| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helene Volkoff, Angela Joy Eykelbosh, Richard Ector Pete. Role of leptin in the control of feeding of goldfish Carassius auratus: interactions with cholecystokinin, neuropeptide Y and orexin A, and modulation by fasting. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711082. |
these results provide strong evidence that, in goldfish, leptin influences food intake, in part by modulating the orexigenic effects of npy and orexin and that its actions are mediated, at least in part, by cck. |
2003-07-11 |
2023-08-12 |
Not clear |
| Ambikaipakan Balasubramania. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Current pharmaceutical design. vol 9. issue 15. 2003-07-11. PMID:12769744. |
the latter observation, and the implication of npy in the pathophysiology of feeding, seizures, diabetes, intestinal dysfunction, cardiovascular diseases and respiratory disorders, have led to vigorous efforts to dissociate various effects of npy and develop receptor selective ligands required for fundamental investigations, and possible clinical utility. |
2003-07-11 |
2023-08-12 |
Not clear |
| Ambikaipakan Balasubramania. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Current pharmaceutical design. vol 9. issue 15. 2003-07-11. PMID:12769744. |
these efforts have made significant advancement in the development of antagonists, especially for y(1) and y(5) receptors mediating npy effects on feeding and/or thermogenesis. |
2003-07-11 |
2023-08-12 |
Not clear |
| William R Crowley, Gina Ramoz, Brianne Hurs. Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacology, biochemistry, and behavior. vol 74. issue 2. 2003-06-18. PMID:12479963. |
a 4-day infusion of [d-tyr (27,36), d-thr (32)] npy (27-36) (d-npy(27-36)), a peptide analogue of npy that antagonizes npy-induced feeding, into the third ventricle at 1 microg/h transiently inhibited nocturnal feeding in nonlactating female rats. |
2003-06-18 |
2023-08-12 |
rat |
| William R Crowley, Gina Ramoz, Brianne Hurs. Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacology, biochemistry, and behavior. vol 74. issue 2. 2003-06-18. PMID:12479963. |
these results provide the first pharmacological evidence implicating specific neuromessengers in mediating the hyperphagia of lactation, and suggest that, while an action of npy may contribute to the increased food intake seen in lactating animals, other systems are also involved. |
2003-06-18 |
2023-08-12 |
rat |
| Amit Varma, Jing He, Lisa Weissfeld, Sherin U Devaska. Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 284. issue 6. 2003-06-17. PMID:12573978. |
we investigated the effect of repetitive postnatal (2-7 days) intracerebroventricular administration of neuropeptide y (npy) on food intake and body weight gain in the 3- to 120-day-old sprague-dawley rats. |
2003-06-17 |
2023-08-12 |
rat |
| Amit Varma, Jing He, Lisa Weissfeld, Sherin U Devaska. Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 284. issue 6. 2003-06-17. PMID:12573978. |
however, when exogenous npy was stereotaxically reinjected into the paraventricular nucleus of the approximately 120-day-old adult females who were pretreated with npy postnatally, an increase in food intake and body weight gain was noted, attesting to no disruption in the npy end-organ responsivity. |
2003-06-17 |
2023-08-12 |
rat |
| Antonio P Silva, Claudia Cavadas, Eric Grouzman. Neuropeptide Y and its receptors as potential therapeutic drug targets. Clinica chimica acta; international journal of clinical chemistry. vol 326. issue 1-2. 2003-06-16. PMID:12417094. |
evidence suggests that npy is involved in the pathophysiology of several disorders, such as the control of food intake, metabolic disorders, anxiety, seizures, memory, circadian rhythm, drug addiction, pain, cardiovascular diseases, rhinitis, and endothelial cell dysfunctions. |
2003-06-16 |
2023-08-12 |
Not clear |
| Jennifer W Hill, Jon E Levin. Abnormal response of the neuropeptide Y-deficient mouse reproductive axis to food deprivation but not lactation. Endocrinology. vol 144. issue 5. 2003-05-22. PMID:12697683. |
neuropeptide y (npy) plays a key role in both food intake and gnrh secretion. |
2003-05-22 |
2023-08-12 |
mouse |
| Satoshi Mashiko, Akane Ishihara, Hisashi Iwaasa, Hideki Sano, Zenjun Oda, Junko Ito, Mariko Yumoto, Mayumi Okawa, Jun Suzuki, Takahiro Fukuroda, Makoto Jitsuoka, Nancy R Morin, Douglas J MacNeil, Lex H T Van der Ploeg, Masaki Ihara, Takehiro Fukami, Akio Kanatan. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY. Endocrinology. vol 144. issue 5. 2003-05-22. PMID:12697685. |
in addition, d-trp(34)npy still resulted in an increase in adipose tissue weight accompanied by hyperleptinemia and hypercholesterolemia, although d-trp(34)npy-induced food intake was restricted by pair-feeding. |
2003-05-22 |
2023-08-12 |
mouse |
| Daisuke Kohno, Hong-Zhi Gao, Shinji Muroya, Sakae Kikuyama, Toshihiko Yad. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes. vol 52. issue 4. 2003-05-19. PMID:12663466. |
neuropeptide-y (npy) neurons in the arc play an important role in the stimulation of food intake. |
2003-05-19 |
2023-08-12 |
rat |
| Daisuke Kohno, Hong-Zhi Gao, Shinji Muroya, Sakae Kikuyama, Toshihiko Yad. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes. vol 52. issue 4. 2003-05-19. PMID:12663466. |
the integration of stimulatory effects of ghrelin and orexin and inhibitory effect of leptin may play an important role in the regulation of the activity of npy neurons and thereby feeding. |
2003-05-19 |
2023-08-12 |
rat |
| b' Joanna M Mory\\xc5\\x9b, Przemys\\xc5\\x82aw Kowia\\xc5\\x84ski, Janusz Mory\\xc5\\x9. Distribution of nitric oxide synthase and neuropeptide Y neurones during the development of the hippocampal formation in the rat. Folia morphologica. vol 61. issue 4. 2003-05-13. PMID:12725488.' |
npy is connected with several vital functions, such as a feeding behaviour, sexual maturation, regulation of circadian rhythms, body temperature, blood pressure and neuroendocrine secretions. |
2003-05-13 |
2023-08-12 |
rat |
| Osamu Muraoka, Bo Xu, Tatsuru Tsurumaki, Shizuo Akira, Tsuyoshi Yamaguchi, Hiroshi Higuch. Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. Neurochemistry international. vol 42. issue 7. 2003-05-01. PMID:12590942. |
neuropeptide y (npy) plays an important role in the central and sympathetic regulation of food intake and blood pressure. |
2003-05-01 |
2023-08-12 |
rat |
| T Pedrazzini, F Pralong, E Grouzman. Neuropeptide Y: the universal soldier. Cellular and molecular life sciences : CMLS. vol 60. issue 2. 2003-04-30. PMID:12678499. |
in particular, npy is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. |
2003-04-30 |
2023-08-12 |
human |
| Y Zhu, A Yamanaka, K Kunii, N Tsujino, K Goto, T Sakura. Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways. Physiology & behavior. vol 77. issue 2-3. 2003-04-18. PMID:12419401. |
neuropeptide y (npy) (0.3 nmol) and galanin (3 nmol) also induced a transient increase in food intake. |
2003-04-18 |
2023-08-12 |
rat |
| Helga Davidowa, Yuzhen Li, Andreas Plageman. Hypothalamic ventromedial and arcuate neurons of normal and postnatally overnourished rats differ in their responses to melanin-concentrating hormone. Regulatory peptides. vol 108. issue 2-3. 2003-04-10. PMID:12220733. |
activation of arcuate neurons may induce feeding in particular through release of neuropeptide y (npy). |
2003-04-10 |
2023-08-12 |
rat |
| Koji Toshinai, Yukari Date, Noboru Murakami, Mitsushi Shimada, Muhtashan S Mondal, Takuya Shimbara, Jian-Lian Guan, Qing-Ping Wang, Hisayuki Funahashi, Takeshi Sakurai, Seiji Shioda, Shigeru Matsukura, Kenji Kangawa, Masamitsu Nakazat. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology. vol 144. issue 4. 2003-04-10. PMID:12639935. |
administration of npy receptor antagonist further attenuated ghrelin-induced feeding in rats treated with anti-orexin-iggs. |
2003-04-10 |
2023-08-12 |
mouse |
| Irina G Makarenko, Michael M Meguid, Louis Gatto, Chung Chen, Michael V Ugrumo. Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Brain research. vol 961. issue 1. 2003-04-01. PMID:12535782. |
whether the decrease in food intake that occurs at the onset of anorexia in tumor bearing (tb) rats is related to a change in the hypothalamic neuropeptide y (npy) system was tested by comparing npy expression in sham operated fischer control and anorectic tb rats. |
2003-04-01 |
2023-08-12 |
rat |
| Irina G Makarenko, Michael M Meguid, Louis Gatto, Chung Chen, Michael V Ugrumo. Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Brain research. vol 961. issue 1. 2003-04-01. PMID:12535782. |
the data support the hypothesis of an altered hypothalamic npy system at the onset of anorexia in tb rats and also reveal the hypothalamic nuclei through which npy influences food intake. |
2003-04-01 |
2023-08-12 |
rat |