| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
to evaluate the role of neuropeptide y (npy), a potent appetite stimulant, in controlling food intake and body weight, we investigated the use of antisense oligodeoxynucleotides (odns) to inhibit npy gene expression in the hypothalamus. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
we compared the hypothalamic distribution of fluorescein-labelled odns administered intracerebroventricularly, and effects on food intake and npy gene expression, of three different structural modifications of an antisense odn sequence against npy. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the phosphorothioate odn was widely distributed throughout the hypothalamus but had nonselective effects, with similar changes in food intake and npy mrna levels in the antisense and missense groups, and was severely toxic. |
1998-06-11 |
2023-08-12 |
rat |
| S Dryden, L Pickavance, D Tidd, G William. The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus. The Journal of endocrinology. vol 157. issue 1. 1998-06-11. PMID:9614370. |
the propyl-protected odn appeared to penetrate the hypothalamus well but had no antisense-selective effects on npy mrna levels or food intake. |
1998-06-11 |
2023-08-12 |
rat |
| C L Marín Bivens, W J Thomas, B G Stanle. Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519273. |
although hypothalamic injections of neuropeptide y (npy) induce robust feeding, there is little information about the patterns of feeding elicited by this peptide. |
1998-05-14 |
2023-08-12 |
rat |
| C L Marín Bivens, W J Thomas, B G Stanle. Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519273. |
to reveal these patterns, npy (0, 8, 24, 78, 235 pmol/10 nl) was injected into the perifornical hypothalamus (pfh) of satiated adult male rats and their subsequent food intake was monitored every minute for 24 h. for comparison, feeding patterns were similarly observed following fasts of 0, 3, 6, 9, 12, and 24 h. the results demonstrated that npy and food deprivation both produced dose- or deprivation-dependent increases in food intake that were most evident in the first 6 h. the increased intakes induced by npy were characterized by combinations of increased meal size and frequency, with the predominant effects being increases in the size of and decreased latency to eat the first meal. |
1998-05-14 |
2023-08-12 |
rat |
| C L Marín Bivens, W J Thomas, B G Stanle. Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519273. |
these similarities between npy-induced and food deprivation-induced feeding are consistent with a stimulatory role for endogenous npy in deprivation-induced feeding. |
1998-05-14 |
2023-08-12 |
rat |
| S L Cummings, B G Truong, D W Gietze. Neuropeptide Y and somatostatin in the anterior piriform cortex alter intake of amino acid-deficient diets. Peptides. vol 19. issue 3. 1998-05-08. PMID:9533641. |
thus, we hypothesized that npy and som administered intracortically to the apc would directly affect food intake in a threonine-imbalanced model. |
1998-05-08 |
2023-08-12 |
Not clear |
| M W Schwartz, J C Erickson, D G Baskin, R D Palmite. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology. vol 139. issue 5. 1998-05-08. PMID:9564880. |
neuropeptide y (npy), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. |
1998-05-08 |
2023-08-12 |
mouse |
| M Tang-Christensen, N Vrang, P J Larse. Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment. Diabetes. vol 47. issue 4. 1998-05-07. PMID:9568683. |
in non-lesioned rats, neuropeptide y (npy)-induced feeding was significantly reduced by concomitant glp-1 administration. |
1998-05-07 |
2023-08-12 |
rat |
| B He, B D White, G L Edwards, R J Marti. Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507187. |
recent studies suggest the possible involvement of neuropeptide y (npy) in 2-dg-induced feeding. |
1998-04-29 |
2023-08-12 |
rat |
| B He, B D White, G L Edwards, R J Marti. Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507187. |
the present study examined the effect of immunoneutralization of endogenous npy on 2-dg-induced feeding. |
1998-04-29 |
2023-08-12 |
rat |
| B He, B D White, G L Edwards, R J Marti. Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507187. |
npy antibody injected into the paraventricular nucleus of the rats significantly attenuated 2-dg-induced feeding, suggesting that hypothalamic npy may mediate, at least partly, the effect of 2-dg on food intake. |
1998-04-29 |
2023-08-12 |
rat |
| C Li, P Chen, M S Smit. The acute suckling stimulus induces expression of neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and increases NPY expression in the arcuate nucleus. Endocrinology. vol 139. issue 4. 1998-04-14. PMID:9528945. |
the increased npy neuronal activity may play an important role in modulating changes in hypothalamic regulation of hormone secretion and food intake. |
1998-04-14 |
2023-08-12 |
rat |
| S F Leibowitz, A Akabayashi, J T Alexander, J Wan. Gonadal steroids and hypothalamic galanin and neuropeptide Y: role in eating behavior and body weight control in female rats. Endocrinology. vol 139. issue 4. 1998-04-14. PMID:9528961. |
in rats consuming lab chow or macronutrient diets, measurements across the estrous cycle were taken of hypothalamic gal and npy, using ria and immunohistochemistry; of the circulating hormones, estradiol, progesterone, and lh; and also of food intake and body weight. |
1998-04-14 |
2023-08-12 |
rat |
| K Rosenkranz, A Hinney, A Ziegler, S von Prittwitz, N Barth, H Roth, H Mayer, W Siegfried, G Lehmkuhl, F Poustka, M Schmidt, H Schäfer, H Remschmidt, J Hebebran. Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 22. issue 2. 1998-04-09. PMID:9504324. |
the neuropeptide y (npy) y5 receptor is presumed to be involved in the regulation of food intake. |
1998-04-09 |
2023-08-12 |
Not clear |
| C S Mantzoros, R C Frederich, D Qu, B B Lowell, E Maratos-Flier, J S Flie. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. vol 47. issue 2. 1998-04-03. PMID:9519718. |
thus food intake, body weight, and insulin and glucose homeostasis of ucp-dta mice are all extraordinarily resistant to leptin, whereas hypothalamic npy and the hypothalamopituitary adrenal (hpa) axis may remain under leptin control. |
1998-04-03 |
2023-08-12 |
mouse |
| P S Widdowson, R Upton, L Henderson, R Buckingham, S Wilson, G William. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain research. vol 774. issue 1-2. 1998-03-11. PMID:9452185. |
neuropeptide y (npy) potently induces feeding, reduces thermogenesis and induces obesity in rats when injected into the cerebral ventricles. |
1998-03-11 |
2023-08-12 |
rat |
| B Beck, R Kozak, A Stricker-Krongrad, C Burle. Neuropeptide Y release in the paraventricular nucleus of Long-Evans rats treated with leptin. Biochemical and biophysical research communications. vol 242. issue 3. 1998-03-06. PMID:9464269. |
neuropeptide y (npy) and leptin are actually two of the most potent peptides involved in the regulation of food intake with their respective stimulatory and inhibitory actions. |
1998-03-06 |
2023-08-12 |
rat |
| C Bing, H M Frankish, L Pickavance, Q Wang, D F Hopkins, M J Stock, G William. Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY. The American journal of physiology. vol 274. issue 1. 1998-02-23. PMID:9458899. |
hypothalamic neuropeptide y (npy) neurons are implicated in stimulating food intake in starvation, but may also suppress sympathetic outflow to bat. |
1998-02-23 |
2023-08-12 |
rat |