| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Audi, J C de Aguiar, F G Graef. Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159666. |
previously reported results indicate that serotonin (5-ht) inhibits the neural sub strate of aversion in the dorsal midbrain central grey (dcg) of the rat. |
2012-10-02 |
2023-08-12 |
rat |
| E A Audi, J C de Aguiar, F G Graef. Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159666. |
in addition, the present results show that microinjection of the 5-ht uptake inhibitor zimelidine (100 nmol) into the dcg of rats with chronically implanted chemitrodes raised the threshold of aversive electrical stimulation. |
2012-10-02 |
2023-08-12 |
rat |
| A Rex, C A Marsden, H Fin. 5-HT 1A receptors and changes in extracellular 5-HT in the guinea-pig prefrontal cortex: involvement in aversive behaviour. Journal of psychopharmacology (Oxford, England). vol 7. issue 4. 2012-10-02. PMID:22290997. |
5-ht 1a receptors and changes in extracellular 5-ht in the guinea-pig prefrontal cortex: involvement in aversive behaviour. |
2012-10-02 |
2023-08-12 |
rat |
| A Rex, C A Marsden, H Fin. 5-HT 1A receptors and changes in extracellular 5-HT in the guinea-pig prefrontal cortex: involvement in aversive behaviour. Journal of psychopharmacology (Oxford, England). vol 7. issue 4. 2012-10-02. PMID:22290997. |
the results show that an increase in cortical extracellular 5-ht occurs in the saline- treated guinea-pig exposed to aversive conditions. |
2012-10-02 |
2023-08-12 |
rat |
| A Rex, H Fink, M Skingle, C A Marsde. Involvement of 5 -HT1D receptors in cortical extracellular 5-HT release in guinea-pigs on exposure to the elevated plus maze. Journal of psychopharmacology (Oxford, England). vol 10. issue 3. 2012-10-02. PMID:22302948. |
under aversive conditions, exposure to the elevated plus maze, the release of extracellular 5-ht increased (155% of basal release), an effect abolished by 5-ct. pre-treatment with the selective 5.ht(1d) antagonist gr 127935 antagonized the effect of 5-ct on the aversion-induced increase in extracellular 5-ht on exposure to the elevated plus maze, but did not change the effects of 5-ct on basal 5-ht release. |
2012-10-02 |
2023-08-12 |
rat |
| A Rex, H Fink, M Skingle, C A Marsde. Involvement of 5 -HT1D receptors in cortical extracellular 5-HT release in guinea-pigs on exposure to the elevated plus maze. Journal of psychopharmacology (Oxford, England). vol 10. issue 3. 2012-10-02. PMID:22302948. |
furthermore, the results indicate that the 5-ht( 1d) receptor in the frontal cortex is functionally active under aversive conditions. |
2012-10-02 |
2023-08-12 |
rat |
| Davide Amato, Sridhar Natesan, Leonid Yavich, Shitij Kapur, Christian P Mülle. Dynamic regulation of dopamine and serotonin responses to salient stimuli during chronic haloperidol treatment. The international journal of neuropsychopharmacology. vol 14. issue 10. 2012-07-30. PMID:21281560. |
dopamine and serotonin basal levels and responses to novelty, appetitive food, and to an aversive tail pinch were measured in the prefrontal cortex, nucleus accumbens and caudate putamen using in-vivo microdialysis, and the behaviour was recorded. |
2012-07-30 |
2023-08-12 |
human |
| Ming Li, Tao Sun, Alexa Mea. Clozapine, but not olanzapine, disrupts conditioned avoidance response in rats by antagonizing 5-HT2A/2C receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:21986871. |
the present study was designed to assess the role of 5-ht(2a/2c) receptors in the acute and repeated effect of clozapine and olanzapine in a rat conditioned avoidance response model, a validated model of antipsychotic activity. |
2012-07-30 |
2023-08-12 |
rat |
| Ming Li, Tao Sun, Alexa Mea. Clozapine, but not olanzapine, disrupts conditioned avoidance response in rats by antagonizing 5-HT2A/2C receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:21986871. |
those who acquired avoidance response were administered with clozapine (10.0 mg/kg, sc) or olanzapine (1.0 mg/kg, sc) together with either saline or 1-2,5-dimethoxy-4-iodo-amphetamine (doi, a selective 5-ht(2a/2c) agonist, 1.0 or 2.5 mg/kg, sc), and their conditioned avoidance responses were tested for four consecutive days. |
2012-07-30 |
2023-08-12 |
rat |
| Ming Li, Tao Sun, Alexa Mea. Clozapine, but not olanzapine, disrupts conditioned avoidance response in rats by antagonizing 5-HT2A/2C receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:21986871. |
these results confirmed our previous findings and suggest that clozapine, but not olanzapine, acts on through 5-ht(2a/2c) receptors to achieve its acute avoidance disruptive effect and likely its therapeutic effects. |
2012-07-30 |
2023-08-12 |
rat |
| Steven J Shabel, Christophe D Proulx, Anthony Trias, Ryan T Murphy, Roberto Malino. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. vol 74. issue 3. 2012-07-12. PMID:22578499. |
input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. |
2012-07-12 |
2023-08-12 |
Not clear |
| Julie Espallergues, Sarah L Teegarden, Avin Veerakumar, Janette Boulden, Collin Challis, Jeanine Jochems, Michael Chan, Tess Petersen, Evan Deneris, Patrick Matthias, Chang-Gyu Hahn, Irwin Lucki, Sheryl G Beck, Olivier Berto. HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457490. |
serotonin-selective depletion of hdac6 also blocked the expression of social avoidance in mice exposed to chronic social defeat and concurrently prevented the electrophysiological and morphological changes induced, in serotonin neurons, by this murine model of traumatic stress. |
2012-05-18 |
2023-08-12 |
mouse |
| Alisa R Kosheleff, Millie Grimes, Steve J O'Dell, John F Marshall, Alicia Izquierd. Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:21643674. |
work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. |
2012-05-01 |
2023-08-12 |
rat |
| Oliver J Robinson, Roshan Cools, Barbara J Sahakia. Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:21769566. |
this provided evidence for a valence-specific role of serotonin (which declines under depleted tryptophan) in aversive processing. |
2012-05-01 |
2023-08-12 |
Not clear |
| M J Crockett, L Clark, L D Smillie, T W Robbin. The effects of acute tryptophan depletion on costly information sampling: impulsivity or aversive processing? Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:22094531. |
the neurotransmitter serotonin (5-ht) has been implicated in both aversive processing and impulsivity. |
2012-05-01 |
2023-08-12 |
Not clear |
| Ross A McDevitt, John F Neumaie. Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21620956. |
experiments targeting 5-ht autoreceptors in awake, behaving animals have generally shown that increasing autoreceptor feedback is anxiolytic and rewarding, while enhanced 5-ht function is aversive and anxiogenic; however, the role of serotonergic activity in behavioral models of helplessness is more complex. |
2012-02-22 |
2023-08-12 |
Not clear |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
5-ht(2a) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated t-maze. |
2012-02-09 |
2023-08-12 |
rat |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
we evaluated the effects of intra-dorsolateral septum (dls) injections of the preferential 5-ht(2a) receptor agonist doi (8 and 16nmol), the 5-ht(2c) selective agonist mk-212 (0.1 and 1nmol) and the preferential 5-ht(2a) antagonist ketanserin (10 and 20nmol) in rats exposed to the elevated t-maze (etm), a model which allows the measurement of two defensive responses: inhibitory avoidance and escape. |
2012-02-09 |
2023-08-12 |
rat |
| D C de Paula, A S Torricelli, M R Lopreato, J O G Nascimento, M B Vian. 5-HT(2A) receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21907244. |
the data suggests that dls 5-ht(2a) receptors are involved in the control of inhibitory avoidance and that a failure in this mechanism may be of importance to the physiopathology of generalized anxiety. |
2012-02-09 |
2023-08-12 |
rat |
| Elizabeth J P O'Nions, Raymond J Dolan, Jonathan P Roise. Serotonin transporter genotype modulates subgenual response to fearful faces using an incidental task. Journal of cognitive neuroscience. vol 23. issue 11. 2012-02-08. PMID:21568644. |
the findings are discussed in relation to the role of sgacc and serotonin in moderating responses to aversive stimuli [dayan, p., & huys, q. j., serotonin, inhibition, and negative mood. |
2012-02-08 |
2023-08-12 |
human |