| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J E Morley, M M Alshaher, S A Farr, J F Flood, V B Kuma. Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides. vol 20. issue 5. 1999-10-26. PMID:10465511. |
these results, taken together, with previously published studies support the concept that nitric oxide may play a role as a mediator of the effects of npy and leptin on food intake. |
1999-10-26 |
2023-08-12 |
mouse |
| P Naveilhan, H Hassani, J M Canals, A J Ekstrand, A Larefalk, V Chhajlani, E Arenas, K Gedda, L Svensson, P Thoren, P Ernfor. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nature medicine. vol 5. issue 10. 1999-10-21. PMID:10502824. |
neuropeptide y (npy), a 36-amino-acid peptide widely expressed in the brain is involved in many physiological responses, including hypothalamic control of food intake and cardiovascular homeostasis. |
1999-10-21 |
2023-08-12 |
mouse |
| M C Flynn, N P Turrin, C R Plata-Salamán, J M Ffrench-Mulle. Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiology & behavior. vol 66. issue 5. 1999-10-19. PMID:10405118. |
neuropeptide y (npy), npy 3-36 and pancreatic polypeptide (pp) increase short-term (2-h) food intake to varying degrees when given intracerebroventricularly (i.c.v.). |
1999-10-19 |
2023-08-12 |
rat |
| M C Flynn, N P Turrin, C R Plata-Salamán, J M Ffrench-Mulle. Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiology & behavior. vol 66. issue 5. 1999-10-19. PMID:10405118. |
the results show that antisense to the y5 receptor had no effect on either spontaneous 2-h or npy-, npy 3-36-, or pp-stimulated 2-h food intake. |
1999-10-19 |
2023-08-12 |
rat |
| M C Flynn, N P Turrin, C R Plata-Salamán, J M Ffrench-Mulle. Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiology & behavior. vol 66. issue 5. 1999-10-19. PMID:10405118. |
however, there was a significant decrease relative to the sense control group in 10-h food intake following the initial 2-h feeding response to npy (n = 10, p < 0.0001) or npy 3-36 (n = 10, p < 0.05). |
1999-10-19 |
2023-08-12 |
rat |
| M C Flynn, N P Turrin, C R Plata-Salamán, J M Ffrench-Mulle. Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiology & behavior. vol 66. issue 5. 1999-10-19. PMID:10405118. |
the data suggest that the y5 receptor has a modulatory role in the maintenance of feeding, but not as the critical receptor to confer for npy and npy 3-36 action on food intake. |
1999-10-19 |
2023-08-12 |
rat |
| P S Widdowson, L Henderson, L Pickavance, R Buckingham, M Tadayyon, J R Arch, G William. Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW 1229U91, on the consumption of highly palatable energy-rich diet. Peptides. vol 20. issue 3. 1999-10-14. PMID:10447095. |
we have studied the hypothalamic activity of the neuropeptide y (npy) system in dietary-induced obese male wistar rats and examined whether the npy antagonist, bw1229u91, can inhibit the hyperphagia during positive energy balance associated with feeding rats an energy-rich, highly palatable diet. |
1999-10-14 |
2023-08-12 |
rat |
| M Yokosuka, P S Kalra, S P Kalr. Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499503. |
intracerebroventricular administration of 1229u91, a selective npy y1 receptor antagonist, affected neither food intake nor c-fos-like immunoreactivity (fli) in these hypothalamic sites. |
1999-10-12 |
2023-08-12 |
Not clear |
| M Yokosuka, P S Kalra, S P Kalr. Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499503. |
co-administration of npy and npy y1 receptor antagonist inhibited npy-induced food intake by 48%, but failed to affect npy-induced fli in the supraoptic nucleus, dorsomedial nucleus, and parvocellular pvn. |
1999-10-12 |
2023-08-12 |
Not clear |
| M Yokosuka, P S Kalra, S P Kalr. Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499503. |
thus, these findings lend credence to the view that a subpopulation of y1 receptor-containing neurons in the mpvn in part mediate stimulation of feeding by npy. |
1999-10-12 |
2023-08-12 |
Not clear |
| G Grignaschi, E Fanelli, I Scagnol, R Samani. Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455265. |
sibutramine dose-dependently reduced feeding caused by food-deprivation (ed50 = 5.1+/-0.8 mg kg(-1)) or by npy injection into the paraventricular nucleus of the hypothalamus (ed50 = 6.0+/-0.5 mg kg(-1)). |
1999-10-05 |
2023-08-12 |
rat |
| C F Elias, C Aschkenasi, C Lee, J Kelly, R S Ahima, C Bjorbaek, J S Flier, C B Saper, J K Elmquis. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. vol 23. issue 4. 1999-09-20. PMID:10482243. |
these findings suggest that leptin directly and differentially engages npy and pomc neurons that project to the lha, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis. |
1999-09-20 |
2023-08-12 |
Not clear |
| E M Parker, L Xi. Extensive alternative splicing in the 5'-untranslated region of the rat and human neuropeptide Y Y5 receptor genes regulates receptor expression. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461880. |
activation of one of these receptors, the npy y5 receptor, is thought to result in increased food intake, anticonvulsant effects, attenuation of opiate withdrawal, inhibition of neuronal activity, and alteration of renal function. |
1999-09-14 |
2023-08-12 |
human |
| S Q Giraudo, M K Grace, C J Billington, A S Levin. Differential effects of neuropeptide Y and the mu-agonist DAMGO on 'palatability' vs. 'energy'. Brain research. vol 834. issue 1-2. 1999-09-10. PMID:10407107. |
in the current study, we stimulated feeding by injecting npy (110 pmol) or the mu-opioid agonist damgo (2 nmol) into the paraventricular nucleus of rats. |
1999-09-10 |
2023-08-12 |
rat |
| P D Raposinho, P Broqua, D D Pierroz, A Hayward, Y Dumont, R Quirion, J L Junien, M L Auber. Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology. vol 140. issue 9. 1999-09-09. PMID:10465275. |
this antagonist (60 microg, icv) also inhibited the stimulatory action of npy (0.7 nmol) on food intake. |
1999-09-09 |
2023-08-12 |
human |
| P D Raposinho, P Broqua, D D Pierroz, A Hayward, Y Dumont, R Quirion, J L Junien, M L Auber. Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology. vol 140. issue 9. 1999-09-09. PMID:10465275. |
with the exception of [d-trp32]npy, all analogs able to inhibit lh secretion were also able to stimulate food intake. |
1999-09-09 |
2023-08-12 |
human |
| C Broberger, J Johansen, H Brismar, C Johansson, M Schalling, T Hökfel. Changes in neuropeptide Y receptors and pro-opiomelanocortin in the anorexia (anx/anx) mouse hypothalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436066. |
both npy and pomc-derived peptides (melanocortins) have been strongly implicated in the control of feeding behavior, with the former exerting orexigenic effects and the latter having anorexigenic properties. |
1999-09-01 |
2023-08-12 |
mouse |
| C M Edwards, S Abusnana, D Sunter, K G Murphy, M A Ghatei, S R Bloo. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. The Journal of endocrinology. vol 160. issue 3. 1999-08-27. PMID:10077743. |
we compared the orexigenic effect of the orexins administered intracerebroventricular (icv) with other known stimulants of food intake, one strong, neuropeptide y (npy), and two weaker, melanin-concentrating hormone (mch) and galanin. |
1999-08-27 |
2023-08-12 |
rat |
| C M Edwards, S Abusnana, D Sunter, K G Murphy, M A Ghatei, S R Bloo. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. The Journal of endocrinology. vol 160. issue 3. 1999-08-27. PMID:10077743. |
both peptides stimulated food intake significantly less than npy, but to a similar extent to mch (2 h food intake: npy 3 nmol, 7.2+/-0.9 g vs saline, 1.5+/-0.2 g, p<0.001, mch 3 nmol, 3.2+/-0.8 g vs saline, p<0.01, orexin-b 30 nmol, 2. |
1999-08-27 |
2023-08-12 |
rat |
| T Hökfelt, C Broberger, M Diez, Z Q Xu, T Shi, J Kopp, X Zhang, K Holmberg, M Landry, J Koistinah. Galanin and NPY, two peptides with multiple putative roles in the nervous system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 5. 1999-08-26. PMID:10422730. |
in the hypothalamic arcuate nucleus npy and its receptors are part of the feeding circuitry, and we suggest that derangement of these npy neurons may at least in part underlay the lethal phenotype of anorectic mice, which die 22 days postnatally after showing decreased food intake and growth retardation. |
1999-08-26 |
2023-08-12 |
mouse |