| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofi da Cunha-Bang, Liv Vadskjær Hjordt, Vibeke Høyrup Dam, Dea Siggaard Stenbæk, Dorte Sestoft, Gitte M Knudse. Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition. Journal of psychiatric research. vol 92. 2018-03-27. PMID:28502766. |
serotonin has a well-established role in emotional processing and is a key neurotransmitter in impulsive aggression, presumably by facilitating response inhibition and regulating subcortical reactivity to aversive stimuli. |
2018-03-27 |
2023-08-13 |
Not clear |
| Pieter Schipper, Marloes J A G Henckens, Bart Borghans, Marlies Hiemstra, Tamas Kozicz, Judith R Homber. Prior fear conditioning does not impede enhanced active avoidance in serotonin transporter knockout rats. Behavioural brain research. vol 326. 2018-03-07. PMID:28286283. |
prior fear conditioning does not impede enhanced active avoidance in serotonin transporter knockout rats. |
2018-03-07 |
2023-08-13 |
rat |
| Minmin Luo, Yi Li, Weixin Zhon. Do dorsal raphe 5-HT neurons encode "beneficialness"? Neurobiology of learning and memory. vol 135. 2018-02-09. PMID:27544850. |
however, experimental data so far support several seeming irreconcilable theories, suggesting that 5-ht neurons mediate behavioral inhibition, aversive processing, or reward signaling. |
2018-02-09 |
2023-08-13 |
Not clear |
| Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Tah. The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption. Behavioural brain research. vol 328. 2018-02-07. PMID:28432009. |
the lateral habenula (lhb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (da) and serotonin (5-ht) systems. |
2018-02-07 |
2023-08-13 |
Not clear |
| Andreas Heinz, Florian Schlagenhauf, Anne Beck, Carolin Wackerhage. Dimensional psychiatry: mental disorders as dysfunctions of basic learning mechanisms. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 8. 2018-01-26. PMID:27145766. |
with respect to negative mood states, it has been shown that both reduced functional activation of the ventral striatum elicited by reward-predicting stimuli and stress-associated activation of the hypothalamic-pituitary-adrenal axis in interaction with reduced serotonin transporter availability and increased amygdala activation by aversive cues contribute to clinical depression; altogether these observations support the notion that basic learning mechanisms, such as pavlovian and instrumental conditioning and pavlovian-to-instrumental transfer, represent a basic dimension of mental disorders that can be mechanistically characterized using computational modeling and associated with specific clinical syndromes across established nosological boundaries. |
2018-01-26 |
2023-08-13 |
Not clear |
| Hailan H. Reward and Aversion. Annual review of neuroscience. vol 39. 2018-01-03. PMID:27145915. |
recent progress is pushing the boundaries of knowledge on two major fronts in research on reward and aversion: first, new layers of complexity have been reported on the functions of dopamine (da) and serotonin (5-ht) neuromodulatory systems in reward and aversion. |
2018-01-03 |
2023-08-13 |
Not clear |
| Giuseppe Musumeci, Paola Castrogiovanni, Marta Anna Szychlinska, Rosa Imbesi, Carla Loreto, Sergio Castorina, Salvatore Giunt. Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis. Brain research bulletin. vol 128. 2017-11-21. PMID:27889579. |
considering that loss or reduction in 5-ht neurotransmission may contribute to age-related cognitive decline, here we have investigated the effect of such diet on passive avoidance (pa) behavior, cell death, pro- and anti- apoptotic molecules (bax, bcl-2 and caspase-3) and an important transcription factor involved in synaptic plasticity and memory (creb). |
2017-11-21 |
2023-08-13 |
rat |
| J K Siemann, C L Muller, C G Forsberg, R D Blakely, J Veenstra-VanderWeele, M T Wallac. An autism-associated serotonin transporter variant disrupts multisensory processing. Translational psychiatry. vol 7. issue 3. 2017-11-16. PMID:28323282. |
a gain-of-function coding variant in the serotonin transporter (sert) associates with sensory aversion in humans, and when expressed in mice produces traits associated with asd, including disruptions in social and communicative function and repetitive behaviors. |
2017-11-16 |
2023-08-13 |
mouse |
| Marit Sijbrandij, Annet Kleiboer, Jonathan I Bisson, Corrado Barbui, Pim Cuijper. Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. The lancet. Psychiatry. vol 2. issue 5. 2017-10-03. PMID:26360285. |
this is the first systematic review to examine the effects of pharmacotherapies (eg, β blockers, hydrocortisone, and selective serotonin re-uptake inhibitors) given within the first month after a traumatic or aversive event to prevent ptsd or asd compared with no pharmacotherapy or placebo control. |
2017-10-03 |
2023-08-13 |
Not clear |
| Anand Kumar Singh, Joanna Zajdel, Elahe Mirrasekhian, Nader Almoosawi, Isabell Frisch, Anna M Klawonn, Maarit Jaarola, Michael Fritz, David Engblo. Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. The Journal of clinical investigation. vol 127. issue 4. 2017-09-12. PMID:28287401. |
further, mice lacking the prostaglandin e2 receptor ep3 selectively on serotonergic cells or selectively in the area of the dorsal raphe nucleus failed to form an aversion to formalin-induced pain, as did mice lacking the serotonin transporter. |
2017-09-12 |
2023-08-13 |
mouse |
| Catherine A Marcinkiewcz, Christopher M Mazzone, Giuseppe D'Agostino, Lindsay R Halladay, J Andrew Hardaway, Jeffrey F DiBerto, Montserrat Navarro, Nathan Burnham, Claudia Cristiano, Cayce E Dorrier, Gregory J Tipton, Charu Ramakrishnan, Tamas Kozicz, Karl Deisseroth, Todd E Thiele, Zoe A McElligott, Andrew Holmes, Lora K Heisler, Thomas L Kas. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. vol 537. issue 7618. 2017-03-14. PMID:27556938. |
however, the precise circuits have not yet been defined through which aversive states are orchestrated by 5-ht. |
2017-03-14 |
2023-08-13 |
Not clear |
| V P Nikitin, S V Solntseva, S A Kozyre. Dynamics of the Development of Amnesia Caused by Disruption of Memory Reconsolidation by Neurotransmitter Receptors Antagonists. Bulletin of experimental biology and medicine. vol 160. issue 5. 2017-01-09. PMID:27021109. |
disruption of reconsolidation of conditioned food aversion memory by antagonists of serotonin or nmda glutamate receptors led to the development of different types of amnesia that had similar strengthening gradient at the early stages, but differed by the possibility of memory formation during re-training at the late stage. |
2017-01-09 |
2023-08-13 |
Not clear |
| Ruey-Kuang Cheng, Seetha Krishnan, Suresh Jesuthasa. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Scientific reports. vol 6. 2016-12-30. PMID:26868164. |
pharmacological inhibition of serotonin synthesis reduces dark avoidance, indicating an involvement of this neuromodulator. |
2016-12-30 |
2023-08-13 |
zebrafish |
| Marco Bocchio, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogn. Serotonin, Amygdala and Fear: Assembling the Puzzle. Frontiers in neural circuits. vol 10. 2016-10-31. PMID:27092057. |
since 5-ht release increases in the basolateral amygdala (bla) during both fear memory acquisition and expression, we examine whether and how 5-ht neurons encode aversive stimuli and aversive cues. |
2016-10-31 |
2023-08-13 |
Not clear |
| N Ahmadi-Mahmoodabadi, M Nasehi, M Emam Ghoreishi, M-R Zarrindas. Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis. Neuroscience. vol 317. 2016-10-24. PMID:26701293. |
the present study investigated the influence of bilateral post-training intra-prelimbic (pl) administrations of serotonergic 5-hydroxytryptamine type-3 (5-ht3) receptor agents on arachidonylcyclopropylamide (acpa) (cannabinoid cb1 receptor agonist)-induced amnesia, using the step-through inhibitory avoidance (ia) task to assess memory in adult male sprague-dawley rats. |
2016-10-24 |
2023-08-13 |
rat |
| E E Palmer, M Leffler, C Rogers, M Shaw, R Carroll, J Earl, N W Cheung, B Champion, H Hu, S A Haas, V M Kalscheuer, J Gecz, M Fiel. New insights into Brunner syndrome and potential for targeted therapy. Clinical genetics. vol 89. issue 1. 2016-10-13. PMID:25807999. |
cautious treatment with a serotonin reuptake inhibitor, dietary modifications and avoidance of medications contraindicated in patients on monoamine oxidase inhibitors can improve symptoms. |
2016-10-13 |
2023-08-13 |
Not clear |
| Masaki Iwai, Yoshikage Muroi, Ken-ichi Kinoshita, Toshiaki Ishi. Serotonin modulates the dehydration-induced changes in tolerance for bitter water. Physiology & behavior. vol 151. 2016-06-28. PMID:26325013. |
moreover, administration of paroxetine, a selective serotonin reuptake inhibitor, decreased the intake of quinine solution, but not water, in mice deprived of water for 48 h, indicating that paroxetine treatment restored the aversion to quinine. |
2016-06-28 |
2023-08-13 |
mouse |
| Felipe Corchs, David J Nutt, Dana A Hince, Simon J C Davies, Marcio Bernik, Sean D Hoo. Evidence for serotonin function as a neurochemical difference between fear and anxiety disorders in humans? Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26187054. |
in accordance with this view, our results give support to a dissociation of the disorders traditionally grouped under fear and anxiety-related disorders in terms of different roles of serotonin in modulation of responses to aversive stimulation. |
2016-06-23 |
2023-08-13 |
Not clear |
| Stephen J Bonasera, A Katrin Schenk, Evan J Luxenberg, Xidao Wang, Allan Basbaum, Laurence H Tecot. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PloS one. vol 10. issue 12. 2016-06-23. PMID:26630489. |
mice lacking serotonin 2c receptors have increased affective responses to aversive stimuli. |
2016-06-23 |
2023-08-13 |
mouse |
| Sudhakar Selvaraj, Elias Mouchlianitis, Paul Faulkner, Federico Turkheimer, Philip J Cowen, Jonathan P Roiser, Oliver Howe. Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study. Biological psychiatry. vol 78. issue 8. 2016-06-09. PMID:24882568. |
the amygdala is a central node in the brain network that processes aversive emotions and is extensively innervated by dorsal raphe nucleus (drn) serotonin (5-hydroxytryptamine [5-ht]) neurons. |
2016-06-09 |
2023-08-13 |
Not clear |