| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Bishop, P J Currie, D V Coscin. Effects of three neurochemical stimuli on delayed feeding and energy metabolism. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814743. |
npy initiates more protracted feeding temporally linked to enhanced carbohydrate metabolism. |
2000-07-21 |
2023-08-12 |
rat |
| C Bishop, P J Currie, D V Coscin. Effects of three neurochemical stimuli on delayed feeding and energy metabolism. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814743. |
this may indicate that part of npy's feeding stimulatory effects are secondary to physiological processes driving ingestion. |
2000-07-21 |
2023-08-12 |
rat |
| A Kanatani, A Ishihara, H Iwaasa, K Nakamura, O Okamoto, M Hidaka, J Ito, T Fukuroda, D J MacNeil, L H Van der Ploeg, Y Ishii, T Okabe, T Fukami, M Ihar. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochemical and biophysical research communications. vol 272. issue 1. 2000-07-17. PMID:10872822. |
neuropeptide y (npy) elicits food intake through the action of hypothalamic g-protein-coupled receptors. |
2000-07-17 |
2023-08-12 |
human |
| A Kanatani, A Ishihara, H Iwaasa, K Nakamura, O Okamoto, M Hidaka, J Ito, T Fukuroda, D J MacNeil, L H Van der Ploeg, Y Ishii, T Okabe, T Fukami, M Ihar. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochemical and biophysical research communications. vol 272. issue 1. 2000-07-17. PMID:10872822. |
npy (5 microg; a y1, y2, y5 agonist)-induced food intake. |
2000-07-17 |
2023-08-12 |
human |
| A Kanatani, A Ishihara, H Iwaasa, K Nakamura, O Okamoto, M Hidaka, J Ito, T Fukuroda, D J MacNeil, L H Van der Ploeg, Y Ishii, T Okabe, T Fukami, M Ihar. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochemical and biophysical research communications. vol 272. issue 1. 2000-07-17. PMID:10872822. |
administration of npy does not appear to significantly contribute to y5 stimulated food intake. |
2000-07-17 |
2023-08-12 |
human |
| J Kauhanen, M K Karvonen, U Pesonen, M Koulu, T P Tuomainen, M I Uusitupa, J T Salone. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. American journal of medical genetics. vol 93. issue 2. 2000-07-14. PMID:10869113. |
neuropeptide y (npy) plays an important role in the hypothalamic regulation of food intake and energy balance. |
2000-07-14 |
2023-08-12 |
human |
| A A Ammar, F Sederholm, T R Saito, A J Scheurink, A E Johnson, P Söderste. NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 6. 2000-07-06. PMID:10848532. |
many studies have indicated that neuropeptide y (npy) stimulates and leptin inhibits food intake. |
2000-07-06 |
2023-08-12 |
rat |
| F Rohner-Jeanrenau. Neuroendocrine regulation of nutrient partitioning. Annals of the New York Academy of Sciences. vol 892. 2000-06-28. PMID:10842667. |
leptin is a satiety factor which acts within the hypothalamus to decrease the levels of several neuropeptides stimulating food intake (among them, neuropeptide y [npy]), while increasing those that inhibit food intake. |
2000-06-28 |
2023-08-12 |
rat |
| F Rohner-Jeanrenau. Neuroendocrine regulation of nutrient partitioning. Annals of the New York Academy of Sciences. vol 892. 2000-06-28. PMID:10842667. |
npy, taken as one example of what an orexigenic agent may produce, increases food intake and body weight. |
2000-06-28 |
2023-08-12 |
rat |
| M Fujimiya, E Itoh, N Kihara, I Yamamoto, M Fujimura, A Inu. Neuropeptide Y induces fasted pattern of duodenal motility via Y(2) receptors in conscious fed rats. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644559. |
these results indicate that fasted and fed motor activities are regulated processes and that npy induces fasted activity through y(2), and possibly y(4), receptors, which may represent an integrated mechanism linked to the onset of feeding behavior. |
2000-06-16 |
2023-08-12 |
rat |
| D R Gehler. Role of hypothalamic neuropeptide Y in feeding and obesity. Neuropeptides. vol 33. issue 5. 2000-06-02. PMID:10657510. |
when administered into the brain, npy produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. |
2000-06-02 |
2023-08-12 |
human |
| D R Gehler. Role of hypothalamic neuropeptide Y in feeding and obesity. Neuropeptides. vol 33. issue 5. 2000-06-02. PMID:10657510. |
studies using peptide analogs, receptor knockout animals and specific receptor antagonists suggest the y1 and y5 receptors are important in mediating the effects of npy on food intake in rats. |
2000-06-02 |
2023-08-12 |
human |
| N A Tritos, E Maratos-Flie. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides. vol 33. issue 5. 2000-06-02. PMID:10657511. |
neuropeptide y (npy), melanin concentrating hormone (mch), orexins a and b, galanin, and agouti -related peptide (agrp) all act to stimulate feeding while alpha-melanocyte stimulating hormone (alphamsh), corticotropin releasing hormone (crh), cholecystokinin (cck), cocaine and amphetamine regulated transcript (cart), neurotensin, glucagon-like peptide 1 (glp 1), and bombesin have anorectic actions. |
2000-06-02 |
2023-08-12 |
Not clear |
| Y Yamamoto, Y Ueta, R Serino, M Nomura, I Shibuya, H Yamashit. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice. Brain research bulletin. vol 51. issue 6. 2000-05-31. PMID:10758342. |
the expression of the neuropeptide y (npy) gene was increased significantly in the arcuate nucleus of obese mice compared to that of control mice during feeding ad libitum. |
2000-05-31 |
2023-08-12 |
mouse |
| T Wisialowski, R Parker, E Preston, A Sainsbury, E Kraegen, H Herzog, G Coone. Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus. The Journal of clinical investigation. vol 105. issue 9. 2000-05-25. PMID:10792000. |
npy-induced food intake was similar in adx and control rats after acute intracerebroventricular injection of npy. |
2000-05-25 |
2023-08-12 |
rat |
| A Kask, H B Schiöth, J Harro, J E Wikberg, L Räg. Orexigenic effect of the melanocortin MC4 receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists. Canadian journal of physiology and pharmacology. vol 78. issue 2. 2000-05-16. PMID:10737677. |
neuropeptide y (npy) and melanocortin (mc) peptides have opposite effects on food intake: npy-like peptides and mc receptor antagonists stimulate feeding and increase body weight, whereas melanocortins and npy antagonists inhibit food intake. |
2000-05-16 |
2023-08-12 |
rat |
| A Kask, H B Schiöth, J Harro, J E Wikberg, L Räg. Orexigenic effect of the melanocortin MC4 receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists. Canadian journal of physiology and pharmacology. vol 78. issue 2. 2000-05-16. PMID:10737677. |
in this study we tested whether the orexigenic effect of the selective mc4 receptor antagonist hs014 (1 nmol) could be inhibited by three different npy antagonists, (r)-n2-(diphenylacetyl)-n-[(4-hydroxy-phenyl)methyl]d-argininam ide (bibp3226), (r)-n-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-n2(diphenyl acetyl)-argininamidetrifluoroacetate (bibo3304), and decapeptide [d-tyr(27,36)d-thr32]npy(27-36), after icv administration in freely feeding male rats. |
2000-05-16 |
2023-08-12 |
rat |
| A Kask, H B Schiöth, J Harro, J E Wikberg, L Räg. Orexigenic effect of the melanocortin MC4 receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists. Canadian journal of physiology and pharmacology. vol 78. issue 2. 2000-05-16. PMID:10737677. |
these results suggest that stimulation of food intake caused by weakening of melanocortinergic tone at the mc4 receptor is partially but not exclusively related to npy y1 receptor activation. |
2000-05-16 |
2023-08-12 |
rat |
| J Duhault, M Boulanger, S Chamorro, J A Boutin, O Della Zuana, E Douillet, J L Fauchère, M Félétou, M Germain, B Husson, A M Vega, P Renard, F Tisseran. Food intake regulation in rodents: Y5 or Y1 NPY receptors or both? Canadian journal of physiology and pharmacology. vol 78. issue 2. 2000-05-16. PMID:10737680. |
food intake regulation in rodents: y5 or y1 npy receptors or both? |
2000-05-16 |
2023-08-12 |
human |
| J Duhault, M Boulanger, S Chamorro, J A Boutin, O Della Zuana, E Douillet, J L Fauchère, M Félétou, M Germain, B Husson, A M Vega, P Renard, F Tisseran. Food intake regulation in rodents: Y5 or Y1 NPY receptors or both? Canadian journal of physiology and pharmacology. vol 78. issue 2. 2000-05-16. PMID:10737680. |
neuropeptide y (npy), one of the most abundant peptides in rat and human brains, appears to act in the hypothalamus to stimulate feeding. |
2000-05-16 |
2023-08-12 |
human |