| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Xu, M G Dube, P S Kalra, W G Farmerie, A Kaibara, L L Moldawer, D Martin, S P Kalr. Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology. vol 139. issue 2. 1998-02-18. PMID:9449612. |
these results suggested that anorexia in cntf-treated rats may be due to a deficit in npy supply and possibly in the release and suppression of npy-induced feeding. |
1998-02-18 |
2023-08-12 |
rat |
| B Xu, M G Dube, P S Kalra, W G Farmerie, A Kaibara, L L Moldawer, D Martin, S P Kalr. Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology. vol 139. issue 2. 1998-02-18. PMID:9449612. |
daily intracerebroventricular injections of leptin (7 microg/rat) decreased food intake, body weight, and hypothalamic npy gene expression in a manner similar to that seen after cntf treatment. |
1998-02-18 |
2023-08-12 |
rat |
| B Xu, M G Dube, P S Kalra, W G Farmerie, A Kaibara, L L Moldawer, D Martin, S P Kalr. Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology. vol 139. issue 2. 1998-02-18. PMID:9449612. |
thus, these results show that a two-pronged central action of cntf, causing diminution in both npy availability and the npy-induced feeding response, may underlie the severe anorexia. |
1998-02-18 |
2023-08-12 |
rat |
| A Sah. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology. vol 139. issue 2. 1998-02-18. PMID:9449656. |
central administration of leptin (5 microg) for 3 days decreased food intake and body weight gain in association with a decrease in hypothalamic galanin (gal), melanin-concentrating hormone (mch), proopiomelanocortin (pomc) and neuropeptide y (npy) gene expression and with an increase in neurotensin (nt) gene expression. |
1998-02-18 |
2023-08-12 |
rat |
| A Sah. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology. vol 139. issue 2. 1998-02-18. PMID:9449656. |
npy, mch, gal, pomc) and stimulating inhibitory (e.g., nt) signals in the feeding circuitry. |
1998-02-18 |
2023-08-12 |
rat |
| P J Currie, D V Coscin. Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. Neuroreport. vol 8. issue 17. 1998-02-17. PMID:9427365. |
injections of npy (100-200 pmol) into each region potentiated food intake. |
1998-02-17 |
2023-08-12 |
Not clear |
| P J Currie, D V Coscin. Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. Neuroreport. vol 8. issue 17. 1998-02-17. PMID:9427365. |
pretreatment with doi (5-20 nmol) into the pvn effectively suppressed feeding elicited by pvn npy (100 pmol). |
1998-02-17 |
2023-08-12 |
Not clear |
| P J Currie, D V Coscin. Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. Neuroreport. vol 8. issue 17. 1998-02-17. PMID:9427365. |
this suggests that 5-ht(2a/2c) receptor modulation of npy feeding within the hypothalamus is localized to the pvn. |
1998-02-17 |
2023-08-12 |
Not clear |
| M J Glass, J P Cleary, C J Billington, A S Levin. Role of carbohydrate type on diet selection in neuropeptide Y-stimulated rats. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435659. |
we tested whether carbohydrate source (corn starch, sucrose, polycose) influences the choice between a high-fat and high-carbohydrate diet in spontaneously feeding rats and in rats stimulated to eat by neuropeptide y (npy) administration or food deprivation. |
1998-02-09 |
2023-08-12 |
rat |
| A Stricker-Krongrad, R Kozak, C Burlet, J P Nicolas, B Bec. Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435668. |
neuropeptide y (npy) injected into this nucleus strongly stimulates food intake. |
1998-02-09 |
2023-08-12 |
rat |
| A Stricker-Krongrad, R Kozak, C Burlet, J P Nicolas, B Bec. Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435668. |
this study performed in very physiological conditions therefore indicates that npy release could drive feeding behavior in the normal life. |
1998-02-09 |
2023-08-12 |
rat |
| Q Wang, S Dryden, H M Frankish, C Bing, L Pickavance, D Hopkins, R Buckingham, G William. Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y. British journal of pharmacology. vol 122. issue 7. 1998-02-05. PMID:9421288. |
in lean rats of either strain, brl 49653 had no effect on food intake, body weight, plasma insulin and corticosterone, npy or npy mrna levels. |
1998-02-05 |
2023-08-12 |
rat |
| Q Wang, S Dryden, H M Frankish, C Bing, L Pickavance, D Hopkins, R Buckingham, G William. Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y. British journal of pharmacology. vol 122. issue 7. 1998-02-05. PMID:9421288. |
fatty rats given brl 49653 showed a 30% increase in food intake and accelerated body weight gain (both p<0.01) after 7 and 20 days, but without significant changes in regional hypothalamic npy or npy mrna levels. |
1998-02-05 |
2023-08-12 |
rat |
| C Broberger, M Landry, H Wong, J N Walsh, T Hökfel. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology. vol 66. issue 6. 1998-02-05. PMID:9430445. |
these results show that the pomc neurons are targets for npy, which is presumably present in, and released from, fibres originating in the ventromedial arcuate nucleus and which may play a role in npy-induced feeding. |
1998-02-05 |
2023-08-12 |
rat |
| P B Jensen, N Blume, J D Mikkelsen, P J Larsen, H I Jensen, J J Holst, O D Madse. Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus. The Journal of clinical investigation. vol 101. issue 2. 1998-02-05. PMID:9435324. |
the adipose satiety factor leptin, known to suppress food intake by reducing hypothalamic neuropeptide y (npy) levels, was not found to be expressed by the tumor, and circulating leptin levels were reduced twofold in the anorectic phase. |
1998-02-05 |
2023-08-12 |
rat |
| M C Lee, P J Mannon, J P Grant, T N Pappa. Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain. Physiology & behavior. vol 62. issue 6. 1997-12-30. PMID:9383105. |
we conclude that continuous parenteral nutrition significantly increases npy receptor density in the rat brain suggesting that tpn may impact feeding via the regulation of npy receptor-mediated effects. |
1997-12-30 |
2023-08-12 |
rat |
| M P Ruffin, P C Even, M El-Ghissassi, S Nicolaidi. Metabolic action of neuropeptide Y in relation to its effect on feeding. Physiology & behavior. vol 62. issue 6. 1997-12-30. PMID:9383111. |
because energy homeostasis depends on a continuous balance between food intake, energy expenditure, and energy storage, it was expected that neuropeptide y (npy) could act not only on food intake but also on metabolic parameters. |
1997-12-30 |
2023-08-12 |
Not clear |
| M P Ruffin, P C Even, M El-Ghissassi, S Nicolaidi. Metabolic action of neuropeptide Y in relation to its effect on feeding. Physiology & behavior. vol 62. issue 6. 1997-12-30. PMID:9383111. |
npy was injected into the juxtafornical hypothalamus at a dose that promotes feeding behavior (1 microg/0.5 microl) and enhances locomotor activity. |
1997-12-30 |
2023-08-12 |
Not clear |
| R Parikh, J L Mark. Metabolic and orexigenic effects of intracerebroventricular neuropeptide Y are attenuated by food deprivation. Journal of neuroendocrinology. vol 9. issue 10. 1997-12-23. PMID:9355048. |
administration of neuropeptide y (npy) into the hypothalamus or cerebral ventricles has been shown to increase food intake, the secretion of hormones such as insulin, glucagon and corticosterone and to alter the metabolism of carbohydrate and lipids. |
1997-12-23 |
2023-08-12 |
rat |
| J Dötsch, M Adelmann, P Englaro, A Dötsch, J Hänze, W F Blum, W Kiess, W Rasche. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid. Journal of the neurological sciences. vol 151. issue 2. 1997-11-26. PMID:9349674. |
leptin and neuropeptide y (npy) are involved in the regulation of food intake and body weight. |
1997-11-26 |
2023-08-12 |
human |