| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Yong-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J Birnbaum, Bettina J Stuck, Barbara B Kah. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. vol 428. issue 6982. 2004-04-14. PMID:15058305. |
amp-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. |
2004-04-14 |
2023-08-12 |
Not clear |
| Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Yong-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J Birnbaum, Bettina J Stuck, Barbara B Kah. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. vol 428. issue 6982. 2004-04-14. PMID:15058305. |
we investigated the potential role of ampk in the hypothalamus in the regulation of food intake. |
2004-04-14 |
2023-08-12 |
Not clear |
| Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Yong-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J Birnbaum, Bettina J Stuck, Barbara B Kah. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. vol 428. issue 6982. 2004-04-14. PMID:15058305. |
dominant negative ampk expression in the hypothalamus is sufficient to reduce food intake and body weight, whereas constitutively active ampk increases both. |
2004-04-14 |
2023-08-12 |
Not clear |
| Sebastien G Bouret, Shin J Draper, Richard B Simerl. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science (New York, N.Y.). vol 304. issue 5667. 2004-04-14. PMID:15064420. |
in adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (arh). |
2004-04-14 |
2023-08-12 |
mouse |
| Sebastien G Bouret, Shin J Draper, Richard B Simerl. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science (New York, N.Y.). vol 304. issue 5667. 2004-04-14. PMID:15064420. |
these results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults. |
2004-04-14 |
2023-08-12 |
mouse |
| Aaron G Roseberry, Hongyan Liu, Alexander C Jackson, Xiaoli Cai, Jeffrey M Friedma. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. vol 41. issue 5. 2004-04-12. PMID:15003171. |
npy and alphamsh are expressed in distinct neurons in the arcuate nucleus of the hypothalamus, where alphamsh decreases and npy increases food intake and body weight. |
2004-04-12 |
2023-08-12 |
mouse |
| Aaron G Roseberry, Hongyan Liu, Alexander C Jackson, Xiaoli Cai, Jeffrey M Friedma. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. vol 41. issue 5. 2004-04-12. PMID:15003171. |
these data reveal an intricate and asymmetric interplay between npy and pomc neurons in the hypothalamus and have important implications for the delineation of the neural circuits that regulate feeding behavior. |
2004-04-12 |
2023-08-12 |
mouse |
| Eiji Suzuki, Haruaki Kageyama, Toshio Nakaki, Shigenobu Kanba, Shuji Inoue, Hitoshi Miyaok. Nitric oxide induced heat shock protein 70 mRNA in rat hypothalamus during acute restraint stress under sucrose diet. Cellular and molecular neurobiology. vol 23. issue 6. 2004-04-09. PMID:14964778. |
sucrose feeding increases the level of stress-induced heat shock protein 70 mrna in the rat hypothalamus. |
2004-04-09 |
2023-08-12 |
rat |
| Johanna Kela, Peter Salmi, Roberto Rimondini-Giorgini, Markus Heilig, Claes Wahlested. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regulatory peptides. vol 114. issue 2-3. 2004-04-07. PMID:12832098. |
melanin-concentrating hormone (mch) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. |
2004-04-07 |
2023-08-12 |
rat |
| Milagros Rocha, Chen Bing, Gareth Williams, Marisa Puert. Pregnancy-induced hyperphagia is associated with increased gene expression of hypothalamic agouti-related peptide in rats. Regulatory peptides. vol 114. issue 2-3. 2004-04-07. PMID:12832105. |
since hypothalamus is a key brain region involved in many peripheral signals and neuronal pathways that control energy homeostasis and food intake, we investigated if during pregnancy the increase in food intake is mediated by stimulating orexigenic and/or inhibiting anorexigenic neural pathways. |
2004-04-07 |
2023-08-12 |
rat |
| M Ribasés, M Gratacòs, L Armengol, R de Cid, A Badía, L Jiménez, R Solano, J Vallejo, F Fernández, X Estivil. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Molecular psychiatry. vol 8. issue 8. 2004-04-01. PMID:12888803. |
these findings, together with the fact that this neurotrophin is expressed in the hypothalamus nuclei associated with weight regulation and feeding control, led us to propose bdnf as a candidate gene for ed. |
2004-04-01 |
2023-08-12 |
mouse |
| Abhiram Sah. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Frontiers in neuroendocrinology. vol 24. issue 4. 2004-03-31. PMID:14726256. |
it is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals, including npy, mch, galanin, orexin, galp, alpha-msh, nt, and crh. |
2004-03-31 |
2023-08-12 |
human |
| Jochen Seufer. Leptin effects on pancreatic beta-cell gene expression and function. Diabetes. vol 53 Suppl 1. 2004-03-23. PMID:14749281. |
leptin was first described to act on the satiety center in the hypothalamus through specific receptors (leptin receptor [obr]) to restrict food intake and enhance energy expenditure. |
2004-03-23 |
2023-08-12 |
Not clear |
| Leslie E Landree, Andrea L Hanlon, David W Strong, Gavin Rumbaugh, Ian M Miller, Jagan N Thupari, Erin C Connolly, Richard L Huganir, Christine Richardson, Lee A Witters, Francis P Kuhajda, Gabriele V Ronnet. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. The Journal of biological chemistry. vol 279. issue 5. 2004-03-11. PMID:14615481. |
c75, a synthetic inhibitor of fatty acid synthase (fas), is hypothesized to alter the metabolism of neurons in the hypothalamus that regulate feeding behavior to contribute to the decreased food intake and profound weight loss seen with c75 treatment. |
2004-03-11 |
2023-08-12 |
Not clear |
| Cheng-Dean Shih, Lo-Chun Au, Julie Y H Cha. Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. Journal of biomedical science. vol 10. issue 4. 2004-03-09. PMID:12824696. |
control application of sense (son, 50 pmol) or a scrambled antisense ob-r oligonucleotide (ason2, 50 pmol) into the bilateral pvn promoted no discernible effect on ob-r protein expression in the hypothalamus, on daily food intake, or on cardiovascular performance. |
2004-03-09 |
2023-08-12 |
rat |
| Stacey R Hettes, James Gonzaga, Theodore W Heyming, Sam Perez, Stefany Wolfsohn, B Glenn Stanle. Dual roles in feeding for AMPA/kainate receptors: receptor activation or inactivation within distinct hypothalamic regions elicits feeding behavior. Brain research. vol 992. issue 2. 2004-02-20. PMID:14625056. |
here we report that nbqx and cnqx elicit feeding in a dose dependent manner and are most effective when injected into the perifornical hypothalamus (pfh), or into the paraventricular nucleus (pvn) and, to a lesser extent, into the lh of satiated rats. |
2004-02-20 |
2023-08-12 |
rat |
| B K ANAND, J R BROBEC. Localization of a "feeding center" in the hypothalamus of the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 77. issue 2. 2004-02-15. PMID:14854036. |
localization of a "feeding center" in the hypothalamus of the rat. |
2004-02-15 |
2023-08-12 |
rat |
| Joanne A Harrold, Peter S Widdowson, Gareth William. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. vol 24. issue 3. 2004-01-30. PMID:12732337. |
alpha-melanocyte stimulating hormone (msh) has generally been assumed to be the endogenous ligand acting at the melanocortin-4 receptor (mc4-r), activation of which in the hypothalamus leads to reduced feeding. |
2004-01-30 |
2023-08-12 |
human |
| Jens Rüter, Peter Kobelt, Johannes J Tebbe, Yeşim Avsar, Rüdiger Veh, Lixin Wang, Burghard F Klapp, Bertram Wiedenmann, Yvette Taché, Hubert Mönnike. Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575873. |
on food intake and neuronal activity in the hypothalamus and brain stem, as assessed by c-fos-like-immunoreactivity (c-fli), using a confocal laser scanning microscope (clsm) as a sensitive microscopic technique to detect c-fli-positive neurons. |
2004-01-22 |
2023-08-12 |
rat |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
the hypothalamus is a region of the brain that plays a critical role in feeding regulation. |
2004-01-21 |
2023-08-12 |
rat |