| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Félétou, Jean-Pierre Galizzi, Nigel R Leven. NPY receptors as drug targets for the central regulation of body weight. CNS & neurological disorders drug targets. vol 5. issue 3. 2006-08-18. PMID:16787228. |
however, attempts to demonstrate an important role for npy in the control of food intake using npy knockout mice, npy antisense oligodeoxynucleotides and anti-npy antibodies has produced equivocal results. |
2006-08-18 |
2023-08-12 |
mouse |
| Michel Félétou, Jean-Pierre Galizzi, Nigel R Leven. NPY receptors as drug targets for the central regulation of body weight. CNS & neurological disorders drug targets. vol 5. issue 3. 2006-08-18. PMID:16787228. |
antagonists of the npy y(1) and npy y(5) receptor subtype initially looked promising since analogs of npy with high selectivity for these receptors strongly stimulated food intake. |
2006-08-18 |
2023-08-12 |
mouse |
| Michel Félétou, Jean-Pierre Galizzi, Nigel R Leven. NPY receptors as drug targets for the central regulation of body weight. CNS & neurological disorders drug targets. vol 5. issue 3. 2006-08-18. PMID:16787228. |
however, attempts to inhibit the signaling of npy through the npy y(1) and npy y(5) receptors has produced equivocal effects on food intake. |
2006-08-18 |
2023-08-12 |
mouse |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
neuropeptide y (npy) is one of the most potent stimulants of food intake in mammals, but very little is known about npy actions in fish. |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
the present study investigated the role of npy in food intake in the rainbow trout (oncorhynchus mykiss). |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
food intake was monitored at different times after intracerebroventricular administration of porcine npy (4 or 8 microg). |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
however, 50 h after administration of npy, food intake was significantly lower than in control fish, and cumulative food intake had returned to levels similar to those seen in the control group. |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
the npy antagonist (d-tyr27,36, d-thr32)-npy (10 microg) inhibited food intake 2 h after icv administration, but did not block the orexigenic effect of npy when administered jointly with 4 microg npy. |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
to identify the npy receptor subtypes involved in the effects of npy on food intake, we studied the effects of the y1 receptor agonist (leu31, pro34)-npy (4 microg), the y2 receptor agonist npy(3-36) (4 microg), and the highly specific y5 receptor agonist (cpp(1-7), npy19-23, ala31, aib32, gln34)-hpp (4 microg). |
2006-08-11 |
2023-08-12 |
Not clear |
| M Aldegunde, M Manceb. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss). Peptides. vol 27. issue 4. 2006-08-11. PMID:16253390. |
these results indicate that npy stimulates feeding in the rainbow trout, and suggest that this effect is cooperatively mediated by y2- and y1-like npy receptors, not by y5-like receptors. |
2006-08-11 |
2023-08-12 |
Not clear |
| Shu Lin, Dana Boey, Nicola Lee, Christoph Schwarzer, Amanda Sainsbury, Herbert Herzo. Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain. Neuropeptides. vol 40. issue 2. 2006-08-04. PMID:16439015. |
in the arcuate nucleus of the hypothalamus (arc), double-labelling in situ hybridisation revealed that prodynorphin expressing neurons also contained npy mrna, with a co-localisation rate of approximately 88% in the lateral part of the arc, and 79% in the dorsal part of the arc, respectively, suggesting potential overlapping functions of these two neurotransmitters in feeding type behaviour. |
2006-08-04 |
2023-08-12 |
mouse |
| A-M Torregrossa, J D Davis, G P Smit. Orosensory stimulation is sufficient and postingestive negative feedback is not necessary for neuropeptide Y to increase sucrose intake. Physiology & behavior. vol 87. issue 4. 2006-07-26. PMID:16540131. |
to clarify this issue, we compared the orexic effect of npy (2 microg) injected into the third ventricle of the brain on the volume and microstructure of intake of 0.8m sucrose during sham feeding (sf) and real feeding (rf) in male sprague dawley rats. |
2006-07-26 |
2023-08-12 |
rat |
| Saeko Akimoto-Takano, Chihiro Sakurai, Setsuko Kanai, Hiroko Hosoya, Minoru Ohta, Kyoko Miyasak. Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721031. |
the appetite-stimulating peptides orexin a, neuropeptide y (npy) and ghrelin are known to play a critical role in food intake. |
2006-07-18 |
2023-08-12 |
rat |
| Saeko Akimoto-Takano, Chihiro Sakurai, Setsuko Kanai, Hiroko Hosoya, Minoru Ohta, Kyoko Miyasak. Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721031. |
intracerebroventricular administration of orexin a and npy stimulated food intake in young and adult rats, but no effects were observed at any dose in old rats. |
2006-07-18 |
2023-08-12 |
rat |
| Saeko Akimoto-Takano, Chihiro Sakurai, Setsuko Kanai, Hiroko Hosoya, Minoru Ohta, Kyoko Miyasak. Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721031. |
in conclusion, the orexigenic effect of the peptides orexin a, npy and ghrelin decreased in old rats, and this reduction may have been responsible for the age-related decrease in food intake. |
2006-07-18 |
2023-08-12 |
rat |
| L Pinilla, R Fernández-Fernández, E Vigo, V M Navarro, J Roa, J M Castellano, R Pineda, M Tena-Sempere, E Aguila. Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16390861. |
polypeptide yy-(3-36) [pyy-(3-36)] is a gastrointestinal secreted molecule recently shown to be involved in the control of food intake with agonistic activity on neuropeptide y (npy) receptor subtypes y2 and y5. |
2006-07-13 |
2023-08-12 |
rat |
| Lourdes Mounien, Patrice Bizet, Isabelle Boutelet, Hubert Vaudry, Sylvie Jégo. Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology. vol 82. issue 3-4. 2006-06-23. PMID:16508337. |
neuropeptide y (npy) and alpha-melanocyte-stimulating hormone (alpha-msh), two neuropeptides that are synthesized in neurons of the arcuate nucleus of the hypothalamus, exert opposite actions on food intake and body weight. |
2006-06-23 |
2023-08-12 |
rat |
| Lourdes Mounien, Patrice Bizet, Isabelle Boutelet, Hubert Vaudry, Sylvie Jégo. Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology. vol 82. issue 3-4. 2006-06-23. PMID:16508337. |
these data provide additional evidence for the complex interactions between the stimulatory (npy) and inhibitory (alpha-msh) pathways controlling feeding behavior and energy homeostasis. |
2006-06-23 |
2023-08-12 |
rat |
| M Hristova, L Alo. Metabolic syndrome--neurotrophic hypothesis. Medical hypotheses. vol 66. issue 3. 2006-06-22. PMID:16298496. |
the specific pathogenic pathways of metsyn development include: (1) increased tissue and plasma levels of proinflammatory cytokines interleukin-1(il-1), interleukin-6 (il-6 ) and tumor necrosis factor - alpha (tnf-alpha) caused by inflammatory and/or emotional distress; (2) increased plasma levels of neurotrophin - nerve growth factor (ngf) caused by the high il-1, il-6 and tnfalpha levels; (3) high plasma levels of ngf which enhance activation of: the autonomous nerve system--vegetodystonia (disbalance of neurotransmitters); neuropeptide y (npy)--enhanced feeding, obesity and increased leptin plasma levels; hypothalamo-pituitary-adrenal axis--increased corticotropin-releasing hormone (crh) and cortisol (hormonal disbalance); immune cells--increased number and degranulation of mastocytes (mc)--immunological disbalance; (4) as a result of 1-3 insulin resistance is exhibited leading to diabetes mellitus. |
2006-06-22 |
2023-08-12 |
Not clear |
| M Mahmoodi, J V Gardiner, G R Asadi Karam, M Khaksari, K G Murphy, M A Ghatei, S R Bloo. Implantation of fibre encapsulated RIN 1056a cells transfected with NPY cDNA into the lateral ventricle of rats alters body weight. Regulatory peptides. vol 132. issue 1-3. 2006-06-20. PMID:16202459. |
neuropeptide y (npy) is a hypothalamic neuropeptide thought to play an important role in the regulation of food intake and energy expenditure. |
2006-06-20 |
2023-08-12 |
rat |