| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin W. The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats. Frontiers in behavioral neuroscience. vol 15. 2021-12-20. PMID:34924971. |
this study supports the role of crf1r in the brain in mediating the central reward processing through d1r in the nac and provided a possibility that crf1r antagonist may be a new therapeutic approach for the treatment of propofol addiction. |
2021-12-20 |
2023-08-13 |
rat |
| Brandon J Polzin, Sarah A Heimovics, Lauren V Riter. Immunolabeling provides evidence for subregions in the songbird nucleus accumbens and suggests a context-dependent role in song in male European starlings (Sturnus vulgaris). Brain, behavior and evolution. 2021-12-08. PMID:34879382. |
the nucleus accumbens (nac) is a brain region well-known to mediate reward and motivation, which suggests it is an ideal candidate to regulate reward associated with gregarious song. |
2021-12-08 |
2023-08-13 |
Not clear |
| Collin D Teague, Eric J Nestle. Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens. Molecular psychiatry. 2021-12-06. PMID:34079067. |
repeated cocaine use induces coordinated changes in gene expression that drive plasticity in the nucleus accumbens (nac), an important component of the brain's reward circuitry, and promote the development of maladaptive, addiction-like behaviors. |
2021-12-06 |
2023-08-13 |
Not clear |
| Asrin Sharifi, Saeideh Karimi-Haghighi, Ronak Shabani, Hamid Reza Asgari, Reza Ahadi, Abbas Haghparas. Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 113. 2021-12-06. PMID:34662693. |
moreover, the nucleus accumbens (nac), as a key area in the reward circuit, extensively receives dopaminergic projections from the ventral tegmentum area. |
2021-12-06 |
2023-08-13 |
rat |
| Zhiyuan Liu, Qiumin Le, Yanbo Lv, Xi Chen, Jian Cui, Yiming Zhou, Deqin Cheng, Chaonan Ma, Xiujuan Su, Lei Xiao, Ruyi Yang, Jiayi Zhang, Lan Ma, Xing Li. A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state. Cell research. 2021-12-01. PMID:34848869. |
dopamine (da) level in the nucleus accumbens (nac) is critical for reward and aversion encoding. |
2021-12-01 |
2023-08-13 |
Not clear |
| Alexander K Zinsmaier, Yan Dong, Yanhua H Huan. Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens. Molecular psychiatry. 2021-11-26. PMID:33963288. |
the nucleus accumbens (nac) integrates and prioritizes different emotional and motivational inputs to the reward system by processing convergent glutamatergic projections from the medial prefrontal cortex, basolateral amygdala, ventral hippocampus, and other limbic and paralimbic brain regions. |
2021-11-26 |
2023-08-13 |
Not clear |
| Dan P Covey, Edith Hernandez, Miguel Á Luján, Joseph F Chee. Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 32. 2021-11-22. PMID:34230105. |
using fast-scan cyclic voltammetry in male and female mice, we find that nac da release diametrically responds to cues signaling increasing cost of reward, while da release to the reward itself is unaffected by its cost. |
2021-11-22 |
2023-08-13 |
mouse |
| Yue-Ying Liu, Le Liu, Lei Zhu, Xiu Yang, Kun Tong, Yue You, Li Yang, Yin Gao, Xu Li, Di-Shi Chen, Jing-Ru Hao, Nan Sun, Can Ga. dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine. Pharmacological research. vol 172. 2021-11-16. PMID:34461223. |
one of the key regions of the reward is the nucleus accumbens (nac) which receives glutamatergic projections from the dorsal hippocampus ca1 (dca1). |
2021-11-16 |
2023-08-13 |
mouse |
| XiangFei Liu, JiaLing Zhou, Tian Zhang, Ken Chen, Min Xu, Lei Wu, Jin Liu, YunKe Huang, BinBin Nie, Xu Shen, Ping Ren, Xi Huan. Meranzin hydrate elicits antidepressant effects and restores reward circuitry. Behavioural brain research. vol 398. 2021-11-15. PMID:32905810. |
a literature search shown that nucleus accumbens (nac) and hypothalamus of the reward system might reveal multiple effects of mh on mdd-fd-cvd comorbidity. |
2021-11-15 |
2023-08-13 |
rat |
| Suchan Chang, Yu Fan, Soo Min Lee, Yeonhee Ryu, Bong Hyo Lee, Sang Chan Kim, Kyle B Bills, Scott C Steffensen, Chae Ha Yang, Hee Young Ki. Acupuncture reduces cocaine psychomotor responses by activating the rostromedial tegmental nucleus. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33969586. |
while previous studies have demonstrated that acupuncture modulates da transmission in the mesolimbic reward system originating in the ventral tegmental area (vta) and projecting to the nucleus accumbens (nac) and can reduce drug self-administration, the central links between peripheral acupuncture signals and brain reward systems are not well-characterized. |
2021-11-10 |
2023-08-13 |
Not clear |
| Loreto S San Martin, Lorena Armijo-Weingart, Anibal Araya, Gonzalo E Yévenes, Robert J Harvey, Luis G Aguay. Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. Frontiers in molecular neuroscience. vol 14. 2021-11-10. PMID:34744627. |
recent data from several laboratories have shown that glyrs are expressed in the brain reward circuitry and that α1 and α2 are the principal subunits expressed in the nucleus accumbens (nac). |
2021-11-10 |
2023-08-13 |
Not clear |
| Jamie L Hanson, Alexia V Williams, Debra A Bangasser, Catherine J Peñ. Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in psychiatry. vol 12. 2021-11-10. PMID:34744836. |
a major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2021-11-10 |
2023-08-13 |
human |
| Jamie L Hanson, Alexia V Williams, Debra A Bangasser, Catherine J Peñ. Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in psychiatry. vol 12. 2021-11-10. PMID:34744836. |
here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the nac. |
2021-11-10 |
2023-08-13 |
human |
| Michał Sobstyl, Anna Kupryjaniuk, Paweł Mierzejewsk. Nucleus accumbens as a stereotactic target for the treatment of addictions in humans: a literature review. Neurologia i neurochirurgia polska. vol 55. issue 5. 2021-11-09. PMID:34633060. |
more recently, a limited number of basic and clinical studies have indicated that dbs of the nucleus accumbens (nac) and other neighbouring structures of the reward circuit may be an effective intervention for patients with treatment-refractory addiction. |
2021-11-09 |
2023-08-13 |
Not clear |
| Casey K Lardner, Yentl van der Zee, Molly S Estill, Hope G Kronman, Marine Salery, Ashley M Cunningham, Arthur Godino, Eric M Parise, Jee Hyun Kim, Rachael L Neve, Li Shen, Peter J Hamilton, Eric J Nestle. Gene-Targeted, CREB-Mediated Induction of ΔFosB Controls Distinct Downstream Transcriptional Patterns Within D1 and D2 Medium Spiny Neurons. Biological psychiatry. vol 90. issue 8. 2021-11-01. PMID:34425966. |
Δfosb is a transcription factor that accumulates in the nucleus accumbens (nac)-a brain region responsible for coordinating reward and motivation-after exposure to virtually every known rewarding substance, including cocaine and opioids. |
2021-11-01 |
2023-08-13 |
Not clear |
| Kolter B Grigsby, Thomas E Childs, Frank W Boot. The role of nucleus accumbens CREB attenuation in rescuing low voluntary running behavior in female rats. Journal of neuroscience research. vol 98. issue 11. 2021-10-29. PMID:32725625. |
nac creb phosphorylation is elevated in these rats, a state previously attributed to deficits in reward valuation. |
2021-10-29 |
2023-08-13 |
human |
| Felix P Mayer, Hideki Iwamoto, Maureen K Hahn, Gregory J Grumbar, Adele Stewart, Yulong Li, Randy D Blakel. There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens. Neurochemistry international. vol 142. 2021-10-27. PMID:33161093. |
various stimuli have been employed as reinforcers in preclinical rodent models to elucidate the underpinnings of reward at a molecular and circuit level, with the release of dopamine (da) in the nucleus accumbens (nac) as a well-replicated, physiological correlate. |
2021-10-27 |
2023-08-13 |
mouse |
| Molly Estill, Efrain Ribeiro, Nancy J Francoeur, Melissa L Smith, Robert Sebra, Szu-Ying Yeh, Ashley M Cunningham, Eric J Nestler, Li She. Long read, isoform aware sequencing of mouse nucleus accumbens after chronic cocaine treatment. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33762610. |
to better understand the full-length transcriptome of the nucleus accumbens (nac)-a key brain reward region-in chronic cocaine treatment, we perform the first single molecule, long-read sequencing analysis using the iso-seq method to detect 42,114 unique transcripts from mouse nac polyadenylated rna. |
2021-10-25 |
2023-08-13 |
mouse |
| Molly Estill, Efrain Ribeiro, Nancy J Francoeur, Melissa L Smith, Robert Sebra, Szu-Ying Yeh, Ashley M Cunningham, Eric J Nestler, Li She. Long read, isoform aware sequencing of mouse nucleus accumbens after chronic cocaine treatment. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33762610. |
these data provide a more complete picture of the nac transcriptome than existing annotations and can serve as a comprehensive reference for future transcriptomic analyses of this important brain reward region. |
2021-10-25 |
2023-08-13 |
mouse |
| Martyna Bayassi-Jakowicka, Grazyna Lietzau, Ewelina Czuba, Aleksandra Steliga, Monika Waśkow, Przemysław Kowiańsk. Neuroplasticity and Multilevel System of Connections Determine the Integrative Role of Nucleus Accumbens in the Brain Reward System. International journal of molecular sciences. vol 22. issue 18. 2021-10-22. PMID:34575969. |
a growing body of evidence suggests that nucleus accumbens (nac) plays a significant role not only in the physiological processes associated with reward and satisfaction but also in many diseases of the central nervous system. |
2021-10-22 |
2023-08-13 |
Not clear |