| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
many kinds of neurons in these areas of the hypothalamus express factors such as melanin-concentrating hormone (mch), neuropeptide y (npy), proopiomelanocortin (pomc), orexin (ox) and ghrelin, which have been implicated in feeding regulation. |
2004-01-21 |
2023-08-12 |
rat |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
morphological and physiological studies on single living cells isolated from fresh rat hypothalamus or with receptor agonist and antagonist combined with immunohistochemisry clearly demonstrate that both leptin and ox reciprocally regulate npy- and pomc-containing neurons in the arc and that ghrelin may regulate feeding status independently through direct ox and npy pathways. |
2004-01-21 |
2023-08-12 |
rat |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
in this way, cross-talking systems in the hypothalamus play a role in determining feeding states. |
2004-01-21 |
2023-08-12 |
rat |
| Miklós Palkovit. Hypothalamic regulation of food intake. Ideggyogyaszati szemle. vol 56. issue 9-10. 2004-01-20. PMID:14608950. |
the central regulation of the food intake is organized by a long-loop mechanism involving humoral signals and afferent neuronal pathways to the hypothalamus, obligatory processing in hypothalamic neuronal circuits, and descending commands through vagal and spinal neurons to the body. |
2004-01-20 |
2023-08-12 |
Not clear |
| Miklós Palkovit. Hypothalamic regulation of food intake. Ideggyogyaszati szemle. vol 56. issue 9-10. 2004-01-20. PMID:14608950. |
five groups of cells in the hypothalamus--arcuate, paraventricular, ventromedial and dorsomedial nuclei, and the dorsolateral hypothalamic area--contain neurons with either anorexic actions (alpha-msh, cart peptide, corticotropin-releasing hormone, urocortin iii, cholecystokinin, glucagon-like peptides) or that stimulate food intake (neuropeptide y, agouti-related peptide, orexins, melanin concentrating hormone, galanin). |
2004-01-20 |
2023-08-12 |
Not clear |
| Sulaiman Sheriff, William T Chance, Sabahat Iqbal, Tilat A Rizvi, Chun Xiao, John W Kasckow, A Balasubramania. Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in rats. Peptides. vol 24. issue 2. 2004-01-12. PMID:12668209. |
in this report, we show that the injection of the membrane-permeable camp agonist, adenosine-3',5'-cyclic monophosphorothioate sp-isomer (sp-camp), into perifornical hypothalamus (pfh) significantly inhibited schedule-induced and npy-induced food intake for up to 4h. |
2004-01-12 |
2023-08-12 |
rat |
| Linda Rinama. Postnatal development of hypothalamic inputs to the dorsal vagal complex in rats. Physiology & behavior. vol 79. issue 1. 2004-01-09. PMID:12818710. |
the hypothalamus is critically involved in energy homeostasis and is an appropriate focus for research investigating the central neural underpinnings of obesity, anorexia and normal food intake. |
2004-01-09 |
2023-08-12 |
rat |
| Steven R Smith, Barbara Gawronska-Kozak, Lenka Janderová, Taylor Nguyen, Angela Murrell, Jacqueline M Stephens, Randall L Mynat. Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes. Diabetes. vol 52. issue 12. 2004-01-09. PMID:14633851. |
the influence of mcr signaling on adipogenesis combined with the well-established role of mcr signaling in the hypothalamus suggest that adipogenesis is coordinately regulated with food intake and energy expenditure. |
2004-01-09 |
2023-08-12 |
mouse |
| J Barrenetxe, R Palacios, A Barber, M P Losta. Functional expression of the short isoform of the murine leptin receptor Ob-Rc (muB1.219) in Xenopus laevis oocytes. Journal of physiology and biochemistry. vol 59. issue 2. 2004-01-07. PMID:14649877. |
leptin, a hormone mainly secreted by the adipose tissue, acts on the hypothalamus to regulate food intake and thermogenesis. |
2004-01-07 |
2023-08-12 |
human |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
neuropeptide y (npy) is present in the hypothalamus, where it is believed to play a key role in the control of food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
evidence for this assertion has come from studies demonstrating that acute administration of npy into the hypothalamus or into the brain ventricles leads to increased food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
npy levels in the hypothalamus are temporally correlated with food intake and are markedly elevated in response to energy depletion. |
2004-01-06 |
2023-08-12 |
mouse |
| Silvana Obici, Luciano Rossett. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12970158. |
the hypothalamus links the sensing of nutrients to the control of metabolism and feeding behavior. |
2004-01-05 |
2023-08-12 |
Not clear |
| Neil B Ruderman, Asish K Saha, Edward W Kraege. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:14500570. |
in addition, preliminary studies suggest that malonyl coa and ampk take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure. |
2004-01-05 |
2023-08-12 |
Not clear |
| Jing-Ning Huan, Ji Li, Yiping Han, Ke Chen, Nancy Wu, Allan Z Zha. Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12925533. |
despite a normal level of leptin receptors in the hypothalamus and normal food intake, mutant mice developed increased adiposity, decreased body temperature, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and insulin sensitivity, as well as elevated hepatic and skeletal muscle triglyceride levels. |
2003-12-24 |
2023-08-12 |
mouse |
| A D Strader, J D Bunti. Changes in agouti-related peptide during the ring dove breeding cycle in relation to prolactin and parental hyperphagia. Journal of neuroendocrinology. vol 15. issue 11. 2003-12-16. PMID:14622434. |
because posthatching elevations in agrp-ir were temporally associated with marked elevations in parental food intake, and because agrp is orexigenic in doves, these findings suggest that increased agrp activity in the dove tuberal hypothalamus may contribute to parental hyperphagia. |
2003-12-16 |
2023-08-12 |
Not clear |
| A D Strader, J D Bunti. Changes in agouti-related peptide during the ring dove breeding cycle in relation to prolactin and parental hyperphagia. Journal of neuroendocrinology. vol 15. issue 11. 2003-12-16. PMID:14622434. |
rising prolactin secretion during late incubation and early posthatching may initiate this increase in agrp-ir, since intracerebroventricular administration of prolactin significantly elevated food intake and agrp-ir cell numbers in the tuberal hypothalamus of nonbreeding doves. |
2003-12-16 |
2023-08-12 |
Not clear |
| Yasuhiro Tsunoda, Hongren Yao, Jung Park, Chung Owyan. Cholecystokinin synthesizes and secretes leptin in isolated canine gastric chief cells. Biochemical and biophysical research communications. vol 310. issue 3. 2003-12-02. PMID:14550255. |
it is well recognized that a product of obese (ob) locus and body weight control hormone, leptin, acts on both short-term satiety for meal-induced termination of food intake (gastric phase) and long-term satiety for energy expenditure via the hypothalamus. |
2003-12-02 |
2023-08-12 |
Not clear |
| I-Wei Shu, Daniel L Lindenberg, Tooru M Mizuno, James L Roberts, Charles V Mobb. The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons. Brain research. vol 985. issue 1. 2003-11-28. PMID:12957363. |
feeding increased fos immunoreactivity in the lateral peri-arcuate area of the hypothalamus of both wild-type and leptin-deficient ob/ob mice (p<0.05), indicating that nutritional activation of the hypothalamus can be leptin-independent. |
2003-11-28 |
2023-08-12 |
mouse |
| Michela Bagnasco, Giovanni Tulipano, Maria R Melis, Antonio Argiolas, Daniela Cocchi, Eugenio E Mulle. Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609764. |
ghrelin, a circulating growth-hormone releasing peptide derived from stomach, stimulates food intake through neuropeptide y (npy) neurons of the arcuate nucleus in the hypothalamus (arc). |
2003-11-21 |
2023-08-12 |
rat |