| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying S Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver P Culver, Tyler B Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C Jho. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell reports. vol 42. issue 5. 2023-04-21. PMID:37083325. |
however, cocaine also blocks serotonin uptake, which we show drives, in rats, individually variable aversive effects that depend on serotonin 2c receptors (5-ht2crs) in the rostromedial tegmental nucleus (rmtg), a major gabaergic afferent to midbrain dopamine neurons. |
2023-04-21 |
2023-08-14 |
rat |
| Getulio Nicola Bressan, Paola Magro Cardoso, Juliane Reckziegel, Roselei Fachinett. Reserpine and PCPA reduce heat tolerance in Drosophila melanogaster. Life sciences. 2023-02-13. PMID:36780938. |
these data suggest that monoamines, particularly serotonin, are associated with the impaired avoidance of noxious heat which could be related to the reduction of heat tolerance in d. melanogaster. |
2023-02-13 |
2023-08-14 |
drosophila_melanogaster |
| Camille de Almeida, Nida Chabbah, Camille Eyraud, Caroline Fasano, Véronique Bernard, Nicolas Pietrancosta, Véronique Fabre, Salah El Mestikawy, Stephanie Dauma. Absence of VGLUT3 expression leads to impaired fear memory in mice. eNeuro. 2023-01-31. PMID:36720646. |
the atypical subtype, vglut3 is responsible for the co-transmission of glutamate with acetylcholine (ach), serotonin (5-ht) or gaba.to understand the involvement of vglut3-dependent cotransmission in aversive memories, we used a pavlovian fear conditioning paradigm in vglut3 |
2023-01-31 |
2023-08-14 |
mouse |
| Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kanek. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nature communications. vol 13. issue 1. 2022-12-22. PMID:36550097. |
although a critical role of serotonergic neurons in the dorsal raphe nucleus (drn) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (ssris) implies the presence of a discrete serotonergic system playing an opposite role to the drn in the processing of reward and aversive stimuli. |
2022-12-22 |
2023-08-14 |
mouse |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
cannabidiol attenuates fear memory expression in female rats via hippocampal 5-ht growing evidence from male rodent and human studies suggests that cannabidiol (cbd) modulates the expression of aversive memories and anxiety-related responses. |
2022-11-05 |
2023-08-14 |
human |
| Verenice Ascencio Gutierrez, Audrey A Carrillo, Gretha J Boersma, Kellie L K Tamashiro, Timothy H Moran, Sergio D Iñiguez, Yada Treesukoso. Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats. Neuroscience letters. 2022-08-05. PMID:35931277. |
to expand on this line of work, we evaluated how juvenile exposure to chronic variable stress (cvs) or the selective serotonin reuptake inhibitor fluoxetine (flx) influences conditioned taste aversion (cta) learning in adulthood. |
2022-08-05 |
2023-08-14 |
rat |
| Ling Bai, Nilla Sivakumar, Shenliang Yu, Sheyda Mesgarzadeh, Tom Ding, Truong Ly, Timothy V Corpuz, James C R Grove, Brooke C Jarvie, Zachary A Knigh. Enteroendocrine cell types that drive food reward and aversion. eLife. vol 11. 2022-08-01. PMID:35913117. |
conditioned flavor preference is driven by release of cholecystokinin whereas conditioned taste aversion is mediated by serotonin and substance p. these positive and negative valence signals are transmitted by vagal and spinal afferents, respectively. |
2022-08-01 |
2023-08-14 |
mouse |
| Carlos Wert-Carvajal, Melissa Reneaux, Tatjana Tchumatchenko, Claudia Clopat. Dopamine and serotonin interplay for valence-based spatial learning. Cell reports. vol 39. issue 2. 2022-04-13. PMID:35417691. |
da has been related to positive valence, from reward consumption or avoidance behavior, and 5-ht to aversive encoding. |
2022-04-13 |
2023-08-13 |
Not clear |
| Lei Cheng, Baolin Yang, Hua Du, Tong Zhou, Yang Li, Jiajie Wu, Zhenxiao Cao, An X. Moderate intensity of static magnetic fields can alter the avoidance behavior and fat storage of Caenorhabditis elegans via serotonin. Environmental science and pollution research international. 2022-01-29. PMID:35092591. |
moderate intensity of static magnetic fields can alter the avoidance behavior and fat storage of caenorhabditis elegans via serotonin. |
2022-01-29 |
2023-08-13 |
human |
| Rachel A Walker, Rebecca L Suthard, Taylor N Perison, Nora M Sheehan, Caitlin C Dwyer, Jillian K Lee, Eghosa K Enabulele, Madelyn H Ray, Michael A McDannal. Dorsal raphe 5-HT neurons utilize, but do not generate, negative aversive prediction errors. eNeuro. 2022-01-26. PMID:35078807. |
dorsal raphe 5-ht neurons utilize, but do not generate, negative aversive prediction errors. |
2022-01-26 |
2023-08-13 |
rat |
| Rhayra Xavier do Carmo Silva, Bianca Gomes do Nascimento, Gabriela Cristini Vidal Gomes, Nadyme Assad Holanda da Silva, Jéssica Souza Pinheiro, Suianny Nayara da Silva Chaves, Ana Flávia Nogueira Pimentel, Bruna Patrícia Dutra Costa, Anderson Manoel Herculano, Monica Lima-Maximino, Caio Maximin. 5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish. Pharmacology, biochemistry, and behavior. vol 210. 2021-11-25. PMID:34555392. |
serotonin (5-ht) receptors have been implicated in responses to aversive stimuli in mammals and fish, but its precise role is still unknown. |
2021-11-25 |
2023-08-13 |
zebrafish |
| Harrison M Fontaine, Phillip R Silva, Carlie Neiswanger, Rachelle Tran, Antony D Abraham, Benjamin B Land, John F Neumaier, Charles Chavki. Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-24. PMID:34564712. |
stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-ht stress-induced release of dynorphins (dyn) activates kappa opioid receptors (kor) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. |
2021-11-24 |
2023-08-13 |
mouse |
| Lorenza Colzato, Wenxin Zhang, Henrik Walter, Christian Beste, Ann-Kathrin Stoc. An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs. Pharmacopsychiatry. vol 54. issue 6. 2021-11-10. PMID:34293810. |
it further proposes drug-specific effects: antidepressants mainly targeting serotonin should primarily impair aversive and emotional processing, those targeting norepinephrine should impair the processing of alerting signals, those targeting dopamine should impair motivational processes and reward processing, and those targeting acetylcholine should impair spatial learning and memory. |
2021-11-10 |
2023-08-13 |
Not clear |
| Magdalena Kusek, Marcin Siwiec, Joanna Ewa Sowa, Bartosz Bobula, Wiktor Bilecki, Izabela Ciurej, Maria Kaczmarczyk, Tomasz Kowalczyk, Marzena Maćkowiak, Grzegorz Hess, Krzysztof Tokarsk. 5-HT Neuropharmacology. vol 198. 2021-10-14. PMID:34481835. |
the level of serotonin (5-ht) in the ba increases due to arousal and stress related to aversive stimuli. |
2021-10-14 |
2023-08-13 |
Not clear |
| Sharon A Smith, Paula D Trotter, Francis P McGlone, Susannah C Walke. Effects of Acute Tryptophan Depletion on Human Taste Perception. Chemical senses. vol 46. 2021-08-26. PMID:33277648. |
these findings show manipulation of central serotonin levels can modulate taste perception and are consistent with previous reports that depletion of central serotonin levels enhances neural and behavioral responsiveness to aversive signals. |
2021-08-26 |
2023-08-13 |
human |
| Eliza G West, Donna J Sellers, Russ Chess-Williams, Catherine McDermot. The anxiolytic sertraline reduces the impact of psychological stress on bladder function in mice. Life sciences. vol 278. 2021-06-28. PMID:33984361. |
to determine if treatment with the selective serotonin reuptake inhibitor (ssri) sertraline reduces the bladder dysfunction caused by water avoidance stress in mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Siamak Beheshti, Mitra Sami, Atefeh Mirzabeh, Azadeh Yazd. D-Lys-3-GHRP-6 impairs memory consolidation and downregulates the hippocampal serotonin HT1A, HT7 receptors and glutamate GluA1 subunit of AMPA receptors. Physiology & behavior. vol 223. 2021-06-21. PMID:32454141. |
we aimed to evaluate the effect of intracerebral injection of a ghrelin receptor antagonist (d-lys-3-ghrp-6) on memory consolidation in the inhibitory avoidance task and on the gene expression levels of serotonin ht1a and ht7 receptors, glutamate glun1 subunit of the nmda and glua1 subunit of the ampa receptors and calcium/calmodulin kinase ii-α in the hippocampus of rats. |
2021-06-21 |
2023-08-13 |
rat |
| Siamak Beheshti, Mitra Sami, Atefeh Mirzabeh, Azadeh Yazd. D-Lys-3-GHRP-6 impairs memory consolidation and downregulates the hippocampal serotonin HT1A, HT7 receptors and glutamate GluA1 subunit of AMPA receptors. Physiology & behavior. vol 223. 2021-06-21. PMID:32454141. |
it seems that part of the impairing effect of d-lys-3-ghrp-6 on inhibitory avoidance memory consolidation might be due to a decrease in the expression of serotonin ht1a and ht7 receptors and glutamate ampa receptors in the hippocampus of rats. |
2021-06-21 |
2023-08-13 |
rat |
| Simone Carneiro-Nascimento, William Powell, Michaela Uebel, Michaela Buerge, Hannes Sigrist, Michael Patterson, Christopher R Pryce, Jolanta Opacka-Juffr. Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice. IBRO neuroscience reports. vol 10. 2021-04-19. PMID:33861815. |
serotonin (5-ht), via its receptors expressed in discrete brain regions, modulates aversion and reward processing and is implicated in various psychiatric disorders including depression. |
2021-04-19 |
2023-08-13 |
mouse |