| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A al-Arabi, J F Andrew. Synergistic action by neuropeptide Y (NPY) and norepinephrine (NE) on food intake, metabolic rate, and brown adipose tissue (BAT) causes remarkable weight loss in the obese (fa/fa) Zucker rat. Biomedical sciences instrumentation. vol 33. 1998-09-24. PMID:9731362. |
in warm environmental conditions the combined treatment with ne and npy was the only treatment that caused significant reduction of total body weight by inhibiting food intake and enhancing rmr. |
1998-09-24 |
2023-08-12 |
rat |
| A al-Arabi, J F Andrew. Synergistic action by neuropeptide Y (NPY) and norepinephrine (NE) on food intake, metabolic rate, and brown adipose tissue (BAT) causes remarkable weight loss in the obese (fa/fa) Zucker rat. Biomedical sciences instrumentation. vol 33. 1998-09-24. PMID:9731362. |
in the cold environment the ne and npy together showed similar but less enhancing effect on body weight; this was mainly due to the significant depression of food intake and slight metabolic response. |
1998-09-24 |
2023-08-12 |
rat |
| J G Mercer, B Beck, A Burlet, K M Moar, N Hoggard, T Atkinson, P Barret. Leptin (ob) mRNA and hypothalamic NPY in food-deprived/refed Syrian hamsters. Physiology & behavior. vol 64. issue 2. 1998-09-16. PMID:9662085. |
food deprivation in the laboratory rat decreases plasma leptin and insulin, elevates glucocorticoid concentration, and increases the activity of the neuropeptide y (npy) system and feeding drive. |
1998-09-16 |
2023-08-12 |
mouse |
| J G Mercer, B Beck, A Burlet, K M Moar, N Hoggard, T Atkinson, P Barret. Leptin (ob) mRNA and hypothalamic NPY in food-deprived/refed Syrian hamsters. Physiology & behavior. vol 64. issue 2. 1998-09-16. PMID:9662085. |
npy concentrations in hypothalamic nuclei were also unaffected by feeding state. |
1998-09-16 |
2023-08-12 |
mouse |
| J G Mercer, B Beck, A Burlet, K M Moar, N Hoggard, T Atkinson, P Barret. Leptin (ob) mRNA and hypothalamic NPY in food-deprived/refed Syrian hamsters. Physiology & behavior. vol 64. issue 2. 1998-09-16. PMID:9662085. |
the failure of food deprivation to affect npy and feeding behaviour in syrian hamsters is unlikely to be due to defects in the leptin system, although there may be region-specific differences in the regulation of leptin signaling in laboratory rats and syrian hamsters. |
1998-09-16 |
2023-08-12 |
mouse |
| T J Kowalski, T A Houpt, J Jahng, N Okada, S C Chua, G P Smit. Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups. The American journal of physiology. vol 275. issue 2. 1998-09-16. PMID:9688681. |
little is known, however, about the role of the hypothalamic npy system in the control of food intake in the preweanling rat. |
1998-09-16 |
2023-08-12 |
rat |
| C M Kotz, J E Briggs, M K Grace, A S Levine, C J Billingto. Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat. The American journal of physiology. vol 275. issue 2. 1998-09-16. PMID:9688682. |
feeding response, bat ucp, and lpl mrna were measured after injection of 0, 5, 10, and 25 microg ntx in the rnts +/- 1 microg npy in the pvn. |
1998-09-16 |
2023-08-12 |
rat |
| C M Kotz, J E Briggs, M K Grace, A S Levine, C J Billingto. Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat. The American journal of physiology. vol 275. issue 2. 1998-09-16. PMID:9688682. |
one-hour feeding response to pvn npy was significantly and dose dependently decreased by 10 and 25 microg rnts ntx (-23 and -31%, respectively). |
1998-09-16 |
2023-08-12 |
rat |
| C M Kotz, J E Briggs, M K Grace, A S Levine, C J Billingto. Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat. The American journal of physiology. vol 275. issue 2. 1998-09-16. PMID:9688682. |
these results indicate a possible divergence in the pvn npy feeding-stimulatory/bat-inhibitory pathway, such that pvn npy feeding effects may be routed through the rnts whereas bat effects may be due to alterations at another neural site. |
1998-09-16 |
2023-08-12 |
rat |
| T Hökfelt, C Broberger, X Zhang, M Diez, J Kopp, Z Xu, M Landry, L Bao, M Schalling, J Koistinaho, S J DeArmond, S Prusiner, J Gong, J H Wals. Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain research. Brain research reviews. vol 26. issue 2-3. 1998-08-28. PMID:9651513. |
taken together these findings are in good agreement with the view that npy in the arcuate nucleus plays an important role in regulating feeding behaviour. |
1998-08-28 |
2023-08-12 |
mouse |
| B A Vuagnat, D D Pierroz, M Lalaoui, P Englaro, F P Pralong, W F Blum, M L Auber. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology. vol 67. issue 5. 1998-08-27. PMID:9641610. |
the obese gene (ob) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide y (npy) neurotransmission. |
1998-08-27 |
2023-08-12 |
rat |
| B A Vuagnat, D D Pierroz, M Lalaoui, P Englaro, F P Pralong, W F Blum, M L Auber. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology. vol 67. issue 5. 1998-08-27. PMID:9641610. |
in rats receiving ad libitum feeding, leptin treatment reduced npy gene expression, consistent with the observed reduction in food intake, whereas pair-fed animals logically exhibited increased npy gene expression. |
1998-08-27 |
2023-08-12 |
rat |
| B A Vuagnat, D D Pierroz, M Lalaoui, P Englaro, F P Pralong, W F Blum, M L Auber. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology. vol 67. issue 5. 1998-08-27. PMID:9641610. |
in both situations with reduced feeding, normal gh secretion was seen in leptin-treated animals exhibiting low npy gene expression, whereas decreased or abolished gh secretion was seen in animals not receiving leptin and exhibiting increased npy mrna levels. |
1998-08-27 |
2023-08-12 |
rat |
| A Kask, L Rägo, P Korrovits, J E Wikberg, H B Schiöt. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Biochemical and biophysical research communications. vol 248. issue 2. 1998-08-27. PMID:9675121. |
in this study, we used the newly discovered selective mc4r antagonist hs014 for increasing food intake in free-feeding rats and evaluated the effects of the npy y1 receptor antagonist 1229u91 and the selective serotonin uptake inhibitor fluoxetine on this increased feeding behavior. |
1998-08-27 |
2023-08-12 |
mouse |
| A Kask, L Rägo, P Korrovits, J E Wikberg, H B Schiöt. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Biochemical and biophysical research communications. vol 248. issue 2. 1998-08-27. PMID:9675121. |
fluoxetine, which has been shown to inhibit npy release, inhibited spontaneous food intake and completely blocked the stimulation of food intake by hs014. |
1998-08-27 |
2023-08-12 |
mouse |
| A Kask, L Rägo, P Korrovits, J E Wikberg, H B Schiöt. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Biochemical and biophysical research communications. vol 248. issue 2. 1998-08-27. PMID:9675121. |
this is the first report showing that physiological feeding response evoked by mc4r blockage is influenced by npy signalling. |
1998-08-27 |
2023-08-12 |
mouse |
| J Lee, M J Morri. Modulation of neuropeptide Y overflow by leptin in the rat hypothalamus, cerebral cortex and medulla. Neuroreport. vol 9. issue 7. 1998-08-24. PMID:9631469. |
in conclusion, the inhibitory effect of leptin on hypothalamic npy overflow provides further evidence for important modulatory actions between these two feeding mediators. |
1998-08-24 |
2023-08-12 |
rat |
| M Chavez, R J Seeley, P J Havel, M I Friedman, C A Matson, S C Woods, M W Schwart. Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes. The Journal of clinical investigation. vol 102. issue 2. 1998-08-20. PMID:9664075. |
insulin and corticosterone, which are known to affect hypothalamic npy and crh expression, were not different between these two groups, making it unlikely that they can account for the differences in either feeding behavior or hypothalamic peptide expression. |
1998-08-20 |
2023-08-12 |
rat |
| M Chavez, R J Seeley, P J Havel, M I Friedman, C A Matson, S C Woods, M W Schwart. Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes. The Journal of clinical investigation. vol 102. issue 2. 1998-08-20. PMID:9664075. |
these observations support the hypothesis that the normalization of food intake observed in diabetic rats consuming a hf diet may in part be mediated by reductions in npy expression and elevations in crh expression. |
1998-08-20 |
2023-08-12 |
rat |
| Y Dumont, A Fournier, R Quirio. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 15. 1998-08-07. PMID:9671648. |
these data suggest that the y5 receptor protein is expressed and translated by a small percentage of hypothalamic neurons and that the effect of npy on feeding behaviors likely is mediated by more than one class of npy receptors. |
1998-08-07 |
2023-08-12 |
rat |