| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Lecklin, Ingrid Lundell, Leena Paananen, Jarl E S Wikberg, Pekka T Männistö, Dan Larhamma. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. British journal of pharmacology. vol 135. issue 8. 2002-09-17. PMID:11959807. |
these data suggest that either y(1) or y(5) receptors or both may mediate npy induced food intake in guinea-pigs. |
2002-09-17 |
2023-08-12 |
mouse |
| Anne Lecklin, Ingrid Lundell, Leena Paananen, Jarl E S Wikberg, Pekka T Männistö, Dan Larhamma. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. British journal of pharmacology. vol 135. issue 8. 2002-09-17. PMID:11959807. |
when cgp 71683a was infused into brain ventricles, the feeding response to npy was attenuated. |
2002-09-17 |
2023-08-12 |
mouse |
| Anne Lecklin, Ingrid Lundell, Leena Paananen, Jarl E S Wikberg, Pekka T Männistö, Dan Larhamma. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. British journal of pharmacology. vol 135. issue 8. 2002-09-17. PMID:11959807. |
the present study shows that npy stimulates feeding in guinea-pigs through y(1) and y(5) receptors. |
2002-09-17 |
2023-08-12 |
mouse |
| Paul J Currie, Christina D Coiro, Tippy Niyomchai, Alena Lira, Farnoosh Farahman. Hypothalamic paraventricular 5-hydroxytryptamine: receptor-specific inhibition of NPY-stimulated eating and energy metabolism. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888562. |
the feeding effects of 5-hydroxytryptamine (5-ht)(1) and 5-ht(2) receptor agonists injected into the hypothalamic paraventricular nucleus (pvn) immediately prior to pvn administration of neuropeptide y (npy) were examined. |
2002-09-11 |
2023-08-12 |
Not clear |
| Paul J Currie, Christina D Coiro, Tippy Niyomchai, Alena Lira, Farnoosh Farahman. Hypothalamic paraventricular 5-hydroxytryptamine: receptor-specific inhibition of NPY-stimulated eating and energy metabolism. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888562. |
in feeding tests conducted at the onset of the dark cycle, drugs were administered 5 min prior to pvn injection of npy and food intake was measured 2 h postinjection. |
2002-09-11 |
2023-08-12 |
Not clear |
| Rachel L Batterham, Michael A Cowley, Caroline J Small, Herbert Herzog, Mark A Cohen, Catherine L Dakin, Alison M Wren, Audrey E Brynes, Malcolm J Low, Mohammad A Ghatei, Roger D Cone, Stephen R Bloo. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. vol 418. issue 6898. 2002-09-09. PMID:12167864. |
food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide y (npy) systems in the arcuate nucleus. |
2002-09-09 |
2023-08-12 |
mouse |
| William J Farrell, Bärbel Böttger, Ferogh Ahmadi, Thomas E Finge. Distribution of cholecystokinin, calcitonin gene-related peptide, neuropeptide Y, and galanin in the primary gustatory nuclei of the goldfish. The Journal of comparative neurology. vol 450. issue 2. 2002-08-28. PMID:12124755. |
cholecystokinin (cck), neuropeptide y (npy), calcitonin gene-related peptide (cgrp), and galanin all are known to have central effects on food intake. |
2002-08-28 |
2023-08-12 |
Not clear |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
selective antagonism of the npy y5 receptor does not have a major effect on feeding in rats. |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
neuropeptide y (npy) is thought to play a key role in stimulating feeding, thus making npy receptors attractive appetite suppressant drug targets for treating obesity. |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
because the orexigenic effects of npy have been ascribed to actions at the npy y5 receptor, we have determined the role of this receptor in feeding in rats, using a small molecule antagonist of this receptor. |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
indeed, at doses to rats as low as 1 mg/kg, npy5ra-972 inhibited feeding induced by intracerebroventricular (icv) administration of a selective npy y5 agonist ([cpp(1-7),npy(19-23),ala(31),aib(32),gln(34)]-hpp). |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
however, in the dose range 1-10 mg/kg, npy5ra-972 had no significant effect on food intake in wistar rats induced to feed by either icv npy or 24 h fasting or in free-feeding wistar or obese zucker rats. |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
these data indicate that npy5ra-972 is a potent, selective, orally active, and cns-penetrant antagonist of the npy y5 receptor that prevents feeding driven by activation of this receptor. |
2002-08-21 |
2023-08-12 |
rat |
| Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J G Loxham, Pat McAulay, Joanne L Teague, Kevin M Foote, J Elizabeth Pease, Michael H Bloc. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145156. |
the data obtained with this antagonist indicate that the npy y5 receptor is not a major regulator of feeding in the rat. |
2002-08-21 |
2023-08-12 |
rat |
| P J Scarpace, M Matheny, Y Zhang, N Tümer, C D Frase, E W Shek, B Hong, V Prima, S Zolotukhi. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology. vol 42. issue 4. 2002-08-07. PMID:11955525. |
to this end, we administered, i.c.v., recombinant adeno-associated virus encoding rat leptin cdna (raav-leptin) or control virus into young and aged-obese rats and after 9 or 46 days, examined food intake, oxygen consumption, body weight, serum leptin, stat3 phosphorylation, hypothalamic npy and pomc mrnas, and ucp1 expression and protein level in brown adipose tissue (bat). |
2002-08-07 |
2023-08-12 |
rat |
| Deborra E Mullins, Xiaoping Zhang, Brian E Hawe. Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes. Regulatory peptides. vol 105. issue 1. 2002-08-02. PMID:11853873. |
neuropeptide y (npy), 36-amino acid amidated peptide expressed in central and peripheral neurons, regulates a variety of physiological activities, including food intake, energy expenditure, vasoconstriction, anxiolysis, nociception and ethanol consumption. |
2002-08-02 |
2023-08-12 |
human |
| Gui-Lan Liu, Si-Wen Jiang, Yuan-Zhu Xiong, Rong Zheng, Yan-Chun Q. [Molecular screening of MC4R gene and association with fat traits in pig resource family]. Yi chuan xue bao = Acta genetica Sinica. vol 29. issue 6. 2002-07-31. PMID:12096626. |
it can cooperate with leptin, neuropeptide y(npy) and melanocyte-stimulating hormone (msh) to regulate body weight and feeding. |
2002-07-31 |
2023-08-12 |
mouse |
| Amanda Sainsbury, Christoph Schwarzer, Michelle Couzens, Serguei Fetissov, Sabine Furtinger, Arthur Jenkins, Helen M Cox, Günther Sperk, Tomas Hökfelt, Herbert Herzo. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 13. 2002-07-19. PMID:12072562. |
hypothalamus-specific y2-deleted mice showed a significant decrease in body weight and a significant increase in food intake that was associated with increased mrna levels for the orexigenic npy and agrp, as well as the anorexic proopiomelanocortin (pomc) and cocaine- and amphetamine-regulated transcript (cart) in the arcuate nucleus. |
2002-07-19 |
2023-08-12 |
mouse |
| Su Qian, Howard Chen, Drew Weingarth, Myrna E Trumbauer, Dawn E Novi, Xiaoming Guan, Hong Yu, Zhu Shen, Yue Feng, Easter Frazier, Airu Chen, Ramon E Camacho, Lauren P Shearman, Shobhna Gopal-Truter, Douglas J MacNeil, Lex H T Van der Ploeg, Donald J Mars. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Molecular and cellular biology. vol 22. issue 14. 2002-07-19. PMID:12077332. |
similarly to mice deficient in either agrp or npy, agrp(-/-);npy(-/-) mice suffer no obvious feeding or body weight deficits and maintain a normal response to starvation. |
2002-07-19 |
2023-08-12 |
mouse |
| D J Toufexis, D Kyriazis, B Woodsid. Chronic neuropeptide Y Y5 receptor stimulation suppresses reproduction in virgin female and lactating rats. Journal of neuroendocrinology. vol 14. issue 6. 2002-07-18. PMID:12047724. |
central application of npy also reliably increases food intake in rats. |
2002-07-18 |
2023-08-12 |
rat |