| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mads Tang-Christensen, Niels Vrang, Sylvia Ortmann, Martin Bidlingmaier, Tamas L Horvath, Matthias Tschö. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. vol 145. issue 10. 2004-10-26. PMID:15231700. |
to examine whether ghrelin-induced feeding resembles npy and agrp [agrp fragment (83-132)] induced orexia, we compared the short- and long-term orexigenic capacity of the three peptides. |
2004-10-26 |
2023-08-12 |
rat |
| Mads Tang-Christensen, Niels Vrang, Sylvia Ortmann, Martin Bidlingmaier, Tamas L Horvath, Matthias Tschö. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. vol 145. issue 10. 2004-10-26. PMID:15231700. |
the prolonged effects on feeding (+72 h) closely resembled those of agrp (83-132) but not npy. |
2004-10-26 |
2023-08-12 |
rat |
| Tim Karl, Shu Lin, Christoph Schwarzer, Amanda Sainsbury, Michelle Couzens, Walter Wittmann, Dana Boey, Stephan von Hörsten, Herbert Herzo. Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 34. 2004-10-18. PMID:15314215. |
neuropeptide y (npy) is pivotal in the coordinated regulation of food intake, growth, and reproduction, ensuring that procreation and growth occur only when food is abundant and allowing for energy conservation when food is scant. |
2004-10-18 |
2023-08-12 |
mouse |
| Tim Karl, Shu Lin, Christoph Schwarzer, Amanda Sainsbury, Michelle Couzens, Walter Wittmann, Dana Boey, Stephan von Hörsten, Herbert Herzo. Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 34. 2004-10-18. PMID:15314215. |
these results suggest that npy acting through y1 receptors regulates the 5-ht system, thereby coordinately linking physiological survival mechanisms such as food intake with enabling territorial aggressive behavior. |
2004-10-18 |
2023-08-12 |
mouse |
| Anita M van den Hoek, Annemieke C Heijboer, Eleonora P M Corssmit, Peter J Voshol, Johannes A Romijn, Louis M Havekes, Hanno Pij. PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277371. |
it modulates the activities of orexigenic neuropeptide y (npy) neurons and anorexigenic proopiomelanocortin (pomc) neurons in the hypothalamus to inhibit food intake. |
2004-09-17 |
2023-08-12 |
mouse |
| Nicholas J Bernier, Nicole Bedard, Richard E Pete. Effects of cortisol on food intake, growth, and forebrain neuropeptide Y and corticotropin-releasing factor gene expression in goldfish. General and comparative endocrinology. vol 135. issue 2. 2004-08-17. PMID:14697310. |
furthermore, our results indicate that forebrain npy and crf may play a role in mediating the effects of cortisol on food intake in goldfish. |
2004-08-17 |
2023-08-12 |
Not clear |
| Sheng Bi, Karen A Scott, Alan S Kopin, Timothy H Mora. Differential roles for cholecystokinin a receptors in energy balance in rats and mice. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15123537. |
furthermore, in intact rats, npy and cck-ar are colocalized in dmh neurons, and parenchymal injection of cck into the dmh reduces food intake and down-regulates dmh npy mrna expression. |
2004-08-17 |
2023-08-12 |
mouse |
| Jason P Schroeder, Kimberly A Iller, Clyde W Hodg. Neuropeptide-Y Y5 receptors modulate the onset and maintenance of operant ethanol self-administration. Alcoholism, clinical and experimental research. vol 27. issue 12. 2004-08-13. PMID:14691378. |
neuropeptide y (npy) is the most abundant and widely distributed peptide in the mammalian central nervous system and increases feeding behavior at npy y1 or y5 receptor subtypes. |
2004-08-13 |
2023-08-12 |
mouse |
| Sara K S Holmberg, Allan E Johnson, Christina Bergqvist, Lillemor Källström, Dan Larhamma. Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain by in situ hybridization. Regulatory peptides. vol 117. issue 1. 2004-08-06. PMID:14687702. |
neuropeptide y (npy) has prominent stimulatory effects on food intake in virtually all animals that have been studied. |
2004-08-06 |
2023-08-12 |
mouse |
| Bastiaan T Heijmans, A Leo Beem, Gonneke Willemsen, Daniëlle Posthuma, P Eline Slagboom, Dorret Boomsm. Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families. Twin research : the official journal of the International Society for Twin Studies. vol 7. issue 2. 2004-07-27. PMID:15181885. |
an obvious positional candidate in the 7p linkage region is the gene encoding neuropeptide y (npy) that controls satiety and food intake. |
2004-07-27 |
2023-08-12 |
Not clear |
| Herbert Herzo. Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623347. |
all these signals act on central nervous system sites which converge on the hypothalamus, an area that contains a large number of peptide and other neurotransmitters that influence food intake with neuropeptide y (npy) being one of the most prominent ones. |
2004-07-22 |
2023-08-12 |
mouse |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
to investigate the role played by the orexigenic peptide, neuropeptide y (npy), in adaptive responses to insulin-induced hypoglycemia, we measured hypothalamic, feeding, and hormonal responses to this stimulus in both wild-type (npy+/+) and npy-deficient (npy-/-) mice. |
2004-07-14 |
2023-08-12 |
mouse |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
hyperphagic feeding in response to insulin-induced hypoglycemia was therefore markedly attenuated in mice lacking npy, and a similar feeding deficit was detected in these animals after neuroglucopenia induced by 2-deoxyglucose (500 mg/kg ip). |
2004-07-14 |
2023-08-12 |
mouse |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
a role for npy in glucoprivic feeding is further supported by our finding that npy mrna content (measured by real-time pcr) increased 2.4-fold in the hypothalamus of npy+/+ mice by 7 h after insulin injection. |
2004-07-14 |
2023-08-12 |
mouse |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
unlike the feeding deficits observed in mice lacking npy, the effect of hypoglycemia to increase plasma glucagon and corticosterone levels was fully intact in these animals, as were both the nadir glucose value and time to recovery of euglycemia after insulin injection (p = not significant). |
2004-07-14 |
2023-08-12 |
mouse |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
we conclude that npy signaling is required for hyperphagic feeding, but not neuroendocrine responses to moderate hypoglycemia. |
2004-07-14 |
2023-08-12 |
mouse |
| Jing He, Amit Varma, Lisa A Weissfeld, Sherin U Devaska. Postnatal glucocorticoid exposure alters the adult phenotype. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15001431. |
this increase in neuropeptide y (npy) during the suckling phase in males and females was associated with a subsequent increase in adult food intake that outweighed the demands of body weight gain. |
2004-07-13 |
2023-08-12 |
rat |
| Jing He, Amit Varma, Lisa A Weissfeld, Sherin U Devaska. Postnatal glucocorticoid exposure alters the adult phenotype. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15001431. |
we conclude that postnatal dex treatment causes permanent sex-specific changes in the adult phenotype, setting the stage for future development of diabetes (increased glucose:insulin ratio), obesity (increased npy and food intake), and neurological impairment (loss of cerebral volume). |
2004-07-13 |
2023-08-12 |
rat |
| Tami Wolden-Hanson, Brett T Marck, Alvin M Matsumot. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15001433. |
to test the food intake response to appetite-stimulating neuropeptides, y, m, o, and very old (vo; 33 mo) rats (n = 4-8/group) received one intracerebroventricular injection of each of three treatments: 0.1 nmol agrp, 2.34 nmol npy, and saline control. |
2004-07-13 |
2023-08-12 |
rat |
| Tami Wolden-Hanson, Brett T Marck, Alvin M Matsumot. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15001433. |
in contrast, npy increased food intake more in y than in older animals and its effects did not last >24 h. we conclude that the mechanisms by which arcuate nucleus neurons influence appetite are differentially affected by age and speculate that the melanocortin system may be a useful target for treatment of the anorexia of aging. |
2004-07-13 |
2023-08-12 |
rat |