| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sahu, L Nguyen, R M O'Dohert. Nutritional regulation of hypothalamic leptin receptor gene expression is defective in diet-induced obesity. Journal of neuroendocrinology. vol 14. issue 11. 2003-01-03. PMID:12421342. |
the current study examined the effects of diet-induced obesity (dio) made by feeding rats a high fat diet for 9 weeks, and nutritional status on levels of long form (ob-rb) and total (ob-rtot) ob-r mrna expression in the hypothalamus. |
2003-01-03 |
2023-08-12 |
rat |
| Karine Proulx, Denis Richard, Claire-Dominique Walke. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology. vol 143. issue 12. 2002-12-24. PMID:12446596. |
leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. |
2002-12-24 |
2023-08-12 |
rat |
| K Czaja, M Łakomy, W Sienkiewicz, J Kaleczyc, Z Pidsudko, C R Barb, G B Rampacek, R R Kraelin. Distribution of neurons containing leptin receptors in the hypothalamus of the pig. Biochemical and biophysical research communications. vol 298. issue 3. 2002-12-12. PMID:12413944. |
these findings indicate that there are distinct obr-ir neuronal populations in the porcine hypothalamus and leptin not only plays an integrative role in feeding behavior, but also in neuroendocrine activity. |
2002-12-12 |
2023-08-12 |
Not clear |
| James E Blevins, Michael W Schwartz, Denis G Baski. Peptide signals regulating food intake and energy homeostasis. Canadian journal of physiology and pharmacology. vol 80. issue 5. 2002-12-10. PMID:12056545. |
the adiposity hormone leptin has been shown to decrease food intake and body weight by acting on neuropeptide circuits in the hypothalamus. |
2002-12-10 |
2023-08-12 |
Not clear |
| James E Blevins, Michael W Schwartz, Denis G Baski. Peptide signals regulating food intake and energy homeostasis. Canadian journal of physiology and pharmacology. vol 80. issue 5. 2002-12-10. PMID:12056545. |
while it is established that leptin acts in the arcuate nucleus in the hypothalamus to stimulate anorexigenic neurons that inhibit food intake while simulataneously inhibiting orexigenic neurons that increase food intake, the mechanisms linking these effects with regions of the caudal brainstem that integrate cues related to meal termination are unclear. |
2002-12-10 |
2023-08-12 |
Not clear |
| Luc Pénicaud, Corinne Leloup, Anne Lorsignol, Thierry Alquier, Elise Guillo. Brain glucose sensing mechanism and glucose homeostasis. Current opinion in clinical nutrition and metabolic care. vol 5. issue 5. 2002-12-09. PMID:12172478. |
it is well established that different parts of the brain, particularly the hypothalamus and the brain stem, are important centres involved in the monitoring of glucose status and the regulation of feeding. |
2002-12-09 |
2023-08-12 |
Not clear |
| T Wenger, G Moldric. The role of endocannabinoids in the hypothalamic regulation of visceral function. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052044. |
the hypothalamus plays an important role in the regulation of several visceral processes, including food intake, thermoregulation and control of anterior pituitary secretion. |
2002-12-06 |
2023-08-12 |
mouse |
| N Sagawa, S Yura, H Itoh, H Mise, K Kakui, D Korita, M Takemura, M A Nuamah, Y Ogawa, H Masuzaki, K Nakao, S Fuji. Role of leptin in pregnancy--a review. Placenta. vol 23 Suppl A. 2002-12-03. PMID:11978063. |
leptin is an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. |
2002-12-03 |
2023-08-12 |
mouse |
| Murad Atmaca, Murat Kuloglu, Ertan Tezcan, Bilal Ustunda. Weight gain and serum leptin levels in patients on lithium treatment. Neuropsychobiology. vol 46. issue 2. 2002-11-25. PMID:12378122. |
leptin is an adipocyte hormone, regulating food intake and energy balance providing the hypothalamus with information on the amount of body fat. |
2002-11-25 |
2023-08-12 |
Not clear |
| Hans-Rudolf Berthou. Multiple neural systems controlling food intake and body weight. Neuroscience and biobehavioral reviews. vol 26. issue 4. 2002-11-22. PMID:12204189. |
discovery of the leptin receptor and its downstream peptidergic pathways has reconfirmed the crucial role of the hypothalamus in the regulation of food intake and energy balance. |
2002-11-22 |
2023-08-12 |
human |
| X-L Li, S Aou, Y Oomura, N Hori, K Fukunaga, T Hor. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience. vol 113. issue 3. 2002-11-13. PMID:12150780. |
leptin is well known to be involved in the control of feeding, reproduction and neuroendocrine functions through its action on the hypothalamus. |
2002-11-13 |
2023-08-12 |
mouse |
| Maria Rosario Melis, Maria Stefania Mascia, Salvatora Succu, Antonio Torsello, Eugenio E Muller, Romano Deghenghi, Antonio Argiola. Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183044. |
ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. |
2002-10-28 |
2023-08-12 |
rat |
| M Atmaca, M Kuloglu, E Tezcan, A Semercioz, B Ustundag, A Aya. Serum leptin levels in patients with premature ejaculation. Archives of andrology. vol 48. issue 5. 2002-10-24. PMID:12230820. |
leptin is a fat cell-derived hormone signaling the hypothalamus about food intake, the regulation of weight, and sexual behavior. |
2002-10-24 |
2023-08-12 |
Not clear |
| Filippo Rossi Fanelli, Alessandro Lavian. Cancer anorexia: a model for the understanding and treatment of secondary anorexia. International journal of cardiology. vol 85. issue 1. 2002-10-10. PMID:12163210. |
under normal conditions, food intake is controlled in the hypothalamus by: (i) transducing metabolic/sensorial inputs arising from the periphery into neuronal response; (ii) integrating the information originating from different tissues; and (iii) triggering the appropriate feeding responses. |
2002-10-10 |
2023-08-12 |
human |
| Filippo Rossi Fanelli, Alessandro Lavian. Cancer anorexia: a model for the understanding and treatment of secondary anorexia. International journal of cardiology. vol 85. issue 1. 2002-10-10. PMID:12163210. |
thus, the anorexia associated with a number of chronic diseases, including cancer, may result from an abnormal input of information to the hypothalamus, or in its defective transduction and integration, or in the induction of exaggerated and inappropriate feeding responses. |
2002-10-10 |
2023-08-12 |
human |
| Sergueï O Fetissov, Michael M Meguid, Tomoi Sato, Li-Hua Zhan. Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. American journal of physiology. Regulatory, integrative and comparative physiology. vol 283. issue 4. 2002-10-09. PMID:12228060. |
expression of dopaminergic receptors in the hypothalamus of lean and obese zucker rats and food intake. |
2002-10-09 |
2023-08-12 |
rat |
| Toru Hosoi, Toru Kawagishi, Yasunobu Okuma, Jun Tanaka, Yasuyuki Nomur. Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193563. |
leptin is a circulating molecule for the regulation of food intake and body weight suggested to be mediated in the hypothalamus via ob-rb receptor, which activates janus kinase-signal transducer and activator of transcription (stat) pathways. |
2002-09-23 |
2023-08-12 |
mouse |
| Mikako Degawa-Yamauchi, Shigeo Uotani, Yoshihiko Yamaguchi, Ryoko Takahashi, Takahiro Abe, Hironaga Kuwahara, Hironori Yamasaki, Katsumi Eguch. Ethanol inhibits leptin-induced STAT3 activation in Huh7 cells. FEBS letters. vol 525. issue 1-3. 2002-09-20. PMID:12163172. |
leptin, an adipocyte-derived hormone, regulates food intake and energy expenditure in the hypothalamus via its receptor, member of the class i cytokine receptor family. |
2002-09-20 |
2023-08-12 |
human |
| Anahita M Mistry, Dale R Romso. Intracerebroventricular leptin administration reduces food intake in pregnant and lactating mice. Experimental biology and medicine (Maywood, N.J.). vol 227. issue 8. 2002-09-17. PMID:12192103. |
leptin acts within the hypothalamus to diminish food intake. |
2002-09-17 |
2023-08-12 |
mouse |
| Anahita M Mistry, Dale R Romso. Intracerebroventricular leptin administration reduces food intake in pregnant and lactating mice. Experimental biology and medicine (Maywood, N.J.). vol 227. issue 8. 2002-09-17. PMID:12192103. |
high plasma concentrations of leptin-binding proteins observed during pregnancy, and probably during lactation, may limit the amount of endogenous leptin reaching the hypothalamus, and may consequently enable increases in food intake concomitant with elevated plasma leptin during these nutritionally demanding periods. |
2002-09-17 |
2023-08-12 |
mouse |