| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brittany L Smith, Collin J Laaker, Kelsey R Lloyd, Adam R Hiltz, Teresa M Reye. Adolescent microglia play a role in executive function in male mice exposed to perinatal high fat diet. Brain, behavior, and immunity. vol 84. 2021-03-12. PMID:31765789. |
we then measured gene expression in adult male pfc, nucleus accumbens (nac), and amygdala (amg), examining targets related to synaptic function, reward, and inflammation. |
2021-03-12 |
2023-08-13 |
mouse |
| C E Strong, D P Hagarty, A Brea Guerrero, K J Schoepfer, S M Cajuste, M Kabba. Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific reports. vol 10. issue 1. 2021-03-09. PMID:33154463. |
the nucleus accumbens (nac), considered the hub of reward circuitry, is comprised of two medium spiny neuron (msn) subtypes that are classified by their enrichment of dopamine 1 (d1) or 2 (d2) receptors. |
2021-03-09 |
2023-08-13 |
rat |
| Joo Han Lee, Efrain A Ribeiro, Jeongseop Kim, Bumjin Ko, Hope Kronman, Yun Ha Jeong, Jong Kyoung Kim, Patricia H Janak, Eric J Nestler, Ja Wook Koo, Joung-Hun Ki. Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction. Biological psychiatry. vol 88. issue 10. 2021-03-08. PMID:32622465. |
cholinergic interneurons (chins) in the nucleus accumbens (nac) play critical roles in processing information related to reward. |
2021-03-08 |
2023-08-13 |
Not clear |
| Shervin Assari, Shanika Boyce, Mohsen Bazarga. Nucleus Accumbens Functional Connectivity with the Frontoparietal Network Predicts Subsequent Change in Body Mass Index for American Children. Brain sciences. vol 10. issue 10. 2021-02-17. PMID:33022949. |
the epidemiological observation that nac functional connectivity is associated with bmi changes in children is an extension of well-controlled laboratory studies that have established the role of the nac in the brain reward processing. |
2021-02-17 |
2023-08-13 |
Not clear |
| Aimilia Lydia Kalafateli, Cajsa Aranäs, Elisabet Jerlha. Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice. Psychopharmacology. vol 237. issue 11. 2021-01-27. PMID:32651639. |
the identification of amylin receptors in areas processing reward, namely laterodorsal tegmental area (ldtg), ventral tegmental area (vta), and nucleus accumbens (nac), has attributed them a role as reward regulators. |
2021-01-27 |
2023-08-13 |
mouse |
| Nadi F Salaya-Velazquez, Luis A López-Muciño, Sara Mejía-Chávez, Pedro Sánchez-Aparicio, Andrés A Domínguez-Guadarrama, Arturo Venebra-Muño. Anandamide and sucralose change ΔFosB expression in the reward system. Neuroreport. vol 31. issue 3. 2021-01-15. PMID:31923023. |
these results suggest that the possible interaction between receptors cb1 and t1r3 has consequences not only in taste perception but also that aea intervenes in the activity of dopaminergic nuclei such as the nac, and that the chronic administration aea and sucralose intake induce long-term changes in the reward system. |
2021-01-15 |
2023-08-13 |
Not clear |
| Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-Peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J Manzoni, Rainer Spanage. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. iScience. vol 23. issue 3. 2021-01-10. PMID:32179475. |
synaptic plasticity in dopamine d1 and d2 receptor medium spiny neurons (msns) of the nac and the endogenous cannabinoid (ecb) system have been implicated in reward seeking. |
2021-01-10 |
2023-08-13 |
Not clear |
| Yao Wang, Zheng Liu, Li Cai, Rong Guo, Yan Dong, Yanhua H Huan. A Critical Role of Basolateral Amygdala-to-Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31924324. |
the nucleus accumbens (nac) is a reward processing hub sensitive to acute sleep deprivation. |
2021-01-06 |
2023-08-13 |
Not clear |
| Yao Wang, Zheng Liu, Li Cai, Rong Guo, Yan Dong, Yanhua H Huan. A Critical Role of Basolateral Amygdala-to-Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31924324. |
the basolateral amygdala projection (blap) innervates broad regions of the nac and critically regulates reward seeking. |
2021-01-06 |
2023-08-13 |
Not clear |
| Urszula Skupio, Magdalena Tertil, Wiktor Bilecki, Justyna Barut, Michal Korostynski, Slawomir Golda, Lucja Kudla, Lucja Wiktorowska, Joanna E Sowa, Marcin Siwiec, Bartosz Bobula, Katarzyna Pels, Krzysztof Tokarski, Grzegorz Hess, Blazej Ruszczycki, Grzegorz Wilczynski, Ryszard Przewlock. Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31254970. |
these findings demonstrate a role of gr-dependent regulation of astrocytic metabolism in the nac and a key role of gr-expressing astrocytes in opioid reward processing. |
2020-12-28 |
2023-08-13 |
mouse |
| Hasan Alhaddad, Woonyen Wong, Adam T Sari, Laura E Crotty Alexander, Youssef Sar. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. vol 8. issue 4. 2020-12-26. PMID:33137879. |
in this study, we evaluated the effect of three months' continuous exposure to e-cig vapor (juul pods), containing a high nicotine concentration, on the expression of glutamate receptors and transporters in drug reward brain regions such as the nucleus accumbens (nac) core (nac-core), nac shell (nac-shell) and hippocampus (hip) in female c57bl/6 mice. |
2020-12-26 |
2023-08-13 |
mouse |
| Sabyasachi Dash, Muthukumar Balasubramaniam, Freddyson J Martínez-Rivera, Arthur Godino, Emily G Peck, Srinivas Patnaik, Mrutyunjay Suar, Erin S Calipari, Eric J Nestler, Fernando Villalta, Chandravanu Dash, Jui Pandhar. Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32641757. |
levels of mir-124 were also downregulated upon acute or chronic cocaine exposure in the mouse nucleus accumbens (nac)-a key reward region of brain. |
2020-12-21 |
2023-08-13 |
mouse |
| Hongliang Su, Tingting Sun, Xiao Wang, Yan Du, Na Zhao, Jie Zhu, Jiangwei Yan, Teng Chen, Keming Yu. Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice. Neuroscience letters. vol 714. 2020-12-07. PMID:31398456. |
besides, l-thp significantly decreased erk phosphorylation's high expression induced by meth, which suggested that the inhibitory effect of l-thp on modulating meth reward behavior may be related to the suppression of erk phosphorylation in nac and pfc of mice. |
2020-12-07 |
2023-08-13 |
mouse |
| Jeff Boissoneault, Bethany Stennett, Michael E Robinso. Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures. Drug and alcohol dependence. vol 207. 2020-11-23. PMID:31891860. |
the nucleus accumbens (nac) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mpfc), amygdala, and insula). |
2020-11-23 |
2023-08-13 |
Not clear |
| Yozo Ishiuj. Addiction and the itch-scratch cycle. What do they have in common? Experimental dermatology. vol 28. issue 12. 2020-10-28. PMID:31482585. |
reward systems, including the ventral tegmental area (vta), nucleus accumbens (nac) and striatum, are important for brain processing of both addiction and itch. |
2020-10-28 |
2023-08-13 |
human |
| Jia-Xi Wang, Jin-Ying Zhuang, Lulu Fu, Qin Lei, Mingxia Fan, Weidong Zhan. How ovarian hormones influence the behavioral activation and inhibition system through the dopamine pathway. PloS one. vol 15. issue 8. 2020-10-07. PMID:32790683. |
on the neural level, we demonstrated bas was related with the vta pathway, included brain reward regions of nucleus accumbens (nac) and orbitofrontal cortex (ofc). |
2020-10-07 |
2023-08-13 |
Not clear |
| Juhwan Kim, Heh-In Im, Changjong Moo. Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain. Neural regeneration research. vol 13. issue 1. 2020-10-01. PMID:29451210. |
the nucleus accumbens (nac) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhao Li, Zhilong Chen, Guoqing Fan, Anan Li, Jing Yuan, Tonghui X. Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell. Frontiers in neuroanatomy. vol 12. 2020-10-01. PMID:30459564. |
the nucleus accumbens (nac) is clearly implicated in reward processing and drug addiction, as well as in numerous neurological and psychiatric disorders; nevertheless, the circuit mechanisms underlying the diverse functions of the nac remain poorly understood. |
2020-10-01 |
2023-08-13 |
Not clear |
| Takahira Shirahase, Yoshihisa Watanabe, Atsushi Tsujimura, Shin Kwak, Toshiro Yamamoto, Narisato Kanamura, Masaki Tanak. Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30697154. |
however, it remains unknown whether rna editing in the nac modulates alcohol addiction through the brain reward system. |
2020-10-01 |
2023-08-13 |
mouse |
| Sandy Overgaauw, Myrthe Jansen, Naomi J Korbee, Ellen R A de Bruij. Neural Mechanisms Involved in Social Conformity and Psychopathic Traits: Prediction Errors, Reward Processing and Saliency. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31379532. |
fmri results showed that both groups activated the nucleus accumbens (nac) following alignment, suggesting the central role of prediction errors and reward. |
2020-10-01 |
2023-08-13 |
human |