding. |
2021-04-30 |
2023-08-13 |
rat |
| Jesper Vestlund, Elisabet Jerlha. The glucagon-like peptide-1 receptor agonist, exendin-4, reduces sexual interaction behaviors in a brain site-specific manner in sexually naïve male mice. Hormones and behavior. vol 124. 2021-04-28. PMID:32450068. |
this reduction in reward involves activation of glp-1 receptors (glp-1r) within areas processing natural and artificial rewards, including the laterodorsal tegmental area (ldtg), ventral tegmental area (vta) and nucleus accumbens (nac) shell. |
2021-04-28 |
2023-08-13 |
mouse |
| Liang Gong, Siyi Yu, Ronghua Xu, Duan Liu, Xijian Dai, Zhengyan Wang, Youping Hu, Bohua Yan, Yu Kui, Bei Zhang, Fen Fen. The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder. Brain imaging and behavior. vol 15. issue 2. 2021-04-27. PMID:32710331. |
nucleus accumbens (nac) - based functional connectivity (nafc) was evaluated to explore the differences in the reward network between the cid and hc groups. |
2021-04-27 |
2023-08-13 |
Not clear |
| Liang Gong, Siyi Yu, Ronghua Xu, Duan Liu, Xijian Dai, Zhengyan Wang, Youping Hu, Bohua Yan, Yu Kui, Bei Zhang, Fen Fen. The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder. Brain imaging and behavior. vol 15. issue 2. 2021-04-27. PMID:32710331. |
in addition, decreased fc between the nac and dmn was associated with insomnia severity, while nafc within the reward network was associated with depression symptoms in patients with cid. |
2021-04-27 |
2023-08-13 |
Not clear |
| E J Fernández-Pérez, S Gallegos, L Armijo-Weingart, A Araya, N O Riffo-Lepe, F Cayuman, L G Aguay. Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model. Scientific reports. vol 10. issue 1. 2021-04-22. PMID:33177601. |
the nac is a key component of the limbic reward system and it is involved in cognition and emotional behaviors such as pleasure, fear, aggression and motivations, all of which are affected in neurodegenerative diseases such as ad. |
2021-04-22 |
2023-08-13 |
mouse |
| Francesca Mottarlini, Giorgia Bottan, Benedetta Tarenzi, Alessandra Colciago, Fabio Fumagalli, Lucia Caffin. Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats. Nutrients. vol 12. issue 12. 2021-04-21. PMID:33260714. |
an patients exhibit an altered activation of nucleus accumbens (nac), revealing a dysfunctional mesocorticolimbic reward circuitry in an. |
2021-04-21 |
2023-08-13 |
rat |
| Francesca Mottarlini, Giorgia Bottan, Benedetta Tarenzi, Alessandra Colciago, Fabio Fumagalli, Lucia Caffin. Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats. Nutrients. vol 12. issue 12. 2021-04-21. PMID:33260714. |
since evidence exists that a dysregulation of the glutamate system in the nac influences reward and taking advantage of the activity-based anorexia (aba) rat model, which closely mimics the hallmarks of an, we investigated the involvement of the glutamatergic signaling in the nac in this experimental model. |
2021-04-21 |
2023-08-13 |
rat |
| Terra A Schall, William J Wright, Yan Don. Nucleus accumbens fast-spiking interneurons in motivational and addictive behaviors. Molecular psychiatry. vol 26. issue 1. 2021-04-14. PMID:32071384. |
the development of drug addiction is associated with functional adaptations within the reward circuitry, within which the nucleus accumbens (nac) is anatomically positioned as an interface between motivational salience and behavioral output. |
2021-04-14 |
2023-08-13 |
Not clear |
| Terra A Schall, William J Wright, Yan Don. Nucleus accumbens fast-spiking interneurons in motivational and addictive behaviors. Molecular psychiatry. vol 26. issue 1. 2021-04-14. PMID:32071384. |
we hope that the conceptual framework proposed in this review may provide a useful guidance for ongoing and future studies to determine how fsis influence the function of nac and related reward circuits, ultimately leading to addictive behaviors. |
2021-04-14 |
2023-08-13 |
Not clear |
| Sharlene D Newman, Hu Cheng, Dae-Jin Kim, Ashley Schnakenberg-Martin, Ulrike Dydak, Shalmali Dharmadhikari, William Hetrick, Brian O'Donnel. An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. Brain imaging and behavior. vol 14. issue 5. 2021-04-13. PMID:31302844. |
the aims of the current preliminary study were to: 1) determine whether dorsal anterior cingulate cortex (dacc) glu is related to rsfc between the dacc and two nodes of the reward network, the nucleus accumbens (nac) and hippocampus (hp); and 2) determine whether cb use interacts with the relationship between dacc glu and rsfc. |
2021-04-13 |
2023-08-13 |
human |
| Inês M Amaral, Cristina Lemos, Isabella Cera, Georg Dechant, Alex Hofer, Rana El Rawa. Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396297. |
the effects of pka inhibition in the nac on the expression of concurrent conditioned place preference (cpp) for cocaine (drug) and social interaction (natural reward) in rats were evaluated. |
2021-03-25 |
2023-08-13 |
rat |
| Inês M Amaral, Cristina Lemos, Isabella Cera, Georg Dechant, Alex Hofer, Rana El Rawa. Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396297. |
these results suggest that pka in the nac is involved in drug reward learning that might lead to addiction and that only drug, but not natural, reward is persistent. |
2021-03-25 |
2023-08-13 |
rat |
| Christopher K Lafferty, Angela K Yang, Jesse A Mendoza, Jonathan P Brit. Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Cell reports. vol 30. issue 11. 2021-03-23. PMID:32187545. |
accordingly, opponent processes between these nac inputs or cell types may underlie efficient reward seeking. |
2021-03-23 |
2023-08-13 |
mouse |
| Christopher K Lafferty, Angela K Yang, Jesse A Mendoza, Jonathan P Brit. Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Cell reports. vol 30. issue 11. 2021-03-23. PMID:32187545. |
these data suggest that efficient reward seeking relies on complementary activity across nac cell types and inputs rather than opponent processes between them. |
2021-03-23 |
2023-08-13 |
mouse |