| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koilmani Emmanuvel Rajan, Hemant K Singh, Arunagiri Parkavi, Prisila Dulcy Charle. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21735137. |
furthermore, 5ht(3a) receptor agonist 1-(m-chlorophenyl)-biguanide (mcpbg) impaired learning in the passive avoidance task followed by reduction of 5ht(3a) receptor expression, 5ht and ach levels. |
2012-01-27 |
2023-08-12 |
rat |
| O Johnson, J Becnel, C D Nichol. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. vol 192. 2012-01-18. PMID:21749913. |
although many neurotransmitters including acetylcholine, dopamine, glutamate, and gaba have previously been demonstrated to be involved in aversive olfactory learning and memory, the role of serotonin has not been well defined. |
2012-01-18 |
2023-08-12 |
drosophila_melanogaster |
| Gareth Harris, Amanda Korchnak, Philip Summers, Vera Hapiak, Wen Jing Law, Andrew M Stein, Patricia Komuniecki, Richard Komunieck. Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans. PloS one. vol 6. issue 7. 2011-12-08. PMID:21814562. |
nsm 5-ht activates ser-5 on the ashs and ser-1 on the ria interneurons and stimulates aversive responses, suggesting that food-dependent serotonergic stimulation involves local changes in 5-ht levels mediated by extrasynaptic 5-ht receptors. |
2011-12-08 |
2023-08-12 |
caenorhabditis_elegans |
| Paula Shimene de Melo Yamashita, Valquiria Camin de Bortoli, Helio Zangross. 5-HT2C receptor regulation of defensive responses in the rat dorsal periaqueductal gray. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20850460. |
our results showed that intra-dpag microinjection of the endogenous agonist 5-ht (20 nmol) or the 5-ht2c receptor agonists mk-212 (1 and 10 nmol) and ro-600175 (40 nmol) significantly increased inhibitory avoidance acquisition in rats tested in the elevated t-maze, suggesting an anxiogenic effect. |
2011-11-22 |
2023-08-12 |
rat |
| Robert D Roger. The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 1. 2011-11-10. PMID:20881944. |
finally, i suggest that the role played by serotonin in the regulation of cognitive biases, and representation of context in learning, point toward a role in the cortically mediated cognitive appraisal of reinforcers when selecting between actions, potentially accounting for its influence upon the processing salient aversive outcomes and social choice. |
2011-11-10 |
2023-08-12 |
human |
| Y-Lan Boureau, Peter Daya. Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 1. 2011-11-10. PMID:20881948. |
there is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. |
2011-11-10 |
2023-08-12 |
Not clear |
| Geraldine A Wrigh. The role of dopamine and serotonin in conditioned food aversion learning in the honeybee. Communicative & integrative biology. vol 4. issue 3. 2011-11-10. PMID:21980568. |
the role of dopamine and serotonin in conditioned food aversion learning in the honeybee. |
2011-11-10 |
2023-08-12 |
Not clear |
| Frederico G Graef. [Serotonin, periaqueductal gray matter and panic disorder]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 25 Suppl 2. 2011-08-15. PMID:14978586. |
results obtained with conflict tests in experimental animals indicate that 5-ht enhances anxiety, whereas results with aversive stimulation of the dorsal pag point to an anxiolytic role of 5-ht. |
2011-08-15 |
2023-08-12 |
human |
| Tomoko Horisawa, Tadashi Ishibashi, Hiroyuki Nishikawa, Takeshi Enomoto, Satoko Toma, Takeo Ishiyama, Mutsuo Taij. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21277905. |
the effects of selective antagonists of serotonin 5-ht7 and 5-ht1a receptors on mk-801-induced impairment of learning and memory in the passive avoidance and morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. |
2011-07-15 |
2023-08-12 |
rat |
| Tomoko Horisawa, Tadashi Ishibashi, Hiroyuki Nishikawa, Takeshi Enomoto, Satoko Toma, Takeo Ishiyama, Mutsuo Taij. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21277905. |
we have previously reported that lurasidone, a novel atypical antipsychotic with potent serotonin 5-ht(7) antagonist and 5-ht(1a) partial agonist activities, is superior to other antipsychotics in improving the n-methyl-d-aspartate (nmda) receptor antagonist mk-801-induced learning and memory impairment in the passive avoidance (pa) and morris water maze (mwm) tests in rats. |
2011-07-15 |
2023-08-12 |
rat |
| Shin-ichi Kimura, Hiroko Togashi, Machiko Matsumoto, Taito Shiozawa, Junko Ishida, Satomi Kano, Atsuko Ohashi, Shyhei Ishikawa, Taku Yamaguchi, Mitsuhiro Yoshioka, Keiichi Shimamur. Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 1. 2011-06-21. PMID:21404951. |
the present study explored whether aversive stress exposure in the second and/or the third week (pnd 21-25, 3w-fs) affects the function of cortical 5-ht(1a) receptors, using in vivo and in vitro experiments. |
2011-06-21 |
2023-08-12 |
rat |
| Shin-ichi Kimura, Hiroko Togashi, Machiko Matsumoto, Taito Shiozawa, Junko Ishida, Satomi Kano, Atsuko Ohashi, Shyhei Ishikawa, Taku Yamaguchi, Mitsuhiro Yoshioka, Keiichi Shimamur. Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 1. 2011-06-21. PMID:21404951. |
thus, aversive stress exposure during the second postnatal period appears to cause persistent changes mediated via 5-ht(1a) receptors, presumably involving signal transduction regulating the development of synaptic connectivity underlying fear circuits. |
2011-06-21 |
2023-08-12 |
rat |
| F A Pamplona, K Henes, V Micale, C P Mauch, R N Takahashi, C T Wotja. Prolonged fear incubation leads to generalized avoidance behavior in mice. Journal of psychiatric research. vol 45. issue 3. 2011-06-14. PMID:20655545. |
we employed our recently established mouse model of ptsd (i) to study the emergence of avoidance behavior in the aftermath of a trauma, (ii) to disentangle the impact of context generalization vs. lack of motivation vs. novelty fear and (iii) to assess the therapeutic value of benzodiazepines and selective serotonin reuptake inhibitors (ssris). |
2011-06-14 |
2023-08-12 |
mouse |
| Nanna Hovelsø, Thomas Nicolaj Sager, Arne Mør. Combination of escitalopram and a 5-HT(₁A) receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT(₂C) receptor stimulation; suggestive of antipsychotic potential. Pharmacology, biochemistry, and behavior. vol 97. issue 3. 2011-04-11. PMID:20937301. |
the antipsychotic potential of the combined treatment with escitalopram, in therapeutic relevant doses, and the 5-ht(₁a) receptor antagonist, way-100635, has been evaluated by assessment of conditioned avoidance (car) behaviour and the use of microdialysis in freely moving rats. |
2011-04-11 |
2023-08-12 |
rat |
| E S da Silva, S C Poltronieri, J O G Nascimento, H Zangrossi, M B Vian. Facilitation of 5-HT(2A/2C)-mediated neurotransmission in the ventromedial hypothalamic nucleus decreases anxiety in the elevated T-maze. Behavioural brain research. vol 216. issue 2. 2011-03-22. PMID:20883726. |
these results suggest that 5-ht(2a/2c) receptors of the vmh are involved in the regulation of inhibitory avoidance and might be of relevance to the physiopathology of generalized anxiety. |
2011-03-22 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
serotonin is widely implicated in aversive processing. |
2011-03-10 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
it is not clear, however, whether serotonin neurons encode information about aversive stimuli. |
2011-03-10 |
2023-08-12 |
rat |
| J V Schweimer, M A Ungles. Phasic responses in dorsal raphe serotonin neurons to noxious stimuli. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20888395. |
these results suggest that discrete groups of serotonin neurons differentially code for aversive stimuli. |
2011-03-10 |
2023-08-12 |
rat |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| Frederico G Graeff, Hélio Zangross. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 3. 2011-01-07. PMID:20528764. |
the dual role of 5-ht in defense hypothesis assumes that 5-ht facilitates defensive responses to potential threat, like inhibitory avoidance, related to anxiety, whereas it inhibits defensive responses to proximal danger, like one-way escape, related to panic. |
2011-01-07 |
2023-08-12 |
human |