| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Wang, Zhi Zhang, Jing Shang, Zhen-Zhou Jiang, Shu Wang, Yong Liu, Lu-Yong Zhan. Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro. Neuroscience research. vol 62. issue 1. 2008-10-24. PMID:18602428. |
in contrast, group ii mglur antagonist (2s)-a-ethylglutamic acid (eglu), n-methyl-d-aspartate (nmda) receptor antagonist apv and voltage-gated calcium channel antagonist nimodipine had no effect on the lfs-induced ltd. taken together, these observations suggest that lfs paired with strong stimulus strength can efficiently induce group i mglur-dependent ltd in the adult hippocampal ca1 region, proving insight into the functional significance of hippocampal mglur-mediated ltd in learning and memory. |
2008-10-24 |
2023-08-12 |
rat |
| Miao-Kun Sun, Jarin Hongpaisan, Thomas J Nelson, Daniel L Alko. Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 36. 2008-09-30. PMID:18768786. |
consequently, we examined the effects of chronic bryostatin-1, a pkc activator, on the cerebral ischemia/hypoxia-induced impairment of synapses and neurotrophic activity in the hippocampal ca1 area and on hippocampus-dependent spatial learning and memory. |
2008-09-30 |
2023-08-12 |
human |
| Zhi He, Yun Liao, Min Zheng, Fan-Dian Zeng, Lian-Jun Gu. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cellular and molecular neurobiology. vol 28. issue 4. 2008-08-07. PMID:17710536. |
cerebral hypoperfusion for 30 days by occlusion of bilateral common carotid arteries induced marked amnesic effects along with neuron damage, including: (1) spatial learning and memory deficits shown by longer escape latency and shorter time spent in the target quadrant; (2) significant neuronal loss and nuclei condensation in the cortex and hippocampus especially in ca1 region; (3) lower induction rate of long term potentiation, overexpression of bax and p53 protein, and lower content of excitatory and inhibitory amino acids in hippocampus. |
2008-08-07 |
2023-08-12 |
rat |
| Hooman Eshagh Harooni, Nasser Naghdi, Hoori Sepehri, Ali Haeri Rohan. Intra hippocampal injection of testosterone impaired acquisition, consolidation and retrieval of inhibitory avoidance learning and memory in adult male rats. Behavioural brain research. vol 188. issue 1. 2008-05-19. PMID:18054400. |
androgen receptors are densely expressed in ca1 of rat hippocampus, and mediate the effects of testosterone (t) on learning and memory. |
2008-05-19 |
2023-08-12 |
rat |
| Hooman Eshagh Harooni, Nasser Naghdi, Hoori Sepehri, Ali Haeri Rohan. Intra hippocampal injection of testosterone impaired acquisition, consolidation and retrieval of inhibitory avoidance learning and memory in adult male rats. Behavioural brain research. vol 188. issue 1. 2008-05-19. PMID:18054400. |
the data suggest that intra ca1 administration of t could impair learning and memory acquisition, consolidation and retrieval, while systemic androgen's depletion have no effect on memory, in inhibitory avoidance task. |
2008-05-19 |
2023-08-12 |
rat |
| Marie-Claude Roberge, Judith Hotte-Bernard, Claude Messier, Hélène Plamondo. Food restriction attenuates ischemia-induced spatial learning and memory deficits despite extensive CA1 ischemic injury. Behavioural brain research. vol 187. issue 1. 2008-03-11. PMID:17949826. |
food restriction attenuates ischemia-induced spatial learning and memory deficits despite extensive ca1 ischemic injury. |
2008-03-11 |
2023-08-12 |
rat |
| Tjerk Bueters, Mia von Euler, Olof Bendel, Gabriel von Eule. Degeneration of newly formed CA1 neurons following global ischemia in the rat. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:17950278. |
the pyramidal neurons of the hippocampal ca1 region are essential for spatial learning and memory and are almost entirely destroyed 7-14 days after transient cerebral ischemia (dai). |
2008-03-05 |
2023-08-12 |
rat |
| Tjerk Bueters, Mia von Euler, Olof Bendel, Gabriel von Eule. Degeneration of newly formed CA1 neurons following global ischemia in the rat. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:17950278. |
recently, we found that ca1 neurons reappeared at 21-90 dai, in association with a recovery of ischemia-induced deficits in spatial learning and memory. |
2008-03-05 |
2023-08-12 |
rat |
| Tjerk Bueters, Mia von Euler, Olof Bendel, Gabriel von Eule. Degeneration of newly formed CA1 neurons following global ischemia in the rat. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:17950278. |
in spite of the extensive ca1 damage, the ischemic rats showed no deficiencies in spatial learning and memory, as analyzed in the morris water maze and a complimentary water maze test based on sequential left-right choices. |
2008-03-05 |
2023-08-12 |
rat |
| I Belcheva, R Tashev, S Belchev. Hippocampal asymmetry in serotonergic modulation of learning and memory in rats. Laterality. vol 12. issue 6. 2008-02-14. PMID:17852699. |
the modulation of learning and memory after left or right microinjections of the selective 5-ht1a receptor agonist 8-oh-dpat and of the 5-ht1a receptor antagonist nan190 into the hippocampal ca1 area of male wistar rats was studied. |
2008-02-14 |
2023-08-12 |
rat |
| I Belcheva, R Tashev, S Belchev. Hippocampal asymmetry in serotonergic modulation of learning and memory in rats. Laterality. vol 12. issue 6. 2008-02-14. PMID:17852699. |
these effects on learning and memory were more pronounced after injection of either of the serotonergic agents into the right ca1 hippocampal area compared to the left. |
2008-02-14 |
2023-08-12 |
rat |
| Luying Liu, Shihong Zhang, Yongping Zhu, Qiuli Fu, Yuanyuan Zhu, Yingxia Gong, Hiroshi Ohtsu, Jianhong Luo, Erqing Wei, Zhong Che. Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice. Hippocampus. vol 17. issue 8. 2007-10-31. PMID:17534971. |
improved learning and memory of contextual fear conditioning and hippocampal ca1 long-term potentiation in histidine decarboxylase knock-out mice. |
2007-10-31 |
2023-08-12 |
mouse |
| Francesca Cacucci, Thomas J Wills, Colin Lever, Karl Peter Giese, John O'Keef. Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of the alpha-isoform of the calcium/calmodulin-dependent protein kinase II. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 29. 2007-08-23. PMID:17634379. |
place cells in hippocampal area ca1 are essential for spatial learning and memory. |
2007-08-23 |
2023-08-12 |
mouse |
| Koji Tomobe, Yasunobu Okuma, Yasuyuki Nomur. Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8. Brain research. vol 1141. 2007-06-01. PMID:17303091. |
since the phosphorylation of creb plays an important role for synaptic plasticity and consolidation of long-term memory, the impairment of creb phosphorylation in the hippocampal ca1 region of samp8 may cause learning and memory deficits. |
2007-06-01 |
2023-08-12 |
mouse |
| Y Oomura, N Hori, T Shiraishi, K Fukunaga, H Takeda, M Tsuji, T Matsumiya, M Ishibashi, S Aou, X L Li, D Kohno, K Uramura, H Sougawa, T Yada, M J Wayner, K Sasak. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides. vol 27. issue 11. 2007-05-10. PMID:16914228. |
leptin facilitates learning and memory performance and enhances hippocampal ca1 long-term potentiation and camk ii phosphorylation in rats. |
2007-05-10 |
2023-08-12 |
rat |
| Wu-Fu Chen, Hung Chang, Chih-Shung Wong, Li-Tung Huang, Chin-Hwa Yang, San-Nan Yan. Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17270176. |
herein we investigated the long-term effects of perinatal hypoxia upon the complex of psd-95 with nmdar subunits by means of downstream signalling camp response element binding protein (creb) phosphorylation at the serine-133 locus (creb(ser-133) phosphorylation) within the hippocampal ca1 area (an essential integration area for mammalian learning and memory) within test-rat brains, as well as the effects upon afflicted-individual long-term learning and memory performance. |
2007-05-10 |
2023-08-12 |
rat |
| M Yu Stepanichev, I M Zdobnova, I I Zarubenko, N A Lazareva, N V Gulyaev. Studies of the effects of central administration of beta-amyloid peptide (25-35): pathomorphological changes in the Hippocampus and impairment of spatial memory. Neuroscience and behavioral physiology. vol 36. issue 1. 2007-05-01. PMID:16328175. |
thus, this is the first demonstration that impairments of learning and memory induced by single doses of abeta(25-35) are specifically associated with neurodegenerative changes in hippocampal field ca1 in rats. |
2007-05-01 |
2023-08-12 |
rat |
| Kang-Yi Su, Wei-Lin Chien, Wen-Mei Fu, I-Shing Yu, Hsiang-Po Huang, Pei-Hsing Huang, Shu-Rung Lin, Jin-Yuan Shih, Yi-Ling Lin, Yi-Ping Hsueh, Pan-Chyr Yang, Shu-Wha Li. Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 10. 2007-04-09. PMID:17344389. |
these changes were consistent with the mutant mice showing a reduction in long-term potentiation (ltp) in the ca1 region and impaired performance in hippocampal-dependent spatial learning and memory tests. |
2007-04-09 |
2023-08-12 |
mouse |
| Graciela Letechipía-Vallejo, Elisa López-Loeza, Verónica Espinoza-González, Ignacio González-Burgos, María Esther Olvera-Cortés, Gabriela Moralí, Miguel Cervante. Long-term morphological and functional evaluation of the neuroprotective effects of post-ischemic treatment with melatonin in rats. Journal of pineal research. vol 42. issue 2. 2007-03-27. PMID:17286745. |
by contrast, a similar performance of the isch + mel group to that in the intact and sham groups and better than that of the isch + veh group, besides a significant reduction of pyramidal neuron loss in the ca subfields (ca1: 79%, ca2: 88% ca3: 86%, hilus: 72% remaining neurons), documented that melatonin treatment led to a long-term preservation of both the neural substrate, and the capability for integration of spatial learning and memory, mainly dependent on a normal hippocampal functioning. |
2007-03-27 |
2023-08-12 |
rat |
| Farshad Moradpour, Nasser Naghdi, Yaghob Fathollah. Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats. Behavioural brain research. vol 175. issue 2. 2007-01-11. PMID:17018237. |
anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal ca1 region in adult male rats. |
2007-01-11 |
2023-08-12 |
rat |