| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Sung Park, Seona Jo, Seong Joon Yi, Jin Sang Kim, Heungshik S Ee, In Se Lee, Kang Moon Seo, Je Kyung Sung, Inhyung Lee, Yeo Sung Yoo. Effect of capsaicin on cholecystokinin and neuropeptide Y expressions in the brain of high-fat diet fed rats. The Journal of veterinary medical science. vol 66. issue 2. 2004-05-19. PMID:15031536. |
especially, in body weight and feeding control, cholecystokinin (cck) has been well known as a satiety signal and neuropeptide y (npy) has been described as one of the most potent orexigenic signals. |
2004-05-19 |
2023-08-12 |
rat |
| Eun Sung Park, Seona Jo, Seong Joon Yi, Jin Sang Kim, Heungshik S Ee, In Se Lee, Kang Moon Seo, Je Kyung Sung, Inhyung Lee, Yeo Sung Yoo. Effect of capsaicin on cholecystokinin and neuropeptide Y expressions in the brain of high-fat diet fed rats. The Journal of veterinary medical science. vol 66. issue 2. 2004-05-19. PMID:15031536. |
it is concluded that (1) npy-ir may react more sensitively on capsaicin than cck-ir, (2) no rapid increase of body weight in capsaicin treated rats may result from the diminished food intake through the low expression of npy in hypothalamus in hf-cap group. |
2004-05-19 |
2023-08-12 |
rat |
| Shane T Hentges, Mitsuru Nishiyama, Linda S Overstreet, Mary Stenzel-Poore, John T Williams, Malcolm J Lo. GABA release from proopiomelanocortin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 7. 2004-05-04. PMID:14973227. |
alpha-melanocyte-stimulating hormone from arcuate pomc neurons potently reduces food intake, whereas arcuate neuropeptide y (npy) neurons act in opposition to stimulate food intake. |
2004-05-04 |
2023-08-12 |
Not clear |
| Hisayuki Funahashi, Shuori Yamada, Haruaki Kageyama, Fumiko Takenoya, Jian Lian Guan, Seiji Shiod. Co-existence of leptin- and orexin-receptors in feeding-regulating neurons in the hypothalamic arcuate nucleus-a triple labeling study. Peptides. vol 24. issue 5. 2004-04-20. PMID:12895654. |
several feeding regulating peptides, such as neuropeptide y (npy) and proopiomelanocortin (pomc), are present in neurons of the arc, which also serves as a primary targeting site for leptin, a feeding inhibiting hormone secreted predominantly by adipose tissues, and for orexin (ox)-containing neurons. |
2004-04-20 |
2023-08-12 |
Not clear |
| Pastor R Couceyro, Tammi Frit. Production of recombinant CART peptides in Escherichia coli with agonist and antagonist effects on food intake in rats. Protein expression and purification. vol 32. issue 2. 2004-04-15. PMID:14965763. |
unfolded cart peptide 55-102 his tag, but not cart peptide 1-102 his tag, stimulated food intake in rats treated with npy or vehicle. |
2004-04-15 |
2023-08-12 |
rat |
| Tim Karl, Torsten Hoffmann, Reinhard Pabst, Stephan von Hörste. Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity. Pharmacology, biochemistry, and behavior. vol 75. issue 4. 2004-04-13. PMID:12957230. |
npy dose-dependently stimulated food intake and feeding motivation, decreased motor activity in the plus maze and social interaction test, and exerted anxiolytic-like effects. |
2004-04-13 |
2023-08-12 |
rat |
| Anne Lecklin, Ingrid Lundell, Suvi Salmela, Pekka T Männistö, Annette G Beck-Sickinger, Dan Larhamma. Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. British journal of pharmacology. vol 139. issue 8. 2004-04-12. PMID:12922930. |
the stimulatory effect of neuropeptide y (npy) on food intake is well established but the roles of the receptor subtypes y(1) and y(5) have been difficult to define. |
2004-04-12 |
2023-08-12 |
Not clear |
| Anne Lecklin, Ingrid Lundell, Suvi Salmela, Pekka T Männistö, Annette G Beck-Sickinger, Dan Larhamma. Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. British journal of pharmacology. vol 139. issue 8. 2004-04-12. PMID:12922930. |
administration of either compound into the third brain ventricle increased food intake equally to npy. |
2004-04-12 |
2023-08-12 |
Not clear |
| Anne Lecklin, Ingrid Lundell, Suvi Salmela, Pekka T Männistö, Annette G Beck-Sickinger, Dan Larhamma. Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. British journal of pharmacology. vol 139. issue 8. 2004-04-12. PMID:12922930. |
it potently stimulated feeding: the food consumption after administration of this peptide was two-fold compared to npy. |
2004-04-12 |
2023-08-12 |
Not clear |
| Aaron G Roseberry, Hongyan Liu, Alexander C Jackson, Xiaoli Cai, Jeffrey M Friedma. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. vol 41. issue 5. 2004-04-12. PMID:15003171. |
npy and alphamsh are expressed in distinct neurons in the arcuate nucleus of the hypothalamus, where alphamsh decreases and npy increases food intake and body weight. |
2004-04-12 |
2023-08-12 |
mouse |
| Aaron G Roseberry, Hongyan Liu, Alexander C Jackson, Xiaoli Cai, Jeffrey M Friedma. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. vol 41. issue 5. 2004-04-12. PMID:15003171. |
these data reveal an intricate and asymmetric interplay between npy and pomc neurons in the hypothalamus and have important implications for the delineation of the neural circuits that regulate feeding behavior. |
2004-04-12 |
2023-08-12 |
mouse |
| Sergueï O Fetissov, Leah C Byrne, Hessameh Hassani, Patrik Ernfors, Tomas Hökfel. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. The Journal of comparative neurology. vol 470. issue 3. 2004-04-09. PMID:14755515. |
the finding that a13 dopaminergic neurons express y2r suggests a new mechanism putatively involved in the central control of feeding, in which npy can modulate dopamine secretion. |
2004-04-09 |
2023-08-12 |
mouse |
| Abhiram Sah. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Frontiers in neuroendocrinology. vol 24. issue 4. 2004-03-31. PMID:14726256. |
it is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals, including npy, mch, galanin, orexin, galp, alpha-msh, nt, and crh. |
2004-03-31 |
2023-08-12 |
human |
| Michelle J Hansen, Valentina Jovanovska, Margaret J Morri. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. Journal of neurochemistry. vol 88. issue 4. 2004-03-15. PMID:14756812. |
animals were implanted with intracerebroventricular cannulae to investigate feeding responses to npy (0.5 nmol, 1 nmol) after 4 or 12 weeks of diet. |
2004-03-15 |
2023-08-12 |
rat |
| Susann Blüher, Mary Ziotopoulou, John W Bullen, Stergios J Moschos, Linda Ungsunan, Efi Kokkotou, Eleftheria Maratos-Flier, Christos S Mantzoro. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. vol 53. issue 1. 2004-02-27. PMID:14693701. |
in summary, 1) mtii is an effective treatment for obesity and related metabolic defects in leptin-resistant (dio, ucp1-dta) and leptin-sensitive (ob/ob) mouse models of obesity; 2) the effects of mtii on food intake and body weight are more pronounced in dio mice than in lean mice; 3) the tachyphylactic effect after prolonged mtii administration appears to be, at least in part, caused by a compensatory upregulation of npy and agrp mrna levels, whereas decreasing leptin levels may play a very minor role in mediating tachyphylaxis; and 4) alterations in adiponectin receptor mrna expression after fasting or mtii treatment may contribute to altered insulin sensitivity and needs to be studied further. |
2004-02-27 |
2023-08-12 |
mouse |
| J B Leonard, G C Waldbieser, J T Silverstei. Neuropeptide Y sequence and messenger RNA distribution in channel catfish (Ictalurus punctatus). Marine biotechnology (New York, N.Y.). vol 3. issue 2. 2004-02-26. PMID:14961373. |
the action of neuropeptide y (npy) on food intake is of interest for the enhancement of growth of channel catfish (ictalurus punctatus) for aquaculture. |
2004-02-26 |
2023-08-12 |
Not clear |
| Meike Körner, Beatrice Waser, Jean Claude Reub. Neuropeptide Y receptor expression in human primary ovarian neoplasms. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 1. 2004-02-17. PMID:14631382. |
one such receptor is the neuropeptide y (npy) receptor, mediating primarily feeding behavior in the brain but shown recently to play a role in breast cancer. |
2004-02-17 |
2023-08-12 |
human |
| Rémy Burcelin, Marc Uldry, Marc Foretz, Christophe Perrin, Anabela Dacosta, Monique Nenniger-Tosato, Josiane Seydoux, Susanna Cotecchia, Bernard Thoren. Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14581480. |
altogether, our results indicate that in the absence of the alpha1b-ar the expression of hypotalamic npy and the parasympathetic nervous activity are both increased resulting in hyperinsulinemia and insulin resistance as well as favoring obesity and glucose intolerance development during high fat feeding. |
2004-02-10 |
2023-08-12 |
mouse |
| Christine Gonzales, Marie-Jeanne Voirol, Marco Giacomini, Rolf C Gaillard, Thierry Pedrazzini, François P Pralon. The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 1. 2004-02-09. PMID:14597564. |
hypothalamic neuropeptide y (npy) plays a central role in the control of food intake, energy balance, and modulation of neuroendocrine functions. |
2004-02-09 |
2023-08-12 |
mouse |
| B G Challis, S B Pinnock, A P Coll, R N Carter, S L Dickson, S O'Rahill. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochemical and biophysical research communications. vol 311. issue 4. 2004-02-09. PMID:14623268. |
in conclusion, peripherally administered pyy(3-36) has a suppressive effect on food intake that is more prominent in recently fasted mice and lasts up to 24 h. this is associated with a short-lived suppression of npy mrna, a longer lasting increase in pomc mrna but no change in mch mrna expression. |
2004-02-09 |
2023-08-12 |
mouse |