| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Mahmoodi, J V Gardiner, G R Asadi Karam, M Khaksari, K G Murphy, M A Ghatei, S R Bloo. Implantation of fibre encapsulated RIN 1056a cells transfected with NPY cDNA into the lateral ventricle of rats alters body weight. Regulatory peptides. vol 132. issue 1-3. 2006-06-20. PMID:16202459. |
cumulative food intake was also increased in rats implanted with npy cdna transfected rin 1056a cells, but this difference failed to reach statistical significance. |
2006-06-20 |
2023-08-12 |
rat |
| Nobukazu Kakui, Jiro Tanaka, Yuji Tabata, Kenji Asai, Naomi Masuda, Takako Miyara, Yuko Nakatani, Fukuichi Ohsawa, Naoyuki Nishikawa, Masaharu Sugai, Makoto Suzuki, Kozo Aoki, Hiroshi Kitaguch. Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16436501. |
an intracerebroventricular injection of npy and y5-selective agonist peptide induced acute and robust feeding responses in satiated rats, and prior administration of fms586 at the doses from 25 to 100 mg/kg clearly inhibited these responses by approximately 55 and 90%, respectively. |
2006-06-09 |
2023-08-12 |
human |
| Yih-Shou Hsieh, Shun-Fa Yang, Hui-Ling Chiou, Dong-Yih Ku. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Toxicology and applied pharmacology. vol 212. issue 2. 2006-05-25. PMID:16084549. |
results showed that amph treatment decreased food intake, which was correlated with changes of npy mrna level, but increased c-fos, c-jun and superoxide dismutase (sod) mrna levels in hypothalamus. |
2006-05-25 |
2023-08-12 |
rat |
| Yih-Shou Hsieh, Shun-Fa Yang, Hui-Ling Chiou, Dong-Yih Ku. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Toxicology and applied pharmacology. vol 212. issue 2. 2006-05-25. PMID:16084549. |
it was suggested that c-fos/c-jun signaling might involve in the central regulation of amph-mediated feeding suppression via the modulation of npy gene expression. |
2006-05-25 |
2023-08-12 |
rat |
| Seetharama D S Jois, Latha M Nagarajarao, M Prabhakaran, A Balasubramania. Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. Journal of biomolecular structure & dynamics. vol 23. issue 5. 2006-05-11. PMID:16494499. |
npy mediates several physiological responses, such as blood pressure, food intake, sedation. |
2006-05-11 |
2023-08-12 |
Not clear |
| Thomas Wultsch, Evelin Painsipp, Sabine Donner, Günther Sperk, Herbert Herzog, Bernhard A Peskar, Peter Holze. Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice. Behavioural brain research. vol 168. issue 2. 2006-05-09. PMID:16364461. |
since deletion of the npy y2 and y4 receptor gene increases and decreases food intake, respectively, we examined whether water intake during the light and dark phases is altered in y2 and y4 receptor knockout mice. |
2006-05-09 |
2023-08-12 |
mouse |
| Jason P Schroeder, David H Overstreet, Clyde W Hodg. The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol (Fayetteville, N.Y.). vol 36. issue 3. 2006-04-19. PMID:16377459. |
neuropeptide-y (npy) is the most abundant and widely distributed peptide in the mammalian central nervous system and increases feeding behavior through actions at the y5 receptor subtype. |
2006-04-19 |
2023-08-12 |
human |
| Motoki Kuramochi, Tatsushi Onaka, Daisuke Kohno, Satoshi Kato, Toshihiko Yad. Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat. Endocrinology. vol 147. issue 4. 2006-04-14. PMID:16410310. |
furthermore, both anti-npy igg and npy antagonists, when preinjected, counteracted the feeding induced by galp injection. |
2006-04-14 |
2023-08-12 |
rat |
| Nihal Tümer, Philip J Scarpace, M Devrim Dogan, Christopher S Broxson, Michael Matheny, David M Yurek, Carmen S Peden, Corinna Burger, Nicholas Muzyczka, Ronald J Mande. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiology of aging. vol 27. issue 3. 2006-04-13. PMID:15964099. |
the weight loss was associated with decreased food intake and increased energy expenditure, but these effects were not mediated by changes in hypothalamic npy or pomc expression. |
2006-04-13 |
2023-08-12 |
rat |
| E A Jørgensen, U Knigge, T Watanabe, J Warberg, A Kjae. Histaminergic neurons are involved in the orexigenic effect of orexin-A. Neuroendocrinology. vol 82. issue 2. 2006-04-04. PMID:16415597. |
to study this, we used histamine knockout animals and pharmacological blockade of the histaminergic system and studied the effect of orexin-a on feeding behavior and gene expression of neuropeptide y (npy). |
2006-04-04 |
2023-08-12 |
mouse |
| Sheng-Huang Hsiao, Hsien-Hui Chung, Akio Inui, Yat-Ching Tong, Juei-Tang Chen. Inhibitory effect of 5-hydroxytryptamine on hyperphagia in mice with genetic overexpression of neuropeptide Y. Neuroscience letters. vol 394. issue 3. 2006-03-30. PMID:16332411. |
the present study examined the effect of 5-hydroxytraptamine (5-ht) on the feeding behavior of transgenic mice with neuropeptide y (npy) overexpression. |
2006-03-30 |
2023-08-12 |
mouse |
| Gavin A Bewick, James V Gardiner, Waljit S Dhillo, Aysha S Kent, Nicholas E White, Zoe Webster, Mohammad A Ghatei, Stephen R Bloo. Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16099943. |
both agrp and npy stimulate food intake when administered into the third ventricle and are up-regulated in states of negative energy balance. |
2006-03-07 |
2023-08-12 |
mouse |
| Dana K Sindelar, Richard D Palmiter, Stephen C Woods, Michael W Schwart. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides. vol 26. issue 12. 2006-02-28. PMID:15923061. |
attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide y. neuropeptide y (npy) is a potent orexigenic peptide that is implicated in the feeding response to a variety of stimuli. |
2006-02-28 |
2023-08-12 |
mouse |
| Dana K Sindelar, Richard D Palmiter, Stephen C Woods, Michael W Schwart. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides. vol 26. issue 12. 2006-02-28. PMID:15923061. |
the current studies employed mice lacking npy (npy-/-) and their wild-type (npy+/+) littermates to investigate the role of this peptide in the feeding response to circadian and palatability cues. |
2006-02-28 |
2023-08-12 |
mouse |
| Dana K Sindelar, Richard D Palmiter, Stephen C Woods, Michael W Schwart. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides. vol 26. issue 12. 2006-02-28. PMID:15923061. |
to investigate the role of npy in the feeding response to palatability cues, mice were presented with a highly palatable diet (hp) for 1h each day (in addition to having ad libitum access to chow) for 18 days. |
2006-02-28 |
2023-08-12 |
mouse |
| Dana K Sindelar, Richard D Palmiter, Stephen C Woods, Michael W Schwart. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides. vol 26. issue 12. 2006-02-28. PMID:15923061. |
these experiments suggest that npy contributes to the mechanism whereby food intake increases in response to circadian and palatability cues and that mechanisms driving food intake in response to these stimuli differ from those activated by energy restriction. |
2006-02-28 |
2023-08-12 |
mouse |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
the purpose of the present study was to investigate the effects of 2 weeks high fat feeding in wildtype mice on (1) insulin sensitivity and triglyceride accumulation in liver and muscle in relation to (2) mrna expression levels of neuropeptide y (npy), agouti-related protein (agrp), pro-opiomelanocortin (pomc), and cocaine- and amphetamine-regulated transcript (cart) in the hypothalamus. |
2006-02-28 |
2023-08-12 |
mouse |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
this study shows that 2 weeks of high fat feeding in mice does not affect mrna expression levels of npy, agrp, pomc or cart, in the whole hypothalamus, despite induction of hepatic, but not peripheral, insulin resistance. |
2006-02-28 |
2023-08-12 |
mouse |
| William T Chance, Ramesh Dayal, Lou Ann Friend, Sulaiman Sherif. Possible role of CRF peptides in burn-induced hypermetabolism. Life sciences. vol 78. issue 7. 2006-02-16. PMID:16125201. |
crf also elicits anorexia, while npy stimulates feeding. |
2006-02-16 |
2023-08-12 |
rat |
| L Lin, D R Gehlert, D A York, G A Bra. Effect of enterostatin on the feeding responses to galanin and NPY. Obesity research. vol 1. issue 3. 2006-02-06. PMID:16353353. |
effect of enterostatin on the feeding responses to galanin and npy. |
2006-02-06 |
2023-08-12 |
rat |