| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Yih Ku. Hypothalamic neuropeptide Y (NPY) and the attenuation of hyperphagia in streptozotocin diabetic rats treated with dopamine D1/D2 agonists. British journal of pharmacology. vol 148. issue 5. 2006-12-26. PMID:16702993. |
changes in food intake and hypothalamic npy content of these rats were assessed and compared. |
2006-12-26 |
2023-08-12 |
rat |
| Carola Eva, Alessandra Oberto, Paolo Mele, Mariangela Serra, Giovanni Biggi. Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala. Pharmacology, biochemistry, and behavior. vol 84. issue 4. 2006-12-20. PMID:16824587. |
various lines of evidence suggest a functional interaction between gaba(a) and neuropeptide y (npy)-y(1) receptor (y(1)r) mediated transmissions in various brain regions, which can be important in the regulation of sedation, feeding, anxious behaviour and neuronal excitability. |
2006-12-20 |
2023-08-12 |
mouse |
| Elizabeth F Gluck, Natalie Stephens, Steven J Swoa. Peripheral ghrelin deepens torpor bouts in mice through the arcuate nucleus neuropeptide Y signaling pathway. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 5. 2006-11-29. PMID:16825418. |
two major pathways that regulate food intake reside in the arc, the anorexigenic alpha-melanocyte stimulating hormone (alpha-msh) pathway and the orexigenic neuropeptide y (npy) signaling pathway. |
2006-11-29 |
2023-08-12 |
mouse |
| Ana Guijarro, Alessandro Laviano, Michael M Megui. Hypothalamic integration of immune function and metabolism. Progress in brain research. vol 153. 2006-11-28. PMID:16876587. |
immunohistochemical studies have shown a decrease in neuropeptide y (npy) and dopamine (da) and an increase in serotonin concentration in tumor-bearing rats, in first- and second-order hypothalamic nuclei, while tumor resection reverted these changes and normalized food intake, suggesting negative regulation of npy and da systems by cytokines during anorexia, probably mediated by serotonin that appears to play a pivotal role in the regulation of food intake in cancer. |
2006-11-28 |
2023-08-12 |
rat |
| Ana Guijarro, Alessandro Laviano, Michael M Megui. Hypothalamic integration of immune function and metabolism. Progress in brain research. vol 153. 2006-11-28. PMID:16876587. |
the sum of these data support the concept that immune cell-derived cytokines are closely related with the regulation of metabolism and have both central and peripheral actions, inducing anorexia via hypothalamic anorectic factors, including serotonin and dopamine, and inhibiting npy leading to a reduction in food intake and body weight, emphasizing the interconnection of the immune and neuroendocrine systems in regulating metabolism during infectious process, cachexia and obesity. |
2006-11-28 |
2023-08-12 |
rat |
| Tohru Miura, Keisuke Maruyama, Sei-Ichi Shimakura, Hiroyuki Kaiya, Minoru Uchiyama, Kenji Kangawa, Seiji Shioda, Kouhei Matsud. Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus. Neuroscience letters. vol 407. issue 3. 2006-11-27. PMID:16979293. |
food intake induced by icv or ip injection of ghrelin was suppressed by icv preinjection of bibp-3226 for 1 h. we then examined whether ghrelin affects the expression of npy mrna in the goldfish brain using a real-time pcr method. |
2006-11-27 |
2023-08-12 |
Not clear |
| Tohru Miura, Keisuke Maruyama, Sei-Ichi Shimakura, Hiroyuki Kaiya, Minoru Uchiyama, Kenji Kangawa, Seiji Shioda, Kouhei Matsud. Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus. Neuroscience letters. vol 407. issue 3. 2006-11-27. PMID:16979293. |
icv, but not ip, administration of ghrelin at a dose sufficient to stimulate food intake increased the expression of brain npy mrna obtained from 2 h after treatment. |
2006-11-27 |
2023-08-12 |
Not clear |
| Tohru Miura, Keisuke Maruyama, Sei-Ichi Shimakura, Hiroyuki Kaiya, Minoru Uchiyama, Kenji Kangawa, Seiji Shioda, Kouhei Matsud. Neuropeptide Y mediates ghrelin-induced feeding in the goldfish, Carassius auratus. Neuroscience letters. vol 407. issue 3. 2006-11-27. PMID:16979293. |
these results indicate that the orexigenic action of central ghrelin is mediated by the release of npy in the brain with stimulating npy synthesis, and that peripheral ghrelin also stimulates food intake via brain npy pathway. |
2006-11-27 |
2023-08-12 |
Not clear |
| Hui Chen, Stephen Kent, Margaret J Morri. Is the CCK2 receptor essential for normal regulation of body weight and adiposity? The European journal of neuroscience. vol 24. issue 5. 2006-11-14. PMID:16965546. |
little is known regarding the effects of cck2 receptor deficiency on adipose distribution and hypothalamic feeding regulators such as neuropeptide y (npy), a powerful stimulator of feeding. |
2006-11-14 |
2023-08-12 |
mouse |
| Hui Chen, Stephen Kent, Margaret J Morri. Is the CCK2 receptor essential for normal regulation of body weight and adiposity? The European journal of neuroscience. vol 24. issue 5. 2006-11-14. PMID:16965546. |
increased npy might contribute to increased food intake in cck2 receptor knockout mice. |
2006-11-14 |
2023-08-12 |
mouse |
| Hélène Volkof. The role of neuropeptide Y, orexins, cocaine and amphetamine-related transcript, cholecystokinin, amylin and leptin in the regulation of feeding in fish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 144. issue 3. 2006-11-08. PMID:16326123. |
studies using brain or peripheral peptide injections have shown that neuropeptide y (npy) and orexins are potent orexigenic factors in fish, whereas cocaine and amphetamine-related transcript (cart) peptides decrease food intake. |
2006-11-08 |
2023-08-12 |
Not clear |
| Hélène Volkof. The role of neuropeptide Y, orexins, cocaine and amphetamine-related transcript, cholecystokinin, amylin and leptin in the regulation of feeding in fish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 144. issue 3. 2006-11-08. PMID:16326123. |
for example, npy and orexins have synergistic effects on food intake and they are both modulated by cart peptides. |
2006-11-08 |
2023-08-12 |
Not clear |
| Nan Tian, Fei Wang, De-Run Tian, Yuan Zou, Shi-Wei Wang, Li-Li Guan, Yu-Shun Shi, Jaw-Kang Chang, Jun Yang, Ji-Sheng Ha. Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats. Peptides. vol 27. issue 9. 2006-11-07. PMID:16644064. |
exploration of the mechanism involved revealed significant downregulation of the orexigenic peptides: ghrelin in the stomach, and neuropeptide y (npy) but not agouti-related peptide (agrp) in the hypothalamus, which was in line with the reduction in food intake in rats receiving ea stimulation as compared with those receiving restraint only. |
2006-11-07 |
2023-08-12 |
mouse |
| Michael G Dube, Satya P Kalra, Pushpa S Kalr. The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action. Peptides. vol 27. issue 9. 2006-11-07. PMID:16759748. |
the orexigenic neuropeptide y (npy) system and the anorexigenic melanocortin system act in the pvn to regulate food intake, and participate in mediating the anorexic effects of leptin. |
2006-11-07 |
2023-08-12 |
rat |
| Michael G Dube, Satya P Kalra, Pushpa S Kalr. The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action. Peptides. vol 27. issue 9. 2006-11-07. PMID:16759748. |
with either 118 pmole or 470 pmole of npy and food intake was measured for 3 h. food intake in response to npy was nearly three-fold higher in pvn-lesioned rats as compared to sham rats. |
2006-11-07 |
2023-08-12 |
rat |
| Michael G Dube, Satya P Kalra, Pushpa S Kalr. The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action. Peptides. vol 27. issue 9. 2006-11-07. PMID:16759748. |
furthermore, based on the similarities of responses of pvn-lesioned and sham control rats to the anorexigenic agents mtii and leptin and the hypersensitivity of lesioned rats to npy, we conclude that the pvn is not essential for npy stimulation of food intake or for melanocortin suppression of food intake and that npy and melanocortin receptors outside of the pvn are sufficient to produce these effects. |
2006-11-07 |
2023-08-12 |
rat |
| Hiroyuki Hozumi, Keitaro Yamanouchi, Masugi Nishihar. Involvement of neuropeptide Y in hyperphagia in human growth hormone transgenic rats. The Journal of veterinary medical science. vol 68. issue 9. 2006-11-01. PMID:17019066. |
in addition, treatment with antagonists for y1 and y5 receptors for npy reduced food intake much more effectively in the tg than wt rats. |
2006-11-01 |
2023-08-12 |
human |
| F Maekawa, K Fujiwara, D Kohno, M Kuramochi, H Kurita, T Yad. Young adult-specific hyperphagia in diabetic Goto-kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus. Journal of neuroendocrinology. vol 18. issue 10. 2006-10-24. PMID:16965293. |
injection of a npy y1 antagonist, 1229u91, the amount of food intake in gk rats was indistinguishable from that in wistar rats, thus eliminating the hyperphagia of gk rats. |
2006-10-24 |
2023-08-12 |
rat |
| Mercedes Gil-Campos, Concepción María Aguilera, Ramón Cañete, Angel Gi. Ghrelin: a hormone regulating food intake and energy homeostasis. The British journal of nutrition. vol 96. issue 2. 2006-10-16. PMID:16923214. |
ghrelin stimulates the synthesis of neuropeptide y (npy) and agouti-related protein (agrp) in the arcuate nucleus neurons of the hypothalamus and hindbrain, which in turn enhance food intake. |
2006-10-16 |
2023-08-12 |
Not clear |
| Fernando Forcada, José-Alfonso Abeci. The effect of nutrition on the seasonality of reproduction in ewes. Reproduction, nutrition, development. vol 46. issue 4. 2006-10-11. PMID:16824445. |
several experimental approaches have elucidated that both high body fat and food intake are able to modify the sensitivity of the hypothalamus to oestradiol negative feedback during seasonal anoestrus, with those effects being associated to a reduced amount of npy mrna and to an increase of plasma insulin, glucose and leptin concentrations, particularly in the late scenario. |
2006-10-11 |
2023-08-12 |
Not clear |