| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Meiste. Control of food intake via leptin receptors in the hypothalamus. Vitamins and hormones. vol 59. 2000-03-28. PMID:10714243. |
indeed, functional studies show that npy, agrp, pomc-derived peptides, cart, mch, and hypocretins/orexins all are important regulators of food intake. |
2000-03-28 |
2023-08-12 |
mouse |
| A Kanatani, S Mashiko, N Murai, N Sugimoto, J Ito, T Fukuroda, T Fukami, N Morin, D J MacNeil, L H Van der Ploeg, Y Saga, S Nishimura, M Ihar. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698177. |
neuropeptide y (npy) increases food intake through the action of hypothalamic npy receptors. |
2000-03-16 |
2023-08-12 |
mouse |
| A Kanatani, S Mashiko, N Murai, N Sugimoto, J Ito, T Fukuroda, T Fukami, N Morin, D J MacNeil, L H Van der Ploeg, Y Saga, S Nishimura, M Ihar. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698177. |
although the involvement of y1 and y5 receptors in feeding regulation has been suggested, the relative importance of each of these npy receptors and the participation of a novel feeding receptor are still unclear. |
2000-03-16 |
2023-08-12 |
mouse |
| A Kanatani, S Mashiko, N Murai, N Sugimoto, J Ito, T Fukuroda, T Fukami, N Morin, D J MacNeil, L H Van der Ploeg, Y Saga, S Nishimura, M Ihar. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698177. |
in addition, the finding that y5-preferring agonists still induce food intake in y5-/- mice suggests a role for another npy receptor(s), including the possibility of novel npy receptors. |
2000-03-16 |
2023-08-12 |
mouse |
| A Kanatani, S Mashiko, N Murai, N Sugimoto, J Ito, T Fukuroda, T Fukami, N Morin, D J MacNeil, L H Van der Ploeg, Y Saga, S Nishimura, M Ihar. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698177. |
these observations suggest that the feeding stimulation induced by npy and its analogs may be directly or indirectly modulated by the action of the y1 receptor. |
2000-03-16 |
2023-08-12 |
mouse |
| A Kanatani, S Mashiko, N Murai, N Sugimoto, J Ito, T Fukuroda, T Fukami, N Morin, D J MacNeil, L H Van der Ploeg, Y Saga, S Nishimura, M Ihar. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698177. |
we conclude that multiple npy receptors, possibly including the novel feeding receptor, are involved in the feeding response evoked by npy and its analogs. |
2000-03-16 |
2023-08-12 |
mouse |
| D H Keisler, J A Daniel, C D Morriso. The role of leptin in nutritional status and reproductive function. Journal of reproduction and fertility. Supplement. vol 54. 2000-03-13. PMID:10692873. |
npy is a potent stimulator of food intake, is present at high concentrations in feed-restricted cattle and ewes, and is an inhibitor of lh secretion in these livestock species. |
2000-03-13 |
2023-08-12 |
cattle |
| D J Marsh, G I Miura, K A Yagaloff, M W Schwartz, G S Barsh, R D Palmite. Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612698. |
consequently, npy is considered to be a physiological effector of feeding behavior. |
2000-02-25 |
2023-08-12 |
mouse |
| D J Marsh, G I Miura, K A Yagaloff, M W Schwartz, G S Barsh, R D Palmite. Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612698. |
surprisingly, npy-deficient (npy-/-) mice feed and grow normally with ad libitum access to food and manifest a normal hyperphagic response after fasting, suggesting that other feeding effectors may compensate for the lack of npy. |
2000-02-25 |
2023-08-12 |
mouse |
| J Wang, J T Dourmashkin, R Yun, S F Leibowit. Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612704. |
in the present experiments, tests involving acute manipulations were conducted to determine whether such diet-induced changes in npy can occur rapidly, perhaps within 1-2 h, and whether these effects can be linked to specific changes in circulating glucoregulatory hormones or glucose itself., in adult, albino rats maintained on lab chow, the acute manipulations included the presentation of either a high-carbohydrate, moderate-carbohydrate or high-fat diet for 90 min at the onset of the natural feeding cycle. |
2000-02-25 |
2023-08-12 |
rat |
| J Wang, J T Dourmashkin, R Yun, S F Leibowit. Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612704. |
a possible effect of circulating glucose on hypothalamic npy is further suggested by the finding that the consumption or a single injection of a glucose solution at the onset of the feeding cycle similarly elevates npy mrna and peptide immunoreactivity in the arc and pvn. |
2000-02-25 |
2023-08-12 |
rat |
| M A Cowley, N Pronchuk, W Fan, D M Dinulescu, W F Colmers, R D Con. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron. vol 24. issue 1. 2000-02-25. PMID:10677034. |
we demonstrate that individual neurons within the paraventricular nucleus of the hypothalamus (pvh) are capable of detection and integration of orexigenic (neuropeptide y [npy]) and anorexigenic (melanocortin) signals, that npy and melanocortins are functional antagonists of each other within the pvh in the regulation of feeding behavior, and that melanocortin administration within the pvh regulates both feeding behavior and energy expenditure. |
2000-02-25 |
2023-08-12 |
Not clear |
| L K Malendowicz, C Tortorella, G G Nussdorfe. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade. The Journal of steroid biochemistry and molecular biology. vol 70. issue 4-6. 2000-01-18. PMID:10622406. |
orexins-a and b are two novel hypothalamic peptides, which, like leptin and neuropeptide-y (npy), are involved in the central regulation of feeding. |
2000-01-18 |
2023-08-12 |
rat |
| A Kanatani, T Kanno, A Ishihara, M Hata, A Sakuraba, T Tanaka, Y Tsuchiya, T Mase, T Fukuroda, T Fukami, M Ihar. The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochemical and biophysical research communications. vol 266. issue 1. 2000-01-06. PMID:10581170. |
neuropeptide y (npy) is known to induce robust feeding through the action of npy receptors in the hypothalamus. |
2000-01-06 |
2023-08-12 |
human |
| A Kanatani, T Kanno, A Ishihara, M Hata, A Sakuraba, T Tanaka, Y Tsuchiya, T Mase, T Fukuroda, T Fukami, M Ihar. The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochemical and biophysical research communications. vol 266. issue 1. 2000-01-06. PMID:10581170. |
among the subtypes of npy receptors, y(1) receptors may play a key role in feeding regulation. |
2000-01-06 |
2023-08-12 |
human |
| A Kanatani, T Kanno, A Ishihara, M Hata, A Sakuraba, T Tanaka, Y Tsuchiya, T Mase, T Fukuroda, T Fukami, M Ihar. The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochemical and biophysical research communications. vol 266. issue 1. 2000-01-06. PMID:10581170. |
intracerebroventricular (icv) injection of j-104870 (200 microg) significantly suppressed npy (5 microg)-induced feeding in satiated sprague-dawley rats by 74%. |
2000-01-06 |
2023-08-12 |
human |
| P J Currie, N Saxena, A Y T. 5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549818. |
pvn, pfh and vmh injections of npy potentiated food intake although only pvn pretreatment with doi (5-20 nmol) suppressed npy-induced eating. |
2000-01-04 |
2023-08-12 |
Not clear |
| P J Currie, N Saxena, A Y T. 5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549818. |
spip or mian, injected immediately prior to pvn doi, reversed the suppressive effect of doi on npy feeding. |
2000-01-04 |
2023-08-12 |
Not clear |
| P J Currie, N Saxena, A Y T. 5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549818. |
these findings are consistent with other recent data showing that 5-ht2a receptors within the pvn modulate npy's effect on food intake at the start of the nocturnal period. |
2000-01-04 |
2023-08-12 |
Not clear |
| J J Hwa, M B Witten, P Williams, L Ghibaudi, J Gao, B G Salisbury, D Mullins, F Hamud, C D Strader, E M Parke. Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. The American journal of physiology. vol 277. issue 5. 1999-12-20. PMID:10564216. |
intracerebroventricular (icv) administration of neuropeptide y (npy) has been shown to decrease energy expenditure, induce hypothermia, and stimulate food intake. |
1999-12-20 |
2023-08-12 |
rat |