| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D G Baskin, M W Schwartz, R J Seeley, S C Woods, D Porte, J F Breininger, Z Jonak, J Schaefer, M Krouse, C Burghardt, L A Campfield, P Burn, J P Kocha. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 47. issue 3. 1999-03-11. PMID:10026237. |
the present finding of ob-rb protein in neurons that express npy mrna supports the hypothesis that arcuate nucleus npy neurons are direct targets of leptin and play an important role in regulation of food intake and body weight. |
1999-03-11 |
2023-08-12 |
human |
| H A Wieland, W Engel, W Eberlein, K Rudolf, H N Dood. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806339. |
30 microg bibo 3304 administered into the paraventricular nucleus inhibited the feeding response induced by 1 microg npy as well as the hyperphagia induced by a 24 h fast implying a role for y1 receptors in npy mediated feeding. |
1999-03-04 |
2023-08-12 |
human |
| H A Wieland, W Engel, W Eberlein, K Rudolf, H N Dood. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806339. |
but it blocked feeding behaviour elicited by both [leu31, pro24]npy and npy (3 36) suggesting an interplay between different npy receptor subtypes in feeding behavior. |
1999-03-04 |
2023-08-12 |
human |
| H A Wieland, W Engel, W Eberlein, K Rudolf, H N Dood. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806339. |
the present study reveals that bibo 3304 is a subtype selective nonpeptide antagonist with subnanomolar affinity for the y1 receptor subtype that significantly inhibits food intake induced by application of npy or by fasting. |
1999-03-04 |
2023-08-12 |
human |
| T L Horvath, S Diano, A N van den Po. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 3. 1999-02-25. PMID:9920670. |
the excitatory actions of hypocretin could increase npy release, resulting in enhanced feeding behavior and altered endocrine regulation, whereas leptin, released from adipose tissue as an indicator of fat stores, would have the opposite effect on the same neurons, leading to a decrease in npy and npy-mediated hypothalamic functions. |
1999-02-25 |
2023-08-12 |
rat |
| S Pu, M R Jain, T L Horvath, S Diano, P S Kalra, S P Kalr. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927326. |
neuropeptide y (npy) produced in neurons in the arcuate nucleus and brain stem and released in the paraventricular nucleus (pvn) and surrounding areas is involved in stimulation of feeding in rats. |
1999-02-23 |
2023-08-12 |
rat |
| S Pu, M R Jain, T L Horvath, S Diano, P S Kalra, S P Kalr. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927326. |
when injected intracerebroventricularly, both npy and mus elicited dose-dependent feeding responses that were blocked by the administration of 1229u91 (a putative y1 receptor antagonist) or bicuculline (a gaba(a) receptor antagonist), respectively. |
1999-02-23 |
2023-08-12 |
rat |
| S Pu, M R Jain, T L Horvath, S Diano, P S Kalra, S P Kalr. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927326. |
coadministration of npy and mus intracerebroventricularly amplified the feeding response over that evoked by npy or mus alone. |
1999-02-23 |
2023-08-12 |
rat |
| S Pu, M R Jain, T L Horvath, S Diano, P S Kalra, S P Kalr. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927326. |
similarly, microinjection of either npy or mus into the pvn stimulated food intake in a dose-related fashion, and coinjection elicited a significantly higher response than that evoked by either individual treatment. |
1999-02-23 |
2023-08-12 |
rat |
| S Pu, M R Jain, T L Horvath, S Diano, P S Kalra, S P Kalr. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. vol 140. issue 2. 1999-02-23. PMID:9927326. |
these results suggest that gaba and npy may coact through distinct receptors and second messenger systems in the pvn to augment food intake. |
1999-02-23 |
2023-08-12 |
rat |
| L Criscione, P Rigollier, C Batzl-Hartmann, H Rüeger, A Stricker-Krongrad, P Wyss, L Brunner, S Whitebread, Y Yamaguchi, C Gerald, R O Heurich, M W Walker, M Chiesi, W Schilling, K G Hofbauer, N Leven. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. The Journal of clinical investigation. vol 102. issue 12. 1999-02-01. PMID:9854049. |
in lean satiated rats cgp 71683a significantly antagonized the increase in food intake induced by intracerebroventricular injection of npy. |
1999-02-01 |
2023-08-12 |
human |
| L Criscione, P Rigollier, C Batzl-Hartmann, H Rüeger, A Stricker-Krongrad, P Wyss, L Brunner, S Whitebread, Y Yamaguchi, C Gerald, R O Heurich, M W Walker, M Chiesi, W Schilling, K G Hofbauer, N Leven. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. The Journal of clinical investigation. vol 102. issue 12. 1999-02-01. PMID:9854049. |
the data demonstrate that the npy y5 receptor subtype plays a role in npy-induced food intake, but also suggest that, with chronic blockade, counterregulatory mechanisms are induced to restore appetite. |
1999-02-01 |
2023-08-12 |
human |
| M A Statnick, D A Schober, S Gackenheimer, D Johnson, L Beavers, N G Mayne, J P Burnett, R Gadski, D R Gehler. Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites. Brain research. vol 810. issue 1-2. 1999-01-29. PMID:9813224. |
neuropeptide y (npy) is a 36-amino-acid peptide that appears to play a central role in the control of feeding behavior. |
1999-01-29 |
2023-08-12 |
human |
| M A Statnick, D A Schober, S Gackenheimer, D Johnson, L Beavers, N G Mayne, J P Burnett, R Gadski, D R Gehler. Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites. Brain research. vol 810. issue 1-2. 1999-01-29. PMID:9813224. |
recently, a cdna encoding a novel npy receptor subtype (y5) was cloned from the rat and human hypothalamus, and shown to have a pharmacology consistent with npy-induced feeding. |
1999-01-29 |
2023-08-12 |
human |
| A Kushi, H Sasai, H Koizumi, N Takeda, M Yokoyama, M Nakamur. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 26. 1999-01-28. PMID:9861026. |
to elucidate the role of neuropeptide y (npy)-y1 receptor (y1-r) in food intake, energy expenditure, and other possible functions, we have generated y1-r-deficient mice (y1-r-/-) by gene targeting. |
1999-01-28 |
2023-08-12 |
mouse |
| B Jeanrenaud, I Cusin, F Rohner-Jeanrenau. [From Claude Bernard to the regulatory system between the hypothalamus and the periphery: implications for homeostasis of body weight and obesity]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 5. 1999-01-28. PMID:9871796. |
released leptin, acting within the hypothalamus, decreases hypothalamic npy levels (probably those of other hypothalamic neuropeptides as well), food intake, insulinemia, insulin sensitivity of white adipose tissue, while increasing that of muscles. |
1999-01-28 |
2023-08-12 |
rat |
| M Tang-Christensen, P Kristensen, C E Stidsen, C L Brand, P J Larse. Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y. The Journal of endocrinology. vol 159. issue 2. 1999-01-27. PMID:9795372. |
a number of neuropeptide y (npy) receptor subtypes, including the recently cloned y5 receptor, have been implicated in the stimulation of food intake. |
1999-01-27 |
2023-08-12 |
Not clear |
| M Tang-Christensen, P Kristensen, C E Stidsen, C L Brand, P J Larse. Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y. The Journal of endocrinology. vol 159. issue 2. 1999-01-27. PMID:9795372. |
furthermore, y5 antisense odn pre-treatment significantly inhibited the robust feeding response elicited by central administration of npy (5.3+/-0. |
1999-01-27 |
2023-08-12 |
Not clear |
| M Jang, D R Romso. Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding. The Journal of nutrition. vol 128. issue 12. 1999-01-27. PMID:9868202. |
leptin is proposed to control food intake at least in part by regulating hypothalamic neuropeptide y (npy), a stimulator of food intake, and corticotropin-releasing hormone (crh), an inhibitor of food intake. |
1999-01-27 |
2023-08-12 |
mouse |
| C Li, P Chen, M S Smit. Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH). Regulatory peptides. vol 75-76. 1999-01-19. PMID:9802398. |
taken together, the increase in npy activity may be important in modulating some of the physiological alterations occurring during lactation, such as the increase in food intake, in part through modulating pvh neuronal activity. |
1999-01-19 |
2023-08-12 |
Not clear |