| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rhiannon Robke, Francesca Sansi, Tara Arbab, Adria Tunez Aquilue, Miranda Moore, Dusan Bartsch, Kai Schönig, Ingo Willuh. Optogenetic stimulation of novel TPH2-Cre rats advances insight into serotonin's role in locomotion, reinforcement, and compulsivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025-04-09. PMID:40204433. |
serotonin critically modulates the activity of many brain networks, including circuits that control motivation and responses to rewarding and aversive stimuli. |
2025-04-09 |
2025-04-12 |
rat |
| João Lima, Marios C Panayi, Trevor Sharp, Stephen B McHugh, David M Bannerma. More and Less Fear in Serotonin Transporter Knockout Mice. Genes, brain, and behavior. vol 24. issue 1. 2025-02-07. PMID:39917838. |
taken together, our results support the idea that loss of 5-htt function, and corresponding increases in synaptic 5-ht availability, may facilitate learning by priming of aversive memories. |
2025-02-07 |
2025-02-09 |
mouse |
| Hiroyuki Kawa. [Role of Median Raphe Serotonergic Neurons in Positive and Negative Information Processing]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 145. issue 2. 2025-02-02. PMID:39894484. |
however, the pharmacological enhancement of serotonin neurotransmission does not induce rewarding or aversive effects. |
2025-02-02 |
2025-02-05 |
mouse |
| Chan-Wei Yu, Pei-Ling Yen, Yu-Hsuan Kuo, Ting-An Lin, Vivian Hsiu-Chuan Lia. Early-life polystyrene nanoplastics exposure impairs pathogen avoidance behavior associated with intestine-derived insulin-like neuropeptide (ins-11) and serotonin signaling in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 288. 2024-11-18. PMID:39557011. |
early-life polystyrene nanoplastics exposure impairs pathogen avoidance behavior associated with intestine-derived insulin-like neuropeptide (ins-11) and serotonin signaling in caenorhabditis elegans. |
2024-11-18 |
2024-11-22 |
caenorhabditis_elegans |
| Chan-Wei Yu, Pei-Ling Yen, Yu-Hsuan Kuo, Ting-An Lin, Vivian Hsiu-Chuan Lia. Early-life polystyrene nanoplastics exposure impairs pathogen avoidance behavior associated with intestine-derived insulin-like neuropeptide (ins-11) and serotonin signaling in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 288. 2024-11-18. PMID:39557011. |
notably, acute serotonin treatment restored the avoidance behavior, indicating a role of serotonin signaling in this process. |
2024-11-18 |
2024-11-22 |
caenorhabditis_elegans |
| Michael J Colwell, Hosana Tagomori, Fei Shang, Hoi Iao Cheng, Chloe E Wigg, Michael Browning, Philip J Cowen, Susannah E Murphy, Catherine J Harme. Direct serotonin release in humans shapes aversive learning and inhibition. Nature communications. vol 15. issue 1. 2024-08-09. PMID:39122687. |
reinforcement learning models reveal that increasing synaptic serotonin reduces sensitivity for outcomes in aversive contexts. |
2024-08-09 |
2024-08-13 |
human |
| Michael J Colwell, Hosana Tagomori, Fei Shang, Hoi Iao Cheng, Chloe E Wigg, Michael Browning, Philip J Cowen, Susannah E Murphy, Catherine J Harme. Direct serotonin release in humans shapes aversive learning and inhibition. Nature communications. vol 15. issue 1. 2024-08-09. PMID:39122687. |
furthermore, increasing synaptic serotonin enhances behavioural inhibition, and shifts bias towards impulse control during exposure to aversive emotional probes. |
2024-08-09 |
2024-08-13 |
human |
| Michael J Colwell, Hosana Tagomori, Fei Shang, Hoi Iao Cheng, Chloe E Wigg, Michael Browning, Philip J Cowen, Susannah E Murphy, Catherine J Harme. Direct serotonin release in humans shapes aversive learning and inhibition. Nature communications. vol 15. issue 1. 2024-08-09. PMID:39122687. |
our findings highlight the direct effects of increasing synaptic serotonin on human behaviour, underlining its role in guiding decision-making within aversive and more neutral contexts, and offering implications for longstanding theories of central serotonin function. |
2024-08-09 |
2024-08-13 |
human |
| Zahra Mashahadi, Hakimeh Saadati, Safa Ghaheri Far. Early-life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-07-10. PMID:38984677. |
our findings showed that postnatal serotonin depletion and sleep deprivation impaired the novel object recognition and passive avoidance memories and changed the bdnf levels. |
2024-07-10 |
2024-07-12 |
Not clear |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
the selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. |
2024-04-17 |
2024-04-19 |
Not clear |
| Xin Deng, I-Shuo Huang, Kourtlin Williams, Marcy L Wainwright, Paul V Zimba, Riccardo Mozzachiod. Role of serotonin in the lack of sensitization caused by prolonged food deprivation in Aplysia. Behavioural brain research. 2023-11-03. PMID:37923220. |
under normal feeding conditions (i.e., two days food deprivation, 2dfd), aversive stimuli lead to serotonin (5-ht) release into the hemolymph and neuropil, which mediates sensitization and its cellular correlates including increased excitability of tail sensory neurons (tsns). |
2023-11-03 |
2023-11-08 |
aplysia |
| Satomi Kobayashi, Mie Kajiwara, Yilong Cui, Takeo Sako, Tetsuya Sasabe, Emi Hayashinaka, Yasuhiro Wada, Masayuki Kobayash. Activation of multiple neuromodulatory systems in alert rats acquiring conditioned taste aversion revealed by positron emission tomography. Brain research. 2023-10-07. PMID:37805008. |
conditioned taste aversion (cta) is an essential ability for animals to consume food safely and is regulated by neuromodulatory systems including the dopamine, noradrenaline, serotonin, and acetylcholine systems. |
2023-10-07 |
2023-10-15 |
rat |
| Chen-Cheng Lin, Chiu-Ping Yang, Pao-Yun Cheng, Michael Hsiao, Yia-Ping Li. Escitalopram reversibility of the impacts following chronic stress on central 5-HT profiles - Implications to depression and anxiety. Behavioural brain research. 2023-08-06. PMID:37544369. |
the present study aims to examine whether the intervention of escitalopram (es, 5mg/kg daily for 14 days) can reverse the behavioral phenotypes of both depression-like [by sucrose preference test (spt) and forced swim test (fst)] and anxiety-like [by avoidance latency and escape latency in elevated-t maze (etm)] behaviors, and the brain area-dependent neurochemical changes of 5-ht profiles of the terminal regions regarding both synaptic efflux and tissue levels in rats of chronic mild stress (cms). |
2023-08-06 |
2023-08-14 |
rat |
| Jochen Michely, Ingrid M Martin, Raymond J Dolan, Tobias U Hause. Boosting serotonin increases information gathering by reducing subjective cognitive costs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-31. PMID:37524494. |
serotonin is implicated in the valuation of aversive costs, such as delay or physical effort. |
2023-07-31 |
2023-08-14 |
human |
| Jochen Michely, Ingrid M Martin, Raymond J Dolan, Tobias U Hause. Boosting serotonin increases information gathering by reducing subjective cognitive costs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-31. PMID:37524494. |
this result is consistent with the notion that serotonin alleviates sensitivity to aversive costs in a domain-general fashion, with implications for its potential contribution to a positive impact on motivational deficits in psychiatric disorders. |
2023-07-31 |
2023-08-14 |
human |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
we report that chronic intermittent ethanol (cie) induces social avoidance in a sex-dependent manner and is associated with hyperactivity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn). |
2023-07-18 |
2023-08-14 |
mouse |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
while 5-htdrn neurons are generally thought to enhance social behavior, recent evidence suggests that specific 5-ht pathways can be aversive. |
2023-07-18 |
2023-08-14 |
mouse |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
we then employed an array of molecular genetic tools in transgenic mice to show that 5-ht drn inputs to nacc dynorphin neurons drive social avoidance in male mice after cie by activating 5-ht2c receptors. |
2023-07-18 |
2023-08-14 |
mouse |
| Ruixiang Wang, Kanza M Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Govindhasamy Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark J Niciu, Marco M Hefti, Catherine A Marcinkiewc. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398335. |
we report that chronic intermittent ethanol (cie) induces social avoidance in a sex-dependent manner and is associated with hyperactivity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn). |
2023-07-03 |
2023-08-14 |
Not clear |
| Hayley N Manke, Kenner C Rice, Anthony L Rile. Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190550. |
to examine the possible role of serotonin (5-ht) in methylone's aversive effects, the present study assessed the effects of methylone pre-exposure on taste avoidance induced by the 5-ht reuptake inhibitor fluoxetine. |
2023-05-16 |
2023-08-14 |
rat |