| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Earl T Larson, Robert Fredriksson, Sara R T Johansson, Dan Larhamma. Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout. Peptides. vol 24. issue 3. 2004-01-30. PMID:12732336. |
npy has a number of important physiological functions such as regulating food intake and reproduction. |
2004-01-30 |
2023-08-12 |
human |
| Paula D Raposinho, Thierry Pedrazzini, Richard B White, Richard D Palmiter, Michel L Auber. Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology. vol 145. issue 1. 2004-01-23. PMID:14525913. |
npy infusion into the lateral ventricle of wild-type mice stimulated food intake and induced obesity over a 7-d period. |
2004-01-23 |
2023-08-12 |
mouse |
| Paula D Raposinho, Thierry Pedrazzini, Richard B White, Richard D Palmiter, Michel L Auber. Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology. vol 145. issue 1. 2004-01-23. PMID:14525913. |
interestingly, the lack of either npy1r or npy5r expression in knockout mice did not affect such feeding response to chronic npy infusion. |
2004-01-23 |
2023-08-12 |
mouse |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
many kinds of neurons in these areas of the hypothalamus express factors such as melanin-concentrating hormone (mch), neuropeptide y (npy), proopiomelanocortin (pomc), orexin (ox) and ghrelin, which have been implicated in feeding regulation. |
2004-01-21 |
2023-08-12 |
rat |
| Hisayuki Funahashi, Fumiko Takenoya, Jian-Lian Guan, Haruaki Kageyama, Toshihiko Yada, Seiji Shiod. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical science international. vol 78. issue 3. 2004-01-21. PMID:14527127. |
morphological and physiological studies on single living cells isolated from fresh rat hypothalamus or with receptor agonist and antagonist combined with immunohistochemisry clearly demonstrate that both leptin and ox reciprocally regulate npy- and pomc-containing neurons in the arc and that ghrelin may regulate feeding status independently through direct ox and npy pathways. |
2004-01-21 |
2023-08-12 |
rat |
| Marco De Ambrogi, Sara Volpe, Carlo Tamanin. Ghrelin: central and peripheral effects of a novel peptydil hormone. Medical science monitor : international medical journal of experimental and clinical research. vol 9. issue 9. 2004-01-06. PMID:12960936. |
furthermore, ghrelin controls energy balance, enhancing fat mass deposition and food intake through the activation of the hypothalamic nuclei and the promotion of npy (neuropeptide y) and agrp (agouti related protein) expression; since it stimulates weight gain, ghrelin is considered a possible important factor in the etiology of obesity. |
2004-01-06 |
2023-08-12 |
rat |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
neuropeptide y (npy) is present in the hypothalamus, where it is believed to play a key role in the control of food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
evidence for this assertion has come from studies demonstrating that acute administration of npy into the hypothalamus or into the brain ventricles leads to increased food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
npy levels in the hypothalamus are temporally correlated with food intake and are markedly elevated in response to energy depletion. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
however, attempts to demonstrate an important role for npy in the control of food intake using npy knockout mice, npy antisense oligodeoxynucleotides and anti-npy antibodies has produced equivocal results. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
antagonists of the npy y5 subtype seemed initially promising since analogs of npy with high selectivity for this receptor strongly stimulated food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
however, once again, attempts to inhibit the signaling of npy through the npy y5 receptor produced equivocal effects on food intake. |
2004-01-06 |
2023-08-12 |
mouse |
| Nigel R Levens, Odile Della-Zuan. Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 10. 2004-01-06. PMID:14649211. |
many thousands of npy y5 antagonists have been made which fall into two main categories: those that influence food intake and those that do not. |
2004-01-06 |
2023-08-12 |
mouse |
| Katsuhiko Nagamori, Masaru Ishibashi, Takemasa Shiraishi, Yutaka Oomura, Kazuo Sasak. Effects of leptin on hypothalamic arcuate neurons in Wistar and Zucker rats: an in vitro study. Experimental biology and medicine (Maywood, N.J.). vol 228. issue 10. 2003-12-23. PMID:14610255. |
these results suggest that reductions in food intake and body weight induced by leptin in both wistar and zucker obese rats are partly mediated via inhibition of an npy signaling pathway in the vmarc. |
2003-12-23 |
2023-08-12 |
rat |
| D Hagemann, J J Meier, B Gallwitz, W E Schmid. [Appetite regulation by ghrelin - a novel neuro-endocrine gastric peptide hormone in the gut-brain-axis]. Zeitschrift fur Gastroenterologie. vol 41. issue 9. 2003-12-05. PMID:13130331. |
ghrelin causes an increase of food intake and body weight by stimulating the production of neuropeptide y (npy) and agouti-related protein (agp) in the nucleus arcuatus. |
2003-12-05 |
2023-08-12 |
human |
| Hyunyoung Kim, Wei-Whan Whang, Hyun-Taek Kim, Kwang-Ho Pyun, Sun-Young Cho, Dae-Hyun Hahm, Hye-Jung Lee, Insop Shi. Expression of neuropeptide Y and cholecystokinin in the rat brain by chronic mild stress. Brain research. vol 983. issue 1-2. 2003-11-28. PMID:12914981. |
these findings suggest that cck and npy systems may play important roles in expressing the symptopathology of the chronic stress responses such as depression, abnormality of food intake or anxiety-related disorders. |
2003-11-28 |
2023-08-12 |
rat |
| Baerbel Laemmle, Marcus Schindler, Mario Beilmann, Bradford S Hamilton, Henri N Doods, Heike A Wielan. Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609745. |
the npgpr is most similar to the recently cloned neuropeptide ff (npff) receptor which lacks exon 1, but also shows high homology to the orexin and neuropeptide y (npy) receptor families, two neuropeptides involved in food intake regulation. |
2003-11-21 |
2023-08-12 |
human |
| Michela Bagnasco, Giovanni Tulipano, Maria R Melis, Antonio Argiolas, Daniela Cocchi, Eugenio E Mulle. Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609764. |
ghrelin, a circulating growth-hormone releasing peptide derived from stomach, stimulates food intake through neuropeptide y (npy) neurons of the arcuate nucleus in the hypothalamus (arc). |
2003-11-21 |
2023-08-12 |
rat |
| Michela Bagnasco, Giovanni Tulipano, Maria R Melis, Antonio Argiolas, Daniela Cocchi, Eugenio E Mulle. Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609764. |
pretreatment with a ghrh or npy receptor antagonist on ghrelin-induced food intake in free-feeding male rats. |
2003-11-21 |
2023-08-12 |
rat |
| Michela Bagnasco, Giovanni Tulipano, Maria R Melis, Antonio Argiolas, Daniela Cocchi, Eugenio E Mulle. Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609764. |
ghrelin (0.1-1 microg) stimulated food intake in a dose-dependent manner, and this effect was reduced by 55-60% by the y(5) npy receptor antagonist (10 microg i.c.v. |
2003-11-21 |
2023-08-12 |
rat |