| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Yih Ku. Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats. Journal of biomedical science. vol 9. issue 2. 2003-01-24. PMID:11914579. |
these results suggest an additive effect during combined activation of d1 and d2 receptor subtypes to decrease food intake and body weight that are mediated by the action of hypothalamic npy. |
2003-01-24 |
2023-08-12 |
rat |
| J P H Wildin. Neuropeptides and appetite control. Diabetic medicine : a journal of the British Diabetic Association. vol 19. issue 8. 2003-01-23. PMID:12147141. |
when energy stores are low, production of leptin from adipose tissue, and thus circulating leptin concentrations fall, leading to increased production of hypothalamic neurotransmitters that strongly increase food intake, such as neuropeptide y (npy), galanin and agouti-related protein (agrp) and decreased levels of alpha-melanocyte-stimulating hormone (alpha-msh), cocaine and amphetamine-regulated transcript (cart) and neurotensin that reduce food intake and increase energy expenditure. |
2003-01-23 |
2023-08-12 |
Not clear |
| G S Fraley, S Ritte. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Endocrinology. vol 144. issue 1. 2003-01-17. PMID:12488332. |
neuropeptide y (npy) and agouti gene-related protein (agrp) are orexigenic peptides of special importance for control of food intake. |
2003-01-17 |
2023-08-12 |
Not clear |
| Cameron J Smith, Nancy R Morin, Gerald F Bills, Anne W Dombrowski, Gino M Salituro, Scott K Smith, Annie Zhao, Douglas J MacNei. Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor. The Journal of organic chemistry. vol 67. issue 14. 2003-01-16. PMID:12098324. |
neuropeptide y (npy) is a polypeptide found in the peripheral and central nervous system and is involved in the regulation of feeding. |
2003-01-16 |
2023-08-12 |
Not clear |
| Anne Remaury, Natalio Vita, Sylvain Gendreau, Mireille Jung, Michelle Arnone, Martine Poncelet, Jean-Michel Culouscou, Gérard Le Fur, Philippe Soubrié, Daniel Caput, David Shire, Manfred Kopf, Pascual Ferrar. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain research. vol 953. issue 1-2. 2003-01-10. PMID:12384239. |
administration of the orexigenic neuropeptide y (npy) stimulated feeding to the same extent in both wild-type and nt-1r(-/-) mice. |
2003-01-10 |
2023-08-12 |
mouse |
| Csaba Fekete, Sumit Sarkar, William M Rand, John W Harney, Charles H Emerson, Antonio C Bianco, Annette Beck-Sickinger, Ronald M Lecha. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology. vol 143. issue 12. 2002-12-24. PMID:12446577. |
central administration of npy not only markedly stimulates food intake, but simultaneously inhibits the hypothalamic-pituitary-thyroid axis (hpt axis), replicating the central hypothyroid state associated with fasting. |
2002-12-24 |
2023-08-12 |
human |
| Csaba Fekete, Sumit Sarkar, William M Rand, John W Harney, Charles H Emerson, Antonio C Bianco, Annette Beck-Sickinger, Ronald M Lecha. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology. vol 143. issue 12. 2002-12-24. PMID:12446577. |
both y1 and y5 receptor agonists nearly doubled food intake compared with that of control animals receiving acsf, similar to the effect observed for npy. |
2002-12-24 |
2023-08-12 |
human |
| Karine Proulx, Denis Richard, Claire-Dominique Walke. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology. vol 143. issue 12. 2002-12-24. PMID:12446596. |
we determined whether two appetite-related neuropeptides [neuropeptide y (npy) and proopiomelanocortin (pomc)] and food intake behavior are sensitive to leptin [3 mg/kg body weight (bw), ip] in neonates. |
2002-12-24 |
2023-08-12 |
rat |
| Karine Proulx, Denis Richard, Claire-Dominique Walke. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology. vol 143. issue 12. 2002-12-24. PMID:12446596. |
we conclude that despite adult-like effects of leptin on pomc, npy, and crfr-2 expression in neonates, leptin does not regulate food intake during early development. |
2002-12-24 |
2023-08-12 |
rat |
| N Nara-ashizawa, T Tsukada, K Maruyama, Y Akiyama, N Kajimura, K Yamaguch. Response of hypothalamic NPY mRNAs to a negative energy balance is less sensitive in cachectic mice bearing human tumor cells. Nutrition and cancer. vol 41. issue 1-2. 2002-12-13. PMID:12094613. |
competitive reverse transcription-polymerase chain reaction analysis showed that, regardless of feeding status, npy mrna levels were elevated in all tumor-bearing mice compared with sham-operated mice, although to a lesser degree than weight-matched pair-weight mice. |
2002-12-13 |
2023-08-12 |
mouse |
| Cheryl C Miller, Philip V Holmes, Gaylen L Edward. Area postrema lesions elevate NPY levels and decrease anxiety-related behavior in rats. Physiology & behavior. vol 77. issue 1. 2002-12-04. PMID:12213511. |
intracerebroventricular administration of neuropeptide y (npy) has been shown to reduce anxiety-like effects in rodents and also profoundly alter feeding. |
2002-12-04 |
2023-08-12 |
rat |
| A Thorsell, R Rimondini, M Heili. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neuroscience letters. vol 332. issue 1. 2002-11-27. PMID:12377370. |
activation of central neuropeptide y (npy) receptors is known to produce several behavioral effects, including feeding, modulation of memory and antagonism of behavioral effects of stress. |
2002-11-27 |
2023-08-12 |
mouse |
| A Thorsell, M Heili. Diverse functions of neuropeptide Y revealed using genetically modified animals. Neuropeptides. vol 36. issue 2-3. 2002-11-26. PMID:12359508. |
central administration of npy or synthetic ligands for its receptors has indicated a role of npy in anxiety-related behaviors, feeding, regulation of blood pressure, circadian rhythm and other functions. |
2002-11-26 |
2023-08-12 |
mouse |
| J Pawłowski, K Kmieciak-Kołada, E Obuchowicz, R Krysiak, Z S Herma. Effect of substituted benzamides on feeding and hypothalamic neuropeptide Y-like immunoreactivity (NPY-LI) in rats. Neuropeptides. vol 35. issue 5-6. 2002-11-25. PMID:12030803. |
the study was conducted: (i) to evaluate the effects of three substituted benzamides on feeding behaviour in rats with free access to food and in those with access to food limited either to the light or to the dark phase of the diurnal cycle; and (ii) to determine whether the hypothalamic neuropeptide y (npy) system is involved in the action of these drugs on feeding. |
2002-11-25 |
2023-08-12 |
rat |
| J Pawłowski, K Kmieciak-Kołada, E Obuchowicz, R Krysiak, Z S Herma. Effect of substituted benzamides on feeding and hypothalamic neuropeptide Y-like immunoreactivity (NPY-LI) in rats. Neuropeptides. vol 35. issue 5-6. 2002-11-25. PMID:12030803. |
the results suggest that the effects of substituted benzamides on feeding behaviour depend on the drug and the time of administration and that these effects are related to the altered function of the hypothalamic npy system. |
2002-11-25 |
2023-08-12 |
rat |
| Eun-Kyoung Kim, Ian Miller, Leslie E Landree, Felice F Borisy-Rudin, Pierre Brown, Tarik Tihan, Craig A Townsend, Lee A Witters, Timothy H Moran, Francis P Kuhajda, Gabriele V Ronnet. Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. American journal of physiology. Endocrinology and metabolism. vol 283. issue 5. 2002-11-08. PMID:12376313. |
collectively, these results demonstrate that fas is present and active in neurons and suggests that c75 may alter food intake via interactions within the arcuate-pvn pathway mediated by npy. |
2002-11-08 |
2023-08-12 |
mouse |
| Maria Rosario Melis, Maria Stefania Mascia, Salvatora Succu, Antonio Torsello, Eugenio E Muller, Romano Deghenghi, Antonio Argiola. Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183044. |
the enhancing effect of ghrelin on feeding was prevented by the prior administration of the neuropeptide y y5 receptor antagonist (dtyr(2), dthr(32)) neuropeptide y (npy, 10 microg), but not by the gh-rh receptor antagonist mz-4-71 (10 microg), or by ep 91073, a hexarelin analogue that antagonizes the pro-erectile effect of ep 80661 (10 microg), given into the lateral ventricles. |
2002-10-28 |
2023-08-12 |
rat |
| Gary J Schwartz, Timothy H Mora. Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake. Endocrinology. vol 143. issue 10. 2002-10-21. PMID:12239088. |
the present experiments were designed to evaluate whether central administration of leptin or one of its downstream mediators, neuropeptide y (npy), could affect food intake by modulating the brain stem neurophysiological response to ascending meal-related feedback signals in the nucleus of the solitary tract (nts) in anesthetized male long-evans rats. |
2002-10-21 |
2023-08-12 |
rat |
| Abhiram Sah. Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain research. vol 944. issue 1-2. 2002-10-11. PMID:12106685. |
amongst various neuropeptidergic systems, neuropeptide y (npy), hypocretin-1 and melanin-concentrating hormone (mch) producing neurons have been shown to play an important role in the regulation of food intake and body weight. |
2002-10-11 |
2023-08-12 |
rat |
| Abhiram Sah. Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain research. vol 944. issue 1-2. 2002-10-11. PMID:12106685. |
the icv administration of npy (0.118, 0.588, 1.176 nmol), hypocretin-1 (1, 3 nmol) and mch (0.42, 1.048, 2.096 nmol) stimulated food intake in a dose dependent manner. |
2002-10-11 |
2023-08-12 |
rat |